{"id":126059,"date":"2025-07-05T11:53:30","date_gmt":"2025-07-05T04:53:30","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=126059"},"modified":"2025-12-23T10:24:27","modified_gmt":"2025-12-23T03:24:27","slug":"holoxan-1g","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/holoxan-1g\/","title":{"rendered":"Holoxan 1g"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Holoxan 1g \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Baxter Oncology GmbH., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-9945-10.<\/strong><\/p>\n<h2>Holoxan 1g l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i l\u1ecd <strong>Holoxan 1g<\/strong> ch\u1ee9a ho\u1ea1t ch\u1ea5t <strong>Ifosfamide 1g<\/strong>.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-9945-10<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n<figure id=\"attachment_126064\" aria-describedby=\"caption-attachment-126064\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-126064\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Holoxan-1g.jpg\" alt=\"Holoxan 1g \u0111i\u1ec1u tr\u1ecb ung th\u01b0\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Holoxan-1g.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Holoxan-1g-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Holoxan-1g-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Holoxan-1g-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-126064\" class=\"wp-caption-text\">Holoxan 1g \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Holoxan 1g<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Ifosfamide l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t c\u1ea7n \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a sinh h\u1ecdc \u0111\u1ec3 ph\u00e1t huy t\u00e1c d\u1ee5ng. Trong c\u01a1 th\u1ec3, ifosfamide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc b\u1edfi h\u1ec7 th\u1ed1ng enzyme cytochrome P450, \u0111\u1eb7c bi\u1ec7t l\u00e0 CYP3A4. C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y t\u1ea1o li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb (alkyl h\u00f3a) v\u1edbi DNA c\u1ee7a t\u1ebf b\u00e0o, ch\u1ee7 y\u1ebfu t\u1ea1i v\u1ecb tr\u00ed guanine. Qu\u00e1 tr\u00ecnh alkyl h\u00f3a n\u00e0y d\u1eabn \u0111\u1ebfn s\u1ef1 \u0111\u1ee9t g\u00e3y v\u00e0 li\u00ean k\u1ebft ch\u00e9o c\u1ee7a chu\u1ed7i DNA, l\u00e0m r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng DNA v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 g\u00e2y ch\u1ebft t\u1ebf b\u00e0o (apoptosis) ho\u1eb7c ng\u1eebng chu k\u1ef3 t\u1ebf b\u00e0o. T\u00e1c d\u1ee5ng n\u00e0y kh\u00f4ng \u0111\u1eb7c hi\u1ec7u theo chu k\u1ef3 t\u1ebf b\u00e0o, ngh\u0129a l\u00e0 n\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ebf b\u00e0o \u1edf t\u1ea5t c\u1ea3 c\u00e1c giai \u0111o\u1ea1n c\u1ee7a chu k\u1ef3 t\u1ebf b\u00e0o.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Ifosfamide \u0111\u01b0\u1ee3c d\u00f9ng qua \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch.<\/li>\n<li>Ph\u00e2n b\u1ed1: Thu\u1ed1c v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp c\u00e1c m\u00f4 trong c\u01a1 th\u1ec3, bao g\u1ed3m c\u1ea3 d\u1ecbch n\u00e3o t\u1ee7y (m\u1eb7c d\u00f9 n\u1ed3ng \u0111\u1ed9 trong d\u1ecbch n\u00e3o t\u1ee7y th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi huy\u1ebft t\u01b0\u01a1ng).<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ifosfamide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan b\u1edfi enzyme cytochrome P450. C\u00e1c con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 hydroxyl h\u00f3a v\u00e0 dechloroethyl h\u00f3a, t\u1ea1o ra c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Thu\u1ed1c v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ifosfamide ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn c\u1ee7a b\u1ec7nh nh\u00e2n.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Holoxan 1g \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Holoxan 1g \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 nh\u1ea1y c\u1ea3m v\u1edbi ifosfamide, th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng trong c\u00e1c ph\u00e1c \u0111\u1ed3 \u0111a h\u00f3a tr\u1ecb. C\u00e1c ch\u1ec9 \u0111\u1ecbnh bao g\u1ed3m:<\/p>\n<ul>\n<li>Ung th\u01b0 tinh ho\u00e0n: Th\u01b0\u1eddng d\u00f9ng trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh \u0111\u00e3 di c\u0103n ho\u1eb7c t\u00e1i ph\u00e1t.<\/li>\n<li>U lympho Hodgkin v\u00e0 non-Hodgkin: \u0110\u1eb7c bi\u1ec7t trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00e1ng tr\u1ecb ho\u1eb7c t\u00e1i ph\u00e1t.<\/li>\n<li>Ung th\u01b0 ph\u1ed5i t\u1ebf b\u00e0o nh\u1ecf.<\/li>\n<li>Ung th\u01b0 v\u00fa: Trong m\u1ed9t s\u1ed1 ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb c\u1ee5 th\u1ec3.<\/li>\n<li>M\u1ed9t s\u1ed1 lo\u1ea1i u b\u01b0\u1edbu kh\u00e1c theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa ung b\u01b0\u1edbu.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Holoxan 1g<\/h2>\n<p>Li\u1ec1u d\u00f9ng c\u1ee7a Holoxan 1g \u0111\u01b0\u1ee3c c\u00e1 th\u1ec3 h\u00f3a t\u00f9y thu\u1ed9c v\u00e0o lo\u1ea1i ung th\u01b0, giai \u0111o\u1ea1n b\u1ec7nh, t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe t\u1ed5ng th\u1ec3 c\u1ee7a b\u1ec7nh nh\u00e2n, c\u00e1c thu\u1ed1c h\u00f3a tr\u1ecb kh\u00e1c d\u00f9ng k\u00e8m v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn, t\u1ee7y x\u01b0\u01a1ng. Thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng theo c\u00e1c ph\u00e1c \u0111\u1ed3 li\u1ec1u cao ho\u1eb7c li\u1ec1u th\u1ea5p, ti\u00eam t\u0129nh m\u1ea1ch h\u00e0ng ng\u00e0y ho\u1eb7c c\u00e1ch ng\u00e0y.<\/p>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Holoxan 1g<\/h2>\n<ul>\n<li>Holoxan 1g l\u00e0 thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch. B\u1ed9t thu\u1ed1c \u0111\u01b0\u1ee3c pha v\u1edbi dung m\u00f4i th\u00edch h\u1ee3p (th\u01b0\u1eddng l\u00e0 n\u01b0\u1edbc c\u1ea5t pha ti\u00eam ho\u1eb7c dung d\u1ecbch natri clorid 0.9%) tr\u01b0\u1edbc khi truy\u1ec1n t\u0129nh m\u1ea1ch ch\u1eadm. \u0110\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 \u0111\u1ed9c t\u00ednh \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, Holoxan th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng k\u00e8m v\u1edbi Mesna (m\u1ed9t ch\u1ea5t gi\u1ea3i \u0111\u1ed9c \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u).<\/li>\n<li>Vi\u1ec7c chu\u1ea9n b\u1ecb v\u00e0 s\u1eed d\u1ee5ng thu\u1ed1c ph\u1ea3i do nh\u00e2n vi\u00ean y t\u1ebf c\u00f3 kinh nghi\u1ec7m th\u1ef1c hi\u1ec7n trong m\u00f4i tr\u01b0\u1eddng v\u00f4 tr\u00f9ng.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Holoxan 1g trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi ifosfamide ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Suy t\u1ee7y x\u01b0\u01a1ng n\u1eb7ng (\u0111\u1eb7c bi\u1ec7t l\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t v\u00e0 gi\u1ea3m ti\u1ec3u c\u1ea7u n\u1eb7ng).<\/li>\n<li>Suy th\u1eadn ho\u1eb7c suy gan n\u1eb7ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c.<\/li>\n<li>Nhi\u1ec5m tr\u00f9ng c\u1ea5p t\u00ednh n\u1eb7ng.<\/li>\n<li>T\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng b\u00e0ng quang nghi\u00eam tr\u1ecdng (tr\u1eeb khi \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t).<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Holoxan 1g<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>C\u1ea7n \u0111\u1eb7c bi\u1ec7t th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, gan, ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim, ph\u1ed5i, th\u1ea7n kinh.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Huy\u1ebft h\u1ecdc: Thi\u1ebfu m\u00e1u, gi\u1ea3m b\u1ea1ch c\u1ea7u\/ti\u1ec3u c\u1ea7u.<\/li>\n<li>Ti\u1ebft ni\u1ec7u: Vi\u00eam b\u00e0ng quang xu\u1ea5t huy\u1ebft (c\u00f3 th\u1ec3 n\u1eb7ng), protein ni\u1ec7u, ti\u1ec3u m\u00e1u.<\/li>\n<li>Th\u1ea7n kinh: Bu\u1ed3n ng\u1ee7, l\u00fa l\u1eabn, \u1ea3o gi\u00e1c, m\u1ea5t \u0111i\u1ec1u h\u00f2a, \u0111\u1ed9ng kinh, h\u00f4n m\u00ea (\u00edt g\u1eb7p).<\/li>\n<li>Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00e1n \u0103n, vi\u00eam ni\u00eam m\u1ea1c.<\/li>\n<li>T\u00f3c: R\u1ee5ng t\u00f3c (th\u01b0\u1eddng h\u1ed3i ph\u1ee5c).<\/li>\n<li>To\u00e0n th\u00e2n: S\u1ed1t, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c.<\/li>\n<li>Kh\u00e1c: \u0110\u1ed9c t\u00ednh tr\u00ean tim, ph\u1ed5i, gan (\u00edt g\u1eb7p h\u01a1n).<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng kh\u00e1c: T\u0103ng nguy c\u01a1 \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng n\u1eb7ng.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u: T\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/li>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 (v\u00ed d\u1ee5: m\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1ng n\u1ea5m, kh\u00e1ng sinh macrolide): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 ifosfamide c\u00f3 ho\u1ea1t t\u00ednh, t\u0103ng \u0111\u1ed9c t\u00ednh.<\/li>\n<li>Thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng CYP3A4 (v\u00ed d\u1ee5: rifampicin, phenytoin): C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 ifosfamide c\u00f3 ho\u1ea1t t\u00ednh, gi\u1ea3m hi\u1ec7u qu\u1ea3.<\/li>\n<li>Mesna: Gi\u1ea3m \u0111\u1ed9c t\u00ednh \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u.<\/li>\n<li>Vaccine s\u1ed1ng gi\u1ea3m \u0111\u1ed9c l\u1ef1c: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh do nguy c\u01a1 nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng.<\/li>\n<li>Thu\u1ed1c g\u00e2y \u0111\u1ed9c th\u1eadn: T\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: Ifosfamide c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y qu\u00e1i thai v\u00e0 \u0111\u1ed9c cho thai nhi. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai.<\/li>\n<li>B\u00e0 m\u1eb9 cho con b\u00fa: Ifosfamide v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u00e0 g\u00e2y h\u1ea1i cho tr\u1ebb b\u00fa m\u1eb9. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng cho b\u00e0 m\u1eb9 \u0111ang cho con b\u00fa.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Holoxan 1g c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 bu\u1ed3n ng\u1ee7, l\u00fa l\u1eabn, m\u1ea5t \u0111i\u1ec1u h\u00f2a. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c n\u1ebfu g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho ifosfamide. X\u1eed tr\u00ed qu\u00e1 li\u1ec1u ch\u1ee7 y\u1ebfu l\u00e0 h\u1ed7 tr\u1ee3, bao g\u1ed3m:<\/p>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/li>\n<li>H\u1ed7 tr\u1ee3 ch\u1ee9c n\u0103ng t\u1ee7y x\u01b0\u01a1ng (truy\u1ec1n m\u00e1u, y\u1ebfu t\u1ed1 k\u00edch th\u00edch t\u1ea1o b\u1ea1ch c\u1ea7u).<\/li>\n<li>\u0110\u1ea3m b\u1ea3o \u0111\u1ee7 n\u01b0\u1edbc v\u00e0 s\u1eed d\u1ee5ng Mesna li\u1ec1u cao h\u01a1n \u0111\u1ec3 ph\u00f2ng ng\u1eeba \u0111\u1ed9c t\u00ednh \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u.<\/li>\n<li>Theo d\u00f5i s\u00e1t c\u00e1c ch\u1ee9c n\u0103ng s\u1ed1ng v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Jeffrey R Idle, Diren Beyo\u011flu. Ifosfamide &#8211; History, efficacy, toxicity and encephalopathy, truy c\u1eadp ng\u00e0y 05 th\u00e1ng 07 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36842616\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36842616\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Holoxan 1g \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Baxter Oncology GmbH., c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-9945-10, ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 nh\u1ea1y c\u1ea3m v\u1edbi ifosfamide.<\/p>\n","protected":false},"author":1,"featured_media":126063,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-126059","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/126059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=126059"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/126063"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=126059"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=126059"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=126059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}