{"id":123146,"date":"2025-06-13T13:22:24","date_gmt":"2025-06-13T06:22:24","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=123146"},"modified":"2025-07-24T11:48:24","modified_gmt":"2025-07-24T04:48:24","slug":"tegretol-cr-200","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tegretol-cr-200\/","title":{"rendered":"Tegretol CR 200"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Tegretol CR 200 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma S.p.A. c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-18777-15<\/strong><\/p>\n<h2>Tegretol CR 200 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean n\u00e9n Tegretol CR 200<\/strong> c\u00f3 ch\u1ee9a: Carbamazepine 200 mg<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-18777-15<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 5 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u00dd<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 24 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tegretol CR 200<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Carbamazepine \u2013 ho\u1ea1t ch\u1ea5t ch\u00ednh trong Tegretol CR 200 \u2013 t\u00e1c \u0111\u1ed9ng ch\u1ee7 y\u1ebfu l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng b\u1eb1ng c\u00e1ch \u1ed5n \u0111\u1ecbnh c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh \u0111ang \u1edf tr\u1ea1ng th\u00e1i k\u00edch th\u00edch qu\u00e1 m\u1ee9c. Thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng h\u1ea1n ch\u1ebf c\u00e1c t\u00edn hi\u1ec7u \u0111i\u1ec7n l\u1eb7p l\u1ea1i m\u1ed9t c\u00e1ch b\u1ea5t th\u01b0\u1eddng \u1edf t\u1ebf b\u00e0o th\u1ea7n kinh, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 lan truy\u1ec1n xung th\u1ea7n kinh qua c\u00e1c kh\u1edbp synap. C\u01a1 ch\u1ebf n\u00e0y ph\u1ea7n l\u1edbn li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf c\u00e1c k\u00eanh natri nh\u1ea1y c\u1ea3m v\u1edbi \u0111i\u1ec7n th\u1ebf, gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 t\u1ea1o l\u1eadp l\u1eb7p l\u1ea1i c\u00e1c \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng \u1edf nh\u1eefng neuron b\u1ecb kh\u1eed c\u1ef1c.<\/p>\n<p>H\u01a1n n\u1eefa, s\u1ef1 gi\u1ea3i ph\u00f3ng glutamate c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf ch\u1ed1ng \u0111\u1ed9ng kinh kh\u00e1c c\u1ee7a thu\u1ed1c. \u0110\u1ed3ng th\u1eddi, vi\u1ec7c \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a dopamine v\u00e0 noradrenaline c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn t\u00e1c d\u1ee5ng \u1ed5n \u0111\u1ecbnh kh\u00ed s\u1eafc, gi\u1ea3i th\u00edch \u0111\u1eb7c t\u00ednh ch\u1ed1ng h\u01b0ng c\u1ea3m c\u1ee7a carbamazepine.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Carbamazepine \u0111\u01b0\u1ee3c h\u1ea5p thu g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n sau khi u\u1ed1ng, tuy nhi\u00ean t\u1ed1c \u0111\u1ed9 h\u1ea5p thu ch\u1eadm v\u00e0 thay \u0111\u1ed5i t\u00f9y v\u00e0o d\u1ea1ng b\u00e0o ch\u1ebf. Sau kho\u1ea3ng 24 gi\u1edd d\u00f9ng <strong>vi\u00ean n\u00e9n gi\u1ea3i ph\u00f3ng ch\u1eadm Tegretol CR 200<\/strong>, n\u1ed3ng \u0111\u1ed9 thu\u1ed1c s\u1ebd \u0111\u1ea1t \u0111\u1ebfn m\u1ee9c t\u1ed1i \u0111a. Kh\u1ea3 d\u1ee5ng sinh h\u1ecdc v\u00e0o kho\u1ea3ng 85\u2013100%, v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 b\u1edfi th\u1ee9c \u0103n.<\/li>\n<li>Ph\u00e2n b\u1ed1: Kho\u1ea3ng 70\u201380% thu\u1ed1c g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Thu\u1ed1c qua \u0111\u01b0\u1ee3c nhau thai v\u00e0 c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u01b0\u1edbc t\u00ednh trong kho\u1ea3ng 0,8\u20131,9 L\/kg.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ch\u1ee7 y\u1ebfu t\u1ea1i gan th\u00f4ng qua h\u1ec7 enzyme cytochrome P450, \u0111\u1eb7c bi\u1ec7t l\u00e0 CYP3A4. Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 carbamazepine-10,11-epoxide, sau \u0111\u00f3 b\u1ecb th\u1ee7y ph\u00e2n th\u00e0nh d\u1eabn xu\u1ea5t transdiol kh\u00f4ng ho\u1ea1t t\u00ednh.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Do s\u1ef1 c\u1ea3m \u1ee9ng enzym, th\u1eddi gian thu\u1ed1c Tegretol CR 200 c\u00f2n l\u1ea1i 1 n\u1eeda b\u1ecb gi\u1ea3m \u0111i t\u1eeb gi\u00e1 tr\u1ecb ban \u0111\u1ea7u x\u1ea5p x\u1ec9 36 gi\u1edd, xu\u1ed1ng c\u00f2n 16\u201324 gi\u1edd n\u1ebfu d\u00f9ng l\u1eb7p l\u1ea1i. Kho\u1ea3ng 70% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u, trong \u0111\u00f3 ch\u1ec9 m\u1ed9t ph\u1ea7n nh\u1ecf d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c nguy\u00ean v\u1eb9n.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Tegretol CR 200 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110\u1ed9ng kinh: D\u1ea1ng to\u00e0n th\u1ec3 v\u00e0 c\u1ee5c b\u1ed9 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh l\u1ea7n \u0111\u1ea7u ho\u1eb7c k\u00e9m \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec7u ph\u00e1p tr\u01b0\u1edbc \u0111\u00f3<\/li>\n<li>\u0110au d\u00e2y th\u1ea7n kinh sinh ba: \u0110i\u1ec1u tr\u1ecb c\u00e1c c\u01a1n \u0111au k\u1ecbch ph\u00e1t.<\/li>\n<li>R\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c: D\u1ef1 ph\u00f2ng lo\u1ea1n th\u1ea7n h\u01b0ng c\u1ea3m khi b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi lithium.<\/li>\n<\/ul>\n<figure id=\"attachment_123154\" aria-describedby=\"caption-attachment-123154\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-123154\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tegretol-CR-200.jpg\" alt=\"Tegretol CR 200\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tegretol-CR-200.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tegretol-CR-200-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tegretol-CR-200-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tegretol-CR-200-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-123154\" class=\"wp-caption-text\">Thu\u1ed1c Tegretol CR 200 ch\u1ee9a ho\u1ea1t ch\u1ea5t Carbamazepine h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t co gi\u1eadt to\u00e0n th\u1ec3 v\u00e0 c\u1ee5c b\u1ed9, gi\u1ea3m \u0111au d\u00e2y th\u1ea7n kinh sinh ba v\u00e0 ng\u0103n ng\u1eeba lo\u1ea1n th\u1ea7n h\u01b0ng c\u1ea3m hi\u1ec7u qu\u1ea3.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>Kh\u1edfi \u0111\u1ea7u \u0111\u01a1n tr\u1ecb li\u1ec7u: 100\u2013200 mg x 1\u20132 l\u1ea7n\/ng\u00e0y, t\u0103ng d\u1ea7n \u0111\u1ebfn 800\u20131200 mg\/ng\u00e0y. C\u00f3 th\u1ec3 l\u00ean t\u1edbi 1600\u20132000 mg\/ng\u00e0y n\u1ebfu c\u1ea7n.<\/p>\n<p><em><strong>\u0110\u1ed9ng kinh:<\/strong> <\/em><\/p>\n<ul>\n<li>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u1ef1a tr\u00ean n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng m\u1ee5c ti\u00eau 4\u201312 mcg\/mL..<\/li>\n<li>Ng\u01b0\u1eddi l\u1edbn: Li\u1ec1u t\u0103ng d\u1ea7n, \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u00e1p \u1ee9ng.<\/li>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: D\u00f9ng li\u1ec1u th\u1eadn tr\u1ecdng do t\u01b0\u01a1ng t\u00e1c thu\u1ed1c.<\/li>\n<li>Tr\u1ebb em: Li\u1ec1u chung: 10\u201320 mg\/kg\/ng\u00e0y, chia nhi\u1ec1u l\u1ea7n.<\/li>\n<\/ul>\n<p>Li\u1ec1u theo tu\u1ed5i:<\/p>\n<ul>\n<li>D\u01b0\u1edbi 5 tu\u1ed5i: Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/li>\n<li>5\u201310 tu\u1ed5i: 400\u2013600 mg\/ng\u00e0y.<\/li>\n<li>10\u201315 tu\u1ed5i: 600\u20131000 mg\/ng\u00e0y.<\/li>\n<li>&gt;15 tu\u1ed5i: 800\u20131200 mg\/ng\u00e0y (nh\u01b0 ng\u01b0\u1eddi l\u1edbn).<\/li>\n<\/ul>\n<p>Li\u1ec1u t\u1ed1i \u0111a:<\/p>\n<ul>\n<li>&lt;6 tu\u1ed5i: 35 mg\/kg\/ng\u00e0y.<\/li>\n<li>6\u201315 tu\u1ed5i: 1000 mg\/ng\u00e0y.<\/li>\n<li>15 tu\u1ed5i: 1200 mg\/ng\u00e0y.<\/li>\n<\/ul>\n<p><em><strong>\u0110au d\u00e2y th\u1ea7n kinh sinh ba:<\/strong><\/em><\/p>\n<ul>\n<li>Kh\u1edfi \u0111\u1ea7u: 200\u2013400 mg\/ng\u00e0y, t\u0103ng d\u1ea7n \u0111\u1ebfn khi gi\u1ea3m \u0111au. Duy tr\u00ec: 200 mg x 3\u20134 l\u1ea7n\/ng\u00e0y, t\u1ed1i \u0111a: 1200 mg\/ng\u00e0y.<\/li>\n<li>Sau khi h\u1ebft \u0111au: gi\u1ea3m d\u1ea7n \u0111\u1ebfn li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3, c\u00f3 th\u1ec3 ng\u01b0ng thu\u1ed1c n\u1ebfu \u0111au kh\u00f4ng t\u00e1i ph\u00e1t.<\/li>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u1edfi \u0111\u1ea7u: 100 mg x 2 l\u1ea7n\/ng\u00e0y, t\u0103ng d\u1ea7n, t\u1ed1i \u0111a: 1200 mg\/ng\u00e0y.<\/li>\n<\/ul>\n<p><em><strong>R\u1ed1i lo\u1ea1n h\u01b0ng c\u1ea3m: <\/strong><\/em><\/p>\n<p>Kh\u1edfi \u0111\u1ea7u: 400 mg\/ng\u00e0y, chia li\u1ec1u, ti\u1ebfp t\u1ee5c t\u0103ng li\u1ec1u \u0111\u1ebfn khi c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1, t\u1ed1i \u0111a 1600 mg\/ng\u00e0y. Li\u1ec1u th\u01b0\u1eddng d\u00f9ng: 400\u2013600 mg\/ng\u00e0y.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<ul>\n<li>U\u1ed1ng nguy\u00ean vi\u00ean ho\u1eb7c n\u1eeda vi\u00ean (kh\u00f4ng nhai) Tegretol CR 200, k\u00e8m \u00edt n\u01b0\u1edbc, tr\u01b0\u1edbc\/trong\/sau b\u1eefa \u0103n.<\/li>\n<li>Li\u1ec1u d\u00f9ng Tegretol CR 200 th\u00f4ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c chia th\u00e0nh 2 l\u1ea7n\/ng\u00e0y<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Tegretol CR 200 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi carbamazepine hay t\u00e1 d\u01b0\u1ee3c b\u1ea5t k\u1ef3 c\u00f3 trong Tegretol CR 200<\/li>\n<li>Block nh\u0129 th\u1ea5t, suy t\u1ee7y x\u01b0\u01a1ng, b\u1ec7nh porphyria gan.<\/li>\n<li>Kh\u00f4ng d\u00f9ng chung v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf MAO (c\u1ea7n ng\u01b0ng MAO \u00edt nh\u1ea5t 2 tu\u1ea7n tr\u01b0\u1edbc khi d\u00f9ng Tegretol).<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: Th\u1eadn tr\u1ecdng do t\u0103ng nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c v\u00e0 thay \u0111\u1ed5i d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc.<\/li>\n<li>Suy gan\/th\u1eadn: Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u r\u00f5 r\u00e0ng \u2192 c\u1ea7n th\u1eadn tr\u1ecdng.<\/li>\n<li>B\u1ec7nh nh\u00e2n g\u1ed1c H\u00e1n v\u00e0 Th\u00e1i Lan: X\u00e9t nghi\u1ec7m HLA-B*1502 tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb v\u00ec nguy c\u01a1 Stevens Johnson.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t th\u01b0\u1eddng g\u1eb7p: gi\u1ea3m b\u1ea1ch c\u1ea7u, m\u1ec7t m\u1ecfi, ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, n\u00f4n, bu\u1ed3n n\u00f4n, m\u1ec1 \u0111ay, d\u1ecb<\/li>\n<li>\u1ee9ng,&#8230;<\/li>\n<li>Hi\u1ebfm g\u1eb7p: t\u0103ng b\u1ea1ch c\u1ea7u, \u1ea3o gi\u00e1c, l\u00fa l\u1eabn, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n tim, t\u0103ng ho\u1eb7c gi\u1ea3m huy\u1ebft \u00e1p, y\u1ebfu c\u01a1, vi\u00eam gan, v\u00e0ng da,&#8230;<\/li>\n<li>R\u1ea5t hi\u1ebfm g\u1eb7p: m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, thi\u1ebfu m\u00e1u, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 , ti\u1ebft s\u1eefa, v\u00fa to \u1edf \u0111\u00e0n \u00f4ng, k\u00edch th\u00edch b\u1ec7nh lo\u1ea1n th\u1ea7n, \u0111\u1ee5c thu\u1ef7 tinh th\u1ec3,&#8230;<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 \u2192 T\u0103ng n\u1ed3ng \u0111\u1ed9 carbamazepine:<\/p>\n<ul>\n<li>Kh\u00e1ng sinh (erythromycin, clarithromycin, ciprofloxacin).<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (fluoxetine, fluvoxamine, paroxetine).<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng n\u1ea5m azole (fluconazole, itraconazole, ketoconazole, voriconazole).<\/li>\n<li>C\u00e1c thu\u1ed1c kh\u00e1c: ritonavir, diltiazem, isoniazid, olanzapine, danazol, dextropropoxyphene&#8230;<\/li>\n<\/ul>\n<p>Ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 \u2192 Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 carbamazepine.<\/p>\n<p>Tegretol g\u00e2y c\u1ea3m \u1ee9ng m\u1ea1nh CYP3A4 v\u00e0 enzyme gan kh\u00e1c \u2192 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u00e1c thu\u1ed1c kh\u00e1c.<\/p>\n<p>T\u01b0\u01a1ng t\u00e1c \u0111\u1eb7c bi\u1ec7t:<\/p>\n<ul>\n<li>Kh\u00f4ng d\u00f9ng v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf MAO.<\/li>\n<li>C\u1ea9n tr\u1ecdng v\u1edbi c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn enzyme epoxide hydrolase (t\u0103ng chuy\u1ec3n h\u00f3a carbamazepine-epoxide \u2192 t\u0103ng \u0111\u1ed9c t\u00ednh).<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh \u1edf ph\u1ee5 n\u1eef mang thai c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u1ef9 do nguy c\u01a1 d\u1ecb t\u1eadt thai nhi. Vi\u1ec7c ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 g\u00e2y t\u00e1i ph\u00e1t c\u01a1n co gi\u1eadt nghi\u00eam tr\u1ecdng. Khi c\u00f3 th\u1ec3, n\u00ean \u01b0u ti\u00ean \u0111\u01a1n tr\u1ecb li\u1ec7u v\u1edbi li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 nh\u1eb1m gi\u1ea3m thi\u1ec3u nguy c\u01a1 d\u1ecb t\u1eadt.<\/p>\n<p>Carbamazepine b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 v\u1edbi n\u1ed3ng \u0111\u1ed9 kho\u1ea3ng 25\u201360% so v\u1edbi huy\u1ebft t\u01b0\u01a1ng. M\u1eb7c d\u00f9 n\u1ed3ng \u0111\u1ed9 n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p, c\u1ea7n theo d\u00f5i tr\u1ebb b\u00fa m\u1eb9 d\u00f9ng thu\u1ed1c \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nh\u01b0 bu\u1ed3n ng\u1ee7 b\u1ea5t th\u01b0\u1eddng, b\u00fa k\u00e9m ho\u1eb7c r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a. Vi\u1ec7c cho con b\u00fa c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c n\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i r\u1ee7i ro v\u00e0 c\u00f3 s\u1ef1 theo d\u00f5i y t\u1ebf \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng Tegretol c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng ph\u1ea3n x\u1ea1 v\u00e0 s\u1ef1 t\u1ec9nh t\u00e1o c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong giai \u0111o\u1ea1n kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c sau \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u. M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ph\u1ed1i v\u1eadn \u0111\u1ed9ng, nh\u00ecn \u0111\u00f4i, suy gi\u1ea3m \u0111i\u1ec1u ti\u1ebft v\u00e0 nh\u00ecn m\u1edd \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn, do \u0111\u00f3 b\u1ec7nh nh\u00e2n n\u00ean th\u1eadn tr\u1ecdng khi th\u1ef1c hi\u1ec7n c\u00e1c c\u00f4ng vi\u1ec7c \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 ph\u1ed1i h\u1ee3p v\u1eadn \u0111\u1ed9ng ch\u00ednh x\u00e1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Bi\u1ec3u hi\u1ec7n qu\u00e1 li\u1ec1u carbamazepine th\u01b0\u1eddng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u c\u01a1 quan, \u0111\u1eb7c bi\u1ec7t l\u00e0 h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, tim m\u1ea1ch v\u00e0 h\u00f4 h\u1ea5p. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 bao g\u1ed3m:<\/p>\n<ul>\n<li>Th\u1ea7n kinh trung \u01b0\u01a1ng: \u1ee9c ch\u1ebf th\u1ea7n kinh; m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, gi\u1ea3m tri gi\u00e1c, bu\u1ed3n ng\u1ee7 s\u00e2u, k\u00edch \u0111\u1ed9ng, \u1ea3o gi\u00e1c, h\u00f4n m\u00ea; n\u00f3i l\u1eafp, kh\u00f3 n\u00f3i, rung gi\u1eadt nh\u00e3n c\u1ea7u, m\u1ea5t \u0111i\u1ec1u h\u00f2a v\u1eadn \u0111\u1ed9ng, lo\u1ea1n v\u1eadn \u0111\u1ed9ng; co gi\u1eadt, r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n v\u1eadn \u0111\u1ed9ng, rung c\u01a1, gi\u00e3n \u0111\u1ed3ng t\u1eed, h\u1ea1 th\u00e2n nhi\u1ec7t.<\/li>\n<li>H\u00f4 h\u1ea5p: Suy h\u00f4 h\u1ea5p c\u1ea5p, ph\u00f9 ph\u1ed5i kh\u00f4ng do tim.<\/li>\n<li>Tim m\u1ea1ch: R\u1ed1i lo\u1ea1n nh\u1ecbp nh\u01b0 nh\u1ecbp nhanh, h\u1ea1 ho\u1eb7c t\u0103ng huy\u1ebft \u00e1p, lo\u1ea1n nh\u1ecbp v\u1edbi ph\u1ee9c h\u1ee3p QRS gi\u00e3n r\u1ed9ng; ng\u1ea5t do ng\u1eebng tim.<\/li>\n<li>Ti\u00eau h\u00f3a: N\u00f4n, tr\u00ec tr\u1ec7 d\u1ea1 d\u00e0y, gi\u1ea3m nhu \u0111\u1ed9ng ru\u1ed9t.<\/li>\n<li>C\u01a1 x\u01b0\u01a1ng kh\u1edbp: C\u00f3 ghi nh\u1eadn hi\u1ebfm g\u1eb7p v\u1ec1 ti\u00eau c\u01a1 v\u00e2n li\u00ean quan \u0111\u1ebfn ng\u1ed9 \u0111\u1ed9c carbamazepine.<\/li>\n<li>Ti\u1ebft ni\u1ec7u: B\u00ed ti\u1ec3u, thi\u1ec3u ni\u1ec7u ho\u1eb7c v\u00f4 ni\u1ec7u; gi\u1eef n\u01b0\u1edbc; ng\u1ed9 \u0111\u1ed9c n\u01b0\u1edbc do t\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 ADH.<\/li>\n<li>X\u00e9t nghi\u1ec7m: H\u1ea1 natri m\u00e1u, nhi\u1ec5m toan chuy\u1ec3n h\u00f3a, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, t\u0103ng creatine kinase c\u01a1.<\/li>\n<\/ul>\n<p>X\u1eed tr\u00ed qu\u00e1 li\u1ec1u<\/p>\n<ul>\n<li>Hi\u1ec7n kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c Tegretol CR 200 \u0111\u1eb7c hi\u1ec7u m\u00e0 th\u01b0\u1eddng x\u1eed l\u00fd d\u1ef1a tr\u00ean \u0111\u1eb7c \u0111i\u1ec3m l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh nh\u00e2n. C\u1ea7n \u0111o n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 ng\u1ed9 \u0111\u1ed9c.<\/li>\n<li>Bi\u1ec7n ph\u00e1p x\u1eed l\u00fd bao g\u1ed3m: r\u1eeda d\u1ea1 d\u00e0y, s\u1eed d\u1ee5ng than ho\u1ea1t t\u00ednh \u2013 ngay c\u1ea3 khi \u0111i\u1ec1u tr\u1ecb mu\u1ed9n do carbamazepine h\u1ea5p thu ch\u1eadm, g\u00e2y t\u00e1i ph\u00e1t tri\u1ec7u ch\u1ee9ng sau giai \u0111o\u1ea1n \u0111\u1ea7u. B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i t\u1ea1i \u0111\u01a1n v\u1ecb h\u1ed3i s\u1ee9c t\u00edch c\u1ef1c v\u1edbi \u0111\u00e1nh gi\u00e1 \u0111i\u1ec7n gi\u1ea3i, ch\u1ee9c n\u0103ng tim v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 s\u1ed1ng c\u00f2n.<\/li>\n<li>L\u1ecdc m\u00e1u b\u1eb1ng than ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb, trong khi th\u1ea9m ph\u00e2n m\u00e1u c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng. C\u1ea7n c\u1ea3nh gi\u00e1c v\u1edbi t\u00ecnh tr\u1ea1ng t\u00e1i ph\u00e1t tri\u1ec7u ch\u1ee9ng sau 48\u201372 gi\u1edd do \u0111\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef Tegretol CR 200 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Tegretol CR 200 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Tegretol CR 200 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Tegretol CR 200 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Tegretol CR 200 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Tegretol CR 200 c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Tegretol CR 200 t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Tegretol CR 200 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/tegretol\/\">Tegretol<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Carbamazepine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty Novartis Pharm UK., Ltd \u2013 ANH, \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/thuoc-tri-dong-kinh-carbatol-200mg\/\">Carbatol 200mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Carbamazepine v\u1edbi h\u00e0m l\u01b0\u1ee3ng 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Torrent, \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Beran, Roy G (2020). Carbamazepine \u2013An oldie but a goodie\u2013A clinician\u2019s perspective. Seizure &#8211; European Journal of Epilepsy. Truy c\u1eadp ng\u00e0y 13 th\u00e1ng 6 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33334543\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33334543\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Tegretol CR 200 ch\u1ee9a ho\u1ea1t ch\u1ea5t Carbamazepine h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t co gi\u1eadt to\u00e0n th\u1ec3 v\u00e0 c\u1ee5c b\u1ed9, gi\u1ea3m \u0111au d\u00e2y th\u1ea7n kinh sinh ba v\u00e0 ng\u0103n ng\u1eeba lo\u1ea1n th\u1ea7n h\u01b0ng c\u1ea3m hi\u1ec7u qu\u1ea3.<\/p>\n","protected":false},"author":1,"featured_media":123151,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-123146","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/123146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=123146"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/123151"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=123146"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=123146"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=123146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}