{"id":127066,"date":"2025-07-15T08:44:47","date_gmt":"2025-07-15T01:44:47","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=127066"},"modified":"2025-07-24T11:46:17","modified_gmt":"2025-07-24T04:46:17","slug":"bifril-15mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/bifril-15mg\/","title":{"rendered":"Bifril 15mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Bifril 15mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi A. Menarini Manufacturing Logistics and Services S.r.l c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110088023 (S\u0110K c\u0169: VN3-33-18)<\/strong><\/p>\n<h2>Bifril 15mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Bifril 15mg<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<p>Zofenopril calcium t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 15 mg zofenopril<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 800110088023 (S\u0110K c\u0169: VN3-33-18)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u00dd<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Bifril 15mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Zofenopril l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t thu\u1ed9c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE), c\u00f3 kh\u1ea3 n\u0103ng chuy\u1ec3n h\u00f3a nhanh ch\u00f3ng th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 zofenoprilat sau khi v\u00e0o c\u01a1 th\u1ec3. C\u01a1 ch\u1ebf ch\u00ednh l\u00e0 ng\u0103n ch\u1eb7n enzym chuy\u1ec3n angiotensin I th\u00e0nh angiotensin II \u2013 ch\u1ea5t g\u00e2y co m\u1ea1ch m\u1ea1nh, nh\u1edd \u0111\u00f3 l\u00e0m gi\u00e3n m\u1ea1ch m\u00e1u, gi\u1ea3m s\u1ee9c c\u1ea3n ngo\u1ea1i vi v\u00e0 h\u1ea1 huy\u1ebft \u00e1p. \u0110\u1ed3ng th\u1eddi, zofenopril c\u0169ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 kallikrein-kinin v\u00e0 l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh prostaglandin \u2013 m\u1ed9t y\u1ebfu t\u1ed1 g\u00f3p ph\u1ea7n v\u00e0o hi\u1ec7u qu\u1ea3 gi\u00e3n m\u1ea1ch v\u00e0 gi\u1ea3m huy\u1ebft \u00e1p.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Zofenopril h\u1ea5p thu g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh zofenoprilat trong v\u00f2ng kho\u1ea3ng 1,5 gi\u1edd. T\u00e1c d\u1ee5ng thu\u1ed1c th\u1ec3 hi\u1ec7n r\u00f5 t\u1eeb li\u1ec1u 10\u201380 mg theo \u0111\u01b0\u1eddng u\u1ed1ng m\u00e0 kh\u00f4ng t\u00edch l\u0169y trong c\u01a1 th\u1ec3. Th\u1ee9c \u0103n c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm th\u1eddi gian h\u1ea5p thu nh\u01b0ng kh\u00f4ng l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 sinh kh\u1ea3 d\u1ee5ng. Zofenopril ho\u1ea1t \u0111\u1ed9ng ch\u1ee7 y\u1ebfu qua th\u1ea3i tr\u1eeb qua th\u1eadn v\u00e0 m\u1ed9t ph\u1ea7n qua gan, v\u00ec v\u1eady c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u \u1edf m\u1ed9t s\u1ed1 nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t.<\/p>\n<h2>Thu\u1ed1c Bifril 15mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p (nh\u1eb9-trung b\u00ecnh)<\/li>\n<li>H\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb \u1edf b\u1ec7nh nh\u00e2n nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p t\u00ednh trong v\u00f2ng 24 gi\u1edd k\u1ec3 t\u1eeb khi kh\u1edfi ph\u00e1t tri\u1ec7u ch\u1ee9ng, b\u1ea5t k\u1ec3 c\u00f3 hay kh\u00f4ng bi\u1ec3u hi\u1ec7n suy tim, mi\u1ec5n l\u00e0 huy\u1ebft \u0111\u1ed9ng \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u00f4ng d\u00f9ng thu\u1ed1c ti\u00eau s\u1ee3i huy\u1ebft.<\/li>\n<\/ul>\n<figure id=\"attachment_127069\" aria-describedby=\"caption-attachment-127069\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-127069\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Bifril-15mg.jpg\" alt=\"Bifril 15mg\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Bifril-15mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Bifril-15mg-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Bifril-15mg-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Bifril-15mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-127069\" class=\"wp-caption-text\">Thu\u1ed1c Bifril 15mg thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE inhibitor) d\u00f9ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00e0 h\u1ed7 tr\u1ee3 c\u1ea3i thi\u1ec7n ti\u00ean l\u01b0\u1ee3ng cho b\u1ec7nh nh\u00e2n v\u1eeba tr\u1ea3i qua nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p><span style=\"text-decoration: underline;\"><em><strong>T\u0103ng huy\u1ebft \u00e1p:<\/strong><\/em><\/span><\/p>\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 15 mg\/l\u1ea7n\/ng\u00e0y \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 r\u1ed1i lo\u1ea1n n\u01b0\u1edbc\u2013\u0111i\u1ec7n gi\u1ea3i.<\/li>\n<li>Li\u1ec1u duy tr\u00ec th\u00f4ng th\u01b0\u1eddng: 30 mg\/ng\u00e0y d\u00f9ng 1 l\u1ea7n.<\/li>\n<li>Li\u1ec1u t\u1ed1i \u0111a: 60 mg\/ng\u00e0y, c\u00f3 th\u1ec3 chia th\u00e0nh 1\u20132 l\u1ea7n.<\/li>\n<li>B\u1ec7nh nh\u00e2n b\u1ecb m\u1ea5t mu\u1ed1i ho\u1eb7c m\u1ea5t n\u01b0\u1edbc n\u00ean \u0111\u01b0\u1ee3c b\u00f9 tr\u01b0\u1edbc khi d\u00f9ng ho\u1eb7c b\u1eaft \u0111\u1ea7u li\u1ec1u th\u1ea5p h\u01a1n (7,5 mg\/ng\u00e0y).<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\"><em><strong>Nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p:<\/strong><\/em><\/span><\/p>\n<ul>\n<li>Ng\u00e0y 1\u20132: 7,5 mg m\u1ed7i 12 gi\u1edd.<\/li>\n<li>Ng\u00e0y 3\u20134: 15 mg m\u1ed7i 12 gi\u1edd.<\/li>\n<li>T\u1eeb ng\u00e0y 5: 30 mg m\u1ed7i 12 gi\u1edd, duy tr\u00ec li\u00ean t\u1ee5c trong 6 tu\u1ea7n.<\/li>\n<li>N\u1ebfu huy\u1ebft \u00e1p t\u00e2m thu \u2264120 mmHg, n\u00ean tr\u00ec ho\u00e3n t\u0103ng li\u1ec1u. Ng\u1eebng thu\u1ed1c n\u1ebfu huy\u1ebft \u00e1p gi\u1ea3m nghi\u00eam tr\u1ecdng (&lt;90 mmHg li\u00ean t\u1ee5c).<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\">Suy th\u1eadn:<\/span><\/p>\n<ul>\n<li>\u0110\u1ed9 thanh th\u1ea3i creatinin &gt; 45 ml\/ph\u00fat: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/li>\n<li>\u0110\u1ed9 thanh th\u1ea3i &lt; 45 ml\/ph\u00fat: D\u00f9ng 1\/2 li\u1ec1u th\u00f4ng th\u01b0\u1eddng.<\/li>\n<li>\u0110ang th\u1ea9m t\u00e1ch: D\u00f9ng 1\/4 li\u1ec1u so v\u1edbi b\u1ec7nh nh\u00e2n b\u00ecnh th\u01b0\u1eddng.<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\">Ng\u01b0\u1eddi cao tu\u1ed5i:<\/span><\/p>\n<ul>\n<li>N\u1ebfu ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng: D\u00f9ng li\u1ec1u nh\u01b0 ng\u01b0\u1eddi l\u1edbn.<\/li>\n<li>N\u1ebfu c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn: Gi\u1ea3m c\u00f2n 1\/2 li\u1ec1u.<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\">Suy gan:<\/span><\/p>\n<ul>\n<li>Suy gan nh\u1eb9\u2013trung b\u00ecnh: D\u00f9ng 1\/2 li\u1ec1u ban \u0111\u1ea7u.<\/li>\n<li>Suy gan n\u1eb7ng: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<\/ul>\n<p><span style=\"text-decoration: underline;\">Tr\u1ebb em:<\/span><\/p>\n<p>Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u2192 Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Bifril c\u00f3 th\u1ec3 u\u1ed1ng v\u00e0o b\u1ea5t k\u1ef3 th\u1eddi \u0111i\u1ec3m n\u00e0o trong ng\u00e0y, kh\u00f4ng ph\u1ee5 thu\u1ed9c b\u1eefa \u0103n. Tuy nhi\u00ean, c\u1ea7n tu\u00e2n theo h\u01b0\u1edbng d\u1eabn v\u1ec1 li\u1ec1u v\u00e0 th\u1eddi \u0111i\u1ec3m t\u0103ng li\u1ec1u \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Bifril 15mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>D\u1ecb \u1ee9ng v\u1edbi zofenopril, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n kh\u00e1c ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u00f3 trong <strong>vi\u00ean n\u00e9n Bifril 15mg<\/strong><\/li>\n<li>Ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch li\u00ean quan \u0111\u1ebfn ACE inhibitor.<\/li>\n<li>Suy gan n\u1eb7ng.<\/li>\n<li>Ph\u1ee5 n\u1eef mang thai trong 3 th\u00e1ng gi\u1eefa v\u00e0 cu\u1ed1i thai k\u1ef3.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai nh\u01b0ng kh\u00f4ng \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3.<\/li>\n<li>B\u1ec7nh nh\u00e2n h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn hai b\u00ean ho\u1eb7c m\u1ed9t b\u00ean khi ch\u1ec9 c\u00f2n m\u1ed9t th\u1eadn.<\/li>\n<li>Ph\u1ed1i h\u1ee3p v\u1edbi aliskiren \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn n\u1eb7ng (GFR &lt; 60 ml\/ph\u00fat\/1,73m\u00b2).<\/li>\n<li>Ph\u00f9 m\u1ea1ch b\u1ea9m sinh ho\u1eb7c ph\u00f9 m\u1ea1ch v\u00f4 c\u0103n<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Theo d\u00f5i huy\u1ebft \u00e1p, \u0111i\u1ec7n gi\u1ea3i v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Bifril 15mg \u1edf ng\u01b0\u1eddi c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn k\u00e9m, m\u1ea5t n\u01b0\u1edbc ho\u1eb7c d\u00f9ng c\u00f9ng c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb huy\u1ebft \u00e1p kh\u00e1c<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: th\u01b0\u1eddng g\u1eb7p l\u00e0 ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u; \u00edt g\u1eb7p h\u01a1n l\u00e0 d\u1ecb c\u1ea3m, m\u1ea5t ng\u1ee7 ho\u1eb7c thay \u0111\u1ed5i v\u1ecb gi\u00e1c.<\/li>\n<li>H\u00f4 h\u1ea5p: ho khan dai d\u1eb3ng l\u00e0 t\u00e1c d\u1ee5ng \u0111i\u1ec3n h\u00ecnh; \u0111\u00f4i khi c\u00f3 kh\u00f3 th\u1edf, vi\u00eam ph\u1ebf qu\u1ea3n ho\u1eb7c ph\u00f9 thanh qu\u1ea3n.<\/li>\n<li>Ti\u00eau h\u00f3a: bu\u1ed3n n\u00f4n, n\u00f4n l\u00e0 ph\u1ed5 bi\u1ebfn; c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, vi\u00eam t\u1ee5y ho\u1eb7c vi\u00eam ru\u1ed9t.<\/li>\n<li>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: ph\u00e1t ban, ng\u1ee9a, m\u1ec1 \u0111ay, hi\u1ebfm h\u01a1n l\u00e0 h\u1ed9i ch\u1ee9ng Stevens-Johnson, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec ho\u1eb7c r\u1ee5ng t\u00f3c.<\/li>\n<li>Huy\u1ebft h\u1ecdc: gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh t\u1ef1 mi\u1ec5n.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng d\u00f9ng insulin ho\u1eb7c sulfonylurea.<\/li>\n<li>Tim m\u1ea1ch: h\u1ea1 huy\u1ebft \u00e1p, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c ho\u1eb7c r\u1ed1i lo\u1ea1n nh\u1ecbp tim, \u0111\u1eb7c bi\u1ec7t khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c t\u0103ng li\u1ec1u.<\/li>\n<li>Th\u1eadn: t\u0103ng creatinin v\u00e0 ure huy\u1ebft, n\u1eb7ng h\u01a1n c\u00f3 th\u1ec3 l\u00e0 suy th\u1eadn c\u1ea5p, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi b\u1ec7nh m\u1ea1ch th\u1eadn ho\u1eb7c d\u00f9ng k\u1ebft h\u1ee3p NSAID.<\/li>\n<li>Sinh d\u1ee5c: m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm ghi nh\u1eadn r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng.<\/li>\n<li>Kh\u00e1c: m\u1ec7t m\u1ecfi, y\u1ebfu c\u01a1, \u0111au ng\u1ef1c, ph\u00f9 ngo\u1ea1i vi.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>C\u00e1c ph\u1ed1i h\u1ee3p c\u1ea7n tr\u00e1nh:<\/p>\n<ul>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, ch\u1ea5t b\u1ed5 sung kali ho\u1eb7c mu\u1ed1i ch\u1ee9a kali: S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 g\u00e2y t\u0103ng kali huy\u1ebft nghi\u00eam tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/li>\n<li>Aliskiren ho\u1eb7c thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II (ARB): L\u00e0m t\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p, t\u0103ng kali v\u00e0 gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c c\u00f3 b\u1ec7nh th\u1eadn m\u1ea1n.<\/li>\n<\/ul>\n<p>T\u01b0\u01a1ng t\u00e1c c\u1ea7n c\u00e2n nh\u1eafc khi ph\u1ed1i h\u1ee3p:<\/p>\n<ul>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u quai ho\u1eb7c thiazid: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c, g\u00e2y h\u1ea1 \u00e1p m\u1ea1nh; n\u00ean ng\u01b0ng ho\u1eb7c gi\u1ea3m li\u1ec1u tr\u01b0\u1edbc khi d\u00f9ng Bifril.<\/li>\n<li>Lithi: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a lithi trong huy\u1ebft t\u01b0\u01a1ng; tr\u00e1nh d\u00f9ng chung n\u1ebfu kh\u00f4ng th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/li>\n<li>Mu\u1ed1i v\u00e0ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam: T\u0103ng nguy c\u01a1 ph\u1ea3n \u1ee9ng gi\u1ed1ng ph\u1ea3n v\u1ec7 nh\u01b0 \u0111\u1ecf b\u1eebng, ch\u00f3ng m\u1eb7t, t\u1ee5t huy\u1ebft \u00e1p.<\/li>\n<li>Thu\u1ed1c g\u00e2y m\u00ea v\u00e0 an th\u1ea7n (bao g\u1ed3m barbiturat, thu\u1ed1c ng\u1ee7, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng): L\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p, nh\u1ea5t l\u00e0 khi \u0111\u1ee9ng d\u1eady.<\/li>\n<li>Cimetidin: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c b\u1eb1ng c\u00e1ch l\u00e0m ch\u1eadm chuy\u1ec3n h\u00f3a.<\/li>\n<li>Allopurinol, cyclosporin, thu\u1ed1c h\u00f3a tr\u1ecb, thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch: t\u0103ng nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5, \u0111\u1eb7c bi\u1ec7t l\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u.<\/li>\n<li>NSAID (g\u1ed3m aspirin li\u1ec1u cao t\u1eeb 2\u20133g\/ng\u00e0y): L\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng th\u1eadn, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c m\u1ea5t n\u01b0\u1edbc.<\/li>\n<li>Thu\u1ed1c kh\u00e1ng acid: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu thu\u1ed1c qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<li>Thu\u1ed1c gi\u1ed1ng giao c\u1ea3m (sympathomimetic): C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/li>\n<li>L\u1ecdc m\u00e1u b\u1eb1ng d\u00f2ng polyacrylonitril cao: l\u00e0m t\u0103ng nguy c\u01a1 ph\u1ea3n \u1ee9ng b\u1ea3o v\u1ec7 \u2013 n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef mang thai: Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Bifril trong 3 th\u00e1ng \u0111\u1ea7u thai k\u1ef3 v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c giai \u0111o\u1ea1n sau \u0111\u00f3. Thu\u1ed1c c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thai nhi, g\u00e2y ra t\u1ed5n th\u01b0\u01a1ng th\u1eadn, gi\u1ea3m \u1ed1i, h\u1ea1 huy\u1ebft \u00e1p ho\u1eb7c t\u0103ng kali m\u00e1u \u1edf tr\u1ebb s\u01a1 sinh. N\u1ebfu ph\u00e1t hi\u1ec7n c\u00f3 thai khi \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c, c\u1ea7n ng\u01b0ng ngay v\u00e0 chuy\u1ec3n sang li\u1ec7u ph\u00e1p kh\u00e1c an to\u00e0n h\u01a1n.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: Hi\u1ec7n ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 s\u1ef1 b\u00e0i ti\u1ebft c\u1ee7a zofenopril qua s\u1eefa m\u1eb9. V\u00ec l\u00fd do an to\u00e0n, n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y trong th\u1eddi k\u1ef3 cho con b\u00fa v\u00e0 c\u00e2n nh\u1eafc chuy\u1ec3n sang thu\u1ed1c kh\u00e1c c\u00f3 d\u1eef li\u1ec7u an to\u00e0n r\u00f5 r\u00e0ng h\u01a1n.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra t\u00ecnh tr\u1ea1ng m\u1ec7t m\u1ecfi, bu\u1ed3n ng\u1ee7 ho\u1eb7c ch\u00f3ng m\u1eb7t, b\u1ec7nh nh\u00e2n c\u1ea7n th\u1eadn tr\u1ecdng khi \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n giao th\u00f4ng ho\u1eb7c l\u00e0m vi\u1ec7c v\u1edbi m\u00e1y m\u00f3c cho \u0111\u1ebfn khi bi\u1ebft ch\u1eafc thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng ph\u1ea3n x\u1ea1 v\u00e0 t\u1ec9nh t\u00e1o c\u1ee7a b\u1ea3n th\u00e2n.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u Bifril th\u01b0\u1eddng g\u00e2y t\u1ee5t huy\u1ebft \u00e1p m\u1ea1nh, nh\u1ecbp tim ch\u1eadm, m\u1ec7t m\u1ecfi, r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i, c\u00f3 th\u1ec3 d\u1eabn t\u1edbi m\u1ea5t \u00fd th\u1ee9c ho\u1eb7c suy th\u1eadn c\u1ea5p.<\/p>\n<p>C\u00e1ch x\u1eed tr\u00ed:<\/p>\n<ul>\n<li>N\u1ebfu c\u00f2n s\u1edbm (m\u1edbi ph\u00e1t hi\u1ec7n qu\u00e1 li\u1ec1u) c\u00f3 th\u1ec3 r\u1eeda d\u1ea1 d\u00e0y (b\u1eb1ng than ho\u1ea1t v\u00e0 natri sulfat)<\/li>\n<li>Theo d\u00f5i ch\u1eb7t ch\u1ebd huy\u1ebft \u00e1p, nh\u1ecbp tim, \u0111i\u1ec7n gi\u1ea3i v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Trong tr\u01b0\u1eddng h\u1ee3p t\u1ee5t huy\u1ebft \u00e1p n\u1eb7ng, c\u00f3 th\u1ec3 truy\u1ec1n d\u1ecbch \u0111\u1ec3 n\u00e2ng huy\u1ebft \u00e1p ho\u1eb7c s\u1eed d\u1ee5ng thu\u1ed1c v\u1eadn m\u1ea1ch nh\u01b0 angiotensin II n\u1ebfu c\u1ea7n.<\/li>\n<li>R\u1ed1i lo\u1ea1n nh\u1ecbp ch\u1eadm c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng atropin ho\u1eb7c m\u00e1y t\u1ea1o nh\u1ecbp t\u1ea1m th\u1eddi.<\/li>\n<li>Zofenopril c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf m\u1ed9t ph\u1ea7n qua l\u1ecdc m\u00e1u, nh\u01b0ng kh\u00f4ng n\u00ean d\u00f9ng m\u00e0ng l\u1ecdc polyacrylonitril do nguy c\u01a1 s\u1ed1c ph\u1ea3n v\u1ec7.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef Bifril 15mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Bifril 15mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Bifril 15mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Bifril 15mg nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/bifril-30\/\">Bifril 30<\/a> c\u00f3 th\u00e0nh ph\u1ea7n Zofenopril calcium v\u1edbi h\u1ea1m l\u01b0\u1ee3ng cao h\u01a1n l\u00e0 30mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH United International Pharma, d\u00f9ng trong t\u0103ng huy\u1ebft \u00e1p m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn v\u1eeba<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Bifril 15mg \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7<a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/To-huong-dan-su-dung-Bifril-15mg_vnra.pdf\"> t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 4 th\u00e1ng 7 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/drugbank.vn\/thuoc\/Bifril&amp;VN3-33-18\" rel=\"noopener\">https:\/\/drugbank.vn\/thuoc\/Bifril&amp;VN3-33-18<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Bifril 15mg thu\u1ed9c nh\u00f3m \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE inhibitor) d\u00f9ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00e0 h\u1ed7 tr\u1ee3 c\u1ea3i thi\u1ec7n ti\u00ean l\u01b0\u1ee3ng cho b\u1ec7nh nh\u00e2n v\u1eeba tr\u1ea3i qua nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p<\/span><\/p>\n","protected":false},"author":1,"featured_media":127077,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-127066","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/127066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=127066"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/127077"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=127066"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=127066"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=127066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}