{"id":126730,"date":"2025-07-11T15:42:02","date_gmt":"2025-07-11T08:42:02","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=126730"},"modified":"2025-07-24T11:46:25","modified_gmt":"2025-07-24T04:46:25","slug":"calquence-100mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/calquence-100mg\/","title":{"rendered":"Calquence 100mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Calquence 100mg c\u00f3 c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t l\u00e0 AstraZeneca AB, \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 730110017023.<\/strong><\/p>\n<h2>Calquence 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Calquence 100mg<\/strong>\u00a0ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Acalabrutinib 100mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf : Vi\u00ean nang c\u1ee9ng<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 730110017023<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9 x 6 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Th\u1ee5y \u0110i\u1ec3n<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Calquence 100mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Bruton tyrosine kinase l\u00e0 th\u00e0nh ph\u1ea7n g\u1ea7n c\u1ee7a con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u th\u1ee5 th\u1ec3 t\u1ebf b\u00e0o B v\u00e0 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb cho nhi\u1ec1u lo\u1ea1i b\u1ec7nh \u00e1c t\u00ednh t\u1ebf b\u00e0o B. Acalabrutinib t\u1ea1o li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi Cys481 trong t\u00fai li\u00ean k\u1ebft ATP d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf bruton tyrosine kinase kh\u00f4ng h\u1ed3i ph\u1ee5c.<\/p>\n<p>Khi Bruton tyrosine kinase b\u1ecb b\u1ea5t ho\u1ea1t, t\u00edn hi\u1ec7u downstream c\u1ee7a B\u2011cell receptor gi\u1ea3m m\u1ea1nh, th\u1ec3 hi\u1ec7n qua s\u1ef1 gi\u1ea3m phosphoryl h\u00f3a PLC\u03b32, ERK v\u00e0 I\u03baB, t\u1eeb \u0111\u00f3 k\u00ecm h\u00e3m con \u0111\u01b0\u1eddng NF\u2011\u03baB v\u00e0 AKT, l\u00e0m gi\u1ea3m t\u0103ng sinh, di c\u01b0 v\u00e0 kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i c\u1ee7a t\u1ebf b\u00e0o B \u00e1c t\u00ednh. Nh\u1edd \u0111\u00f3 ccalabrutinib \u1ee9c ch\u1ebf m\u1ea1nh s\u1ef1 h\u00ecnh th\u00e0nh kh\u1ed1i u v\u00e0 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian s\u1ed1ng s\u00f3t c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>Kh\u00f4ng gi\u1ed1ng nh\u01b0 ibrutinib, acalabrutinib c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc cao h\u01a1n v\u00e0 kh\u00f4ng \u1ee9c ch\u1ebf c\u00e1c kinase kh\u00e1c, bao g\u1ed3m EGFR, TEC ho\u1eb7c ITK. Nh\u1edd \u0111\u00f3 acalabrutinib \u00edt g\u00e2y ra t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n h\u01a1n ibrutinib.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<h4>H\u1ea5p thu<\/h4>\n<p>Sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 25-40% sau khi u\u1ed1ng.<\/p>\n<h4>Ph\u00e2n b\u1ed1<\/h4>\n<p>Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 101L, li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng<\/p>\n<h4>Chuy\u1ec3n h\u00f3a<\/h4>\n<p>Acalabrutinib \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu b\u1edfi enzyme CYP3A4 (oxi h\u00f3a v\u00f2ng pyrrolidin), k\u00e8m theo li\u00ean k\u1ebft v\u1edbi glutathione v\u00e0 th\u1ee7y ph\u00e2n amid, t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t \u0111\u1ed9ng ACP\u20115862.<\/p>\n<h4>Th\u1ea3i tr\u1eeb<\/h4>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 1-2 gi\u1edd.<\/p>\n<h2>Calquence 100mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p><strong>Calquence 100mg Acalabrutinib<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong :<\/p>\n<ul>\n<li>U lympho t\u1ebf b\u00e0o v\u1ecf (MCL): \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi l\u1edbn \u0111\u00e3 nh\u1eadn \u00edt nh\u1ea5t m\u1ed9t li\u1ec7u ph\u00e1p tr\u01b0\u1edbc \u0111\u00f3 nh\u01b0ng b\u1ec7nh c\u00f2n t\u00e1i ph\u00e1t ho\u1eb7c kh\u00e1ng tr\u1ecb.<\/li>\n<li>B\u1ec7nh b\u1ea1ch c\u1ea7u lympho m\u1ea1n t\u00ednh (CLL) ho\u1eb7c u lympho nh\u1ecf (SLL): \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi l\u1edbn, c\u1ea3 tr\u01b0\u1eddng h\u1ee3p \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3 ho\u1eb7c \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u tay (\u0111\u01a1n \u0111\u1ed9c ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi obinutuzumab).<\/li>\n<\/ul>\n<figure id=\"attachment_126731\" aria-describedby=\"caption-attachment-126731\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-126731\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/calquence-100mg-dieu-tri-u-lympho-te-bao-vo.jpg\" alt=\"Calquence 100mg \u0111i\u1ec1u tr\u1ecb u lympho t\u1ebf b\u00e0o v\u1ecf\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/calquence-100mg-dieu-tri-u-lympho-te-bao-vo.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/calquence-100mg-dieu-tri-u-lympho-te-bao-vo-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/calquence-100mg-dieu-tri-u-lympho-te-bao-vo-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/calquence-100mg-dieu-tri-u-lympho-te-bao-vo-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-126731\" class=\"wp-caption-text\">Calquence 100mg \u0111i\u1ec1u tr\u1ecb u lympho t\u1ebf b\u00e0o v\u1ecf<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Calquence 100mg<\/h2>\n<ul>\n<li>1\u202fvi\u00ean\/l\u1ea7n, 2\u202fl\u1ea7n\/ng\u00e0y<\/li>\n<li>Kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c li\u1ec1u:\u202f12\u202fgi\u1edd<\/li>\n<li>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 d\u1ef1a tr\u00ean t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Calquence 100mg<\/h2>\n<ul>\n<li>Nu\u1ed1t nguy\u00ean vi\u00ean, kh\u00f4ng b\u1ebb, nhai, nghi\u1ec1n hay chia nh\u1ecf.<\/li>\n<li>C\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/li>\n<li>U\u1ed1ng \u0111\u1ee7 li\u1ec1u v\u00e0 \u0111\u00fang gi\u1edd \u0111\u1ec3 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1ed5n \u0111\u1ecbnh trong m\u00e1u.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Calquence 100mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Kh\u00f4ng d\u00f9ng Calquence 100mg cho ng\u01b0\u1eddi c\u00f3 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Tr\u1ebb d\u01b0\u1edbi 18 tu\u1ed5i.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Calquence 100mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Tr\u01b0\u1edbc khi d\u00f9ng Calquence\u202f100\u202fmg, th\u00f4ng b\u00e1o v\u1edbi b\u00e1c s\u0129 n\u1ebfu b\u1ec7nh nh\u00e2n v\u1eeba ph\u1eabu thu\u1eadt ho\u1eb7c c\u00f3 k\u1ebf ho\u1ea1ch ph\u1eabu thu\u1eadt, c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ea3y m\u00e1u, v\u1ea5n \u0111\u1ec1 tim m\u1ea1ch, gan ho\u1eb7c \u0111ang \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i.<\/li>\n<li>Kh\u00f4ng t\u1ef1 \u00fd thay \u0111\u1ed5i li\u1ec1u; lu\u00f4n \u0111\u1ecdc k\u1ef9 v\u00e0 tu\u00e2n th\u1ee7 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Hay g\u1eb7p : nh\u1ee9c \u0111\u1ea7u, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, \u0111au b\u1ee5ng, t\u00e1o\u202fb\u00f3n, n\u00f4n<\/li>\n<li>Th\u01b0\u1eddng g\u1eb7p : m\u1ec7t m\u1ecfi, b\u1ea7m t\u00edm, vi\u00eam ph\u1ed5i<\/li>\n<li>\u00cdt g\u1eb7p : t\u0103ng huy\u1ebft \u00e1p, t\u0103ng creatinine<\/li>\n<li>Hi\u1ebfm g\u1eb7p : r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh khi d\u00f9ng c\u00f9ng ch\u1ea5t \u1ee9c ch\u1ebf CYP3A m\u1ea1nh (ritonavir, itraconazol, ketoconazol) v\u00ec l\u00e0m t\u0103ng di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) acalabrutinib kho\u1ea3ng 5\u202fl\u1ea7n, t\u0103ng nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5.<\/li>\n<li>Kh\u00f4ng ph\u1ed1i h\u1ee3p Calquence 100mg v\u1edbi c\u00e1c NSAIDs (ibuprofen, aspirin), thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u (ticagrelor, clopidogrel, acid acetylsalicylic) ho\u1eb7c thu\u1ed1c kh\u00e1ng \u0111\u00f4ng (warfarin, enoxaparin, apixaban) v\u00ec c\u00f3 th\u1ec3 l\u00e0m gia t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft.<\/li>\n<li>U\u1ed1ng Calquence 100mg c\u00f9ng n\u01b0\u1edbc \u00e9p b\u01b0\u1edfi (\u1ee9c ch\u1ebf men CYP3A ru\u1ed9t) c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ec9nh n\u1ed3ng \u0111\u1ed9 acalabrutinib, c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tr\u00e1nh.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng d\u00f9ng Calquence 100mg cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/p>\n<h3>Kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng : h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng, s\u1ed1c, nh\u1ecbp tim ch\u1eadm<\/p>\n<p>X\u1eed tr\u00ed : B\u00e1o ngay v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>\u0110\u1ec3 thu\u1ed1c Calquence 100mg tr\u00e1nh xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c \u1edf n\u01a1i tho\u00e1ng m\u00e1t, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30 \u0111\u1ed9 C, tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp t\u1eeb m\u1eb7t tr\u1eddi.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Bita Fakhri and Charalambos Andreadis (2021), The role of acalabrutinib in adults with chronic lymphocytic leukemia. Truy c\u1eadp ng\u00e0y 11\/07\/2025 t\u1eeb <a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/2040620721990553\" rel=\"noopener\">https:\/\/journals.sagepub.com\/doi\/10.1177\/2040620721990553<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Calquence 100mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb u lympho t\u1ebf b\u00e0o v\u1ecf (MCL) cho ng\u01b0\u1eddi l\u1edbn \u0111\u00e3 nh\u1eadn \u00edt nh\u1ea5t m\u1ed9t li\u1ec7u ph\u00e1p tr\u01b0\u1edbc \u0111\u00f3 nh\u01b0ng b\u1ec7nh c\u00f2n t\u00e1i ph\u00e1t ho\u1eb7c kh\u00e1ng tr\u1ecb.<\/p>\n","protected":false},"author":1,"featured_media":126732,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-126730","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/126730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=126730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/126732"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=126730"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=126730"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=126730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}