{"id":122393,"date":"2025-06-07T16:21:31","date_gmt":"2025-06-07T09:21:31","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122393"},"modified":"2025-12-23T15:27:38","modified_gmt":"2025-12-23T08:27:38","slug":"uperio-50mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/uperio-50mg\/","title":{"rendered":"Uperio 50mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Uperio 50mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436223.<\/strong><\/p>\n<h2>Uperio 50mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean <strong>Uperio 50mg<\/strong> ch\u1ee9a:<\/p>\n<ul>\n<li>24,3 mg Sacubitril<\/li>\n<li>25,7 mg <strong>Valsartan<\/strong><\/li>\n<\/ul>\n<p>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 800110436223<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u00f4\u0323\u0323p 2 vi\u0309 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Italy<\/p>\n<figure id=\"attachment_122566\" aria-describedby=\"caption-attachment-122566\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122566\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-50MG-7.jpg\" alt=\"UPERIO 50MG \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng suy tim\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-50MG-7.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-50MG-7-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-50MG-7-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/UPERIO-50MG-7-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122566\" class=\"wp-caption-text\">UPERIO 50MG \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng suy tim<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Uperio 50mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<ul>\n<li>Uperio \u1ee9c ch\u1ebf \u0111\u1ed3ng th\u1eddi neprilysin v\u00e0 th\u1ee5 th\u1ec3 angiotensin II typ 1 (AT1).<\/li>\n<li>Sacubitrilat (ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a sacubitril) t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u00e1c peptide natriuretic (NP) c\u00f3 l\u1ee3i, gi\u00fap gi\u00e3n m\u1ea1ch, l\u1ee3i ti\u1ec3u, t\u0103ng th\u1ea3i natri.<\/li>\n<li>Valsartan \u1ee9c ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u00f3 h\u1ea1i c\u1ee7a angiotensin II, gi\u1ea3m co m\u1ea1ch, gi\u1eef n\u01b0\u1edbc v\u00e0 mu\u1ed1i, ng\u0103n ch\u1eb7n t\u00e1i c\u1ea5u tr\u00fac tim.<\/li>\n<li>Uperio \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0m gi\u1ea3m NT-proBNP huy\u1ebft t\u01b0\u01a1ng (ch\u1ea5t ch\u1ec9 \u0111i\u1ec3m ph\u00f9 h\u1ee3p cho suy tim khi d\u00f9ng Uperio) v\u00e0 t\u0103ng BNP huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Sacubitril nhanh ch\u00f3ng chuy\u1ec3n h\u00f3a th\u00e0nh sacubitrilat. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 0,5 gi\u1edd (sacubitril), 2 gi\u1edd (sacubitrilat) v\u00e0 1,5 gi\u1edd (valsartan). Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a sacubitril v\u00e0 valsartan l\u1ea7n l\u01b0\u1ee3t l\u00e0 \u2265 60% v\u00e0 23%.<\/li>\n<li>Ph\u00e2n b\u1ed1: Li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (94% &#8211; 97%).<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Sacubitril chuy\u1ec3n h\u00f3a th\u00e0nh sacubitrilat. Valsartan chuy\u1ec3n h\u00f3a \u1edf m\u1ee9c t\u1ed1i thi\u1ec3u.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n. 8 .Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh: sacubitril kho\u1ea3ng 1,43 gi\u1edd, sacubitrilat kho\u1ea3ng 11,48 gi\u1edd, valsartan kho\u1ea3ng 9,90 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Uperio 50mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb suy tim c\u00f3 tri\u1ec7u ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u00e2m thu.<\/li>\n<li>L\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do b\u1ec7nh tim m\u1ea1ch v\u00e0 nh\u1eadp vi\u1ec7n do suy tim.<\/li>\n<li>Gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do m\u1ecdi nguy\u00ean nh\u00e2n.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Uperio 50mg<\/h2>\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 100 mg, hai l\u1ea7n\/ng\u00e0y (tr\u1eeb m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p \u0111\u1eb7c bi\u1ec7t).<\/li>\n<li>Li\u1ec1u m\u1ee5c ti\u00eau: C\u00f3 th\u1ec3 t\u0103ng l\u00ean 200 mg, hai l\u1ea7n\/ng\u00e0y sau 2-4 tu\u1ea7n, t\u00f9y theo dung n\u1ea1p.<\/li>\n<li>C\u00e1ch d\u00f9ng: U\u1ed1ng qua \u0111\u01b0\u1eddng mi\u1ec7ng, c\u00f3 th\u1ec3 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/li>\n<li>Quan tr\u1ecdng: Kh\u00f4ng d\u00f9ng Uperio c\u00f9ng v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE). Ph\u1ea3i \u0111\u1ee3i \u00edt nh\u1ea5t 36 gi\u1edd sau khi ng\u1eebng ACEI m\u1edbi \u0111\u01b0\u1ee3c d\u00f9ng Uperio.<\/li>\n<li>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng cho ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n suy th\u1eadn, suy gan.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Uperio 50mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi c\u00e1c th\u00e0nh ph\u1ea7n c\u00f3 trong thu\u1ed1c Uperio 50mg.<\/li>\n<li>\u0110ang d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n (ACE) ho\u1eb7c trong v\u00f2ng 36 gi\u1edd sau khi ng\u1eebng ACEI.<\/li>\n<li>Ti\u1ec1n s\u1eed ph\u00f9 m\u1ea1ch (s\u01b0ng ph\u00f9 nghi\u00eam tr\u1ecdng).<\/li>\n<li>\u0110ang d\u00f9ng Aliskiren (\u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn).<\/li>\n<li>Suy gan n\u1eb7ng, x\u01a1 gan m\u1eadt ho\u1eb7c \u1ee9 m\u1eadt.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Uperio 50mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>C\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p v\u00e0 n\u1ed3ng \u0111\u1ed9 kali m\u00e1u th\u01b0\u1eddng xuy\u00ean.<\/li>\n<li>N\u1ebfu xu\u1ea5t hi\u1ec7n ph\u00f9 m\u1ea1ch, c\u1ea7n ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c v\u00e0 t\u00ecm ki\u1ebfm s\u1ef1 h\u1ed7 tr\u1ee3 y t\u1ebf.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t bao g\u1ed3m:<\/li>\n<li>H\u1ea1 huy\u1ebft \u00e1p<\/li>\n<li>T\u0103ng kali m\u00e1u<\/li>\n<li>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn<\/li>\n<li>Ph\u00f9 m\u1ea1ch, ho, ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<h4>T\u01b0\u01a1ng t\u00e1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/h4>\n<ul>\n<li>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE): T\u0103ng nguy c\u01a1 ph\u00f9 m\u1ea1ch.<\/li>\n<li>Aliskiren: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng typ 2.<\/li>\n<\/ul>\n<h4>T\u01b0\u01a1ng t\u00e1c kh\u00f4ng khuy\u1ebfn c\u00e1o<\/h4>\n<ul>\n<li>Aliskiren: N\u00ean tr\u00e1nh d\u00f9ng tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn (eGFR &lt; 60 mL\/ph\u00fat\/1.73 m2).<\/li>\n<li>Thu\u1ed1c ch\u1eb9n th\u1ee5 th\u1ec3 angiotensin II (ARB).<\/li>\n<\/ul>\n<h4>T\u01b0\u01a1ng t\u00e1c c\u1ea7n c\u00e2n nh\u1eafc khi ph\u1ed1i h\u1ee3p<\/h4>\n<ul>\n<li>C\u00e1c Statin: Uperio c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 to\u00e0n th\u00e2n c\u1ee7a c\u00e1c statin. Th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/li>\n<li>\u1ee8c ch\u1ebf PDE5 (bao g\u1ed3m sildenafil): C\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p m\u1ea1nh h\u01a1n.<\/li>\n<li>Kali: C\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, thu\u1ed1c b\u1ed5 sung kali c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh. Khuy\u1ebfn c\u00e1o theo d\u00f5i.<\/li>\n<li>C\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAID): T\u0103ng nguy c\u01a1 l\u00e0m x\u1ea5u \u0111i ch\u1ee9c n\u0103ng th\u1eadn, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i ho\u1eb7c suy th\u1eadn.<\/li>\n<li>Lithi: T\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft thanh v\u00e0 \u0111\u1ed9c t\u00ednh. Khuy\u1ebfn c\u00e1o theo d\u00f5i n\u1ed3ng \u0111\u1ed9 lithi.<\/li>\n<li>Furosemide: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m Cmax v\u00e0 AUC c\u1ee7a furosemide.<\/li>\n<li>Nitrate (nh\u01b0 nitroglycerine): Kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn gi\u1ea3m huy\u1ebft \u00e1p, nh\u01b0ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim.<\/li>\n<li>C\u00e1c ch\u1ea5t v\u1eadn chuy\u1ec3n OATP v\u00e0 MRP2 (nh\u01b0 rifampin, cyclosporin, ritonavir): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 sacubitrilat ho\u1eb7c valsartan. C\u1ea7n th\u1eadn tr\u1ecdng.<\/li>\n<li>Metformin: Uperio c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m Cmax v\u00e0 AUC c\u1ee7a metformin. C\u1ea7n \u0111\u00e1nh gi\u00e1 t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng.<\/li>\n<\/ul>\n<h4>T\u01b0\u01a1ng t\u00e1c kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng<\/h4>\n<ul>\n<li>Furosemide, digoxin, warfarin, hydrochlorothiazid, amlodipin, metformin, omeprazol, carvedilol, nitroglycerin \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch ho\u1eb7c d\u1ea1ng k\u1ebft h\u1ee3p levonorgestrel\/ethinyl estradiol.<\/li>\n<li>Atenolol, indomethacin, glyburid ho\u1eb7c cimetidin.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh. 2 .Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng nghi\u00eam tr\u1ecdng \u0111\u1ebfn thai nhi.<\/li>\n<li>Ph\u1ee5 n\u1eef cho con b\u00fa: Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng do nguy c\u01a1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i tr\u00ean tr\u1ebb b\u00fa m\u1eb9.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng do thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t v\u00e0 m\u1ec7t m\u1ecfi.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng g\u1eb7p nh\u1ea5t khi qu\u00e1 li\u1ec1u l\u00e0 h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng. Uperio kh\u00f4ng \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 b\u1eb1ng l\u1ecdc m\u00e1u do li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Kazuhiko Kido, Bailey M Colvin, Thomas W Szymanski, Maya Guglin. Sacubitril\/Valsartan Off-Label Uses for Heart Failure, truy c\u1eadp ng\u00e0y 07 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35405341\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35405341\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Uperio 50mg (sacubitril\/valsartan) \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Novartis Farma SpA, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 800110436223, gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do b\u1ec7nh tim m\u1ea1ch v\u00e0 gi\u1ea3m s\u1ed1 l\u1ea7n nh\u1eadp vi\u1ec7n do suy tim.<\/p>\n","protected":false},"author":1,"featured_media":122395,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122393","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122393"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122395"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122393"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122393"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}