{"id":125315,"date":"2025-06-28T16:39:49","date_gmt":"2025-06-28T09:39:49","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=125315"},"modified":"2025-07-24T11:47:47","modified_gmt":"2025-07-24T04:47:47","slug":"jasugrel-5mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/jasugrel-5mg\/","title":{"rendered":"Jasugrel 5mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Jasugrel 5mg c\u00f3 c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t l\u00e0 Daiichi Sankyo Europe GmbH, \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 VN3-416-22.<\/strong><\/p>\n<h2>Jasugrel 5mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean<strong>\u00a0Jasugrel 5mg<\/strong>\u00a0ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Prasugrel (d\u01b0\u1edbi d\u1ea1ng prasugrel hydroclorid) 5mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf : Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN3-416-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: B\u1ed3 \u0110\u00e0o Nha<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Jasugrel 5mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Prasugrel l\u00e0 d\u1eabn xu\u1ea5t thienopyridine c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ed1i kh\u00e1ng adenosine diphosphate (ADP) v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong c\u00e1c ph\u00f2ng kh\u00e1m \u0111\u1ec3 ph\u00f2ng ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n<p>Prasugrel l\u00e0\u00a0 ti\u1ec1n ch\u1ea5t kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng, \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t \u0111\u1ed9ng li\u00ean k\u1ebft kh\u00f4ng thu\u1eadn ngh\u1ecbch v\u1edbi th\u1ee5 th\u1ec3 ADP c\u1ee7a ti\u1ec3u c\u1ea7u P2Y12.<\/p>\n<p>Prasugrel \u1ee9c ch\u1ebf s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u do adenosine diphosphate g\u00e2y ra nhanh h\u01a1n, nh\u1ea5t qu\u00e1n h\u01a1n v\u00e0 \u1edf m\u1ee9c \u0111\u1ed9 l\u1edbn h\u01a1n so v\u1edbi clopidogrel.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<h4>H\u1ea5p thu<\/h4>\n<p>Prasugrel \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n sau khi u\u1ed1ng.<\/p>\n<h4>Ph\u00e2n b\u1ed1<\/h4>\n<p>Ch\u1ea5t chuy\u1ec3n h\u00f3a R\u2011138727 c\u00f3 t\u1ec9 l\u1ec7 g\u1eafn protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 98\u202f%, ph\u00e2n b\u1ed1 \u00edt v\u00e0o h\u1ed3ng c\u1ea7u, t\u1ed5ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng cao h\u01a1n trong m\u00e1u to\u00e0n ph\u1ea7n.<\/p>\n<h4>Chuy\u1ec3n h\u00f3a<\/h4>\n<p>Prasugrel ban \u0111\u1ea7u b\u1ecb th\u1ee7y ph\u00e2n b\u1edfi carboxylesterase\u202f2 \u1edf ru\u1ed9t v\u00e0 carboxylesterase\u202f1 \u1edf gan th\u00e0nh thiolactone kh\u00f4ng ho\u1ea1t t\u00ednh, sau \u0111\u00f3 qua CYP3A4 v\u00e0 CYP2B6 (v\u00e0 m\u1ed9t ph\u1ea7n CYP2C9, CYP2C19) chuy\u1ec3n th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t \u0111\u1ed9ng R\u2011138727.<\/p>\n<h4>Th\u1ea3i tr\u1eeb<\/h4>\n<p>Kho\u1ea3ng 68% li\u1ec1u d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<h2>Jasugrel 5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p><strong>Jasugrel 5mg Prasugrel<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 ng\u0103n ng\u1eeba h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i \u1edf b\u1ec7nh nh\u00e2n \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n<figure id=\"attachment_125311\" aria-describedby=\"caption-attachment-125311\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-125311\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-du-phong-huyet-khoi.jpg\" alt=\"Jasugrel 5mg d\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-du-phong-huyet-khoi.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-du-phong-huyet-khoi-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-du-phong-huyet-khoi-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-du-phong-huyet-khoi-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-125311\" class=\"wp-caption-text\">Jasugrel 5mg d\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Jasugrel 5mg<\/h2>\n<p>Ng\u01b0\u1eddi \u2265\u202f60kg<\/p>\n<ul>\n<li>Kh\u1edfi \u0111\u1ea7u: 60mg\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y<\/li>\n<li>Duy tr\u00ec: 10mg\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y<\/li>\n<\/ul>\n<p>Ng\u01b0\u1eddi &lt;\u202f60kg<\/p>\n<ul>\n<li>T\u1ea5n c\u00f4ng: 60mg\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y<\/li>\n<li>Duy tr\u00ec: 5mg\/l\u1ea7n, 1 l\u1ea7n\/ng\u00e0y<\/li>\n<\/ul>\n<p>L\u01b0u \u00fd \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u v\u1edbi b\u1ec7nh nh\u00e2n suy gan, suy th\u1eadn ho\u1eb7c ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Jasugrel 5mg<\/h2>\n<ul>\n<li>U\u1ed1ng trong b\u1eefa \u0103n<\/li>\n<li>Nu\u1ed1t nguy\u00ean vi\u00ean c\u00f9ng v\u1edbi n\u01b0\u1edbc<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Jasugrel 5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Kh\u00f4ng d\u00f9ng Jasugrel 5mg\u00a0cho ng\u01b0\u1eddi c\u00f3 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi \u0111ang b\u1ecb vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi \u0111ang thi\u1ebfu m\u00e1u<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi \u0111ang \u0111\u1ed9t qu\u1ef5<\/li>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n \u0111ang ch\u1ea3y m\u00e1u<\/li>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng<\/li>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh khi c\u00f3 c\u01a1n thi\u1ebfu m\u00e1u n\u00e3o tho\u00e1ng qua<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Jasugrel 5mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Th\u1eadn tr\u1ecdng \u1edf tr\u1ebb em, ph\u1ee5 n\u1eef mang thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa.<\/li>\n<li>Th\u1eadn tr\u1ecdng \u1edf ng\u01b0\u1eddi suy gan v\u00e0 suy th\u1eadn.<\/li>\n<li>Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u cao hay sau ph\u1eabu thu\u1eadt ho\u1eb7c ti\u1ec3u ph\u1eabu.<\/li>\n<li>Theo d\u00f5i s\u00e1t \u0111\u1ec3 ph\u00e1t hi\u1ec7n ph\u00f9 m\u1ea1ch trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi k\u00e9m dung n\u1ea1p galactose ho\u1eb7c kh\u00f4ng h\u1ea5p thu glucose v\u00e0 galactose.<\/li>\n<li>Tu\u00e2n th\u1ee7 \u0111\u00fang li\u1ec1u, kh\u00f4ng t\u1ef1 \u00fd t\u0103ng ho\u1eb7c gi\u1ea3m li\u1ec1u thu\u1ed1c.<\/li>\n<li>Tham v\u1ea5n \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc khi ng\u01b0ng \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Hay g\u1eb7p : ch\u1ea3y m\u00e1u<\/li>\n<li>Th\u01b0\u1eddng g\u1eb7p : \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, bu\u1ed3n n\u00f4n<\/li>\n<li>\u00cdt g\u1eb7p : thi\u1ebfu m\u00e1u, gi\u1ea3m b\u1ea1ch c\u1ea7u<\/li>\n<li>Hi\u1ebfm g\u1eb7p : ph\u00f9 m\u1ea1ch<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (PPI): c\u00f3 th\u1ec3 ph\u1ed1i h\u1ee3p v\u1edbi omeprazole ho\u1eb7c pantoprazole \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a m\u00e0 kh\u00f4ng l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 \u1ee9c ch\u1ebf ti\u1ec3u c\u1ea7u c\u1ee7a prasugrel.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/p>\n<h3>Kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Th\u1eadn tr\u1ecdng khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng : k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u, xu\u1ea5t huy\u1ebft.<\/p>\n<p>X\u1eed tr\u00ed : B\u00e1o ngay v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi.<\/p>\n<h2>Jasugrel 5mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Jasugrel 5mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng v\u1edbi nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/zurelsavi-5\/\">Thu\u1ed1c Zurelsavi 5<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m SaVi, ph\u00f2ng ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch, bao g\u1ed3m huy\u1ebft kh\u1ed1i, x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, th\u01b0\u1eddng g\u1eb7p \u1edf b\u1ec7nh nh\u00e2n b\u1ecb nh\u1ed3i m\u00e1u c\u01a1 tim,\u2026<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/thuoc-brilinta-90mg\/\">Thu\u1ed1c Brilinta 90mg<\/a> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i, h\u1ed9p 6 v\u1ec9 x 10 vi\u00ean n\u00e9n bao phim.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>1. H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng \u0111\u01b0\u1ee3c C\u1ee5c qu\u1ea3n l\u00fd ph\u00ea duy\u1ec7t. Xem ngay <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/jasugrel-5mg-huong-dan-su-dung.pdf\">T\u1ea0I \u0110\u00c2Y<\/a>.<\/p>\n<p>2. Kazuo Umemura, Takayuki Iwaki (2016), The Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Japanese Volunteers. Truy c\u1eadp ng\u00e0y 28\/06\/2025 t\u1eeb <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5132138\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5132138\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jasugrel 5mg ch\u1ee9a ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 Prasugrel, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 ng\u0103n ng\u1eeba h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i \u1edf b\u1ec7nh nh\u00e2n \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n","protected":false},"author":1,"featured_media":125313,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-125315","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/125315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=125315"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/125313"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=125315"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=125315"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=125315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}