{"id":122430,"date":"2025-06-07T16:57:03","date_gmt":"2025-06-07T09:57:03","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122430"},"modified":"2025-12-23T15:27:14","modified_gmt":"2025-12-23T08:27:14","slug":"uperio-200mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/uperio-200mg\/","title":{"rendered":"Uperio 200mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Uperio 200mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436123.<\/strong><\/p>\n<h2>Uperio 200mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Uperio 200mg <\/strong>ch\u1ee9a s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a <strong>sacubitril<\/strong> (97,2mg) v\u00e0 valsartan (102,8mg).<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 800110436123<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u00f4\u0323\u0323p 4 vi\u0309 x 7 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Italy<\/p>\n<figure id=\"attachment_122431\" aria-describedby=\"caption-attachment-122431\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122431\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-200MG.jpg\" alt=\"Uperio 200mg \u0111i\u1ec1u tr\u1ecb suy tim\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-200MG.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-200MG-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-200MG-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-200MG-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122431\" class=\"wp-caption-text\">Uperio 200mg \u0111i\u1ec1u tr\u1ecb suy tim<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Uperio 200mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Thu\u1ed1c ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf m\u1ed9t enzyme t\u00ean l\u00e0 neprilysin (th\u00f4ng qua sacubitrilat) v\u00e0 ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng c\u1ee7a angiotensin II (th\u00f4ng qua valsartan). S\u1ef1 ph\u1ed1i h\u1ee3p n\u00e0y gi\u00fap t\u0103ng c\u01b0\u1eddng c\u00e1c peptide c\u00f3 l\u1ee3i cho tim m\u1ea1ch v\u00e0 th\u1eadn, \u0111\u1ed3ng th\u1eddi gi\u1ea3m c\u00e1c t\u00e1c \u0111\u1ed9ng c\u00f3 h\u1ea1i c\u1ee7a hormone angiotensin II, t\u1eeb \u0111\u00f3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng tim v\u00e0 m\u1ea1ch m\u00e1u.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Sau khi u\u1ed1ng, sacubitril nhanh ch\u00f3ng chuy\u1ec3n h\u00f3a th\u00e0nh sacubitrilat c\u00f3 ho\u1ea1t t\u00ednh, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 2 gi\u1edd, trong khi valsartan \u0111\u1ea1t \u0111\u1ec9nh sau 1,5 gi\u1edd. Thu\u1ed1c li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (94% &#8211; 97%). Kho\u1ea3ng 52% &#8211; 68% sacubitril (ch\u1ee7 y\u1ebfu l\u00e0 sacubitrilat) v\u00e0 13% valsartan \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u, ph\u1ea7n c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb qua ph\u00e2n. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a sacubitril, sacubitrilat v\u00e0 valsartan l\u1ea7n l\u01b0\u1ee3t l\u00e0 1,43 gi\u1edd, 11,48 gi\u1edd v\u00e0 9,90 gi\u1edd.<\/p>\n<h2>Thu\u1ed1c Uperio 200mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 suy tim c\u00f3 ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u gi\u1ea3m.<\/li>\n<li>Gi\u1ea3m nguy c\u01a1 t\u1eed vong do c\u00e1c b\u1ec7nh tim m\u1ea1ch v\u00e0 nhu c\u1ea7u nh\u1eadp vi\u1ec7n do suy tim.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Uperio 200mg<\/h2>\n<ul>\n<li>Thu\u1ed1c \u0111\u01b0\u1ee3c u\u1ed1ng nguy\u00ean vi\u00ean v\u1edbi n\u01b0\u1edbc, c\u00f3 th\u1ec3 d\u00f9ng k\u00e8m ho\u1eb7c kh\u00f4ng k\u00e8m th\u1ee9c \u0103n.<\/li>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn ngh\u1ecb l\u00e0 100mg, hai l\u1ea7n m\u1ed7i ng\u00e0y, sau \u0111\u00f3 c\u00f3 th\u1ec3 t\u0103ng l\u00ean li\u1ec1u m\u1ee5c ti\u00eau 200mg, hai l\u1ea7n m\u1ed7i ng\u00e0y, t\u00f9y thu\u1ed9c v\u00e0o kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n.<\/li>\n<li>C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u1eb7c bi\u1ec7t nh\u01b0 suy th\u1eadn ho\u1eb7c suy gan trung b\u00ecnh.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch do thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Uperio 200mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Uperio 200mg ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c, \u0111ang d\u00f9ng ho\u1eb7c \u0111\u00e3 d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI) trong v\u00f2ng 36 gi\u1edd, c\u00f3 ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch do ACEI ho\u1eb7c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin II (ARB), ph\u00f9 m\u1ea1ch di truy\u1ec1n\/v\u00f4 c\u0103n, \u0111ang d\u00f9ng \u0111\u1ed3ng th\u1eddi aliskiren (\u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn eGFR &lt; 60 ml\/ph\u00fat\/1,73 m2), suy gan n\u1eb7ng\/x\u01a1 gan m\u1eadt\/\u1ee9 m\u1eadt, ho\u1eb7c ph\u1ee5 n\u1eef c\u00f3 thai.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Uperio 200mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>H\u1ea1 huy\u1ebft \u00e1p: Uperio c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p tri\u1ec7u ch\u1ee9ng, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n th\u1eadn ho\u1eb7c huy\u1ebft \u00e1p th\u1ea5p. C\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p th\u01b0\u1eddng xuy\u00ean.<\/li>\n<li>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn: Theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3. Nguy c\u01a1 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u00f3 th\u1ec3 t\u0103ng khi m\u1ea5t n\u01b0\u1edbc ho\u1eb7c d\u00f9ng NSAID.<\/li>\n<li>T\u0103ng kali m\u00e1u: Theo d\u00f5i kali huy\u1ebft thanh th\u01b0\u1eddng xuy\u00ean, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao (suy th\u1eadn, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng).<\/li>\n<li>Ph\u00f9 m\u1ea1ch: Ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c n\u1ebfu xu\u1ea5t hi\u1ec7n ph\u00f9 m\u1ea1ch. Ph\u00f9 m\u1ea1ch \u1edf l\u01b0\u1ee1i, thanh m\u00f4n, thanh qu\u1ea3n c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong, c\u1ea7n c\u1ea5p c\u1ee9u k\u1ecbp th\u1eddi.<\/li>\n<li>H\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn: Th\u1eadn tr\u1ecdng v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p: H\u1ea1 huy\u1ebft \u00e1p, t\u0103ng\/gi\u1ea3m kali m\u00e1u, thi\u1ebfu m\u00e1u, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, cho\u00e1ng v\u00e1ng, nh\u1ee9c \u0111\u1ea7u, ng\u1ea5t, ho, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, vi\u00eam d\u1ea1 d\u00e0y, suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c.<\/li>\n<li>\u00cdt g\u1eb7p: Qu\u00e1 m\u1eabn, ch\u00f3ng m\u1eb7t t\u01b0 th\u1ebf, ng\u1ee9a, ph\u00e1t ban, ph\u00f9 m\u1ea1ch.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p: Thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACEI), aliskiren (\u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2).<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o ph\u1ed1i h\u1ee3p: Thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II (ARB).<\/p>\n<p>C\u1ea7n c\u00e2n nh\u1eafc khi ph\u1ed1i h\u1ee3p: C\u00e1c statin (c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 statin), thu\u1ed1c \u1ee9c ch\u1ebf PDE5 (t\u0103ng nguy c\u01a1 h\u1ea1 huy\u1ebft \u00e1p), thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, thu\u1ed1c b\u1ed5 sung kali, NSAID (t\u0103ng nguy c\u01a1 suy th\u1eadn), lithi (t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi), furosemide (gi\u1ea3m t\u00e1c d\u1ee5ng furosemide), nitrate (kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3), metformin (gi\u1ea3m n\u1ed3ng \u0111\u1ed9 metformin).<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Kh\u00f4ng d\u00f9ng trong thai k\u1ef3. C\u00e2n nh\u1eafc ng\u1eebng cho con b\u00fa ho\u1eb7c ng\u1eebng d\u00f9ng thu\u1ed1c trong th\u1eddi gian cho con b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t v\u00e0 m\u1ec7t m\u1ecfi, c\u1ea7n th\u1eadn tr\u1ecdng.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 h\u1ea1 huy\u1ebft \u00e1p. C\u1ea7n \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t. Thu\u1ed1c li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng n\u00ean kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf b\u1eb1ng l\u1ecdc m\u00e1u.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Amr Abdin, Martin Schulz, Uwe Riemer, Bledar Had\u00ebri, Rolf Wachter, Ulrich Laufs, Johann Bauersachs, Ingrid Kindermann, Davor Vukadinovi\u0107, Michael B\u00f6hm. Sacubitril\/valsartan in heart failure: efficacy and safety in and outside clinical trials, truy c\u1eadp ng\u00e0y 07 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35921043\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35921043\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1ea3n ph\u1ea9m thu\u1ed1c Uperio 200mg (sacubitril\/valsartan) \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436123, \u0111i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng.<\/p>\n","protected":false},"author":1,"featured_media":122432,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122430","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122432"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122430"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122430"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}