{"id":125132,"date":"2025-06-27T23:31:30","date_gmt":"2025-06-27T16:31:30","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=125132"},"modified":"2025-12-23T11:17:50","modified_gmt":"2025-12-23T04:17:50","slug":"ivaswift-5","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/ivaswift-5\/","title":{"rendered":"Ivaswift 5"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Ivaswift 5 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Ind-Swift Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-22118-19.<\/strong><\/p>\n<h2>Ivaswift 5 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Ivaswift 5<\/strong> ch\u1ee9a 5mg <strong>Ivabradine<\/strong> v\u00e0 t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-22118-19<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 4 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: India<\/p>\n<figure id=\"attachment_125136\" aria-describedby=\"caption-attachment-125136\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-125136\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Ivaswift-5.jpg\" alt=\"Ivaswift 5 \u0111i\u1ec1u tr\u1ecb \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Ivaswift-5.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Ivaswift-5-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Ivaswift-5-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Ivaswift-5-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-125136\" class=\"wp-caption-text\">Ivaswift 5 \u0111i\u1ec1u tr\u1ecb \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Ivaswift 5<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Ivabradine ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc d\u00f2ng \u0111i\u1ec7n &#8220;If&#8221; (funny current) trong n\u00fat xoang nh\u0129 c\u1ee7a tim. D\u00f2ng If l\u00e0 y\u1ebfu t\u1ed1 ch\u00ednh \u0111i\u1ec1u h\u00f2a nh\u1ecbp tim. Khi d\u00f2ng If b\u1ecb \u1ee9c ch\u1ebf, t\u1ed1c \u0111\u1ed9 kh\u1eed c\u1ef1c t\u00e2m tr\u01b0\u01a1ng t\u1ef1 ph\u00e1t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u00fat xoang gi\u1ea3m, l\u00e0m ch\u1eadm nh\u1ecbp tim m\u1ed9t c\u00e1ch ch\u1ecdn l\u1ecdc. \u0110i\u1ec1u n\u00e0y gi\u00fap k\u00e9o d\u00e0i th\u1eddi gian t\u00e2m tr\u01b0\u01a1ng, t\u0103ng c\u01b0\u1eddng cung c\u1ea5p m\u00e1u gi\u00e0u oxy cho tim v\u00e0 gi\u1ea3m c\u00f4ng vi\u1ec7c c\u1ee7a tim. Ivabradine kh\u00e1c bi\u1ec7t so v\u1edbi c\u00e1c thu\u1ed1c l\u00e0m ch\u1eadm nh\u1ecbp tim truy\u1ec1n th\u1ed1ng \u1edf ch\u1ed7 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00ednh co b\u00f3p c\u01a1 tim, d\u1eabn truy\u1ec1n trong tim hay huy\u1ebft \u00e1p to\u00e0n th\u00e2n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Ivabradine h\u1ea5p thu nhanh v\u00e0 g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a sau khi u\u1ed1ng. U\u1ed1ng thu\u1ed1c c\u00f9ng b\u1eefa \u0103n c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh h\u1ea5p thu nh\u01b0ng l\u1ea1i t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng t\u1eeb 20% \u0111\u1ebfn 40%, do \u0111\u00f3 n\u00ean u\u1ed1ng c\u00f9ng b\u1eefa \u0103n.<\/li>\n<li>Ph\u00e2n b\u1ed1: Ivabradine li\u00ean k\u1ebft kho\u1ea3ng 70% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1ed5n \u0111\u1ecbnh kho\u1ea3ng 100 l\u00edt.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ivabradine \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh \u1edf gan v\u00e0 ru\u1ed9t, ch\u1ee7 y\u1ebfu qua enzyme cytochrome P450 3A4 (CYP3A4). Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 N-desmethyl ivabradine (S18982). Con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a n\u00e0y r\u1ea5t quan tr\u1ecdng v\u00ec n\u00f3 l\u00e0 nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y ra nhi\u1ec1u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u1ee7a Ivabradine.<\/li>\n<li>Th\u1ea3i tr\u1eeb: N\u1ed3ng \u0111\u1ed9 Ivabradine trong huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i ph\u00e2n b\u1ed1 l\u00e0 2 gi\u1edd v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb hi\u1ec7u qu\u1ea3 kho\u1ea3ng 6 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Ivaswift 5 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c m\u1ea1n t\u00ednh \u1ed5n \u0111\u1ecbnh: D\u00e0nh cho ng\u01b0\u1eddi l\u1edbn m\u1eafc b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh c\u00f3 nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng v\u00e0 nh\u1ecbp tim l\u00fac ngh\u1ec9 \u226570 nh\u1ecbp\/ph\u00fat (theo EMA v\u00e0 FDA), ho\u1eb7c &gt;77 nh\u1ecbp\/ph\u00fat (theo C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c Vi\u1ec7t Nam). Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng khi b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p ho\u1eb7c c\u00f3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi thu\u1ed1c ch\u1eb9n beta, ho\u1eb7c d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c ch\u1eb9n beta khi kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u1ea7y \u0111\u1ee7.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb suy tim m\u1ea1n t\u00ednh: D\u00e0nh cho ng\u01b0\u1eddi l\u1edbn suy tim m\u1ea1n t\u00ednh \u0111\u1ed9 II \u0111\u1ebfn IV (NYHA) c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u00e2m thu th\u1ea5t tr\u00e1i, nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng v\u00e0 nh\u1ecbp tim l\u00fac ngh\u1ec9 \u226575 nh\u1ecbp\/ph\u00fat (EMA) ho\u1eb7c \u226570 nh\u1ecbp\/ph\u00fat (FDA). \u1ede Vi\u1ec7t Nam, ng\u01b0\u1ee1ng nh\u1ecbp tim \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh l\u00e0 &gt;77 nh\u1ecbp\/ph\u00fat. Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p ti\u00eau chu\u1ea9n, ho\u1eb7c khi thu\u1ed1c ch\u1eb9n beta b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\/kh\u00f4ng dung n\u1ea1p. M\u1ee5c ti\u00eau ch\u00ednh l\u00e0 gi\u1ea3m nguy c\u01a1 nh\u1eadp vi\u1ec7n do suy tim n\u1eb7ng h\u01a1n \u1edf b\u1ec7nh nh\u00e2n suy tim m\u1ea1n t\u00ednh \u1ed5n \u0111\u1ecbnh v\u1edbi ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u th\u1ea5t tr\u00e1i \u226435%. Ivabradine c\u0169ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb suy tim \u1edf b\u1ec7nh nhi t\u1eeb 6 th\u00e1ng tu\u1ed5i tr\u1edf l\u00ean do b\u1ec7nh c\u01a1 tim gi\u00e3n n\u1edf.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Ivaswift 5<\/h2>\n<p>Li\u1ec1u d\u00f9ng c\u1ee7a Ivaswift 5 c\u1ea7n \u0111\u01b0\u1ee3c c\u00e1 th\u1ec3 h\u00f3a d\u1ef1a tr\u00ean nh\u1ecbp tim v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n. Thu\u1ed1c n\u00ean \u0111\u01b0\u1ee3c u\u1ed1ng c\u00f9ng b\u1eefa \u0103n \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a s\u1ef1 h\u1ea5p thu.<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn:\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o: 5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n tr\u00ean 75 tu\u1ed5i, b\u1ec7nh nh\u00e2n d\u1ec5 b\u1ecb t\u1ed5n th\u01b0\u01a1ng, ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n: Li\u1ec1u kh\u1edfi \u0111\u1ea7u c\u00f3 th\u1ec3 l\u00e0 2.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u sau 2 tu\u1ea7n d\u1ef1a tr\u00ean nh\u1ecbp tim l\u00fac ngh\u1ec9 \u0111\u1ec3 \u0111\u1ea1t m\u1ee5c ti\u00eau 50-60 nh\u1ecbp\/ph\u00fat.\n<ul>\n<li>Nh\u1ecbp tim &gt;60 nh\u1ecbp\/ph\u00fat: T\u0103ng 2.5 mg x 2 l\u1ea7n\/ng\u00e0y, t\u1ed1i \u0111a 7.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Nh\u1ecbp tim 50-60 nh\u1ecbp\/ph\u00fat: Duy tr\u00ec li\u1ec1u hi\u1ec7n t\u1ea1i.<\/li>\n<li>Nh\u1ecbp tim &lt;50 nh\u1ecbp\/ph\u00fat ho\u1eb7c c\u00f3 tri\u1ec7u ch\u1ee9ng nh\u1ecbp ch\u1eadm: Gi\u1ea3m 2.5 mg x 2 l\u1ea7n\/ng\u00e0y. N\u1ebfu \u0111ang d\u00f9ng 2.5 mg x 2 l\u1ea7n\/ng\u00e0y th\u00ec ng\u1eebng \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<\/li>\n<li>Li\u1ec1u duy tr\u00ec: 2.5 &#8211; 7.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Li\u1ec1u t\u1ed1i \u0111a: 7.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<li>B\u1ec7nh nhi (t\u1eeb 6 th\u00e1ng tu\u1ed5i tr\u1edf l\u00ean):\n<ul>\n<li>C\u00e2n n\u1eb7ng d\u01b0\u1edbi 40 kg (d\u1ea1ng dung d\u1ecbch u\u1ed1ng): Kh\u1edfi \u0111\u1ea7u 0.05 mg\/kg x 2 l\u1ea7n\/ng\u00e0y, u\u1ed1ng c\u00f9ng b\u1eefa \u0103n. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u 0.05 mg\/kg sau m\u1ed7i 2 tu\u1ea7n \u0111\u1ec3 \u0111\u1ea1t gi\u1ea3m nh\u1ecbp tim \u226520%. Li\u1ec1u t\u1ed1i \u0111a: 0.2 mg\/kg x 2 l\u1ea7n\/ng\u00e0y (d\u01b0\u1edbi 1 tu\u1ed5i) ho\u1eb7c 0.3 mg\/kg x 2 l\u1ea7n\/ng\u00e0y (\u22651 tu\u1ed5i), t\u1ed5ng li\u1ec1u kh\u00f4ng qu\u00e1 7.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>C\u00e2n n\u1eb7ng t\u1eeb 40 kg tr\u1edf l\u00ean (d\u1ea1ng vi\u00ean n\u00e9n): Kh\u1edfi \u0111\u1ea7u 2.5 mg x 2 l\u1ea7n\/ng\u00e0y, u\u1ed1ng c\u00f9ng b\u1eefa \u0103n. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u 2.5 mg sau m\u1ed7i 2 tu\u1ea7n \u0111\u1ec3 \u0111\u1ea1t gi\u1ea3m nh\u1ecbp tim \u226520%. Li\u1ec1u t\u1ed1i \u0111a: 7.5 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>Vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u Ivabradine c\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd nh\u1ecbp tim v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Ivaswift 5<\/h2>\n<p>Ivaswift 5 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, hai l\u1ea7n m\u1ed7i ng\u00e0y, v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 bu\u1ed5i t\u1ed1i, c\u00f9ng v\u1edbi b\u1eefa \u0103n. U\u1ed1ng thu\u1ed1c c\u00f9ng b\u1eefa \u0103n gi\u00fap t\u0103ng c\u01b0\u1eddng h\u1ea5p thu thu\u1ed1c. Vi\u00ean n\u00e9n 5mg c\u00f3 th\u1ec3 b\u1ebb \u0111\u00f4i t\u1ea1i v\u1ea1ch chia \u0111\u1ec3 cung c\u1ea5p li\u1ec1u 2.5mg khi c\u1ea7n. B\u1ec7nh nh\u00e2n n\u00ean u\u1ed1ng thu\u1ed1c v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y \u0111\u1ec3 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1ed5n \u0111\u1ecbnh. Kh\u00f4ng n\u00ean ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t m\u00e0 kh\u00f4ng h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129. N\u1ebfu qu\u00ean m\u1ed9t li\u1ec1u, b\u1ecf qua li\u1ec1u \u0111\u00f3 v\u00e0 ti\u1ebfp t\u1ee5c l\u1ecbch tr\u00ecnh b\u00ecnh th\u01b0\u1eddng, kh\u00f4ng d\u00f9ng li\u1ec1u g\u1ea5p \u0111\u00f4i \u0111\u1ec3 b\u00f9.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Ivaswift 5 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Suy tim c\u1ea5p t\u00ednh m\u1ea5t b\u00f9.<\/li>\n<li>H\u1ea1 huy\u1ebft \u00e1p c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng (huy\u1ebft \u00e1p t\u00e2m thu &lt;90 mmHg v\u00e0\/ho\u1eb7c huy\u1ebft \u00e1p t\u00e2m tr\u01b0\u01a1ng &lt;50 mmHg).<\/li>\n<li>Nh\u1ecbp tim ch\u1eadm c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng (nh\u1ecbp tim l\u00fac ngh\u1ec9 &lt;50 nh\u1ecbp\/ph\u00fat tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb).<\/li>\n<li>H\u1ed9i ch\u1ee9ng n\u00fat xoang b\u1ec7nh l\u00fd, block xoang nh\u0129 ho\u1eb7c block nh\u0129 th\u1ea5t \u0111\u1ed9 3, tr\u1eeb khi b\u1ec7nh nh\u00e2n c\u00f3 m\u00e1y t\u1ea1o nh\u1ecbp tim ho\u1ea1t \u0111\u1ed9ng theo y\u00eau c\u1ea7u.<\/li>\n<li>Ph\u1ee5 thu\u1ed9c m\u00e1y t\u1ea1o nh\u1ecbp.<\/li>\n<li>Suy gan n\u1eb7ng.<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (v\u00ed d\u1ee5: ketoconazole, itraconazole, clarithromycin, telithromycin, nelfinavir, nefazodone).<\/li>\n<li>Ph\u1ee5 n\u1eef \u0111ang mang thai ho\u1eb7c \u0111ang cho con b\u00fa.<\/li>\n<li>Qu\u00e1 m\u1eabn v\u1edbi Ivabradine ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Ivaswift 5<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh v\u00f5ng m\u1ea1c m\u1ea1n t\u00ednh, ti\u1ec1n s\u1eed tai bi\u1ebfn m\u1ea1ch m\u00e1u n\u00e3o g\u1ea7n \u0111\u00e2y, h\u1ea1 huy\u1ebft \u00e1p nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, ho\u1eb7c suy tim m\u1ea1n t\u00ednh n\u00f3i chung.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t th\u01b0\u1eddng g\u1eb7p (\u22651\/10) v\u00e0 th\u01b0\u1eddng g\u1eb7p (\u22651\/100 \u0111\u1ebfn &lt;1\/10):\n<ul>\n<li>Hi\u1ec7n t\u01b0\u1ee3ng ch\u00f3i s\u00e1ng (Phosphenes): R\u1ea5t th\u01b0\u1eddng g\u1eb7p (14.5% theo EMA, 2.8% theo FDA), th\u01b0\u1eddng nh\u1eb9 v\u00e0 t\u1ef1 bi\u1ebfn m\u1ea5t.<\/li>\n<li>Nh\u1ecbp tim ch\u1eadm (Bradycardia): Th\u01b0\u1eddng g\u1eb7p (3.3% theo EMA, 10% theo FDA), \u0111\u1eb7c bi\u1ec7t trong 2-3 th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>\u0110au \u0111\u1ea7u: Th\u01b0\u1eddng g\u1eb7p, th\u01b0\u1eddng trong th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Ch\u00f3ng m\u1eb7t: Th\u01b0\u1eddng g\u1eb7p, c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn nh\u1ecbp tim ch\u1eadm.<\/li>\n<li>M\u1edd m\u1eaft, block nh\u0129 th\u1ea5t \u0111\u1ed9 1, ngo\u1ea1i t\u00e2m thu th\u1ea5t, rung nh\u0129, t\u0103ng huy\u1ebft \u00e1p\/huy\u1ebft \u00e1p kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c.<\/li>\n<\/ul>\n<\/li>\n<li>\u00cdt g\u1eb7p (\u22651\/1.000 \u0111\u1ebfn &lt;1\/100): T\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, t\u0103ng acid uric m\u00e1u, ng\u1ea5t, song th\u1ecb, gi\u1ea3m th\u1ecb l\u1ef1c, ch\u00f3ng m\u1eb7t (vertigo), \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, ngo\u1ea1i t\u00e2m thu tr\u00ean th\u1ea5t, k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean ECG, h\u1ea1 huy\u1ebft \u00e1p, kh\u00f3 th\u1edf, bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, ph\u00f9 m\u1ea1ch, ph\u00e1t ban, co r\u00fat c\u01a1, t\u0103ng creatinin m\u00e1u, suy nh\u01b0\u1ee3c, m\u1ec7t m\u1ecfi.<\/li>\n<li>Hi\u1ebfm g\u1eb7p (\u22651\/10.000 \u0111\u1ebfn &lt;1\/1.000): M\u00e0y \u0111ay, ng\u1ee9a, \u0111\u1ecf da, kh\u00f3 ch\u1ecbu.<\/li>\n<li>R\u1ea5t hi\u1ebfm g\u1eb7p (&lt;1\/10.000): Block nh\u0129 th\u1ea5t \u0111\u1ed9 2, block nh\u0129 th\u1ea5t \u0111\u1ed9 3, h\u1ed9i ch\u1ee9ng n\u00fat xoang b\u1ec7nh l\u00fd.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (CH\u1ed0NG CH\u1ec8 \u0110\u1ecaNH): T\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Ivabradine, g\u00e2y nguy c\u01a1 nh\u1ecbp tim ch\u1eadm v\u00e0 r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n nghi\u00eam tr\u1ecdng (v\u00ed d\u1ee5: ketoconazole, itraconazole, clarithromycin, telithromycin, nelfinavir, nefazodone).<\/li>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf trung b\u00ecnh CYP3A4 (N\u00caN TR\u00c1NH): C\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 Ivabradine (v\u00ed d\u1ee5: diltiazem, verapamil).<\/li>\n<li>Thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 (N\u00caN TR\u00c1NH): Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Ivabradine, gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb (v\u00ed d\u1ee5: St. John&#8217;s wort, rifampicin, barbiturat, phenytoin).<\/li>\n<li>C\u00e1c thu\u1ed1c l\u00e0m ch\u1eadm nh\u1ecbp tim kh\u00e1c (C\u1ea6N THEO D\u00d5I NH\u1ecaP TIM): T\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng l\u00e0m ch\u1eadm nh\u1ecbp tim (v\u00ed d\u1ee5: digoxin, amiodarone, thu\u1ed1c ch\u1eb9n beta).<\/li>\n<li>C\u00e1c thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT: Th\u1eadn tr\u1ecdng do nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QTc v\u00e0 g\u00e2y xo\u1eafn \u0111\u1ec9nh.<\/li>\n<li>T\u01b0\u01a1ng t\u00e1c v\u1edbi th\u1ef1c ph\u1ea9m\/\u0111\u1ed3 u\u1ed1ng: N\u01b0\u1edbc \u00e9p b\u01b0\u1edfi c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Ivabradine \u0111\u00e1ng k\u1ec3, n\u00ean tr\u00e1nh ho\u1eb7c h\u1ea1n ch\u1ebf. Ivabradine n\u00ean \u0111\u01b0\u1ee3c u\u1ed1ng c\u00f9ng b\u1eefa \u0103n \u0111\u1ec3 t\u0103ng h\u1ea5p thu.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ivabradine b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf ph\u1ee5 n\u1eef c\u00f3 thai do c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c cho thai nhi. Ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n ph\u1ea3i d\u00f9ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3. Hi\u1ec7n ch\u01b0a c\u00f3 \u0111\u1ee7 th\u00f4ng tin v\u1ec1 vi\u1ec7c thu\u1ed1c c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng, n\u00ean \u01b0u ti\u00ean d\u00f9ng thu\u1ed1c thay th\u1ebf khi cho con b\u00fa, \u0111\u1eb7c bi\u1ec7t l\u00e0 tr\u1ebb s\u01a1 sinh ho\u1eb7c sinh non.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Ivabradine c\u00f3 th\u1ec3 g\u00e2y r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c (ch\u00f3i s\u00e1ng, m\u1edd m\u1eaft, ch\u00f3ng m\u1eb7t), \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. B\u1ec7nh nh\u00e2n n\u00ean th\u1eadn tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t khi c\u00f3 s\u1ef1 thay \u0111\u1ed5i c\u01b0\u1eddng \u0111\u1ed9 \u00e1nh s\u00e1ng \u0111\u1ed9t ng\u1ed9t, v\u00e0 tr\u00e1nh l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c cho \u0111\u1ebfn khi hi\u1ec3u r\u00f5 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Qu\u00e1 li\u1ec1u Ivabradine ch\u1ee7 y\u1ebfu g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c nh\u01b0 nh\u1ecbp tim ch\u1eadm nghi\u00eam tr\u1ecdng, h\u1ea1 huy\u1ebft \u00e1p, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi qu\u00e1 m\u1ee9c. X\u1eed tr\u00ed:<\/p>\n<ul>\n<li>Kh\u1eed \u0111\u1ed9c \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<li>X\u1eed tr\u00ed nh\u1ecbp tim ch\u1eadm.<\/li>\n<li>X\u1eed tr\u00ed h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>Theo d\u00f5i kho\u1ea3ng QT v\u00e0 r\u1ed1i lo\u1ea1n nh\u1ecbp.<\/li>\n<li>Theo d\u00f5i.<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Ivaswift 5<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/ivaprex-5-tablet\/\">Thu\u1ed1c Ivaprex 5 Tablet <\/a>c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n Ivabradin 5 mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH D\u01b0\u1ee3c ph\u1ea9m Incepta, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c \u1ed5n \u0111\u1ecbnh m\u1ea1n t\u00ednh \u1edf b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh m\u1ea1ch v\u00e0nh.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Pam R Taub, Adena Zadourian, Hannah C Lo, Cameron K Ormiston, Shahrokh Golshan, Jonathan C Hsu. Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome, truy c\u1eadp ng\u00e0y 27 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33602468\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33602468\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Ivaswift 5 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Ind-Swift Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-22118-19, ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c m\u1ea1n t\u00ednh \u1ed5n \u0111\u1ecbnh.<\/p>\n","protected":false},"author":1,"featured_media":125135,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-125132","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/125132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=125132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/125135"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=125132"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=125132"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=125132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}