{"id":122409,"date":"2025-06-07T16:38:51","date_gmt":"2025-06-07T09:38:51","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122409"},"modified":"2025-12-23T15:28:21","modified_gmt":"2025-12-23T08:28:21","slug":"uperio-100mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/uperio-100mg\/","title":{"rendered":"Uperio 100mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Uperio 100mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436023.<\/strong><\/p>\n<h2>Uperio 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean n\u00e9n bao phim <strong>Uperio 100mg<\/strong> ch\u1ee9a:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: 48,6 mg sacubitril v\u00e0 51,4 mg<strong> valsartan<\/strong> (d\u01b0\u1edbi d\u1ea1ng mu\u1ed1i ph\u1ee9c h\u1ee3p sacubitril valsartan natri 113,103 mg).<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Cellulose vi tinh th\u1ec3, cellulose \u0111\u01b0\u1ee3c thay th\u1ebf hydroxypropyl m\u1ee9c th\u1ea5p, crospovidon, magnesium stearat, talc v\u00e0 silicon dioxid d\u1ea1ng keo.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c m\u00e0ng bao phim: Hypromellose, titanium dioxid (E 171), Macrogol 4000, talc, s\u1eaft oxyd v\u00e0ng (E 172).<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 800110436023<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u00f4\u0323\u0323p 2 vi\u0309 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Italy<\/p>\n<figure id=\"attachment_122410\" aria-describedby=\"caption-attachment-122410\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122410\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-100MG.jpg\" alt=\"Uperio 100mg \u0111i\u1ec1u tr\u1ecb suy tim\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-100MG.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-100MG-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-100MG-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-100MG-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122410\" class=\"wp-caption-text\">Uperio 100mg \u0111i\u1ec1u tr\u1ecb suy tim<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Uperio 100mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Uperio ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin neprilysin (ARNI). Thu\u1ed1c \u1ee9c ch\u1ebf neprilysin th\u00f4ng qua sacubitrilat, m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a sacubitril, v\u00e0 \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin II typ 1 (AT1) c\u1ee7a valsartan.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: sacubitril v\u00e0 valsartan \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau 0,5 gi\u1edd (sacubitril), 2 gi\u1edd (sacubitrilat) v\u00e0 1,5 gi\u1edd (valsartan).<\/li>\n<li>Ph\u00e2n b\u1ed1: Uperio li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (94%-97%). Sacubitrilat qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o v\u1edbi m\u1ee9c \u0111\u1ed9 h\u1ea1n ch\u1ebf (0,28%).<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Sacubitril chuy\u1ec3n h\u00f3a th\u00e0nh sacubitrilat b\u1edfi c\u00e1c men esterase. Valsartan chuy\u1ec3n h\u00f3a \u1edf m\u1ee9c \u0111\u1ed9 t\u1ed1i thi\u1ec3u (kho\u1ea3ng 20% li\u1ec1u).<\/li>\n<li>Th\u1ea3i tr\u1eeb: 52%-68% sacubitril (ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng sacubitrilat) v\u00e0 kho\u1ea3ng 13% valsartan \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a sacubitril, sacubitrilat v\u00e0 valsartan l\u1ea7n l\u01b0\u1ee3t l\u00e0 kho\u1ea3ng 1,43 gi\u1edd, 11,48 gi\u1edd v\u00e0 9,90 gi\u1edd<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Uperio 100mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Uperio \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u00e2m thu. Thu\u1ed1c gi\u00fap gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do b\u1ec7nh tim m\u1ea1ch v\u00e0 nh\u1eadp vi\u1ec7n do suy tim so v\u1edbi enalapril.<\/p>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Uperio 100mg<\/h2>\n<ul>\n<li>Li\u1ec1u m\u1ee5c ti\u00eau: 200 mg, hai l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o: 100 mg, hai l\u1ea7n\/ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng g\u1ea5p \u0111\u00f4i sau m\u1ed7i 2-4 tu\u1ea7n \u0111\u1ebfn li\u1ec1u m\u1ee5c ti\u00eau 200 mg, hai l\u1ea7n\/ng\u00e0y, t\u00f9y theo s\u1ef1 dung n\u1ea1p c\u1ee7a b\u1ec7nh nh\u00e2n.<\/li>\n<li>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE) ho\u1eb7c thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II (ARB) tr\u01b0\u1edbc \u0111\u00e2y, ho\u1eb7c nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 d\u00f9ng c\u00e1c thu\u1ed1c n\u00e0y \u1edf li\u1ec1u th\u1ea5p, li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o l\u00e0 50 mg, hai l\u1ea7n\/ng\u00e0y.<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Uperio 100mg<\/h2>\n<p>Thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Uperio 100mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi sacubitril, valsartan ho\u1eb7c b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o.<\/li>\n<li>Kh\u00f4ng d\u00f9ng Uperio trong v\u00f2ng 36 gi\u1edd sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n.<\/li>\n<li>Ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n ho\u1eb7c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin.<\/li>\n<li>Ph\u00f9 m\u1ea1ch di truy\u1ec1n ho\u1eb7c t\u1ef1 ph\u00e1t.<\/li>\n<li>\u1ee8 m\u1eadt, x\u01a1 gan m\u1eadt, suy gan n\u1eb7ng.<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi aliskiren tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2.<\/li>\n<li>Giai \u0111o\u1ea1n 2 v\u00e0 3 c\u1ee7a thai k\u1ef3.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Uperio 100mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>H\u1ea1 huy\u1ebft \u00e1p: Kh\u00f4ng n\u00ean b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb n\u1ebfu huy\u1ebft \u00e1p t\u00e2m thu \u2264100 mmHg. C\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p th\u01b0\u1eddng xuy\u00ean khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c trong khi chu\u1ea9n \u0111\u1ed9 li\u1ec1u.<\/li>\n<li>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn: C\u1ea7n \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn \u1edf b\u1ec7nh nh\u00e2n suy tim. Th\u1eadn tr\u1ecdng khi d\u00f9ng Uperio \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn trung b\u00ecnh (eGFR 30\u221260 ml\/ph\u00fat\/1,73 m2) v\u1edbi li\u1ec1u kh\u1edfi \u0111\u1ea7u 50mg, hai l\u1ea7n m\u1ed7i ng\u00e0y. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Uperio \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i.<\/li>\n<li>Ph\u00f9 m\u1ea1ch: \u0110\u00e3 ghi nh\u1eadn ph\u00f9 m\u1ea1ch tr\u00ean b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Uperio. N\u1ebfu x\u1ea3y ra ph\u00f9 m\u1ea1ch, c\u1ea7n ng\u1eebng thu\u1ed1c ngay v\u00e0 c\u00f3 bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p. Ph\u00f9 m\u1ea1ch \u1edf l\u01b0\u1ee1i, thanh m\u00f4n, ho\u1eb7c thanh qu\u1ea3n g\u00e2y t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy gan: Th\u1eadn tr\u1ecdng khi d\u00f9ng Uperio cho b\u1ec7nh nh\u00e2n suy gan nh\u1eb9 (Child-Pugh A) v\u00e0 trung b\u00ecnh (Child-Pugh B).<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ed1i lo\u1ea1n m\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft: Thi\u1ebfu m\u00e1u (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch: Qu\u00e1 m\u1eabn (\u00cdt g\u1eb7p).<\/li>\n<li>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng:\n<ul>\n<li>T\u0103ng kali m\u00e1u (R\u1ea5t th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Gi\u1ea3m kali m\u00e1u (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>H\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh:\n<ul>\n<li>Cho\u00e1ng v\u00e1ng (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Nh\u1ee9c \u0111\u1ea7u (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Ng\u1ea5t (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Ch\u00f3ng m\u1eb7t t\u01b0 th\u1ebf (\u00cdt g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n tai v\u00e0 m\u00ea \u0111\u1ea1o: Ch\u00f3ng m\u1eb7t (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>R\u1ed1i lo\u1ea1n m\u1ea1ch:\n<ul>\n<li>H\u1ea1 huy\u1ebft \u00e1p (R\u1ea5t th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>H\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, ng\u1ef1c v\u00e0 trung th\u1ea5t: Ho (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a:\n<ul>\n<li>Ti\u00eau ch\u1ea3y (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Bu\u1ed3n n\u00f4n (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Vi\u00eam d\u1ea1 d\u00e0y (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da:\n<ul>\n<li>Ng\u1ee9a (\u00cdt g\u1eb7p).<\/li>\n<li>Ph\u00e1t ban (\u00cdt g\u1eb7p).<\/li>\n<li>Ph\u00f9 m\u1ea1ch (\u00cdt g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u:\n<ul>\n<li>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn (R\u1ea5t th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Suy th\u1eadn (Suy th\u1eadn, suy th\u1eadn c\u1ea5p) (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<li>R\u1ed1i lo\u1ea1n to\u00e0n th\u00e2n v\u00e0 t\u00ecnh tr\u1ea1ng t\u1ea1i ch\u1ed7 d\u00f9ng thu\u1ed1c:\n<ul>\n<li>M\u1ec7t m\u1ecfi (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<li>Suy nh\u01b0\u1ee3c (Th\u01b0\u1eddng g\u1eb7p).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE): Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi Uperio v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n do nguy c\u01a1 ph\u00f9 m\u1ea1ch t\u0103ng l\u00ean.<\/li>\n<li>Aliskiren: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi Uperio v\u1edbi aliskiren cho b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2.<\/li>\n<li>Thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II (ARB): Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi Uperio v\u1edbi thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II.<\/li>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 corticoid kho\u00e1ng, ch\u1ebf ph\u1ea9m b\u1ed5 sung kali: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh.<\/li>\n<li>Thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAID): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 l\u00e0m x\u1ea5u \u0111i ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<li>Lithi: C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi Uperio v\u1edbi lithi do c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft thanh.<\/li>\n<li>Statin: Uperio c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 to\u00e0n th\u00e2n c\u1ee7a c\u00e1c c\u01a1 ch\u1ea5t c\u1ee7a OATP1B1 v\u00e0 OATP1B3 nh\u01b0 c\u00e1c statin.<\/li>\n<li>C\u00e1c ch\u1ea5t v\u1eadn chuy\u1ec3n OATP v\u00e0 MRP2: C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Uperio v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf OATP1B1, OATP1B3, OAT3 (nh\u01b0 rifampin, cyclosporin) ho\u1eb7c MPR2 (nh\u01b0 ritonavir) do c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 sacubitrilat ho\u1eb7c valsartan trong tu\u1ea7n ho\u00e0n.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng Uperio trong 3 th\u00e1ng \u0111\u1ea7u thai k\u1ef3 v\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong giai \u0111o\u1ea1n 2 v\u00e0 3 c\u1ee7a thai k\u1ef3. Valsartan \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o g\u00e2y t\u1ed5n th\u01b0\u01a1ng thai nhi. Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u00ean s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Uperio v\u00e0 1 tu\u1ea7n sau li\u1ec1u cu\u1ed1i c\u00f9ng.<\/li>\n<li>Ph\u1ee5 n\u1eef cho con b\u00fa: Ch\u01b0a bi\u1ebft Uperio c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng. Do nguy c\u01a1 c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u1edf tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb nh\u1ecf b\u00fa m\u1eb9, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng Uperio trong th\u1eddi gian cho con b\u00fa.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng m\u00e1y m\u00f3c ho\u1eb7c l\u00e1i xe, do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t v\u00e0 m\u1ec7t m\u1ecfi.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 h\u1ea1 huy\u1ebft \u00e1p. X\u1eed tr\u00ed qu\u00e1 li\u1ec1u b\u1eb1ng c\u00e1ch \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng. Uperio kh\u00f4ng \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 b\u1eb1ng l\u1ecdc m\u00e1u do li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>David A Morrow, Eric J Velazquez, Akshay S Desai, Adam D DeVore, Serge Lepage, Jeong-Gun Park, Kavita Sharma, Scott D Solomon, Randall C Starling, Jonathan H Ward, Kristin M Williamson, Shelley Zieroth, Adrian F Hernandez, Robert J Mentz, Eugene Braunwald. Sacubitril\/Valsartan in Patients Hospitalized With Decompensated Heart Failure, truy c\u1eadp ng\u00e0y 07 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38508844\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38508844\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Uperio 100mg (sacubitril\/valsartan) \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436023, ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng.<\/p>\n","protected":false},"author":1,"featured_media":122411,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122409","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122409"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122411"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122409"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122409"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}