{"id":122870,"date":"2025-06-11T16:28:46","date_gmt":"2025-06-11T09:28:46","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122870"},"modified":"2025-07-24T13:13:01","modified_gmt":"2025-07-24T06:13:01","slug":"stilaren","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/stilaren\/","title":{"rendered":"Stilaren 850\/50"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Stilaren \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH DRP Inter, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110238623.<\/strong><\/p>\n<h2>Stilaren 850\/50 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean<strong> Stilaren 850\/50<\/strong> ch\u1ee9a:<\/p>\n<ul>\n<li><strong>Vildagliptin<\/strong>: 50mg<\/li>\n<li><strong>Metformin HCl<\/strong>: 850mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: V\u1eeba \u0111\u1ee7 m\u1ed9t vi\u00ean<\/li>\n<\/ul>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n bao phim, c\u00f3 h\u00ecnh oval, m\u00e0u v\u00e0ng, v\u1edbi hai m\u1eb7t tr\u01a1n v\u00e0 c\u1ea1nh, th\u00e0nh vi\u00ean l\u00e0nh l\u1eb7n.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110238623<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_122871\" aria-describedby=\"caption-attachment-122871\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122871\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/stiralen-.jpg\" alt=\"Stilaren \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/stiralen-.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/stiralen--600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/stiralen--768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/stiralen--350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122871\" class=\"wp-caption-text\">Stilaren \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Stilaren 850\/50<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<ul>\n<li>Stilaren ho\u1ea1t \u0111\u1ed9ng d\u1ef1a tr\u00ean c\u01a1 ch\u1ebf b\u1ed5 tr\u1ee3 c\u1ee7a hai ho\u1ea1t ch\u1ea5t:<\/li>\n<li>Vildagliptin: Ho\u1ea1t ch\u1ea5t n\u00e0y \u1ee9c ch\u1ebf enzyme Dipeptidyl Peptidase-4 (DPP-4), gi\u00fap k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c hormone incretin (GLP-1 v\u00e0 GIP). \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn t\u0103ng ti\u1ebft insulin ph\u1ee5 thu\u1ed9c glucose t\u1eeb t\u1ebf b\u00e0o beta c\u1ee7a t\u1ee5y v\u00e0 \u1ee9c ch\u1ebf ti\u1ebft glucagon t\u1eeb t\u1ebf b\u00e0o alpha, t\u1eeb \u0111\u00f3 gi\u1ea3m s\u1ea3n xu\u1ea5t glucose \u1edf gan v\u00e0 c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft c\u1ea3 l\u00fac \u0111\u00f3i v\u00e0 sau \u0103n m\u00e0 kh\u00f4ng g\u00e2y t\u0103ng c\u00e2n hay nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u00e1ng k\u1ec3.<\/li>\n<li>Metformin: Metformin l\u00e0 m\u1ed9t biguanide c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng c\u00e1ch:\n<ul>\n<li>Gi\u1ea3m s\u1ea3n xu\u1ea5t glucose t\u1ea1i gan (\u1ee9c ch\u1ebf t\u00e2n t\u1ea1o \u0111\u01b0\u1eddng v\u00e0 ly gi\u1ea3i glycogen).<\/li>\n<li>T\u0103ng \u0111\u1ed9 nh\u1ea1y insulin c\u1ee7a c\u00e1c m\u00f4 ngo\u1ea1i vi (c\u01a1 v\u00e0 m\u00f4 m\u1ee1), gi\u00fap t\u0103ng thu nh\u1eadn v\u00e0 s\u1eed d\u1ee5ng glucose.<\/li>\n<li>L\u00e0m ch\u1eadm h\u1ea5p thu glucose t\u1ea1i ru\u1ed9t. Metformin kh\u00f4ng k\u00edch th\u00edch ti\u1ebft insulin v\u00e0 kh\u00f4ng g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c t\u0103ng c\u00e2n.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>Vildagliptin\n<ul>\n<li>H\u1ea5p thu nhanh, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau kho\u1ea3ng 1.7 gi\u1edd. Th\u1ee9c \u0103n \u00edt \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn l\u01b0\u1ee3ng h\u1ea5p thu.<\/li>\n<li>Ph\u00e2n b\u1ed1 r\u1ed9ng trong c\u00e1c m\u00f4.<\/li>\n<li>Chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua th\u1ee7y ph\u00e2n, kh\u00f4ng li\u00ean quan \u0111\u1ebfn h\u1ec7 enzyme CYP450, n\u00ean \u00edt kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c thu\u1ed1c d\u1ef1a tr\u00ean h\u1ec7 enzyme n\u00e0y.<\/li>\n<li>Th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn, v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 3 gi\u1edd.<\/li>\n<\/ul>\n<\/li>\n<li>Metformin\n<ul>\n<li>H\u1ea5p thu ch\u1eadm h\u01a1n, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau kho\u1ea3ng 2.5 gi\u1edd. Th\u1ee9c \u0103n l\u00e0m ch\u1eadm v\u00e0 gi\u1ea3m m\u1ee9c \u0111\u1ed9 h\u1ea5p thu.<\/li>\n<li>Ph\u00e2n b\u1ed1 kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<li>Kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a trong c\u01a1 th\u1ec3.<\/li>\n<li>Th\u1ea3i tr\u1eeb ho\u00e0n to\u00e0n qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i, v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 6.5 gi\u1edd. Ch\u1ee9c n\u0103ng th\u1eadn suy gi\u1ea3m s\u1ebd l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 metformin trong m\u00e1u.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Stilaren 850\/50 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Thay th\u1ebf metformin \u0111\u01a1n tr\u1ecb li\u1ec7u: Khi b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau HbA1c d\u00f9 \u0111\u00e3 d\u00f9ng li\u1ec1u metformin t\u1ed1i \u0111a ho\u1eb7c kh\u00f4ng dung n\u1ea1p li\u1ec1u cao.<\/li>\n<li>Thay th\u1ebf ph\u00e1c \u0111\u1ed3 ri\u00eang l\u1ebb: Gi\u00fap gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng vi\u00ean thu\u1ed1c ph\u1ea3i u\u1ed1ng, t\u0103ng c\u01b0\u1eddng s\u1ef1 tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng ri\u00eang l\u1ebb vildagliptin v\u00e0 metformin.<\/li>\n<li>Ph\u1ed1i h\u1ee3p ba thu\u1ed1c: V\u1edbi sulfonylurea (SU) khi metformin v\u00e0 SU ch\u01b0a ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c \u0111\u01b0\u1eddng huy\u1ebft.<\/li>\n<li>Ph\u1ed1i h\u1ee3p c\u00f9ng Insulin n\u1ec1n \u1ed5n \u0111\u1ecbnh: \u1ede b\u1ec7nh nh\u00e2n ch\u01b0a ki\u1ec3m so\u00e1t t\u1ed1t \u0111\u01b0\u1eddng huy\u1ebft d\u00f9 \u0111\u00e3 d\u00f9ng insulin k\u1ebft h\u1ee3p metformin.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Stilaren 850\/50<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng (eGFR \u2265 90 mL\/ph\u00fat):\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o: 1 vi\u00ean (50 mg\/850 mg) x 2 l\u1ea7n\/ng\u00e0y, u\u1ed1ng s\u00e1ng v\u00e0 t\u1ed1i.<\/li>\n<li>Kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 100 mg vildagliptin\/ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<li>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn:\n<ul>\n<li>eGFR 60 \u2013 89 mL\/ph\u00fat: Metformin t\u1ed1i \u0111a 3g\/ng\u00e0y (c\u00f3 th\u1ec3 gi\u1ea3m li\u1ec1u n\u1ebfu ch\u1ee9c n\u0103ng th\u1eadn suy gi\u1ea3m); kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u vildagliptin.<\/li>\n<li>eGFR 45 \u2013 59 mL\/ph\u00fat: Metformin t\u1ed1i \u0111a 2g\/ng\u00e0y (kh\u1edfi \u0111\u1ea7u \u2264 1g); vildagliptin t\u1ed1i \u0111a 50mg\/ng\u00e0y.<\/li>\n<li>eGFR 30 \u2013 44 mL\/ph\u00fat: Metformin t\u1ed1i \u0111a 1g\/ng\u00e0y (kh\u1edfi \u0111\u1ea7u \u2264 500mg); vildagliptin t\u1ed1i \u0111a 50mg\/ng\u00e0y. Tr\u00e1nh t\u0103ng li\u1ec1u, theo d\u00f5i s\u00e1t.<\/li>\n<li>eGFR &lt; 30 mL\/ph\u00fat: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ea3 metformin v\u00e0 vildagliptin.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Stilaren 850\/50<\/h2>\n<ul>\n<li>U\u1ed1ng nguy\u00ean vi\u00ean v\u1edbi m\u1ed9t c\u1ed1c n\u01b0\u1edbc \u0111\u1ea7y.<\/li>\n<li>N\u00ean u\u1ed1ng trong ho\u1eb7c ngay sau b\u1eefa \u0103n \u0111\u1ec3 gi\u1ea3m k\u00edch \u1ee9ng ti\u00eau h\u00f3a do metformin.<\/li>\n<li>Khuy\u1ebfn kh\u00edch d\u00f9ng v\u00e0o c\u00e1c b\u1eefa ch\u00ednh c\u1ed1 \u0111\u1ecbnh (s\u00e1ng, t\u1ed1i) \u0111\u1ec3 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1ed5n \u0111\u1ecbnh v\u00e0 gi\u1ea3m qu\u00ean li\u1ec1u.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Stilaren 850\/50 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi vildagliptin, metformin ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Suy th\u1eadn n\u1eb7ng (eGFR &lt; 30 mL\/ph\u00fat) ho\u1eb7c c\u00e1c t\u00ecnh tr\u1ea1ng c\u1ea5p t\u00ednh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9c n\u0103ng th\u1eadn (m\u1ea5t n\u01b0\u1edbc, s\u1ed1c, nhi\u1ec5m khu\u1ea9n n\u1eb7ng, s\u1eed d\u1ee5ng thu\u1ed1c c\u1ea3n quang iod t\u0129nh m\u1ea1ch).<\/li>\n<li>Nhi\u1ec5m toan chuy\u1ec3n h\u00f3a c\u1ea5p (nhi\u1ec5m toan lactic, nhi\u1ec5m toan ceton) ho\u1eb7c ti\u1ec1n h\u00f4n m\u00ea \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/li>\n<li>C\u00e1c b\u1ec7nh c\u1ea5p\/m\u1ea1n t\u00ednh g\u00e2y thi\u1ebfu oxy m\u00f4 (suy tim, suy h\u00f4 h\u1ea5p, nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p, s\u1ed1c).<\/li>\n<li>Suy gan ho\u1eb7c n\u1ed3ng \u0111\u1ed9 ALT\/AST &gt; 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng.<\/li>\n<li>Ng\u1ed9 \u0111\u1ed9c r\u01b0\u1ee3u c\u1ea5p t\u00ednh ho\u1eb7c nghi\u1ec7n r\u01b0\u1ee3u.<\/li>\n<li>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Stilaren 850\/50<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Nhi\u1ec5m toan lactic: L\u00e0 bi\u1ebfn ch\u1ee9ng hi\u1ebfm g\u1eb7p nh\u01b0ng nghi\u00eam tr\u1ecdng. B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o v\u1ec1 c\u00e1c tri\u1ec7u ch\u1ee9ng (kh\u00f3 th\u1edf, \u0111au b\u1ee5ng, chu\u1ed9t r\u00fat, m\u1ec7t l\u1ea3, h\u1ea1 th\u00e2n nhi\u1ec7t) v\u00e0 ph\u1ea3i ng\u01b0ng thu\u1ed1c, nh\u1eadp vi\u1ec7n kh\u1ea9n c\u1ea5p n\u1ebfu nghi ng\u1edd.<\/li>\n<li>Ch\u1ee9c n\u0103ng th\u1eadn: \u0110\u00e1nh gi\u00e1 eGFR tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb, sau \u0111\u00f3 \u0111\u1ecbnh k\u1ef3 (6-12 th\u00e1ng\/l\u1ea7n ho\u1eb7c 3-6 th\u00e1ng\/l\u1ea7n \u1edf ng\u01b0\u1eddi cao tu\u1ed5i\/c\u00f3 nguy c\u01a1). Ng\u01b0ng thu\u1ed1c t\u1ea1m th\u1eddi n\u1ebfu c\u00f3 t\u00ecnh tr\u1ea1ng c\u1ea5p t\u00ednh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1eadn.<\/li>\n<li>Ch\u1ee9c n\u0103ng gan: Ki\u1ec3m tra ALT\/AST tr\u01b0\u1edbc v\u00e0 trong 3 th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, sau \u0111\u00f3 \u0111\u1ecbnh k\u1ef3. Ng\u01b0ng thu\u1ed1c v\u0129nh vi\u1ec5n n\u1ebfu men gan t\u0103ng dai d\u1eb3ng ho\u1eb7c c\u00f3 tri\u1ec7u ch\u1ee9ng vi\u00eam gan.<\/li>\n<li>Vi\u00eam t\u1ee5y c\u1ea5p: C\u1ea7n th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed vi\u00eam t\u1ee5y c\u1ea5p. N\u1ebfu nghi ng\u1edd, ph\u1ea3i ng\u01b0ng thu\u1ed1c ngay l\u1eadp t\u1ee9c.<\/li>\n<li>T\u1ed5n th\u01b0\u01a1ng da: Theo d\u00f5i c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 ph\u1ed3ng r\u1ed9p, lo\u00e9t da.<\/li>\n<li>H\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft: D\u00f9 Stilaren \u00edt g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, nh\u01b0ng khi ph\u1ed1i h\u1ee3p v\u1edbi sulfonylurea ho\u1eb7c insulin, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u00e1c thu\u1ed1c n\u00e0y v\u00e0 b\u1ec7nh nh\u00e2n n\u00ean mang theo k\u1eb9o glucose.<\/li>\n<li>Ph\u1eabu thu\u1eadt l\u1edbn\/g\u00e2y m\u00ea: T\u1ea1m ng\u01b0ng metformin 48 gi\u1edd tr\u01b0\u1edbc ph\u1eabu thu\u1eadt v\u00e0 ch\u1ec9 d\u00f9ng l\u1ea1i khi ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng v\u00e0 b\u1ec7nh nh\u00e2n \u0103n u\u1ed1ng \u1ed5n \u0111\u1ecbnh.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p: H\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft (\u0111\u1eb7c bi\u1ec7t khi ph\u1ed1i h\u1ee3p SU\/insulin), run tay, ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n n\u00f4n, kh\u00f3 ti\u00eau, \u0111\u1ea7y b\u1ee5ng, ti\u00eau ch\u1ea3y.<\/li>\n<li>\u00cdt g\u1eb7p: M\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i, t\u00e1o b\u00f3n, tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n, ph\u00f9 ngo\u1ea1i vi, \u0111au kh\u1edbp.<\/li>\n<li>Hi\u1ebfm\/R\u1ea5t hi\u1ebfm: R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan (vi\u00eam gan, t\u0103ng ALT\/AST h\u1ed3i ph\u1ee5c khi ng\u01b0ng thu\u1ed1c), ph\u00f9 m\u1ea1ch, m\u00e0y \u0111ay, bong tr\u00f3c da, b\u1ecdng n\u01b0\u1edbc, gi\u1ea3m h\u1ea5p thu Vitamin B12 (khi d\u00f9ng metformin l\u00e2u d\u00e0i), nhi\u1ec5m toan lactic (r\u1ea5t hi\u1ebfm nh\u01b0ng nghi\u00eam tr\u1ecdng), vi\u00eam t\u1ee5y c\u1ea5p.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>R\u01b0\u1ee3u, th\u1ee9c u\u1ed1ng c\u00f3 c\u1ed3n: T\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic.<\/li>\n<li>Thu\u1ed1c c\u1ea3n quang iod: Nguy c\u01a1 suy th\u1eadn c\u1ea5p, nhi\u1ec5m toan lactic; c\u1ea7n ng\u01b0ng metformin tr\u01b0\u1edbc v\u00e0 ch\u1ec9 d\u00f9ng l\u1ea1i sau 48 gi\u1edd khi ch\u1ee9c n\u0103ng th\u1eadn \u1ed5n \u0111\u1ecbnh.<\/li>\n<li>Thu\u1ed1c cation b\u00e0i ti\u1ebft qua \u1ed1ng th\u1eadn (v\u00ed d\u1ee5: cimetidin, ranolazin): C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m th\u1ea3i tr\u1eeb metformin, t\u0103ng n\u1ed3ng \u0111\u1ed9 metformin trong m\u00e1u.<\/li>\n<li>NSAID, ACEI, ARB, l\u1ee3i ti\u1ec3u quai: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m eGFR c\u1ea5p th\u1eddi, c\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<li>Glucocorticoid, thu\u1ed1c c\u01b0\u1eddng \u03b2\u2082, l\u1ee3i ti\u1ec3u thiazid, hormon tuy\u1ebfn gi\u00e1p: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft n\u1ed9i sinh, gi\u1ea3m hi\u1ec7u l\u1ef1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a Stilaren.<\/li>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI): T\u0103ng nh\u1eb9 nguy c\u01a1 ph\u00f9 m\u1ea1ch khi d\u00f9ng c\u00f9ng vildagliptin.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Thai k\u1ef3: Kh\u00f4ng \u0111\u1ee7 d\u1eef li\u1ec7u an to\u00e0n. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng. N\u1ebfu c\u00f3 thai, n\u00ean chuy\u1ec3n sang insulin (n\u1ebfu c\u1ea7n) sau khi tham v\u1ea5n b\u00e1c s\u0129.<\/li>\n<li>Cho con b\u00fa: Metformin b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9, vildagliptin ch\u01b0a r\u00f5. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong th\u1eddi k\u1ef3 cho con b\u00fa do nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u1edf tr\u1ebb s\u01a1 sinh.<\/li>\n<\/ul>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>\u0110\u01b0a b\u1ec7nh nh\u00e2n \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t. \u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3, \u0111i\u1ec1u ch\u1ec9nh toan m\u00e1u, \u0111i\u1ec7n gi\u1ea3i. Th\u1ea9m t\u00e1ch m\u00e1u c\u00f3 hi\u1ec7u qu\u1ea3 lo\u1ea1i b\u1ecf metformin v\u00e0 m\u1ed9t ph\u1ea7n ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a vildagliptin.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c Stilaren 850\/50<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/galvus-met\/\">Thu\u1ed1c Galvus met<\/a> \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng typ 2, do c\u00f4ng ty Novartis Pharm Stein A.G \u2013 TH\u1ee4Y S\u0128 s\u1ea3n xu\u1ea5t, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-18651-15.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>David R Matthews, P\u00e4ivi M Pald\u00e1nius, Pieter Proot, YannTong Chiang, Michael Stumvoll, Stefano Del Prato; VERIFY study group. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial, truy c\u1eadp ng\u00e0y 11 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31542292\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31542292\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Stilaren \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH DRP Inter, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110238623. Stilaren 850\/50 l\u00e0 thu\u1ed1c g\u00ec? Th\u00e0nh ph\u1ea7n M\u1ed7i vi\u00ean Stilaren 850\/50 ch\u1ee9a: Vildagliptin: 50mg Metformin HCl: 850mg [&#8230;]\n","protected":false},"author":1,"featured_media":122872,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122870","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122872"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122870"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122870"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}