{"id":123916,"date":"2025-06-19T15:53:19","date_gmt":"2025-06-19T08:53:19","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=123916"},"modified":"2025-07-24T11:48:11","modified_gmt":"2025-07-24T04:48:11","slug":"noclaud-100mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/noclaud-100mg\/","title":{"rendered":"Noclaud 100mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Noclaud 100mg c\u00f3 c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t l\u00e0 Egis Pharmaceuticals Private Limited Company, \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam v\u1edbi s\u1ed1 \u0111\u0103ng k\u00fd l\u00e0 599110407723.<\/strong><\/p>\n<h2>Noclaud 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean<strong> Noclaud 100mg<\/strong>\u00a0ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Cilostazol 100mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf : Vi\u00ean n\u00e9n<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 599110407723<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 4 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Hungary<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Noclaud 100mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Cilostazol l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc c\u1ee7a cyclic nucleotide phosphodiesterase 3 (PDE3). C\u00e1c \u0111\u1eb7c t\u00ednh ch\u1ed1ng ti\u1ec3u c\u1ea7u v\u00e0 gi\u00e3n m\u1ea1ch c\u1ee7a cilostazol\u00a0 g\u00f3p ph\u1ea7n v\u00e0o nhi\u1ec1u t\u00e1c d\u1ee5ng l\u00e2m s\u00e0ng nh\u01b0 \u0111i\u1ec1u tr\u1ecb kh\u1eadp khi\u1ec5ng c\u00e1ch h\u1ed3i v\u00e0 \u0111\u1ed9t qu\u1ef5 t\u00e1i ph\u00e1t.<\/p>\n<p>Cilostazol \u1ee9c ch\u1ebf s\u1ef1 suy gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng do TNF-alpha g\u00e2y ra c\u1ee7a c\u00e1c t\u1ebf b\u00e0o SK-N-SH (u nguy\u00ean b\u00e0o th\u1ea7n kinh ng\u01b0\u1eddi) v\u00e0 c\u00e1c t\u1ebf b\u00e0o HCN-1A (t\u1ebf b\u00e0o th\u1ea7n kinh v\u1ecf n\u00e3o ng\u01b0\u1eddi) li\u00ean quan \u0111\u1ebfn s\u1ef1 gi\u1ea3m phosphoryl h\u00f3a PTEN v\u00e0 t\u0103ng phosphoryl h\u00f3a Akt\/CREB v\u1edbi s\u1ef1 \u1ee9c ch\u1ebf ph\u00e2n m\u1ea3nh DNA, t\u1ea5t c\u1ea3 \u0111\u1ec1u \u0111\u01b0\u1ee3c \u0111\u1ed1i kh\u00e1ng b\u1edfi iberiotoxin, m\u1ed9t ch\u1ea5t ch\u1eb9n k\u00eanh maxi-K(+). H\u01a1n n\u1eefa, cilostazol ng\u0103n ng\u1eeba phosphoryl h\u00f3a PTEN do TNF-alpha g\u00e2y ra v\u00e0 ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh th\u00f4ng qua vi\u1ec7c t\u0103ng phosphoryl h\u00f3a CK2 trong c\u00e1c t\u1ebf b\u00e0o SK-N-SH. Cilostazol l\u00e0m t\u0103ng d\u00f2ng \u0111i\u1ec7n K(+) trong c\u00e1c t\u1ebf b\u00e0o SK-N-SH b\u1eb1ng c\u00e1ch m\u1edf c\u00e1c k\u00eanh maxi-K.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<h4>H\u1ea5p Thu<\/h4>\n<p>Cilostazol \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh sau 2,4\u202fgi\u1edd<\/p>\n<h4>Ph\u00e2n B\u1ed1<\/h4>\n<p>Thu\u1ed1c g\u1eafn h\u1ea7u nh\u01b0 ho\u00e0n to\u00e0n v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 albumin.<\/p>\n<h4>Chuy\u1ec3n H\u00f3a<\/h4>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua enzym CYP3A4, t\u1ea1o th\u00e0nh 2 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n<h4>Th\u1ea3i Tr\u1eeb<\/h4>\n<p>Thu\u1ed1c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u (74%, d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a) v\u00e0 ph\u00e2n (20%).<\/p>\n<h2>Noclaud 100mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p><strong>Noclaud 100mg Cilostazol<\/strong>\u00a0\u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong tr\u01b0\u1eddng h\u1ee3p :<\/p>\n<ul>\n<li>\u0110au nh\u1ee9c, kh\u00f3 ch\u1ecbu \u1edf c\u01a1 b\u1eafp ch\u00e2n khi \u0111i b\u1ed9 do l\u01b0\u1ee3ng oxy cung c\u1ea5p kh\u00f4ng \u0111\u1ee7 trong b\u1ec7nh \u0111au c\u00e1ch h\u1ed3i.<\/li>\n<li>\u0110au, lo\u00e9t ho\u1eb7c c\u1ea3m gi\u00e1c l\u1ea1nh \u1edf tay v\u00e0 ch\u00e2n do t\u1eafc ngh\u1ebdn \u0111\u1ed9ng m\u1ea1ch m\u00e3n t\u00ednh, d\u1eabn \u0111\u1ebfn thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u00e1c chi.<\/li>\n<li>Ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t nh\u1ed3i m\u00e1u n\u00e3o, tr\u1eeb c\u00e1c tr\u01b0\u1eddng h\u1ee3p nguy\u00ean nh\u00e2n t\u1eeb tim m\u1ea1ch.<\/li>\n<\/ul>\n<figure id=\"attachment_123917\" aria-describedby=\"caption-attachment-123917\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-123917\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/noclaud-100mg-dieu-tri-thieu-mau-cuc-bo.jpg\" alt=\"Noclaud 100mg \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/noclaud-100mg-dieu-tri-thieu-mau-cuc-bo.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/noclaud-100mg-dieu-tri-thieu-mau-cuc-bo-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/noclaud-100mg-dieu-tri-thieu-mau-cuc-bo-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/noclaud-100mg-dieu-tri-thieu-mau-cuc-bo-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-123917\" class=\"wp-caption-text\">Noclaud 100mg \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Noclaud 100mg<\/h2>\n<p>Ng\u01b0\u1eddi l\u1edbn : 1 vi\u00ean\/l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y. C\u1ea7n duy tr\u00ec l\u1ed1i s\u1ed1ng l\u00e0nh m\u1ea1nh, c\u00f3 th\u1ec3 hi\u1ec7u ch\u1ec9nh li\u1ec1u sau 3 th\u00e1ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh enzyme CYP3A4 : 50mg\/l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn (Clcr &gt; 25ml\/ph\u00fat) : kh\u00f4ng hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n<p>Tr\u1ebb em, b\u1ec7nh nh\u00e2n suy gan, b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (Clcr &lt; 25ml\/ph\u00fat) : kh\u00f4ng d\u00f9ng.<\/p>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Noclaud 100mg<\/h2>\n<p>U\u1ed1ng nguy\u00ean vi\u00ean c\u00f9ng n\u01b0\u1edbc l\u1ecdc, d\u00f9ng 30 ph\u00fat tr\u01b0\u1edbc ho\u1eb7c 2 gi\u1edd sau khi \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Noclaud 100mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Kh\u00f4ng d\u00f9ng Noclaud 100mg cho ng\u01b0\u1eddi c\u00f3 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Ng\u01b0\u1eddi b\u1ecb suy gan trung b\u00ecnh v\u00e0 n\u1eb7ng, suy th\u1eadn n\u1eb7ng, suy tim sung huy\u1ebft, nguy c\u01a1 ch\u1ea3y m\u00e1u, ti\u1ec1n s\u1eed r\u1ed1i lo\u1ea1n nh\u1ecbp tim nghi\u00eam tr\u1ecdng.<\/li>\n<li>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng \u0111\u1ed3ng th\u1eddi 2 ho\u1eb7c nhi\u1ec1u h\u01a1n 2 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng ho\u1eb7c thu\u1ed1c k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u tr\u1edf l\u00ean.<\/li>\n<li>Ng\u01b0\u1eddi b\u1ecb \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh, \u0111\u00e3 can thi\u1ec7p m\u1ea1ch v\u00e0nh trong v\u00f2ng 6 th\u00e1ng g\u1ea7n \u0111\u00e2y ho\u1eb7c b\u1ecb nh\u1ed3i m\u00e1u c\u01a1 tim.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Noclaud 100mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Ng\u1eebng thu\u1ed1c 5 ng\u00e0y tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/p>\n<p>Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n b\u1ecb h\u1eb9p van tim (t\u00e2m th\u1ea5t, t\u00e2m nh\u0129), nh\u1ecbp tim nhanh, rung nh\u0129..<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p : \u0111au \u0111\u1ea7u,\u00a0 ti\u00eau ch\u1ea3y, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, ch\u00f3ng m\u1eb7t, h\u1ea1 huy\u1ebft \u00e1p tho\u00e1ng qua.<\/li>\n<li>\u00cdt g\u1eb7p : r\u1ed1i lo\u1ea1n nh\u1ecbp tim, \u0111au ng\u1ef1c, kh\u00f3 th\u1edf<\/li>\n<li>Hi\u1ebfm g\u1eb7p : k\u00e9o d\u00e0i th\u1eddi gian ch\u1ea3y m\u00e1u.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>D\u00f9ng c\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u, thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/li>\n<li>D\u00f9ng c\u00f9ng thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p c\u00f3 nguy c\u01a1 g\u00e2y gi\u1ea3m huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa do ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<h3>Kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Th\u1eadn tr\u1ecdng khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c do thu\u1ed1c g\u00e2y ch\u00f3ng m\u1eb7t.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>\u0110\u1ebfn ngay c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t \u0111\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 x\u1eed tr\u00ed tri\u1ec7u ch\u1ee9ng k\u1ecbp th\u1eddi.<\/p>\n<h2>Noclaud 100mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Noclaud 100mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng v\u1edbi nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/zilamac-50\/\">Thu\u1ed1c Zilamac-50<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Macleods Pharmaceuticals Limited, \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng \u0111au c\u00e1ch h\u1ed3i \u1edf ch\u00e2n, ng\u0103n ng\u1eeba bi\u1ebfn ch\u1ee9ng huy\u1ebft kh\u1ed1i do nong m\u1ea1ch v\u00e0nh.<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/zilamac-100\/\">Thu\u1ed1c Zilamac 100<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Macleods Pharmaceuticals Ltd., c\u1ea3i thi\u1ec7n kho\u1ea3ng c\u00e1ch \u0111i l\u1ea1i \u1edf b\u1ec7nh nh\u00e2n \u0111au ch\u00e2n c\u00e1ch h\u1ed3i, kh\u00f4ng b\u1ecb \u0111au khi kh\u00f4ng di chuy\u1ec3n<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Ki Whan Hong, Jeong Hyun Lee, Ki Young Kima, So Youn Park, Won Suk Lee (2006), Cilostazol: therapeutic potential against focal cerebral ischemic damage. Truy c\u1eadp ng\u00e0y 19\/06\/2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16472148\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/16472148\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Noclaud 100mg \u0111i\u1ec1u tr\u1ecb \u0111au nh\u1ee9c, kh\u00f3 ch\u1ecbu \u1edf c\u01a1 b\u1eafp ch\u00e2n khi \u0111i b\u1ed9 trong b\u1ec7nh \u0111au c\u00e1ch h\u1ed3i v\u00e0 \u0111au, lo\u00e9t do t\u1eafc ngh\u1ebdn \u0111\u00f4ng m\u1ea1ch trong b\u1ec7nh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf c\u00e1c chi.<\/p>\n","protected":false},"author":1,"featured_media":123918,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-123916","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/123916","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=123916"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/123918"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=123916"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=123916"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=123916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}