{"id":124418,"date":"2025-06-24T10:11:31","date_gmt":"2025-06-24T03:11:31","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=124418"},"modified":"2025-12-23T10:15:40","modified_gmt":"2025-12-23T03:15:40","slug":"methotrexat-ebewe-500mg-5ml","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/methotrexat-ebewe-500mg-5ml\/","title":{"rendered":"Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Fareva Unterach GmbH, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 900114446923 (VN2-634-17).<\/strong><\/p>\n<h2>Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml<\/strong> l\u00e0 dung d\u1ecbch ti\u00eam ch\u1ee9a ho\u1ea1t ch\u1ea5t <strong>Methotrexat<\/strong> h\u00e0m l\u01b0\u1ee3ng 500mg\/5ml, c\u00f9ng c\u00e1c t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 900114446923 (VN2-634-17)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd 5ml<\/p>\n<p>Xu\u1ea5t x\u1ee9: Austria<\/p>\n<figure id=\"attachment_124422\" aria-describedby=\"caption-attachment-124422\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-124422\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Methotrexat-Ebewe-500mg5ml.jpg\" alt=\"Methotrexat &quot;Ebewe&quot; 500mg\/5ml thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Methotrexat-Ebewe-500mg5ml.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Methotrexat-Ebewe-500mg5ml-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Methotrexat-Ebewe-500mg5ml-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Methotrexat-Ebewe-500mg5ml-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-124422\" class=\"wp-caption-text\">Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Methotrexat l\u00e0 m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m \u0111\u1ed1i kh\u00e1ng acid folic, c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o m\u1ea1nh m\u1ebd. C\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a thu\u1ed1c l\u00e0 \u1ee9c ch\u1ebf enzyme dihydrofolat reductase, ng\u0103n c\u1ea3n qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a acid folic th\u00e0nh acid tetrahydrofolic. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn s\u1ef1 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p DNA v\u00e0 RNA, t\u1eeb \u0111\u00f3 k\u00ecm h\u00e3m qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o m\u1edbi. Methotrexat c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1eb7c hi\u1ec7u t\u1ea1i pha S c\u1ee7a chu k\u1ef3 ph\u00e2n b\u00e0o, \u0111\u1eb7c bi\u1ec7t nh\u1ea1y c\u1ea3m v\u1edbi c\u00e1c m\u00f4 \u0111ang t\u0103ng sinh nhanh nh\u01b0 t\u1ebf b\u00e0o \u00e1c t\u00ednh, t\u1ee7y x\u01b0\u01a1ng, t\u1ebf b\u00e0o thai nhi, bi\u1ec3u m\u00f4 v\u00e0 ni\u00eam m\u1ea1c.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Sau khi ti\u00eam t\u0129nh m\u1ea1ch, n\u1ed3ng \u0111\u1ed9 Methotrexat \u0111\u1ea1t \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 0,5 &#8211; 1 gi\u1edd. H\u1ea5p thu qua \u0111\u01b0\u1eddng u\u1ed1ng s\u1ebd b\u00e3o h\u00f2a \u1edf li\u1ec1u 30mg\/m2.<\/li>\n<li>Ph\u00e2n b\u1ed1: Kho\u1ea3ng 50% Methotrexat li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Thu\u1ed1c d\u1ec5 d\u00e0ng khu\u1ebfch t\u00e1n v\u00e0o b\u00ean trong t\u1ebf b\u00e0o, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 cao nh\u1ea5t \u1edf gan, l\u00e1ch v\u00e0 th\u1eadn d\u01b0\u1edbi d\u1ea1ng polyglutamate, c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i trong v\u00e0i tu\u1ea7n \u0111\u1ebfn v\u00e0i th\u00e1ng. Methotrexat c\u0169ng ph\u00e2n b\u1ed1 v\u00e0o d\u1ecbch n\u00e3o t\u1ee7y nh\u01b0ng v\u1edbi n\u1ed3ng \u0111\u1ed9 th\u1ea5p.<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 th\u1ea3i tr\u1eeb: Methotrexat c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 3 &#8211; 10 gi\u1edd \u0111\u1ed1i v\u1edbi li\u1ec1u th\u1ea5p v\u00e0 8 &#8211; 15 gi\u1edd \u0111\u1ed1i v\u1edbi li\u1ec1u cao. Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng theo 3 pha, ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng bi\u1ebfn \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u trong v\u00f2ng 24 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 v\u00e0 b\u1ec7nh l\u00fd t\u0103ng sinh t\u1ebf b\u00e0o \u00e1c t\u00ednh, bao g\u1ed3m:<\/p>\n<ul>\n<li>U l\u00e1 nu\u00f4i \u00e1c t\u00ednh<\/li>\n<li>Ung th\u01b0 v\u00fa<\/li>\n<li>Ung th\u01b0 bi\u1ec3u m\u00f4 v\u00f9ng \u0111\u1ea7u m\u1eb7t c\u1ed5<\/li>\n<li>B\u1ec7nh b\u1ea1ch c\u1ea7u lympho c\u1ea5p<\/li>\n<li>U lympho kh\u00f4ng Hodgkin<\/li>\n<li>Sarcoma x\u01b0\u01a1ng<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml<\/h2>\n<p>Li\u1ec1u l\u01b0\u1ee3ng Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml s\u1ebd \u0111\u01b0\u1ee3c b\u00e1c s\u0129 \u0111i\u1ec1u ch\u1ec9nh t\u00f9y thu\u1ed9c v\u00e0o t\u00ecnh tr\u1ea1ng v\u00e0 ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb c\u1ee5 th\u1ec3 c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n. C\u00e1c ph\u00e1c \u0111\u1ed3 th\u01b0\u1eddng \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i nh\u01b0 sau:<\/p>\n<ul>\n<li>Ph\u00e1c \u0111\u1ed3 li\u1ec1u th\u1ea5p: D\u01b0\u1edbi 100mg\/m2<\/li>\n<li>Ph\u00e1c \u0111\u1ed3 li\u1ec1u trung b\u00ecnh: T\u1eeb 100 &#8211; 1000mg\/m2<\/li>\n<li>Ph\u00e1c \u0111\u1ed3 li\u1ec1u cao: Tr\u00ean 1000mg\/m2<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml<\/h2>\n<ul>\n<li>Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch, \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u00e0 gi\u00e1m s\u00e1t b\u1edfi nh\u00e2n vi\u00ean y t\u1ebf. Tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng, dung d\u1ecbch thu\u1ed1c c\u1ea7n \u0111\u01b0\u1ee3c pha lo\u00e3ng v\u1edbi dung d\u1ecbch Natri Clorid 0.9% v\u00e0 dung d\u1ecbch Ringer.<\/li>\n<li>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1edfi c\u00e1n b\u1ed9 y t\u1ebf, b\u00e1c s\u0129 chuy\u00ean m\u00f4n c\u00f3 kinh nghi\u1ec7m trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Tuy\u1ec7t \u0111\u1ed1i tr\u00e1nh \u0111\u1ec3 thu\u1ed1c ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi da v\u00e0 ni\u00eam m\u1ea1c.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u1edbi Methotrexat ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>B\u1ec7nh nh\u00e2n nhi\u1ec5m tr\u00f9ng n\u1eb7ng ho\u1eb7c \u0111ang ti\u1ebfn tri\u1ec3n.<\/li>\n<li>Suy gan, suy th\u1eadn r\u00f5 r\u1ec7t.<\/li>\n<li>B\u1ec7nh nh\u00e2n c\u00f3 vi\u00eam lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u0111ang ho\u1ea1t \u0111\u1ed9ng.<\/li>\n<li>Ng\u01b0\u1eddi b\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u1ea1o m\u00e1u (suy t\u1ee7y).<\/li>\n<li>Ng\u01b0\u1eddi c\u00f3 suy gi\u1ea3m mi\u1ec5n d\u1ecbch.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c \u0111ang cho con b\u00fa.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1ec7nh nh\u00e2n: C\u1ea7n theo d\u00f5i s\u00e1t sao b\u1ec7nh nh\u00e2n trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c bi\u1ec3u hi\u1ec7n \u0111\u1ed9c t\u00ednh. N\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 vi\u00eam mi\u1ec7ng, n\u00f4n ra m\u00e1u, ti\u00eau ch\u1ea3y, ph\u00e2n \u0111en, c\u1ea7n ng\u01b0ng s\u1eed d\u1ee5ng thu\u1ed1c ngay l\u1eadp t\u1ee9c.<\/li>\n<li>\u1ee8 d\u1ecbch trong c\u01a1 th\u1ec3: \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb \u1ee9 d\u1ecbch t\u1ea1i c\u00e1c khoang c\u1ee7a c\u01a1 th\u1ec3 (v\u00ed d\u1ee5: tr\u00e0n d\u1ecbch m\u00e0ng ph\u1ed5i, c\u1ed5 tr\u01b0\u1edbng), c\u1ea7n \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng \u1ee9 d\u1ecbch n\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Methotrexat.<\/li>\n<li>B\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ph\u1ee5 thu\u1ed9c insulin: C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng.<\/li>\n<li>S\u1eed d\u1ee5ng d\u00e0i h\u1ea1n: N\u1ebfu \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i, c\u00f3 th\u1ec3 c\u1ea7n ti\u1ebfn h\u00e0nh sinh thi\u1ebft t\u1ee7y x\u01b0\u01a1ng.<\/li>\n<li>Ph\u1ed1i h\u1ee3p v\u1edbi x\u1ea1 tr\u1ecb: S\u1eed d\u1ee5ng Methotrexat c\u00f9ng v\u1edbi ph\u01b0\u01a1ng ph\u00e1p x\u1ea1 tr\u1ecb c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ho\u1ea1i t\u1eed m\u00f4 m\u1ec1m v\u00e0 ho\u1ea1i t\u1eed x\u01b0\u01a1ng.<\/li>\n<li>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t: Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi suy gan, suy th\u1eadn v\u00e0 ng\u01b0\u1eddi cao tu\u1ed5i.<\/li>\n<li>H\u1ed9i ch\u1ee9ng ly gi\u1ea3i kh\u1ed1i u: Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra h\u1ed9i ch\u1ee9ng ly gi\u1ea3i kh\u1ed1i u trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p: B\u1ec7nh u lympho \u00e1c t\u00ednh, Herpes zoster, gi\u1ea3m b\u1ea1ch c\u1ea7u\/ti\u1ec3u c\u1ea7u\/to\u00e0n b\u1ed9 huy\u1ebft c\u1ea7u, bu\u1ed3n ng\u1ee7, \u0111au \u0111\u1ea7u, m\u1ec7t m\u1ecfi, d\u1ecb c\u1ea3m, ngo\u1ea1i ban, m\u1ea9n \u0111\u1ecf, ng\u1ee9a da, gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i creatinin.<\/li>\n<li>\u00cdt g\u1eb7p: Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng (s\u1ed1c ph\u1ea3n v\u1ec7, vi\u00eam m\u1ea1ch d\u1ecb \u1ee9ng), s\u1ed1t, suy gi\u1ea3m mi\u1ec5n d\u1ecbch, nhi\u1ec5m tr\u00f9ng c\u01a1 h\u1ed9i, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, r\u1ed1i lo\u1ea1n th\u1ea7n kinh (co gi\u1eadt, tr\u1ea7m c\u1ea3m, li\u1ec7t n\u1eeda ng\u01b0\u1eddi, b\u1ec7nh n\u00e3o, l\u00fa l\u1eabn, ch\u00f3ng m\u1eb7t), r\u1ed1i lo\u1ea1n gan (gan nhi\u1ec5m m\u1ee1, x\u01a1 gan), r\u1ed1i lo\u1ea1n x\u01b0\u01a1ng kh\u1edbp (lo\u00e3ng x\u01b0\u01a1ng, \u0111au x\u01b0\u01a1ng\/c\u01a1), vi\u00eam m\u1ea1ch, t\u0103ng nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng, t\u0103ng s\u1eafc t\u1ed1 da, r\u1ed1i lo\u1ea1n ti\u1ebft ni\u1ec7u (vi\u00eam lo\u00e9t b\u00e0ng quang, suy th\u1eadn, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn).<\/li>\n<li>Hi\u1ebfm g\u1eb7p: H\u1ed9i ch\u1ee9ng ly gi\u1ea3i kh\u1ed1i u, thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3, nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng, gi\u1ea3m gammaglobulin m\u00e1u, h\u1ea1 huy\u1ebft \u00e1p, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c (suy gi\u1ea3m th\u1ecb l\u1ef1c, s\u1ee3 \u00e1nh s\u00e1ng, vi\u00eam b\u1edd mi, ch\u1ea3y n\u01b0\u1edbc m\u1eaft), huy\u1ebft kh\u1ed1i (m\u1ea1ch n\u00e3o, \u0111\u1ed9ng m\u1ea1ch), \u0111\u1ed9c t\u00ednh\/vi\u00eam gan c\u1ea5p, g\u00e3y x\u01b0\u01a1ng, t\u0103ng ure\/acid uric\/creatinin huy\u1ebft thanh.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Thu\u1ed1c g\u00e2y m\u00ea: T\u0103ng nguy c\u01a1 vi\u00eam mi\u1ec7ng, suy t\u1ee7y nghi\u00eam tr\u1ecdng.<\/li>\n<li>L-asparaginase: \u0110\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng.<\/li>\n<li>Phenytoin: T\u0103ng nguy c\u01a1 b\u1ec7nh b\u1ea1ch c\u1ea7u lympho th\u1ea5p.<\/li>\n<li>Cholestyramin: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng th\u1ea3i tr\u1eeb Methotrexat.<\/li>\n<li>Azathioprin, Leflunomide, Retinol: T\u0103ng \u0111\u1ed9c t\u00ednh tr\u00ean gan.<\/li>\n<li>Corticosteroid: T\u0103ng nguy c\u01a1 nhi\u1ec5m Herpes.<\/li>\n<li>Mercaptopurine: T\u0103ng n\u1ed3ng \u0111\u1ed9 Methotrexat trong huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<li>Tetracycline, Chloramphenicol: Gi\u1ea3m kh\u1ea3 n\u0103ng h\u1ea5p thu c\u1ee7a Methotrexat qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/li>\n<li>Penicilin, Sulphonamide, Ciprofloxacin: Gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i Methotrexat qua th\u1eadn.<\/li>\n<li>Trimethoprim-sulfamethoxazole: \u1ee8c ch\u1ebf b\u00e0i ti\u1ebft qua \u1ed1ng th\u1eadn.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: Methotrexat c\u00f3 th\u1ec3 g\u00e2y d\u1ecb t\u1eadt thai nhi (d\u1ecb t\u1eadt s\u1ecd m\u1eb7t, tim m\u1ea1ch, c\u00e1c chi). Do \u0111\u00f3, ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n c\u1ea7n s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 c\u1ea7n x\u00e1c \u0111\u1ecbnh ch\u1eafc ch\u1eafn kh\u00f4ng mang thai tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c.<\/li>\n<li>B\u00e0 m\u1eb9 cho con b\u00fa: Methotrexat b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. V\u00ec v\u1eady, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 m\u1ec7t m\u1ecfi, ch\u00f3ng m\u1eb7t, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u1eadp trung v\u00e0 t\u1ec9nh t\u00e1o. Do \u0111\u00f3, c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. \u1ea2nh h\u01b0\u1edfng n\u00e0y c\u00f3 th\u1ec3 t\u0103ng l\u00ean khi s\u1eed d\u1ee5ng thu\u1ed1c c\u00f9ng v\u1edbi r\u01b0\u1ee3u.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>N\u1ebfu d\u00f9ng qu\u00e1 li\u1ec1u Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0: gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u, suy t\u1ee7y, gi\u1ea3m to\u00e0n b\u1ed9 huy\u1ebft c\u1ea7u, vi\u00eam mi\u1ec7ng, vi\u00eam ni\u00eam m\u1ea1c, lo\u00e9t mi\u1ec7ng, bu\u1ed3n n\u00f4n, n\u00f4n, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a.<\/li>\n<li>Khi b\u1ec7nh nh\u00e2n d\u00f9ng qu\u00e1 li\u1ec1u, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c v\u00e0 \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 c\u1ea7n thi\u1ebft.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>L Puig. Methotrexate: new therapeutic approaches, truy c\u1eadp ng\u00e0y 24 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23434058\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/23434058\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Methotrexat &#8220;Ebewe&#8221; 500mg\/5ml \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Fareva Unterach GmbH, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 900114446923 (VN2-634-17), \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o \u00e1c t\u00ednh.<\/p>\n","protected":false},"author":1,"featured_media":124421,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-124418","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/124418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=124418"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/124421"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=124418"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=124418"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=124418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}