{"id":126108,"date":"2025-07-05T12:35:36","date_gmt":"2025-07-05T05:35:36","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=126108"},"modified":"2025-12-23T11:22:16","modified_gmt":"2025-12-23T04:22:16","slug":"dloe-4","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/dloe-4\/","title":{"rendered":"Dloe 4"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Dloe 4 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Neuraxpharm Pharmaceuticals, S.L., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 840110072423 (VN-16668-13).<\/strong><\/p>\n<h2>Dloe 4 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean n\u00e9n bao phim<strong> Dloe 4<\/strong> ch\u1ee9a <strong>Ondansetron<\/strong> (d\u01b0\u1edbi d\u1ea1ng Ondansetron hydroclorid dihydrat) 4 mg.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 840110072423 (VN-16668-13)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 6 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Spain<\/p>\n<figure id=\"attachment_126110\" aria-describedby=\"caption-attachment-126110\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-126110\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Dloe-4.jpg\" alt=\"Dloe 4 d\u1ef1 ph\u00f2ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n do h\u00f3a tr\u1ecb ung th\u01b0\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Dloe-4.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Dloe-4-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Dloe-4-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Dloe-4-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-126110\" class=\"wp-caption-text\">Dloe 4 d\u1ef1 ph\u00f2ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n do h\u00f3a tr\u1ecb ung th\u01b0<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Dloe 4<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Ondansetron l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc cao t\u1ea1i th\u1ee5 th\u1ec3 Serotonin type 3 (5-HT3). C\u01a1 ch\u1ebf ch\u1ed1ng n\u00f4n c\u1ee7a n\u00f3 ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m s\u00e1ng t\u1ecf ho\u00e0n to\u00e0n nh\u01b0ng \u0111\u01b0\u1ee3c cho l\u00e0 th\u00f4ng qua hai con \u0111\u01b0\u1eddng ch\u00ednh:<\/p>\n<ul>\n<li>Ngo\u1ea1i vi: Ondansetron \u1ee9c ch\u1ebf c\u00e1c th\u1ee5 th\u1ec3 5-HT3 tr\u00ean c\u00e1c \u0111\u1ea7u d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. C\u00e1c h\u00f3a ch\u1ea5t trong h\u00f3a tr\u1ecb li\u1ec7u c\u00f3 th\u1ec3 g\u00e2y gi\u1ea3i ph\u00f3ng Serotonin t\u1eeb c\u00e1c t\u1ebf b\u00e0o ru\u1ed9t, kh\u1edfi ph\u00e1t ph\u1ea3n x\u1ea1 n\u00f4n th\u00f4ng qua c\u00e1c s\u1ee3i th\u1ea7n kinh h\u01b0\u1edbng t\u00e2m n\u00e0y.<\/li>\n<li>Trung \u01b0\u01a1ng: Thu\u1ed1c c\u0169ng t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c th\u1ee5 th\u1ec3 5-HT3 t\u1ea1i v\u00f9ng postrema (chemoreceptor trigger zone &#8211; CTZ) \u1edf n\u00e3o b\u1ed9, m\u1ed9t trung t\u00e2m quan tr\u1ecdng \u0111i\u1ec1u ph\u1ed1i ph\u1ea3n x\u1ea1 n\u00f4n.<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Ondansetron \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Do b\u1ecb chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u qua gan, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng \u0111\u1ea1t kho\u1ea3ng 60%.<\/li>\n<li>Ph\u00e2n b\u1ed1: Thu\u1ed1c li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u1edf m\u1ee9c \u0111\u1ed9 trung b\u00ecnh (kho\u1ea3ng 70-76%).<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ondansetron \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh m\u1ebd t\u1ea1i gan b\u1edfi h\u1ec7 th\u1ed1ng enzyme Cytochrome P450, ch\u1ee7 y\u1ebfu l\u00e0 CYP3A4, CYP2D6 v\u00e0 CYP1A2.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua th\u1eadn, v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh kho\u1ea3ng 3-4 gi\u1edd \u1edf ng\u01b0\u1eddi l\u1edbn kh\u1ecfe m\u1ea1nh.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Dloe 4 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do h\u00f3a tr\u1ecb li\u1ec7u g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o.<\/li>\n<li>Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do x\u1ea1 tr\u1ecb.<\/li>\n<li>Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau ph\u1eabu thu\u1eadt.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Dloe 4<\/h2>\n<ul>\n<li>C\u00e1ch d\u00f9ng: D\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/li>\n<li>Li\u1ec1u d\u00f9ng:\n<ul>\n<li>Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb: Ng\u01b0\u1eddi l\u1edbn: Th\u01b0\u1eddng d\u00f9ng 8 mg, u\u1ed1ng 1-2 gi\u1edd tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb, sau \u0111\u00f3 8 mg m\u1ed7i 12 gi\u1edd trong t\u1ed1i \u0111a 5 ng\u00e0y.<\/li>\n<li>Ph\u00f2ng ng\u1eeba bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau ph\u1eabu thu\u1eadt: Ng\u01b0\u1eddi l\u1edbn: D\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t 16 mg, u\u1ed1ng 1 gi\u1edd tr\u01b0\u1edbc khi g\u00e2y m\u00ea.<\/li>\n<li>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t: C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng (t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y kh\u00f4ng qu\u00e1 8 mg).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Dloe 4 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi Ondansetron ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c Dloe 4.<\/li>\n<li>\u0110ang s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Apomorphine (do nguy c\u01a1 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p s\u00e2u v\u00e0 m\u1ea5t \u00fd th\u1ee9c).<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Dloe 4<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ondansetron c\u00f3 th\u1ec3 g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 m\u1ed9t c\u00e1ch ph\u1ee5 thu\u1ed9c li\u1ec1u. C\u1ea7n th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 s\u1eb5n ho\u1eb7c c\u00f3 nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, bao g\u1ed3m ng\u01b0\u1eddi c\u00f3 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i, suy tim sung huy\u1ebft, ho\u1eb7c nh\u1ecbp tim ch\u1eadm.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t th\u01b0\u1eddng g\u1eb7p (&gt;1\/10): \u0110au \u0111\u1ea7u.<\/li>\n<li>Th\u01b0\u1eddng g\u1eb7p (&gt;1\/100): C\u1ea3m gi\u00e1c n\u00f3ng b\u1eebng, t\u00e1o b\u00f3n.<\/li>\n<li>\u00cdt g\u1eb7p (&gt;1\/1000): Co gi\u1eadt, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, \u0111au ng\u1ef1c, h\u1ea1 huy\u1ebft \u00e1p, nh\u1ecbp tim ch\u1eadm.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>C\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng m\u1ea1nh CYP3A4 (v\u00ed d\u1ee5: Phenytoin, Carbamazepine, Rifampicin) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Ondansetron trong m\u00e1u.<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT ho\u1eb7c c\u00e1c thu\u1ed1c \u0111\u1ed9c v\u1edbi tim c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 n\u00e0y.<\/li>\n<li>Tuy\u1ec7t \u0111\u1ed1i kh\u00f4ng d\u00f9ng chung v\u1edbi Apomorphine.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: C\u00e1c nghi\u00ean c\u1ee9u ch\u1ec9 ra m\u1ed9t s\u1ef1 gia t\u0103ng nh\u1ecf nguy c\u01a1 d\u1ecb t\u1eadt h\u1edf mi\u1ec7ng (h\u1edf h\u00e0m \u1ebfch) \u1edf tr\u1ebb c\u00f3 m\u1eb9 d\u00f9ng Ondansetron trong 3 th\u00e1ng \u0111\u1ea7u thai k\u1ef3. Ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng khi l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1 v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/li>\n<li>B\u00e0 m\u1eb9 cho con b\u00fa: Ondansetron \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9. Kh\u00f4ng khuy\u1ebfn c\u00e1o cho con b\u00fa trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng ho\u1eb7c \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn kh\u1ea3 n\u0103ng n\u00e0y. Tuy nhi\u00ean, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t c\u00f3 th\u1ec3 x\u1ea3y ra.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Tri\u1ec7u ch\u1ee9ng: R\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, t\u00e1o b\u00f3n n\u1eb7ng, h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>X\u1eed tr\u00ed: Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. Ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>B\u1ea3o qu\u1ea3n Vi\u00ean n\u00e9n bao phim Dloe 4 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tr\u00e1nh \u00e1nh s\u00e1ng tr\u1ef1c ti\u1ebfp v\u00e0 nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi <span class=\"math-inline\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\">3<\/span><span class=\"mord\">0<span class=\"msupsub\"><span class=\"vlist-t\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mbin mtight\">\u2218<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><span class=\"mord text\"><span class=\"mord\">C.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Dloe 4<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/ondansetron-8mg\/\">Thu\u1ed1c Ondansetron 8mg<\/a> v\u1edbi h\u00e0m l\u01b0\u1ee3ng cao h\u01a1n, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Minh D\u00e2n, gi\u1ea3m t\u00ecnh tr\u1ea1ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do h\u00f3a tr\u1ecb li\u1ec7u ung th\u01b0.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>C R Culy, N Bhana, G L Plosker. Ondansetron: a review of its use as an antiemetic in children, truy c\u1eadp ng\u00e0y 07 th\u00e1ng 05 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11437189\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/11437189\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Dloe 4 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Neuraxpharm Pharmaceuticals, S.L., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 840110072423 (VN-16668-13), \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do h\u00f3a tr\u1ecb li\u1ec7u g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o.<\/p>\n","protected":false},"author":1,"featured_media":126109,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-126108","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/126108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=126108"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/126109"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=126108"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=126108"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=126108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}