{"id":123096,"date":"2025-06-12T17:03:56","date_gmt":"2025-06-12T10:03:56","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=123096"},"modified":"2025-07-24T11:48:24","modified_gmt":"2025-07-24T04:48:24","slug":"simvofix-1020mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/simvofix-1020mg\/","title":{"rendered":"SIMVOFIX 10+20MG"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>SIMVOFIX 10+20MG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Sun Pharmaceutical Industries Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-23050-22.<\/strong><\/p>\n<h2>SIMVOFIX 10+20MG l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>SIMVOFIX 10+20MG<\/strong> ch\u1ee9a 10mg<strong> ezetimibe<\/strong> v\u00e0 20mg <strong>simvastatin<\/strong>, c\u00f9ng v\u1edbi c\u00e1c t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-23050-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: India<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c SIMVOFIX 10+20MG<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>SIMVOFIX ho\u1ea1t \u0111\u1ed9ng th\u00f4ng qua c\u01a1 ch\u1ebf b\u1ed5 sung: ezetimibe \u1ee9c ch\u1ebf h\u1ea5p thu cholesterol t\u1eeb ru\u1ed9t, trong khi simvastatin \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p cholesterol \u1edf gan. S\u1ef1 k\u1ebft h\u1ee3p n\u00e0y mang l\u1ea1i hi\u1ec7u qu\u1ea3 gi\u1ea3m cholesterol to\u00e0n di\u1ec7n v\u00e0 m\u1ea1nh m\u1ebd h\u01a1n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Ezetimibe \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 chuy\u1ec3n h\u00f3a th\u00e0nh d\u1ea1ng glucuronide ho\u1ea1t t\u00ednh. Simvastatin \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n th\u00e0nh \u03b2-hydroxyacid c\u00f3 ho\u1ea1t t\u00ednh.<\/li>\n<li>Ph\u00e2n b\u1ed1: C\u1ea3 ezetimibe v\u00e0 simvastatin \u0111\u1ec1u li\u00ean k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ezetimibe ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u1edf ru\u1ed9t non v\u00e0 gan. Simvastatin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh \u1edf gan b\u1edfi CYP3A4.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Ezetimibe v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u. Simvastatin \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c SIMVOFIX 10+20MG \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>T\u0103ng cholesterol m\u00e1u nguy\u00ean ph\u00e1t: Bao g\u1ed3m c\u1ea3 t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh d\u1ecb h\u1ee3p t\u1eed v\u00e0 kh\u00f4ng c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh, c\u0169ng nh\u01b0 t\u0103ng lipid m\u00e1u h\u1ed7n h\u1ee3p. Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng b\u1ed5 sung cho ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang nh\u1eb1m \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau lipid m\u00e1u.<\/li>\n<li>T\u0103ng cholesterol m\u00e1u \u0111\u1ed3ng h\u1ee3p t\u1eed gia \u0111\u00ecnh (HoFH): SIMVOFIX gi\u00fap gi\u1ea3m cholesterol to\u00e0n ph\u1ea7n v\u00e0 LDL-C \u1edf b\u1ec7nh nh\u00e2n HoFH. Thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1ed5 tr\u1ee3 cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3m lipid m\u00e1u kh\u00e1c nh\u01b0 l\u1ecdc b\u1ecf LDL.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c SIMVOFIX 10+20MG<\/h2>\n<p>SIMVOFIX ch\u1ec9 d\u00e0nh cho ng\u01b0\u1eddi l\u1edbn. B\u1ec7nh nh\u00e2n c\u1ea7n duy tr\u00ec ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang cholesterol trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. Li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a d\u1ef1a tr\u00ean n\u1ed3ng \u0111\u1ed9 LDL-C ban \u0111\u1ea7u, m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<ul>\n<li>Li\u1ec1u khuy\u1ebfn c\u00e1o: Th\u01b0\u1eddng l\u00e0 1 vi\u00ean\/ng\u00e0y, u\u1ed1ng v\u00e0o bu\u1ed5i t\u1ed1i, c\u00f3 th\u1ec3 c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n. Li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u1ea5p nh\u1ea5t th\u01b0\u1eddng c\u00f3 t\u00e1c d\u1ee5ng l\u00e0 10\/10mg\/ng\u00e0y, c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh sau \u00edt nh\u1ea5t 4 tu\u1ea7n. Li\u1ec1u t\u1ed1i \u0111a l\u00e0 10\/80mg\/ng\u00e0y.<\/li>\n<li>L\u01b0u \u00fd li\u1ec1u 10\/80mg: Ch\u1ec9 d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 bi\u1ebfn ch\u1ee9ng tim m\u1ea1ch cao, kh\u00f4ng \u0111\u1ea1t m\u1ee5c ti\u00eau v\u1edbi li\u1ec1u th\u1ea5p h\u01a1n v\u00e0 khi l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1. C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u00e1c d\u1ee5ng tr\u00ean c\u01a1.<\/li>\n<li>B\u1ec7nh nh\u00e2n HoFH: Li\u1ec1u \u0111\u1ec1 ngh\u1ecb l\u00e0 10\/40mg\/ng\u00e0y ho\u1eb7c 10\/80mg\/ng\u00e0y v\u00e0o bu\u1ed5i t\u1ed1i.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c SIMVOFIX 10+20MG trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Suy gan v\u1eeba \u0111\u1ebfn n\u1eb7ng (\u0111i\u1ec3m Child-Pugh &gt; 7).<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa.<\/li>\n<li>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 (v\u00ed d\u1ee5: itraconazole, ketoconazole, posaconazole, thu\u1ed1c \u1ee9c ch\u1ebf HIV protease, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, cobicistat).<\/li>\n<li>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi gemfibrozil, cyclosporine ho\u1eb7c danazol.<\/li>\n<li>B\u1ec7nh c\u01a1 th\u1ee9 ph\u00e1t do s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c h\u1ea1 lipid kh\u00e1c.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c SIMVOFIX 10+20MG<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>C\u1ea7n ki\u1ec3m tra ch\u1ee9c n\u0103ng gan tr\u01b0\u1edbc v\u00e0 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t khi t\u0103ng li\u1ec1u l\u00ean 10\/80mg. Ng\u1eebng thu\u1ed1c ngay n\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u t\u1ed5n th\u01b0\u01a1ng gan nghi\u00eam tr\u1ecdng.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn bao g\u1ed3m t\u0103ng men gan (ALT, AST), t\u0103ng CK m\u00e1u. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u00edt ph\u1ed5 bi\u1ebfn h\u01a1n c\u00f3 th\u1ec3 bao g\u1ed3m \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, n\u00f4n, ph\u00e1t ban, ng\u1ee9a, \u0111au kh\u1edbp, \u0111au c\u01a1, y\u1ebfu c\u01a1, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh, fibrate, cyclosporine, gemfibrozil, danazol, amiodarone, amlodipine, verapamil, diltiazem, lomitapide, dronedaron, ranolazin, axit fusidic, niacin v\u00e0 colchicine.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>SIMVOFIX 10+20MG c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t ho\u1eb7c c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00f4ng vi\u1ec7c c\u1ea7n s\u1ef1 t\u1eadp trung cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Khi nghi ng\u1edd s\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u SIMVOFIX 10+20MG, c\u1ea7n theo d\u00f5i tri\u1ec7u ch\u1ee9ng v\u00e0 c\u00f3 nh\u1eefng bi\u1ec7n ph\u00e1p x\u1eed l\u00ed k\u1ecbp th\u1eddi t\u1eeb nh\u00e2n vi\u00ean y t\u1ebf.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c SIMVOFIX 10+20MG<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/vytorin\/\">Thu\u1ed1c Vytorin<\/a> c\u00f9ng th\u00e0nh ph\u1ea7n, l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 cholesterol v\u00e0 lipid trong m\u00e1u\u00a0 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty MSD International GmbH (Singapore Branch) \u2013 Singapore.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Fabrizio Montecucco, Ezetimibe\/simvastatin, truy c\u1eadp ng\u00e0y 11 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19968571\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/19968571\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c SIMVOFIX 10+20MG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Sun Pharmaceutical Industries Limited, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-23050-22, \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng t\u0103ng cholesterol m\u00e1u nguy\u00ean ph\u00e1t.<\/p>\n","protected":false},"author":1,"featured_media":123098,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-123096","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/123096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=123096"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/123098"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=123096"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=123096"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=123096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}