{"id":125983,"date":"2025-07-04T16:35:36","date_gmt":"2025-07-04T09:35:36","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=125983"},"modified":"2025-12-23T10:24:09","modified_gmt":"2025-12-23T03:24:09","slug":"huether-50","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/huether-50\/","title":{"rendered":"Huether-50"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Huether-50 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa (Davipharm), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110593524 (VD-28463-17).<\/strong><\/p>\n<h2>Huether-50 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean n\u00e9n bao phim <strong>Huether-50<\/strong> ch\u1ee9a <strong>Topiramate 50mg<\/strong>. Ngo\u00e0i ra, vi\u00ean n\u00e9n c\u00f2n bao g\u1ed3m c\u00e1c t\u00e1 d\u01b0\u1ee3c kh\u00e1c.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110593524 (VD-28463-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_125989\" aria-describedby=\"caption-attachment-125989\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-125989\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Huether-50.jpg\" alt=\"Huether-50 \u0111i\u1ec1u tr\u1ecb c\u01a1n \u0111\u1ed9ng kinh kh\u1edfi ph\u00e1t c\u1ee5c b\u1ed9\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Huether-50.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Huether-50-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Huether-50-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/07\/Huether-50-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-125989\" class=\"wp-caption-text\">Huether-50 \u0111i\u1ec1u tr\u1ecb c\u01a1n \u0111\u1ed9ng kinh kh\u1edfi ph\u00e1t c\u1ee5c b\u1ed9<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Huether-50<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Ho\u1ea1t t\u00ednh ch\u1ed1ng co gi\u1eadt v\u00e0 d\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u th\u00f4ng qua c\u00e1c con \u0111\u01b0\u1eddng sau:<\/p>\n<ul>\n<li>Ch\u1eb9n k\u00eanh natri ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n th\u1ebf: Ng\u0103n ch\u1eb7n c\u00e1c \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng \u0111\u01b0\u1ee3c t\u1ea1o ra l\u1eb7p \u0111i l\u1eb7p l\u1ea1i khi c\u00e1c neuron b\u1ecb kh\u1eed c\u1ef1c k\u00e9o d\u00e0i, gi\u00fap ki\u1ec3m so\u00e1t s\u1ef1 kh\u1eed c\u1ef1c qu\u00e1 m\u1ee9c trong c\u00e1c c\u01a1n \u0111\u1ed9ng kinh.<\/li>\n<li>T\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng GABA: T\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh \u1ee9c ch\u1ebf GABA, gi\u00fap gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng \u0111i\u1ec7n b\u1ea5t th\u01b0\u1eddng trong n\u00e3o.<\/li>\n<li>\u0110\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 AMPA\/kainate c\u1ee7a glutamat: L\u00e0m gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a glutamate (ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh k\u00edch th\u00edch) b\u1eb1ng c\u00e1ch \u0111\u1ed1i kh\u00e1ng c\u00e1c th\u1ee5 th\u1ec3 AMPA v\u00e0 kainate, ng\u0103n ch\u1eb7n s\u1ef1 lan truy\u1ec1n c\u1ee7a c\u00e1c c\u01a1n \u0111\u1ed9ng kinh.<\/li>\n<li>\u1ee8c ch\u1ebf enzym carbonic anhydrase: C\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf c\u00e1c isoenzyme carbonic anhydrase, li\u00ean quan \u0111\u1ebfn m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 toan chuy\u1ec3n h\u00f3a v\u00e0 s\u1ecfi th\u1eadn<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Topiramate \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t v\u00e0 nhanh ch\u00f3ng qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a sau khi u\u1ed1ng, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng cao (81-95%). N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (Tmax) \u0111\u1ea1t \u0111\u01b0\u1ee3c trong 2-3 gi\u1edd. C\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n.<\/li>\n<li>Ph\u00e2n b\u1ed1: C\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn (0,6-0,8 L\/kg) , t\u1ef7 l\u1ec7 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng th\u1ea5p (15-41%).<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Kh\u00f4ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i khi d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u (kho\u1ea3ng 20% li\u1ec1u d\u00f9ng). T\u1ef7 l\u1ec7 chuy\u1ec3n h\u00f3a c\u00f3 th\u1ec3 t\u0103ng l\u00ean \u0111\u1ebfn 50% khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng enzyme gan m\u1ea1nh.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 21 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Huether-50 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110\u1ed9ng kinh:\n<ul>\n<li>\u0110\u01a1n tr\u1ecb li\u1ec7u: Cho b\u1ec7nh nh\u00e2n t\u1eeb 2 tu\u1ed5i tr\u1edf l\u00ean m\u1eafc c\u00e1c c\u01a1n \u0111\u1ed9ng kinh kh\u1edfi ph\u00e1t c\u1ee5c b\u1ed9 ho\u1eb7c c\u00e1c c\u01a1n \u0111\u1ed9ng kinh co c\u1ee9ng-gi\u1eadt rung to\u00e0n th\u00e2n nguy\u00ean ph\u00e1t.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3: D\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 2-16 tu\u1ed5i c\u00f3 c\u00e1c c\u01a1n \u0111\u1ed9ng kinh kh\u1edfi ph\u00e1t c\u1ee5c b\u1ed9 ho\u1eb7c c\u00e1c c\u01a1n \u0111\u1ed9ng kinh co c\u1ee9ng-gi\u1eadt rung to\u00e0n th\u00e2n nguy\u00ean ph\u00e1t. Thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n t\u1eeb 2 tu\u1ed5i tr\u1edf l\u00ean b\u1ecb c\u00e1c c\u01a1n \u0111\u1ed9ng kinh li\u00ean quan \u0111\u1ebfn h\u1ed9i ch\u1ee9ng Lennox-Gastaut.<\/li>\n<\/ul>\n<\/li>\n<li>D\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u: Cho ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean \u0111\u1ec3 ng\u0103n ng\u1eeba c\u00e1c c\u01a1n \u0111au n\u1eeda \u0111\u1ea7u. Thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u01a1n \u0111au n\u1eeda \u0111\u1ea7u c\u1ea5p t\u00ednh.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Huether-50<\/h2>\n<p>Li\u1ec1u d\u00f9ng c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh c\u1ea9n th\u1eadn, b\u1eaft \u0111\u1ea7u t\u1eeb li\u1ec1u th\u1ea5p v\u00e0 t\u0103ng d\u1ea7n \u0111\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u1ed1i \u01b0u v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb \u0111\u01a1n \u0111\u1ed9c cho b\u1ec7nh \u0111\u1ed9ng kinh:\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 10 tu\u1ed5i tr\u1edf l\u00ean: Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 400 mg\/ng\u00e0y, chia 2 l\u1ea7n. L\u1ecbch tr\u00ecnh t\u0103ng li\u1ec1u chu\u1ea9n trong 6 tu\u1ea7n \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o. Li\u1ec1u t\u1ed1i \u0111a c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 500 mg\/ng\u00e0y, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p kh\u00f3 ch\u1eefa c\u00f3 th\u1ec3 dung n\u1ea1p \u0111\u1ebfn 1000 mg\/ng\u00e0y.<\/li>\n<li>Tr\u1ebb em t\u1eeb 2 \u0111\u1ebfn 9 tu\u1ed5i: Li\u1ec1u d\u00f9ng t\u00ednh theo c\u00e2n n\u1eb7ng, chia 2 l\u1ea7n\/ng\u00e0y. Li\u1ec1u kh\u1edfi \u0111\u1ea7u 1-3 mg\/kg\/\u0111\u00eam trong 1 tu\u1ea7n, sau \u0111\u00f3 t\u0103ng d\u1ea7n. Li\u1ec1u duy tr\u00ec khuy\u1ebfn c\u00e1o: 5-9 mg\/kg\/ng\u00e0y, t\u1ed1i \u0111a 400 mg\/ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<li>H\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb trong b\u1ec7nh \u0111\u1ed9ng kinh:\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn: Li\u1ec1u kh\u1edfi \u0111\u1ea7u 25-50 mg\/\u0111\u00eam trong 1 tu\u1ea7n, sau \u0111\u00f3 t\u0103ng d\u1ea7n h\u00e0ng tu\u1ea7n ho\u1eb7c c\u00e1ch 2 tu\u1ea7n. Li\u1ec1u th\u01b0\u1eddng d\u00f9ng 200-400 mg\/ng\u00e0y, t\u1ed1i \u0111a 1000 mg\/ng\u00e0y.<\/li>\n<li>Tr\u1ebb em t\u1eeb 2 \u0111\u1ebfn 16 tu\u1ed5i: Li\u1ec1u kh\u1edfi \u0111\u1ea7u 1-3 mg\/kg\/\u0111\u00eam trong 1 tu\u1ea7n, sau \u0111\u00f3 t\u0103ng d\u1ea7n. Li\u1ec1u duy tr\u00ec khuy\u1ebfn c\u00e1o 5-9 mg\/kg\/ng\u00e0y, chia 2 l\u1ea7n.<\/li>\n<\/ul>\n<\/li>\n<li>D\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u:\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean: Li\u1ec1u kh\u1edfi \u0111\u1ea7u 25 mg\/\u0111\u00eam trong 1 tu\u1ea7n. Sau \u0111\u00f3 c\u00f3 th\u1ec3 t\u0103ng l\u00ean 25-50 mg\/ng\u00e0y, chia 2 l\u1ea7n. Li\u1ec1u khuy\u1ebfn c\u00e1o 50-100 mg\/ng\u00e0y, chia 2 l\u1ea7n.<\/li>\n<\/ul>\n<\/li>\n<li>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan v\u00e0 th\u1eadn: C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f2 li\u1ec1u \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n suy th\u1eadn ho\u1eb7c suy gan. B\u1ec7nh nh\u00e2n suy th\u1eadn trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng c\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Huether-50<\/h2>\n<ul>\n<li>U\u1ed1ng nguy\u00ean vi\u00ean: Vi\u00ean n\u00e9n n\u00ean \u0111\u01b0\u1ee3c nu\u1ed1t nguy\u00ean, kh\u00f4ng c\u1eaft, nghi\u1ec1n ho\u1eb7c nhai.<\/li>\n<li>Th\u1eddi \u0111i\u1ec3m d\u00f9ng thu\u1ed1c: C\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng b\u1eefa \u0103n. N\u1ebfu thu\u1ed1c g\u00e2y kh\u00f3 ch\u1ecbu d\u1ea1 d\u00e0y, n\u00ean u\u1ed1ng c\u00f9ng th\u1ee9c \u0103n.<\/li>\n<li>Duy tr\u00ec \u0111\u1ee7 n\u01b0\u1edbc: U\u1ed1ng \u0111\u1ee7 ch\u1ea5t l\u1ecfng gi\u00fap gi\u1ea3m nguy c\u01a1 h\u00ecnh th\u00e0nh s\u1ecfi th\u1eadn.<\/li>\n<li>Tu\u00e2n th\u1ee7 li\u1ec1u l\u01b0\u1ee3ng: B\u1ec7nh nh\u00e2n c\u1ea7n tu\u00e2n th\u1ee7 ch\u00ednh x\u00e1c li\u1ec1u l\u01b0\u1ee3ng v\u00e0 l\u1ecbch tr\u00ecnh d\u00f9ng thu\u1ed1c theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129. Kh\u00f4ng t\u1ef1 \u00fd ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t \u0111\u1ec3 tr\u00e1nh t\u0103ng t\u1ea7n su\u1ea5t c\u00e1c c\u01a1n \u0111\u1ed9ng kinh.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Huether-50 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn: B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn v\u1edbi Topiramate ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng mang thai:\n<ul>\n<li>D\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u v\u00e0 qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh tuy\u1ec7t \u0111\u1ed1i trong thai k\u1ef3. Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai ph\u1ea3i s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 cao trong v\u00e0 sau \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong thai k\u1ef3 tr\u1eeb khi kh\u00f4ng c\u00f3 li\u1ec7u ph\u00e1p thay th\u1ebf ph\u00f9 h\u1ee3p kh\u00e1c v\u00e0 b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 r\u1ee7i ro. Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai m\u1eafc \u0111\u1ed9ng kinh c\u0169ng ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh n\u1ebfu kh\u00f4ng s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 cao.<\/li>\n<\/ul>\n<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Metformin: Do t\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a.<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase kh\u00e1c: Nh\u01b0 acetazolamide, dorzolamide, brinzolamide, v\u00ec t\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a v\u00e0 s\u1ecfi th\u1eadn.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Huether-50<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Gi\u1ea3m ti\u1ebft m\u1ed3 h\u00f4i v\u00e0 t\u0103ng th\u00e2n nhi\u1ec7t: \u0110\u1eb7c bi\u1ec7t \u1edf tr\u1ebb em v\u00e0 trong th\u1eddi ti\u1ebft n\u00f3ng. C\u1ea7n tr\u00e1nh m\u1ea5t n\u01b0\u1edbc.<\/li>\n<li>H\u00e0nh vi v\u00e0 \u00fd ngh\u0129 t\u1ef1 t\u1eed: C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 n\u00e0y. C\u1ea7n theo d\u00f5i c\u00e1c thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng ho\u1eb7c h\u00e0nh vi.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t th\u01b0\u1eddng g\u1eb7p (\u2265 10%): D\u1ecb c\u1ea3m, bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, gi\u1ea3m c\u00e2n, ch\u00e1n \u0103n, m\u1ec7t m\u1ecfi, vi\u00eam m\u0169i h\u1ecdng.<\/li>\n<li>Th\u01b0\u1eddng g\u1eb7p (1% \u0111\u1ebfn 10%): R\u1ed1i lo\u1ea1n ch\u00fa \u00fd, suy gi\u1ea3m tr\u00ed nh\u1edb, tr\u1ea7m c\u1ea3m, bu\u1ed3n n\u00f4n, ti\u00eau ch\u1ea3y, r\u1ee5ng t\u00f3c, \u0111au kh\u1edbp, nh\u00ecn m\u1edd, s\u1ecfi th\u1eadn.<\/li>\n<li>\u00cdt g\u1eb7p (0.1% \u0111\u1ebfn 1%): Gi\u1ea3m m\u1ee9c \u0111\u1ed9 \u00fd th\u1ee9c, \u00fd ngh\u0129 t\u1ef1 t\u1eed, vi\u00eam t\u1ee5y, kh\u00f4ng ti\u1ebft m\u1ed3 h\u00f4i, toan chuy\u1ec3n h\u00f3a, gi\u1ea3m th\u1ecb l\u1ef1c.<\/li>\n<li>Hi\u1ebfm g\u1eb7p (&lt; 0.1%): M\u1ea5t kh\u1ee9u gi\u00e1c, h\u01b0ng c\u1ea3m, vi\u00eam gan, suy gan, t\u0103ng men gan, m\u00f9 m\u1ed9t b\u00ean, glaucoma.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c:<\/p>\n<ul>\n<li>Phenytoin v\u00e0 Carbamazepine: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Topiramate.<\/li>\n<li>Acid Valproic: T\u0103ng nguy c\u01a1 t\u0103ng amoniac m\u00e1u v\u00e0 h\u1ea1 th\u00e2n nhi\u1ec7t.<\/li>\n<li>Thu\u1ed1c ng\u1eeba thai \u0111\u01b0\u1eddng u\u1ed1ng (ch\u1ee9a estrogen): Topiramate (li\u1ec1u &gt;200 mg\/ng\u00e0y) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 tr\u00e1nh thai.<\/li>\n<li>Metformin: T\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<li>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase kh\u00e1c: T\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a v\u00e0 s\u1ecfi th\u1eadn, n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p.<\/li>\n<li>C\u00e1c thu\u1ed1c g\u00e2y \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng: T\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng an th\u1ea7n v\u00e0 \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.<\/li>\n<li>Lithium: Li\u1ec1u cao Topiramate (600 mg\/ng\u00e0y) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 lithium.<\/li>\n<\/ul>\n<p>T\u01b0\u01a1ng t\u00e1c v\u1edbi th\u1ef1c ph\u1ea9m\/\u0111\u1ed3 u\u1ed1ng:<\/p>\n<ul>\n<li>R\u01b0\u1ee3u: Kh\u00f4ng n\u00ean u\u1ed1ng r\u01b0\u1ee3u khi \u0111ang d\u00f9ng Topiramate, v\u00ec c\u00f3 th\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 nguy c\u01a1 co gi\u1eadt.<\/li>\n<li>Ch\u1ebf \u0111\u1ed9 \u0103n ketogenic: Tr\u00e1nh ch\u1ebf \u0111\u1ed9 \u0103n n\u00e0y do t\u0103ng nguy c\u01a1 nhi\u1ec5m toan chuy\u1ec3n h\u00f3a.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: Topiramate g\u00e2y d\u1ecb t\u1eadt b\u1ea9m sinh nghi\u00eam tr\u1ecdng (\u0111\u1eb7c bi\u1ec7t l\u00e0 h\u1edf h\u00e0m \u1ebfch) v\u00e0 t\u0103ng nguy c\u01a1 ch\u1eadm ph\u00e1t tri\u1ec3n thai nhi, r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong thai k\u1ef3 \u0111\u1ed1i v\u1edbi d\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u v\u00e0 qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng. \u0110\u1ed1i v\u1edbi \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh, ch\u1ec9 d\u00f9ng khi kh\u00f4ng c\u00f3 l\u1ef1a ch\u1ecdn thay th\u1ebf ph\u00f9 h\u1ee3p v\u00e0 b\u1ec7nh nh\u00e2n ph\u1ea3i s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 cao. C\u1ea7n \u0111\u01b0\u1ee3c b\u00e1c s\u0129 t\u01b0 v\u1ea5n k\u1ef9 l\u01b0\u1ee1ng v\u1ec1 r\u1ee7i ro.<\/li>\n<li>B\u00e0 m\u1eb9 cho con b\u00fa: C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef cho con b\u00fa.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Topiramate c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t, l\u00fa l\u1eabn, r\u1ed1i lo\u1ea1n ch\u00fa \u00fd, suy gi\u1ea3m tr\u00ed nh\u1edb ho\u1eb7c c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 th\u1ecb l\u1ef1c. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ho\u1eb7c th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o cho \u0111\u1ebfn khi bi\u1ebft r\u00f5 t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u: Gi\u1ea3m nh\u1eadn th\u1ee9c, bu\u1ed3n ng\u1ee7 nghi\u00eam tr\u1ecdng, ch\u00f3ng m\u1eb7t, k\u00edch \u0111\u1ed9ng, tr\u1ea7m c\u1ea3m, nh\u00ecn \u0111\u00f4i, c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 t\u01b0 duy\/l\u1eddi n\u00f3i\/ph\u1ed1i h\u1ee3p v\u1eadn \u0111\u1ed9ng, co gi\u1eadt, nhi\u1ec5m toan chuy\u1ec3n h\u00f3a, h\u1ea1 kali huy\u1ebft, th\u1eadm ch\u00ed h\u00f4n m\u00ea.<\/li>\n<li>X\u1eed tr\u00ed qu\u00e1 li\u1ec1u: Ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c v\u00e0 cung c\u1ea5p c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 chung. Th\u1ea9m ph\u00e2n m\u00e1u c\u00f3 th\u1ec3 gi\u00fap lo\u1ea1i b\u1ecf Topiramate kh\u1ecfi c\u01a1 th\u1ec3. \u0110\u1ea3m b\u1ea3o b\u00f9 n\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7. C\u1ea7n li\u00ean h\u1ec7 trung t\u00e2m ch\u1ed1ng \u0111\u1ed9c ho\u1eb7c c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n v\u00e0 x\u1eed tr\u00ed.<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Huether-50<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/thuoc-topamax-50mg\/\">Thu\u1ed1c Topamax 50<\/a> c\u1ee7a Cilag AG -Switzerland, ph\u00e2n ph\u1ed1i t\u1ea1i Vi\u1ec7t Nam v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh l\u00e0 VN-20529-17 b\u1edfi C\u00f4ng ty TNHH Johnson &amp; Johnson (Vi\u1ec7t Nam),<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Ali Sahraian, Mohammad Bigdeli, Ahmad Ghanizadeh, Shahin Akhondzadeh. Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial, truy c\u1eadp ng\u00e0y 04 th\u00e1ng 07 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25012432\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25012432\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Huether-50 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa (Davipharm), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-28463-17, \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh v\u00e0 d\u1ef1 ph\u00f2ng \u0111au n\u1eeda \u0111\u1ea7u.<\/p>\n","protected":false},"author":1,"featured_media":125984,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-125983","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/125983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=125983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/125984"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=125983"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=125983"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=125983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}