{"id":126508,"date":"2025-07-09T21:51:50","date_gmt":"2025-07-09T14:51:50","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=126508"},"modified":"2025-07-24T11:46:28","modified_gmt":"2025-07-24T04:46:28","slug":"colosar-denk-50-12-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/colosar-denk-50-12-5\/","title":{"rendered":"Colosar-Denk 50\/12.5"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <a href=\"https:\/\/vnras.com\/drug\/\">d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Colosar-Denk 50\/12.5 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Denk Pharma GmbH &amp; Co. KG c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 400110026023 (VN-18888-15)<\/strong><\/p>\n<h2>Colosar-Denk 50\/12.5 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Colosar-Denk 50\/12.5<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<p>Losartan kali \u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..50mg<\/p>\n<p>Hydroclorothiazid \u2026\u2026\u2026\u2026\u2026\u2026.\u2026\u2026.12,5mg<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 400110026023 (VN-18888-15)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 48 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Colosar-Denk 50\/12.5<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Colosar-Denk 50\/12.5 l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai ho\u1ea1t ch\u1ea5t c\u00f3 c\u01a1 ch\u1ebf b\u1ed5 tr\u1ee3 trong ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p. Losartan l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 angiotensin II lo\u1ea1i 1 (AT1), gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 co m\u1ea1ch v\u00e0 \u1ee9c ch\u1ebf ti\u1ebft aldosteron \u2013 y\u1ebfu t\u1ed1 g\u00f3p ph\u1ea7n l\u00e0m t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Trong khi \u0111\u00f3, hydroclorothiazid l\u00e0 m\u1ed9t thu\u1ed1c l\u1ee3i ti\u1ec3u nh\u00f3m thiazid, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu natri v\u00e0 clorid \u1edf \u1ed1ng l\u01b0\u1ee3n xa, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng v\u00e0 gi\u1ea3m \u00e1p l\u1ef1c th\u00e0nh m\u1ea1ch.<br \/>\nNh\u1edd t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng c\u1ee7a 2 ho\u1ea1t ch\u1ea5t n\u00e0y m\u00e0 huy\u1ebft \u00e1p \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t hi\u1ec7u qu\u1ea3 h\u01a1n so v\u1edbi t\u1eebng ho\u1ea1t ch\u1ea5t \u0111\u01a1n l\u1ebb.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Losartan \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 1 gi\u1edd sau khi u\u1ed1ng. Sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n x\u1ea5p x\u1ec9 33%, v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 b\u1edfi th\u1ee9c \u0103n. Thu\u1ed1c g\u1eafn m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (&gt;99%) v\u00e0 c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 34 l\u00edt. Losartan \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u t\u1ea1i gan, t\u1ea1o ra ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh ch\u00ednh (E-3174). Sau khi d\u00f9ng, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a losartan l\u00e0 kho\u1ea3ng 2 gi\u1edd, c\u00f2n ch\u1ea5t chuy\u1ec3n h\u00f3a l\u00e0 t\u1eeb 6 \u0111\u1ebfn 9 gi\u1edd. B\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua m\u1eadt v\u00e0 th\u1eadn.<\/p>\n<p>Hydroclorothiazid h\u1ea5p thu nhanh v\u00e0 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 l\u1ee3i ti\u1ec3u trong v\u00f2ng 2 gi\u1edd, \u0111\u1ea1t \u0111\u1ec9nh sau 4 gi\u1edd. Th\u1eddi gian t\u00e1c \u0111\u1ed9ng t\u1eeb 6 \u0111\u1ebfn 12 gi\u1edd, v\u00e0 hi\u1ec7u l\u1ef1c h\u1ea1 \u00e1p k\u00e9o d\u00e0i t\u1edbi 24 gi\u1edd. Thu\u1ed1c kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a v\u00e0 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua th\u1eadn, v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i thay \u0111\u1ed5i t\u1eeb 5,6 \u0111\u1ebfn 14,8 gi\u1edd. Hydroclorothiazid kh\u00f4ng qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, nh\u01b0ng c\u00f3 th\u1ec3 \u0111i qua nhau thai v\u00e0 ti\u1ebft v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<h2>Thu\u1ed1c Colosar-Denk 50\/12.5 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p><strong>Vi\u00ean n\u00e9n Colosar-Denk 50\/12.5<\/strong> \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p nguy\u00ean ph\u00e1t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p \u0111\u1ea7y \u0111\u1ee7 khi ch\u1ec9 d\u00f9ng \u0111\u01a1n l\u1ebb losartan ho\u1eb7c hydroclorothiazid.<\/p>\n<figure id=\"attachment_126566\" aria-describedby=\"caption-attachment-126566\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-126566\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Colosar-Denk-5012.5.jpg\" alt=\"Colosar-Denk 50\/12.5\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Colosar-Denk-5012.5.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Colosar-Denk-5012.5-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Colosar-Denk-5012.5-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Colosar-Denk-5012.5-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-126566\" class=\"wp-caption-text\">Thu\u1ed1c Colosar-Denk 50\/12.5 l\u00e0 thu\u1ed1c nh\u1eadp kh\u1ea9u t\u1eeb \u0110\u1ee9c ch\u1ee9a losartan v\u00e0 hydroclorothiazid \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi \u0111\u01a1n tr\u1ecb li\u1ec7u<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<ul>\n<li>Li\u1ec1u th\u01b0\u1eddng d\u00f9ng l\u00e0 1 vi\u00ean\/l\u1ea7n\/ng\u00e0y, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 50 mg losartan v\u00e0 12,5 mg hydroclorothiazid.<\/li>\n<li>N\u1ebfu huy\u1ebft \u00e1p kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1t v\u1edbi li\u1ec1u n\u00e0y, c\u00f3 th\u1ec3 t\u0103ng l\u00ean t\u1ed1i \u0111a 2 vi\u00ean\/l\u1ea7n\/ng\u00e0y (100mg losartan v\u00e0 25 mg hydroclorothiazid).<\/li>\n<li>T\u00e1c d\u1ee5ng \u1ed5n \u0111\u1ecbnh th\u01b0\u1eddng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 3\u20134 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c.<\/li>\n<\/ul>\n<p>Li\u1ec1u d\u00f9ng \u0111\u1eb7c bi\u1ec7t:<\/p>\n<ul>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn m\u1ee9c \u0111\u1ed9 v\u1eeba (ClCr 30\u201350 mL\/ph\u00fat): Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/li>\n<li>Suy th\u1eadn n\u1eb7ng (ClCr &lt;30 mL\/ph\u00fat): Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng.<\/li>\n<li>B\u1ec7nh nh\u00e2n ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o: Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c.<\/li>\n<li>Suy gan n\u1eb7ng: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/li>\n<li>Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean d\u01b0\u1edbi 18 tu\u1ed5i: Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n, kh\u00f4ng s\u1eed d\u1ee5ng.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>U\u1ed1ng nguy\u00ean vi\u00ean n\u00e9n Colosar-Denk 50\/12.5 v\u1edbi n\u01b0\u1edbc, kh\u00f4ng nhai hay nghi\u1ec1n n\u00e1t, d\u00f9ng trong\u00a0 ho\u1eb7c ngo\u00e0i b\u1eefa \u0103n nh\u01b0ng n\u00ean c\u00f3 th\u1eddi \u0111i\u1ec3m d\u00f9ng c\u1ed1 \u0111\u1ecbnh \u0111\u1ec3 tr\u00e1nh qu\u00ean li\u1ec1u<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Colosar-Denk 50\/12.5 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>D\u1ecb \u1ee9ng v\u1edbi losartan, hydroclorothiazid ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u00f3 trong Colosar-Denk 50\/12.5<\/li>\n<li>Ti\u1ec1n s\u1eed ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u nh\u00f3m sulfonamid.<\/li>\n<li>\u0110ang b\u1ecb gi\u1ea3m kali m\u00e1u ho\u1eb7c t\u0103ng calci huy\u1ebft k\u00e9o d\u00e0i.<\/li>\n<li>Suy gan n\u1eb7ng, t\u1eafc m\u1eadt ho\u1eb7c r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan m\u1eadt r\u00f5 r\u1ec7t.<\/li>\n<li>H\u1ea1 natri trong th\u1eddi gian d\u00e0i nh\u01b0ng ch\u01b0a ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c.<\/li>\n<li>Gout ho\u1eb7c t\u0103ng acid uric m\u00e1u c\u00f3 tri\u1ec7u ch\u1ee9ng.<\/li>\n<li>Ph\u1ee5 n\u1eef \u0111ang c\u00f3 b\u1ea7u\/cho con b\u00fa.<\/li>\n<li>Suy th\u1eadn n\u1eb7ng c\u00f3 \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn d\u01b0\u1edbi 30 ml\/ph\u00fat ho\u1eb7c v\u00f4 ni\u1ec7u.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c, c\u1ea7n ki\u1ec3m tra v\u00e0 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i nh\u01b0 h\u1ea1 kali, h\u1ea1 natri ho\u1eb7c m\u1ea5t c\u00e2n b\u1eb1ng th\u1ec3 t\u00edch.<\/li>\n<li>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh gan, th\u1eadn ho\u1eb7c b\u1ec7nh chuy\u1ec3n h\u00f3a nh\u01b0 gout, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u1ea7n theo d\u00f5i s\u00e1t khi d\u00f9ng thu\u1ed1c.<\/li>\n<li>Khi ph\u1ed1i h\u1ee3p thu\u1ed1c v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u kh\u00e1c, thu\u1ed1c NSAID ho\u1eb7c ch\u1ea5t b\u1ed5 sung kali, c\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft.<\/li>\n<li>Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, n\u00ean ki\u1ec3m tra \u0111\u1ecbnh k\u1ef3 huy\u1ebft \u00e1p, ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 \u0111i\u1ec7n gi\u1ea3i.<\/li>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c c\u00f3 t\u00ecnh tr\u1ea1ng gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n c\u00f3 th\u1ec3 nh\u1ea1y c\u1ea3m h\u01a1n v\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p:<\/p>\n<ul>\n<li>Hoa m\u1eaft, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.<\/li>\n<li>Ho khan, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c.<\/li>\n<li>\u0110au c\u01a1, \u0111au l\u01b0ng, chu\u1ed9t r\u00fat.<\/li>\n<li>Bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, kh\u00f3 ti\u00eau.<\/li>\n<li>Gi\u1ea3m kali huy\u1ebft, t\u0103ng acid uric m\u00e1u.<\/li>\n<\/ul>\n<p>\u00cdt g\u1eb7p \u2013 hi\u1ebfm g\u1eb7p:<\/p>\n<ul>\n<li>R\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, lo \u00e2u, m\u01a1 b\u1ea5t th\u01b0\u1eddng.<\/li>\n<li>T\u0103ng men gan, vi\u00eam gan, v\u00e0ng da.<\/li>\n<li>T\u0103ng ur\u00ea, creatinin huy\u1ebft.<\/li>\n<li>Vi\u00eam ph\u1ebf qu\u1ea3n, vi\u00eam m\u0169i, vi\u00eam thanh qu\u1ea3n.<\/li>\n<li>R\u1ed1i lo\u1ea1n nh\u1ecbp tim, tr\u1ed1ng ng\u1ef1c, t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf.<\/li>\n<li>Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng nh\u01b0 ph\u00f9 m\u1ea1ch, n\u1ed5i m\u1ec1 \u0111ay, ban da.<\/li>\n<li>Vi\u00eam t\u1ee5y, suy th\u1eadn, gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, b\u1ed5 sung kali ho\u1eb7c mu\u1ed1i thay th\u1ebf ch\u1ee9a kali: t\u0103ng nguy c\u01a1 t\u0103ng kali huy\u1ebft.<\/li>\n<li>NSAID (ibuprofen, naproxen, COX-2): c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p v\u00e0 t\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng th\u1eadn.<\/li>\n<li>Lithi: nguy c\u01a1 t\u0103ng \u0111\u1ed9c t\u00ednh tr\u00ean th\u1ea7n kinh, c\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft.<\/li>\n<li>Digitalis glycoside: gi\u1ea3m kali\/magnesi huy\u1ebft l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp.<\/li>\n<li>Thu\u1ed1c \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng: c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ki\u1ec3m so\u00e1t glucose.<\/li>\n<li>Cholestyramin, colestipol: l\u00e0m gi\u1ea3m h\u1ea5p thu hydroclorothiazid.<\/li>\n<li>Methyldopa, ciclosporin, carbamazepin, thu\u1ed1c g\u00e2y m\u00ea, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m: c\u00f3 th\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p ho\u1eb7c t\u0103ng \u0111\u1ed9c t\u00ednh.<\/li>\n<li>C\u00e1c thu\u1ed1c g\u00e2y xo\u1eafn \u0111\u1ec9nh: nguy c\u01a1 lo\u1ea1n nh\u1ecbp t\u0103ng khi r\u1ed1i lo\u1ea1n kali huy\u1ebft \u0111i k\u00e8m.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<ul>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y trong th\u1eddi k\u1ef3 mang thai v\u00ec th\u00e0nh ph\u1ea7n losartan c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c cho thai nhi \u1edf qu\u00fd II v\u00e0 III nh\u01b0: t\u1ed5n th\u01b0\u01a1ng th\u1eadn, thi\u1ec3u \u1ed1i, ch\u1eadm ph\u00e1t tri\u1ec3n x\u01b0\u01a1ng s\u1ecd.<\/li>\n<li>Hydroclorothiazid c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tu\u1ea7n ho\u00e0n nhau thai v\u00e0 g\u00e2y v\u00e0ng da, gi\u1ea3m ti\u1ec3u c\u1ea7u \u1edf tr\u1ebb.<\/li>\n<li>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c trong th\u1eddi k\u1ef3 cho con b\u00fa, v\u00ec ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n v\u00e0 c\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<ul>\n<li>M\u1ed9t s\u1ed1 ng\u01b0\u1eddi c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 ch\u00f3ng m\u1eb7t, hoa m\u1eaft, m\u1ec7t m\u1ecfi \u2014 \u0111\u1eb7c bi\u1ec7t l\u00e0 khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c khi t\u0103ng li\u1ec1u.<\/li>\n<li>N\u00ean th\u1eadn tr\u1ecdng khi v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n cho \u0111\u1ebfn khi bi\u1ebft ch\u1eafc ch\u1eafn kh\u1ea3 n\u0103ng dung n\u1ea1p thu\u1ed1c c\u1ee7a b\u1ea3n th\u00e2n.<\/li>\n<\/ul>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Hi\u1ec7n ch\u01b0a c\u00f3 b\u00e1o c\u00e1o c\u1ee5 th\u1ec3 v\u1ec1 qu\u00e1 li\u1ec1u c\u1ee7a s\u1ef1 k\u1ebft h\u1ee3p losartan v\u00e0 hydroclorothiazid. Trong tr\u01b0\u1eddng h\u1ee3p nghi ng\u1edd qu\u00e1 li\u1ec1u, c\u1ea7n ng\u01b0ng thu\u1ed1c v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi.<\/li>\n<li>Losartan: C\u00f3 th\u1ec3 g\u00e2y t\u1ee5t huy\u1ebft \u00e1p, nh\u1ecbp tim nhanh ho\u1eb7c ch\u1eadm. H\u1ed7 tr\u1ee3 h\u00f4 h\u1ea5p tu\u1ea7n ho\u00e0n v\u00e0 theo d\u00f5i huy\u1ebft \u0111\u1ed9ng h\u1ecdc l\u00e0 c\u1ea7n thi\u1ebft. Kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf losartan ho\u1eb7c ch\u1ea5t chuy\u1ec3n h\u00f3a qua l\u1ecdc m\u00e1u.<\/li>\n<li>Hydroclorothiazid: D\u1ec5 g\u00e2y m\u1ea5t n\u01b0\u1edbc, gi\u1ea3m kali, gi\u1ea3m natri v\u00e0 clo huy\u1ebft. Tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng c\u00f3 th\u1ec3 g\u00e2y r\u1ed1i lo\u1ea1n nh\u1ecbp tim, \u0111\u1eb7c bi\u1ec7t n\u1ebfu \u0111ang d\u00f9ng digitalis. Th\u1ea9m t\u00e1ch m\u00e1u kh\u00f4ng hi\u1ec7u qu\u1ea3 r\u00f5 r\u1ec7t trong lo\u1ea1i b\u1ecf thu\u1ed1c.<\/li>\n<li>Vi\u1ec7c x\u1eed tr\u00ed qu\u00e1 li\u1ec1u ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed3i s\u1ee9c t\u00edch c\u1ef1c, ki\u1ec3m so\u00e1t \u0111i\u1ec7n gi\u1ea3i, b\u00f9 n\u01b0\u1edbc, v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 huy\u1ebft \u00e1p s\u00e1t sao.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef Colosar-Denk 50\/12.5 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Colosar-Denk 50\/12.5 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Colosar-Denk 50\/12.5 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Colosar-Denk 50\/12.5 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/lostad-hct-50-12-5mg\/\">Lostad HCT 50\/12.5mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 h\u1ed7n h\u1ee3p 2 ch\u1ea5t losartan v\u00e0 hydroclorothiazid, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty li\u00ean doanh TNHH Stada-Vi\u1ec7t Nam \u2013 VI\u1ec6T NAM, d\u00f9ng ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p khi d\u00f9ng \u0111\u01a1n l\u1ebb t\u1eebng th\u00e0nh ph\u1ea7n kh\u00f4ng hi\u00eau qu\u1ea3<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/hyzaar\/\">Hyzaar 50\/12.5mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 h\u1ed7n h\u1ee3p 2 ch\u1ea5t losartan v\u00e0 hydroclorothiazid, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Merck Sharp &amp; Dohme (I.A) Corp, d\u00f9ng ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p khi d\u00f9ng \u0111\u01a1n l\u1ebb t\u1eebng th\u00e0nh ph\u1ea7n kh\u00f4ng hi\u00eau qu\u1ea3<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Colosar-Denk 50\/12.5 \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/To-huong-dan-su-dung-Colosar-Denk-50_12.5_vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 9 th\u00e1ng 7 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/drugbank.vn\/thuoc\/Colosar-Denk-50-12-5&amp;VN-18888-15\" rel=\"noopener\">https:\/\/drugbank.vn\/thuoc\/Colosar-Denk-50-12-5&amp;VN-18888-15<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Colosar-Denk 50\/12.5 l\u00e0 thu\u1ed1c nh\u1eadp kh\u1ea9u t\u1eeb \u0110\u1ee9c ch\u1ee9a losartan v\u00e0 hydroclorothiazid \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi \u0111\u01a1n tr\u1ecb li\u1ec7u<\/span><\/p>\n","protected":false},"author":1,"featured_media":126565,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-126508","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/126508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=126508"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/126565"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=126508"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=126508"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=126508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}