{"id":122660,"date":"2025-06-09T23:24:10","date_gmt":"2025-06-09T16:24:10","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122660"},"modified":"2025-07-24T13:13:04","modified_gmt":"2025-07-24T06:13:04","slug":"tracleer-125mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tracleer-125mg\/","title":{"rendered":"Tracleer 125mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Tracleer 125mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Patheon Inc. (CS xu\u1ea5t x\u01b0\u1edfng: Actelion Pharmaceuticals Ltd) c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-18486-14<\/strong><\/p>\n<h2>Tracleer 125mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean u\u1ed1ng Tracleer 125mg<\/strong> c\u00f3 ch\u1ee9a: Bosentan (d\u01b0\u1edbi d\u1ea1ng bosentan monohydrate) 125mg<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN-18486-14<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd 60 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Canada<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 60 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tracleer 125mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Bosentan l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng k\u00e9p tr\u00ean c\u1ea3 hai lo\u1ea1i th\u1ee5 th\u1ec3 endothelin A v\u00e0 B, v\u1ed1n l\u00e0 nh\u1eefng th\u1ee5 th\u1ec3 n\u1ed9i sinh c\u00f3 vai tr\u00f2 trong c\u01a1 ch\u1ebf co m\u1ea1ch v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o th\u00e0nh m\u1ea1ch. Khi g\u1eafn v\u00e0o c\u00e1c th\u1ee5 th\u1ec3 n\u00e0y, endothelin-1 \u2013 m\u1ed9t peptide n\u1ed9i sinh g\u00e2y co m\u1ea1ch m\u1ea1nh \u2013 s\u1ebd b\u1ecb Bosentan c\u1ea1nh tranh v\u00e0 ch\u1eb7n l\u1ea1i, t\u1eeb \u0111\u00f3 gi\u00fap l\u00e0m gi\u00e3n m\u1ea1ch m\u00e1u ph\u1ed5i, gi\u1ea3m s\u1ee9c c\u1ea3n m\u1ea1ch v\u00e0 c\u1ea3i thi\u1ec7n l\u01b0u l\u01b0\u1ee3ng tu\u1ea7n ho\u00e0n. Bosentan kh\u00f4ng l\u00e0m t\u0103ng nh\u1ecbp tim, nh\u01b0ng c\u00f3 t\u00e1c \u0111\u1ed9ng t\u00edch c\u1ef1c \u0111\u1ebfn huy\u1ebft \u00e1p \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i v\u00e0 to\u00e0n th\u00e2n.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Bosentan c\u00f3 kh\u1ea3 n\u0103ng h\u1ea5p thu t\u01b0\u01a1ng \u0111\u1ed1i t\u1ed1t qua \u0111\u01b0\u1eddng u\u1ed1ng, v\u1edbi sinh kh\u1ea3 d\u1ee5ng \u0111\u1ea1t kho\u1ea3ng 50%, kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng nhi\u1ec1u b\u1edfi th\u1ee9c \u0103n. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u \u0111\u1ea1t \u0111\u1ec9nh sau kho\u1ea3ng 3\u20135 gi\u1edd k\u1ec3 t\u1eeb khi u\u1ed1ng.<\/li>\n<li>Ph\u00e2n b\u1ed1: Thu\u1ed1c g\u1eafn k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 albumin (~98%). M\u1eb7c d\u00f9 thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng trong m\u00f4 c\u01a1 th\u1ec3 nh\u01b0ng kh\u00f4ng v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o nhau thai m\u1ed9t c\u00e1ch d\u1ec5 d\u00e0ng.<\/li>\n<li>Chuy\u1ec3n ho\u00e1: Qu\u00e1 tr\u00ecnh chuy\u1ec3n ho\u00e1 ch\u1ee7 y\u1ebfu x\u1ea3y ra t\u1ea1i gan th\u00f4ng qua c\u00e1c enzyme CYP3A4 v\u00e0 CYP2C9. Bosentan c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 c\u1ea3m \u1ee9ng men gan, l\u00e0m t\u0103ng chuy\u1ec3n ho\u00e1 c\u1ee7a ch\u00ednh n\u00f3 v\u00e0 c\u00e1c thu\u1ed1c chuy\u1ec3n ho\u00e1 qua c\u00f9ng enzym.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua m\u1eadt. Ch\u1ec9 m\u1ed9t ph\u1ea7n r\u1ea5t nh\u1ecf (d\u01b0\u1edbi 3%) \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i sau m\u1ed9t li\u1ec1u \u0111\u01a1n trung b\u00ecnh kho\u1ea3ng 5,4 gi\u1edd, nh\u01b0ng c\u00f3 th\u1ec3 gi\u1ea3m khi d\u00f9ng k\u00e9o d\u00e0i do t\u1ef1 c\u1ea3m \u1ee9ng chuy\u1ec3n ho\u00e1.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Tracleer 125mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>T\u0103ng \u00e1p \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i nguy\u00ean ph\u00e1t ho\u1eb7c th\u1ee9 ph\u00e1t (WHO nh\u00f3m II \u0111\u1ebfn IV)<\/li>\n<li>Gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ed5n th\u01b0\u01a1ng lo\u00e9t \u0111\u1ea7u chi do x\u01a1 c\u1ee9ng b\u00ec h\u1ec7 th\u1ed1ng<\/li>\n<\/ul>\n<figure id=\"attachment_122665\" aria-describedby=\"caption-attachment-122665\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122665\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tracleer-125mg.jpg\" alt=\"Tracleer 125mg\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tracleer-125mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tracleer-125mg-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tracleer-125mg-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Tracleer-125mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122665\" class=\"wp-caption-text\">Thu\u1ed1c Tracleer 125mg ch\u1ee9a Bosentan gi\u00fap gi\u1ea3m g\u00e1nh n\u1eb7ng l\u00ean tim v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 kh\u00f3 th\u1edf, m\u1ec7t m\u1ecfi, th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<p>T\u0103ng \u00e1p \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i:<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn: Kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u th\u1ea5p 62,5 mg x 2 l\u1ea7n\/ng\u00e0y trong 4 tu\u1ea7n, sau \u0111\u00f3 t\u0103ng l\u00ean li\u1ec1u duy tr\u00ec 125 mg x 2 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Tr\u1ebb \u2265 10kg: Li\u1ec1u kh\u1edfi \u0111\u1ea7u v\u00e0 duy tr\u00ec t\u00f9y theo c\u00e2n n\u1eb7ng, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u01b0\u01a1ng \u1ee9ng, n\u00ean d\u00f9ng d\u1ea1ng h\u00e0m l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p \u0111\u1ec3 d\u1ec5 chia li\u1ec1u.<\/li>\n<\/ul>\n<p>Lo\u00e9t do x\u01a1 c\u1ee9ng b\u00ec h\u1ec7 th\u1ed1ng:<\/p>\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn: B\u1eaft \u0111\u1ea7u 62,5 mg x 2 l\u1ea7n\/ng\u00e0y trong 4 tu\u1ea7n, sau \u0111\u00f3 t\u0103ng l\u00ean 125 mg x 2 l\u1ea7n\/ng\u00e0y, duy tr\u00ec t\u1ed1i \u0111a 6 th\u00e1ng.<\/li>\n<li>C\u1ea7n \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 quy\u1ebft \u0111\u1ecbnh ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb hay kh\u00f4ng.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>N\u00ean u\u1ed1ng nguy\u00ean vi\u00ean Tracleer 125mg v\u1edbi m\u1ed9t l\u01b0\u1ee3ng n\u01b0\u1edbc v\u1eeba \u0111\u1ee7, kh\u00f4ng \u0111\u01b0\u1ee3c b\u1ebb, nghi\u1ec1n hay nhai vi\u00ean. C\u00f3 th\u1ec3 d\u00f9ng b\u1ea5t k\u1ef3 th\u1eddi \u0111i\u1ec3m n\u00e0o trong ng\u00e0y, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Tracleer 125mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi ho\u1ea1t ch\u1ea5t Bosentan v\u00e0 t\u00e1 d\u01b0\u1ee3c c\u00f3 trong Tracleer 125mg<\/li>\n<li>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan v\u1eeba \u0111\u1ebfn n\u1eb7ng ho\u1eb7c men gan t\u0103ng &gt;3 l\u1ea7n m\u1ee9c b\u00ecnh th\u01b0\u1eddng<\/li>\n<li>Ph\u1ee5 n\u1eef \u0111ang mang thai ho\u1eb7c kh\u00f4ng s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3<\/li>\n<li>D\u00f9ng chung v\u1edbi cyclosporin A ho\u1eb7c glibenclamid<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Tr\u01b0\u1edbc khi ng\u01b0ng thu\u1ed1c c\u1ea7n gi\u1ea3m li\u1ec1u d\u1ea7n trong kho\u1ea3ng 3 \u0111\u1ebfn 7 ng\u00e0y.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n thu\u1ed9c nh\u00f3m I theo ph\u00e2n lo\u1ea1i WHO v\u1ec1 t\u0103ng \u00e1p ph\u1ed5i.<\/li>\n<li>C\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng gan \u0111\u1ecbnh k\u1ef3.<\/li>\n<li>N\u00ean ki\u1ec3m tra ch\u1ec9 s\u1ed1 huy\u1ebft h\u1ecdc th\u01b0\u1eddng xuy\u00ean \u0111\u1ec3 ph\u00e1t hi\u1ec7n s\u1edbm c\u00e1c b\u1ea5t th\u01b0\u1eddng.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Huy\u1ebft h\u1ecdc: Gi\u1ea3m h\u1ed3ng c\u1ea7u ho\u1eb7c ti\u1ec3u c\u1ea7u c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng l\u00e2u d\u00e0i. M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u1ea7n truy\u1ec1n m\u00e1u n\u1ebfu thi\u1ebfu m\u00e1u n\u1eb7ng.<\/li>\n<li>Mi\u1ec5n d\u1ecbch: D\u1ecb \u1ee9ng nh\u01b0 n\u1ed5i m\u1ea9n, m\u1ec1 \u0111ay ho\u1eb7c ng\u1ee9a c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n. Hi\u1ebfm g\u1eb7p h\u01a1n l\u00e0 ph\u00f9 m\u1ea1ch ho\u1eb7c s\u1ed1c ph\u1ea3n v\u1ec7.<\/li>\n<li>Th\u1ea7n kinh: Nh\u1ee9c \u0111\u1ea7u l\u00e0 ph\u1ea3n \u1ee9ng hay g\u1eb7p. M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb cho\u00e1ng v\u00e1ng ho\u1eb7c b\u1ea5t t\u1ec9nh nh\u1eb9.<\/li>\n<li>Tim m\u1ea1ch: C\u1ea3m gi\u00e1c h\u1ed3i h\u1ed9p, \u0111\u1ecf b\u1eebng v\u00e0 h\u1ea1 huy\u1ebft \u00e1p c\u00f3 th\u1ec3 x\u1ea3y ra, th\u01b0\u1eddng \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Ti\u00eau ho\u00e1: Kh\u00f3 ti\u00eau, ti\u00eau ch\u1ea3y ho\u1eb7c tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n c\u00f3 th\u1ec3 g\u1eb7p nh\u01b0ng th\u01b0\u1eddng kh\u00f4ng nghi\u00eam tr\u1ecdng.<\/li>\n<li>Gan \u2013 m\u1eadt: T\u0103ng men gan l\u00e0 ph\u1ea3n \u1ee9ng th\u01b0\u1eddng g\u1eb7p nh\u1ea5t v\u00e0 c\u1ea7n theo d\u00f5i th\u01b0\u1eddng xuy\u00ean. Hi\u1ebfm g\u1eb7p h\u01a1n l\u00e0 vi\u00eam gan ho\u1eb7c r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan nghi\u00eam tr\u1ecdng.<\/li>\n<li>Da li\u1ec5u: N\u1ed5i ban, \u0111\u1ecf da v\u00e0 m\u1ea9n ng\u1ee9a c\u00f3 th\u1ec3 x\u1ea3y ra, th\u01b0\u1eddng t\u1ef1 h\u1ebft khi ng\u01b0ng thu\u1ed1c.<\/li>\n<li>To\u00e0n th\u00e2n: Gi\u1eef n\u01b0\u1edbc, ph\u00f9 ngo\u1ea1i vi c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i ho\u1eb7c d\u00f9ng li\u1ec1u cao k\u00e9o d\u00e0i.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Bosentan c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 c\u1ee7a nhi\u1ec1u thu\u1ed1c kh\u00e1c:<\/p>\n<ul>\n<li>Gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a: thu\u1ed1c ng\u1eeba thai u\u1ed1ng, warfarin, simvastatin, lovastatin.<\/li>\n<li>T\u0103ng n\u1ed3ng \u0111\u1ed9 bosentan khi ph\u1ed1i h\u1ee3p v\u1edbi: ketoconazol, ritonavir, fluconazol.<\/li>\n<li>Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 bosentan khi d\u00f9ng chung v\u1edbi: rifampicin, phenytoin, carbamazepin.<\/li>\n<li>T\u0103ng nguy c\u01a1 \u0111\u1ed9c gan khi ph\u1ed1i h\u1ee3p: cyclosporin A, tacrolimus.<\/li>\n<li>Kh\u00f4ng n\u00ean ph\u1ed1i h\u1ee3p v\u1edbi glibenclamid: do nguy c\u01a1 gi\u1ea3m t\u00e1c d\u1ee5ng v\u00e0 \u0111\u1ed9c gan.<\/li>\n<li>\u1ea2nh h\u01b0\u1edfng t\u1edbi digoxin: c\u1ea7n theo d\u00f5i khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Bosentan c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c d\u1ecb t\u1eadt b\u1ea9m sinh ho\u1eb7c \u1ea3nh h\u01b0\u1edfng x\u1ea5u t\u1edbi thai nhi. Do \u0111\u00f3, kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef \u0111ang mang thai ho\u1eb7c c\u00f3 k\u1ebf ho\u1ea1ch mang thai, tr\u1eeb khi \u0111\u00e3 c\u00f3 bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3. Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng khi \u0111ang cho con b\u00fa v\u00ec ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c thu\u1ed1c b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Tuy hi\u1ec7n nay ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u ch\u00ednh x\u00e1c v\u00e0 c\u1ee5 th\u1ec3 t\u1eebng \u0111\u1ed1i t\u01b0\u1ee3ng khi d\u00f9ng thu\u1ed1c nh\u01b0ng do <strong>vi\u00ean n\u00e9n Tracleer 125mg<\/strong> c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t ho\u1eb7c gi\u1ea3m t\u1eadp trung \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi d\u00f9ng, n\u00ean \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd ph\u1ea3n \u1ee9ng c\u01a1 th\u1ec3 khi \u0111i\u1ec1u h\u00e0nh m\u00e1y m\u00f3c v\u00e0 xe c\u1ed9. Ch\u1ec9 n\u00ean th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y khi ch\u1eafc ch\u1eafn r\u1eb1ng c\u01a1 th\u1ec3 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi thu\u1ed1c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Bosentan \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m v\u1edbi li\u1ec1u \u0111\u01a1n l\u00ean \u0111\u1ebfn 2400 mg \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh v\u00e0 li\u1ec1u 200 mg\/ng\u00e0y trong 2 th\u00e1ng \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh kh\u00e1c ngo\u00e0i t\u0103ng \u00e1p l\u1ef1c \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i. T\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 \u0111au \u0111\u1ea7u m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<\/p>\n<p>Li\u1ec1u qu\u00e1 cao c\u00f3 th\u1ec3 g\u00e2y t\u1ee5t huy\u1ebft \u00e1p nghi\u00eam tr\u1ecdng, c\u1ea7n can thi\u1ec7p tim m\u1ea1ch. C\u00f3 b\u00e1o c\u00e1o m\u1ed9t tr\u01b0\u1eddng h\u1ee3p d\u00f9ng t\u1edbi 10.000 mg \u1edf nam thanh thi\u1ebfu ni\u00ean v\u1edbi tri\u1ec7u ch\u1ee9ng nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n, h\u1ea1 huy\u1ebft \u00e1p, hoa m\u1eaft, v\u00e3 m\u1ed3 h\u00f4i v\u00e0 nh\u00ecn m\u1edd, \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 ph\u1ee5 h\u1ed3i sau 24 gi\u1edd.. Ngo\u00e0i ra vi\u1ec7c lo\u1ea1i b\u1ecf bosentan b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p th\u1ea9m t\u00e1ch m\u00e1u l\u00e0 kh\u00f4ng hi\u1ec7u qu\u1ea3.<\/p>\n<h2>B\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>Gi\u1eef Tracleer 125mg \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Tracleer 125mg trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Tracleer 125mg khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Tracleer 125mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Tracleer 125mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Tracleer 125mg c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Tracleer 125mg t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Tracleer 125mg nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/ravenell-625\/\">Ravenell-62,5<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Bosentan (d\u01b0\u1edbi d\u1ea1ng Bosentan monohydrat) 62,5 mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa, \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng b\u1ec7nh t\u0103ng \u00e1p ph\u1ed5i v\u00e0 c\u00e1c b\u1ec7nh tim m\u1ea1ch<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Tracleer 125mg \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/To-huong-dan-su-dung-Tracleer-125-mg.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 9 th\u00e1ng 6 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/drugbank.vn\/\" rel=\"noopener\">https:\/\/drugbank.vn\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Tracleer 125mg ch\u1ee9a Bosentan gi\u00fap gi\u1ea3m g\u00e1nh n\u1eb7ng l\u00ean tim v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 kh\u00f3 th\u1edf, m\u1ec7t m\u1ecfi, th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa.<\/span><\/p>\n","protected":false},"author":1,"featured_media":122662,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122660","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122662"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122660"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122660"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}