{"id":131400,"date":"2025-08-08T15:34:40","date_gmt":"2025-08-08T08:34:40","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=131400"},"modified":"2025-12-24T23:19:03","modified_gmt":"2025-12-24T16:19:03","slug":"pantoprazol-40mg-domesco","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/pantoprazol-40mg-domesco\/","title":{"rendered":"Pantoprazol 40mg Domesco"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> Pantoprazol 40mg Domesco \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-23901-15.<\/strong><\/p>\n

Pantoprazol 40mg Domesco l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

M\u1ed7i vi\u00ean n\u00e9n Pantoprazol 40mg Domesco<\/strong> ch\u1ee9a Pantoprazol<\/strong> natri t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 40mg Pantoprazol.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n

S\u0110K: VD-23901-15<\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim tan trong ru\u1ed9t<\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9, 10 v\u1ec9 x 14 vi\u00ean; h\u1ed9p 2 v\u1ec9 x 7 vi\u00ean; h\u1ed9p 3 v\u1ec9, 10 v\u1ec9 x 10 vi\u00ean<\/p>\n

Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n

\"Pantoprazol
Pantoprazol 40mg Domesco \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng<\/figcaption><\/figure>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Pantoprazol 40mg Domesco<\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n

Pantoprazol l\u00e0 m\u1ed9t d\u1eabn xu\u1ea5t c\u1ee7a benzimidazol, c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf chuy\u00ean bi\u1ec7t v\u00e0 kh\u00f4ng h\u1ed3i ph\u1ee5c tr\u00ean b\u01a1m proton. C\u01a1 ch\u1ebf n\u00e0y di\u1ec5n ra t\u1ea1i t\u1ebf b\u00e0o th\u00e0nh c\u1ee7a d\u1ea1 d\u00e0y, n\u01a1i Pantoprazol \u0111\u01b0\u1ee3c ho\u1ea1t h\u00f3a trong m\u00f4i tr\u01b0\u1eddng acid c\u1ee7a c\u00e1c \u1ed1ng ti\u1ebft, chuy\u1ec3n th\u00e0nh d\u1ea1ng sulfenamid c\u00f3 ho\u1ea1t t\u00ednh. Ch\u1ea5t n\u00e0y sau \u0111\u00f3 li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi c\u00e1c nh\u00f3m sulfhydryl c\u1ee7a enzyme H+\/K+-ATPase (b\u01a1m proton).<\/p>\n

Enzyme H+\/K+-ATPase l\u00e0 kh\u00e2u cu\u1ed1i c\u00f9ng trong chu tr\u00ecnh s\u1ea3n xu\u1ea5t acid, ch\u1ecbu tr\u00e1ch nhi\u1ec7m b\u01a1m ion H+ (proton) v\u00e0o l\u00f2ng d\u1ea1 d\u00e0y. B\u1eb1ng c\u00e1ch kh\u00f3a ch\u1eb7t enzyme n\u00e0y, Pantoprazol ng\u0103n ch\u1eb7n hi\u1ec7u qu\u1ea3 c\u1ea3 s\u1ef1 ti\u1ebft acid c\u01a1 b\u1ea3n l\u1eabn khi b\u1ecb k\u00edch th\u00edch b\u1edfi b\u1ea5t k\u1ef3 t\u00e1c nh\u00e2n n\u00e0o (th\u1ee9c \u0103n, hormone gastrin, acetylcholin). V\u00ec s\u1ef1 \u1ee9c ch\u1ebf n\u00e0y l\u00e0 kh\u00f4ng h\u1ed3i ph\u1ee5c, qu\u00e1 tr\u00ecnh ti\u1ebft acid ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u1ee5c h\u1ed3i khi c\u00e1c b\u01a1m proton m\u1edbi \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p, gi\u1ea3i th\u00edch t\u1ea1i sao t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd m\u1eb7c d\u00f9 th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng kh\u00e1 ng\u1eafn (kho\u1ea3ng 0.7 – 1.9 gi\u1edd).<\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

H\u1ea5p thu: Pantoprazol \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng sau khi u\u1ed1ng. D\u1ea1ng b\u00e0o ch\u1ebf vi\u00ean bao tan trong ru\u1ed9t gi\u00fap b\u1ea3o v\u1ec7 ho\u1ea1t ch\u1ea5t kh\u1ecfi m\u00f4i tr\u01b0\u1eddng acid d\u1ea1 d\u00e0y v\u00e0 ch\u1ec9 tan ra \u1edf ru\u1ed9t non. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng \u0111\u1ea1t kho\u1ea3ng 77%.<\/p>\n

Ph\u00e2n b\u1ed1: Thu\u1ed1c li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (kho\u1ea3ng 98%).<\/p>\n

Chuy\u1ec3n h\u00f3a: Pantoprazol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu t\u1ea1i gan th\u00f4ng qua h\u1ec7 enzyme Cytochrom P450, m\u00e0 c\u1ee5 th\u1ec3 l\u00e0 isoenzyme CYP2C19. Nh\u1eefng ng\u01b0\u1eddi thi\u1ebfu h\u1ee5t enzyme n\u00e0y do di truy\u1ec1n (ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a ch\u1eadm) c\u00f3 th\u1ec3 c\u00f3 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u cao h\u01a1n v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i h\u01a1n.<\/p>\n

Th\u1ea3i tr\u1eeb: C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (kho\u1ea3ng 80%), ph\u1ea7n c\u00f2n l\u1ea1i qua m\u1eadt v\u00e0 ph\u00e2n.<\/p>\n

Thu\u1ed1c Pantoprazol 40mg Domesco \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n (GERD): \u0110i\u1ec1u tr\u1ecb v\u00e0 l\u00e0m gi\u1ea3m tri\u1ec7u ch\u1ee9ng \u1ee3 n\u00f3ng, \u1ee3 chua, kh\u00f3 nu\u1ed1t.<\/p>\n

Lo\u00e9t d\u1ea1 d\u00e0y – t\u00e1 tr\u00e0ng: Th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh l\u00e0nh v\u1ebft lo\u00e9t.<\/p>\n

Ph\u1ed1i h\u1ee3p trong ph\u00e1c \u0111\u1ed3 di\u1ec7t tr\u1eeb Helicobacter pylori<\/em>: K\u1ebft h\u1ee3p v\u1edbi kh\u00e1ng sinh \u0111\u1ec3 lo\u1ea1i b\u1ecf vi khu\u1ea9n H. pylori<\/em>, m\u1ed9t nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y lo\u00e9t v\u00e0 vi\u00eam d\u1ea1 d\u00e0y.<\/p>\n

H\u1ed9i ch\u1ee9ng Zollinger-Ellison: \u0110i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft acid b\u1ec7nh l\u00fd do kh\u1ed1i u \u1edf t\u1ee5y ho\u1eb7c t\u00e1 tr\u00e0ng.<\/p>\n

D\u1ef1 ph\u00f2ng lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng do s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID).<\/p>\n

Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Pantoprazol 40mg Domesco<\/h2>\n

Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n (GERD): 20 – 40 mg\/l\u1ea7n\/ng\u00e0y, trong 4-8 tu\u1ea7n.<\/p>\n

Lo\u00e9t d\u1ea1 d\u00e0y – t\u00e1 tr\u00e0ng: 40 mg\/l\u1ea7n\/ng\u00e0y, trong 2-4 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t t\u00e1 tr\u00e0ng v\u00e0 4-8 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t d\u1ea1 d\u00e0y.<\/p>\n

Di\u1ec7t tr\u1eeb H. pylori<\/em>: 40 mg x 2 l\u1ea7n\/ng\u00e0y, ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c kh\u00e1ng sinh ph\u00f9 h\u1ee3p trong 1 tu\u1ea7n.<\/p>\n

H\u1ed9i ch\u1ee9ng Zollinger-Ellison: Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u01b0\u1eddng l\u00e0 80 mg\/ng\u00e0y, c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u0103ng l\u00ean t\u00f9y theo \u0111\u00e1p \u1ee9ng.<\/p>\n

C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Pantoprazol 40mg Domesco<\/h2>\n

Vi\u1ec7c tu\u00e2n th\u1ee7 \u0111\u00fang c\u00e1ch d\u00f9ng l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t \u0111\u1ec3 thu\u1ed1c ph\u00e1t huy hi\u1ec7u qu\u1ea3 t\u1ed1i \u0111a:<\/p>\n