{"id":122223,"date":"2025-06-06T14:23:22","date_gmt":"2025-06-06T07:23:22","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122223"},"modified":"2025-12-23T15:25:50","modified_gmt":"2025-12-23T08:25:50","slug":"xaravix-15","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/xaravix-15\/","title":{"rendered":"XARAVIX 15"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>XARAVIX 15 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang &#8211; Chi nh\u00e1nh nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m DHG t\u1ea1i H\u1eadu Giang, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35984-22.<\/strong><\/p>\n<h2>XARAVIX 15 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean n\u00e9n bao phim <strong>XARAVIX 15mg<\/strong> ch\u1ee9a <strong>Rivaroxaban<\/strong> 15mg c\u00f9ng v\u1edbi c\u00e1c t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-35984-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_122224\" aria-describedby=\"caption-attachment-122224\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122224\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-15.jpg\" alt=\"XARAVIX 15 d\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-15.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-15-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-15-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-15-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122224\" class=\"wp-caption-text\">XARAVIX 15 d\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c XARAVIX 15<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Rivaroxaban l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf tr\u1ef1c ti\u1ebfp v\u00e0 ch\u1ecdn l\u1ecdc cao y\u1ebfu t\u1ed1 Xa (FXa). Y\u1ebfu t\u1ed1 Xa \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u b\u1eb1ng c\u00e1ch chuy\u1ec3n \u0111\u1ed5i prothrombin th\u00e0nh thrombin. Rivaroxaban ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh n\u00e0y, l\u00e0m gi\u1ea3m s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng fibrin v\u00e0 ho\u1ea1t h\u00f3a ti\u1ec3u c\u1ea7u.<\/p>\n<p>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/p>\n<ul>\n<li>\u1ee8c ch\u1ebf y\u1ebfu t\u1ed1 Xa ph\u1ee5 thu\u1ed9c li\u1ec1u.<\/li>\n<li>K\u00e9o d\u00e0i th\u1eddi gian prothrombin (PT), th\u1eddi gian prothrombin \u0111\u01b0\u1ee3c ho\u1ea1t h\u00f3a t\u1eebng ph\u1ea7n (aPTT) v\u00e0 HepTest\u00ae ph\u1ee5 thu\u1ed9c li\u1ec1u.<\/li>\n<li>Kh\u00f4ng c\u1ea7n theo d\u00f5i c\u00e1c th\u00f4ng s\u1ed1 \u0111\u00f4ng m\u00e1u th\u01b0\u1eddng quy trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Thu\u1ed1c h\u1ea5p thu nhanh v\u00e0 g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a (Cmax) sau 2-4 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng cao (80-100%).<\/li>\n<li>Ph\u00e2n b\u1ed1: Li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 92-95%. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 50 L.<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 Th\u1ea3i tr\u1eeb: Rivaroxaban \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu qua gan (CYP 3A4, CYP 2J2 v\u00e0 c\u01a1 ch\u1ebf kh\u00f4ng ph\u1ee5 thu\u1ed9c CYP) v\u00e0 th\u1ea3i tr\u1eeb qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 5-9 gi\u1edd \u1edf ng\u01b0\u1eddi tr\u1ebb v\u00e0 11-13 gi\u1edd \u1edf ng\u01b0\u1eddi cao tu\u1ed5i.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c XARAVIX 15 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>XARAVIX 15mg l\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3:<\/p>\n<ul>\n<li>Ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n: \u1ede b\u1ec7nh nh\u00e2n rung nh\u0129 kh\u00f4ng do b\u1ec7nh van tim c\u00f3 m\u1ed9t ho\u1eb7c nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 (v\u00ed d\u1ee5: suy tim, t\u0103ng huy\u1ebft \u00e1p, tr\u00ean 75 tu\u1ed5i, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, ti\u1ec1n s\u1eed \u0111\u1ed9t qu\u1ef5 ho\u1eb7c thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 tho\u00e1ng qua).<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u (DVT) v\u00e0 thuy\u00ean t\u1eafc ph\u1ed5i (PE).<\/li>\n<li>Ph\u00f2ng ng\u1eeba huy\u1ebft kh\u1ed1i t\u1eafc t\u0129nh m\u1ea1ch (VTE): \u1ede ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh sau ph\u1eabu thu\u1eadt thay kh\u1edbp g\u1ed1i ho\u1eb7c kh\u1edbp h\u00e1ng.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c XARAVIX 15<\/h2>\n<ul>\n<li>D\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129: 20mg x 1 l\u1ea7n\/ng\u00e0y. \u0110i\u1ec1u tr\u1ecb duy tr\u00ec d\u00e0i h\u1ea1n n\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t DVT v\u00e0 PE:\n<ul>\n<li>Ng\u00e0y 1-21: 15mg x 2 l\u1ea7n\/ng\u00e0y (t\u1ed1i \u0111a 30mg\/ng\u00e0y).<\/li>\n<li>T\u1eeb ng\u00e0y 22 tr\u1edf \u0111i: 20mg x 1 l\u1ea7n\/ng\u00e0y (t\u1ed1i \u0111a 20mg\/ng\u00e0y).<\/li>\n<li>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb t\u00f9y thu\u1ed9c v\u00e0o y\u1ebfu t\u1ed1 nguy c\u01a1 (ng\u1eafn h\u1ea1n cho y\u1ebfu t\u1ed1 t\u1ea1m th\u1eddi, d\u00e0i h\u1ea1n cho y\u1ebfu t\u1ed1 th\u01b0\u1eddng tr\u1ef1c ho\u1eb7c kh\u00f4ng y\u1ebfu t\u1ed1 kh\u1edfi ph\u00e1t).<\/li>\n<\/ul>\n<\/li>\n<li>Ph\u00f2ng ng\u1eeba VTE sau thay kh\u1edbp h\u00e1ng ho\u1eb7c g\u1ed1i: 10mg x 1 l\u1ea7n\/ng\u00e0y. Li\u1ec1u kh\u1edfi \u0111\u1ea7u 6-10 gi\u1edd sau m\u1ed5 (khi c\u1ea7m m\u00e1u). Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb 5 tu\u1ea7n cho kh\u1edbp h\u00e1ng, 2 tu\u1ea7n cho kh\u1edbp g\u1ed1i.<\/li>\n<li>D\u1ef1 ph\u00f2ng k\u00e9o d\u00e0i sau \u22656 th\u00e1ng \u0111i\u1ec1u tr\u1ecb DVT\/PE: 10mg x 1 l\u1ea7n\/ng\u00e0y d\u00e0i h\u1ea1n, c\u00e2n nh\u1eafc 20mg\/ng\u00e0y n\u1ebfu nguy c\u01a1 t\u00e1i ph\u00e1t cao.<\/li>\n<li>Chuy\u1ec3n \u0111\u1ed5i t\u1eeb\/sang c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c: C\u1ea7n tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi \u0111i\u1ec3m chuy\u1ec3n \u0111\u1ed5i ph\u00f9 h\u1ee3p, \u0111\u1eb7c bi\u1ec7t khi chuy\u1ec3n t\u1eeb\/sang Kh\u00e1ng Vitamin K (VKA) ho\u1eb7c c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng ti\u00eam.<\/li>\n<li>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:\n<ul>\n<li>Suy th\u1eadn: C\u1ea7n ch\u1ec9nh li\u1ec1u t\u00f9y theo m\u1ee9c \u0111\u1ed9 suy th\u1eadn (CrCl).\n<ul>\n<li>CrCl 30-49 mL\/ph\u00fat ho\u1eb7c 15-29 mL\/ph\u00fat: 15mg x 1 l\u1ea7n\/ng\u00e0y (d\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5\/thuy\u00ean t\u1eafc m\u1ea1ch).<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb DVT\/PE v\u00e0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t: 15mg x 2 l\u1ea7n\/ng\u00e0y trong 3 tu\u1ea7n \u0111\u1ea7u, sau \u0111\u00f3 c\u00e2n nh\u1eafc gi\u1ea3m t\u1eeb 20mg xu\u1ed1ng 15mg x 1 l\u1ea7n\/ng\u00e0y n\u1ebfu nguy c\u01a1 ch\u1ea3y m\u00e1u cao.<\/li>\n<li>Kh\u00f4ng khuy\u1ebfn c\u00e1o cho b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (CrCl &lt; 15 mL\/ph\u00fat).<\/li>\n<\/ul>\n<\/li>\n<li>Ng\u01b0\u1eddi gi\u00e0: Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u.<\/li>\n<li>Tr\u1ebb em: Kh\u00f4ng khuy\u1ebfn c\u00e1o cho tr\u1ebb d\u01b0\u1edbi 18 tu\u1ed5i.<\/li>\n<li>B\u1ec7nh nh\u00e2n c\u1ea7n chuy\u1ec3n nh\u1ecbp: U\u1ed1ng XARAVIX \u00edt nh\u1ea5t 4 gi\u1edd tr\u01b0\u1edbc chuy\u1ec3n nh\u1ecbp.<\/li>\n<li>B\u1ec7nh nh\u00e2n PCI c\u00f3 \u0111\u1eb7t stent: Li\u1ec1u gi\u1ea3m 15mg x 1 l\u1ea7n\/ng\u00e0y (ho\u1eb7c 10mg x 1 l\u1ea7n\/ng\u00e0y cho suy th\u1eadn trung b\u00ecnh) b\u1ed5 sung v\u00e0o ph\u00e1c \u0111\u1ed3 \u1ee9c ch\u1ebf P2Y12, t\u1ed1i \u0111a 12 th\u00e1ng. Sau \u0111\u00f3 t\u0103ng li\u1ec1u Rivaroxaban l\u00ean li\u1ec1u chu\u1ea9n.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c XARAVIX 15<\/h2>\n<ul>\n<li>XARAVIX 15mg \u0111\u01b0\u1ee3c d\u00f9ng theo \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 n\u00ean u\u1ed1ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/li>\n<li>C\u00e1ch d\u00f9ng \u0111\u1eb7c bi\u1ec7t:\n<ul>\n<li>C\u00f3 th\u1ec3 nghi\u1ec1n vi\u00ean thu\u1ed1c v\u00e0 tr\u1ed9n v\u1edbi n\u01b0\u1edbc ho\u1eb7c th\u1ee9c \u0103n m\u1ec1m (nh\u01b0 n\u01b0\u1edbc t\u00e1o) ngay tr\u01b0\u1edbc khi d\u00f9ng.<\/li>\n<li>Vi\u00ean nghi\u1ec1n c\u00f3 th\u1ec3 d\u00f9ng qua \u1ed1ng th\u00f4ng d\u1ea1 d\u00e0y, sau \u0111\u00f3 c\u1ea7n tr\u00e1ng th\u00eam n\u01b0\u1edbc v\u00e0 ti\u1ebfp theo l\u00e0 nu\u00f4i \u0103n qua \u0111\u01b0\u1eddng ru\u1ed9t.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c XARAVIX 15 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>M\u1eabn c\u1ea3m v\u1edbi Rivaroxaban ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>\u0110ang ch\u1ea3y m\u00e1u li\u00ean quan l\u00e2m s\u00e0ng (ch\u1ea3y m\u00e1u n\u1ed9i s\u1ecd, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a).<\/li>\n<li>\u0110ang \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c (tr\u1eeb giai \u0111o\u1ea1n chuy\u1ec3n \u0111\u1ed5i ho\u1eb7c khi d\u00f9ng heparin kh\u00f4ng ph\u00e2n \u0111o\u1ea1n \u0111\u1ec3 duy tr\u00ec th\u00f4ng \u0111\u1ed9ng\/t\u0129nh m\u1ea1ch trung t\u00e2m).<\/li>\n<li>B\u1ec7nh gan k\u00e8m r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u v\u00e0 nguy c\u01a1 ch\u1ea3y m\u00e1u \u0111\u00e1ng k\u1ec3 (k\u1ec3 c\u1ea3 x\u01a1 gan Child-Pugh B v\u00e0 C).<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c XARAVIX 15<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Nguy c\u01a1 xu\u1ea5t huy\u1ebft: Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n c\u00f3 t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft (r\u1ed1i lo\u1ea1n ch\u1ea3y m\u00e1u b\u1ea9m sinh\/m\u1eafc ph\u1ea3i, t\u0103ng huy\u1ebft \u00e1p \u0111\u1ed9ng m\u1ea1ch nghi\u00eam tr\u1ecdng kh\u00f4ng ki\u1ec3m so\u00e1t, lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u0111ang ti\u1ebfn tri\u1ec3n\/g\u1ea7n \u0111\u00e2y, b\u1ec7nh l\u00fd v\u00f5ng m\u1ea1c do m\u1ea1ch m\u00e1u, ch\u1ea3y m\u00e1u n\u1ed9i s\u1ecd\/n\u00e3o g\u1ea7n \u0111\u00e2y, b\u1ea5t th\u01b0\u1eddng m\u1ea1ch m\u00e1u, ph\u1eabu thu\u1eadt n\u00e3o\/t\u1ee7y s\u1ed1ng\/nh\u00e3n khoa g\u1ea7n \u0111\u00e2y, gi\u00e3n ph\u1ebf qu\u1ea3n ho\u1eb7c ti\u1ec1n s\u1eed ch\u1ea3y m\u00e1u ph\u1ed5i). C\u1ea7n theo d\u00f5i hemoglobin\/hematocrit \u0111\u1ec3 ph\u00e1t hi\u1ec7n ch\u1ea3y m\u00e1u \u1ea9n. Ng\u1eebng XARAVIX n\u1ebfu x\u1ea3y ra xu\u1ea5t huy\u1ebft.<\/li>\n<li>Ph\u1eabu thu\u1eadt v\u00e0 can thi\u1ec7p: N\u00ean ng\u1eebng XARAVIX t\u1ed1i thi\u1ec3u 24 gi\u1edd tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt\/can thi\u1ec7p n\u1ebfu c\u00f3 th\u1ec3. B\u1eaft \u0111\u1ea7u l\u1ea1i khi t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng cho ph\u00e9p v\u00e0 v\u1ebft th\u01b0\u01a1ng \u0111\u00e3 c\u1ea7m m\u00e1u.<\/li>\n<li>G\u00e2y t\u00ea tr\u1ee5c th\u1ea7n kinh (ngo\u00e0i m\u00e0ng c\u1ee9ng\/t\u1ee7y s\u1ed1ng): C\u00e2n nh\u1eafc l\u1ee3i \u00edch v\u00e0 nguy c\u01a1. Kh\u00f4ng r\u00fat \u1ed1ng th\u00f4ng ngo\u00e0i m\u00e0ng c\u1ee9ng s\u1edbm h\u01a1n 18 gi\u1edd sau li\u1ec1u cu\u1ed1i c\u00f9ng. U\u1ed1ng XARAVIX s\u1edbm nh\u1ea5t 6 gi\u1edd sau khi r\u00fat \u1ed1ng th\u00f4ng. N\u1ebfu c\u00f3 sang th\u01b0\u01a1ng do ch\u1ecdc d\u00f2, tr\u00ec ho\u00e3n 24 gi\u1edd. Theo d\u00f5i d\u1ea5u hi\u1ec7u suy gi\u1ea3m th\u1ea7n kinh.<\/li>\n<li>\u0110\u1ed1i t\u01b0\u1ee3ng h\u1ea1n ch\u1ebf d\u1eef li\u1ec7u l\u00e2m s\u00e0ng: Th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n thay van tim nh\u00e2n t\u1ea1o, DVT\/PE c\u00f3 huy\u1ebft \u0111\u1ed9ng h\u1ecdc kh\u00f4ng \u1ed5n \u0111\u1ecbnh, c\u1ea7n l\u00e0m tan huy\u1ebft kh\u1ed1i\/l\u1ea5y b\u1ecf v\u1eadt ngh\u1ebdn m\u1ea1ch ph\u1ed5i, ho\u1eb7c b\u1ec7nh nh\u00e2n PCI c\u00f3 \u0111\u1eb7t stent.<\/li>\n<li>Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn: Th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 rivaroxaban. Kh\u00f4ng khuy\u1ebfn c\u00e1o cho b\u1ec7nh nh\u00e2n c\u00f3 CrCl &lt; 15 mL\/ph\u00fat.<\/li>\n<li>Ph\u1ee5 n\u1eef \u1edf \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n: Ch\u1ec9 s\u1eed d\u1ee5ng khi \u0111ang d\u00f9ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p (&gt;1\/100): Thi\u1ebfu m\u00e1u, ch\u1ea3y m\u00e1u m\u1eaft, ch\u1ea3y m\u00e1u n\u01b0\u1edbu r\u0103ng, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, \u0111au b\u1ee5ng, kh\u00f3 ti\u00eau, bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, n\u00f4n, \u0111au chi, ch\u1ea3y m\u00e1u h\u1eadu ph\u1eabu, \u0111\u1ee5ng d\u1eadp, \u0111au \u0111\u1ea7u, cho\u00e1ng v\u00e1ng, s\u1ed1t, ph\u00f9 ngo\u1ea1i vi, gi\u1ea3m s\u1ee9c l\u1ef1c, ch\u1ea3y m\u00e1u cam, ng\u1ee9a, xu\u1ea5t huy\u1ebft da, t\u1ee5 m\u00e1u da.<\/li>\n<li>\u00cdt g\u1eb7p (1\/1000 &lt; ADR &lt; 1\/100): T\u0103ng ti\u1ec3u c\u1ea7u, nh\u1ecbp tim nhanh, kh\u00f4 mi\u1ec7ng, v\u1ebft th\u01b0\u01a1ng xu\u1ea5t huy\u1ebft, ch\u1ea3y m\u00e1u n\u00e3o v\u00e0 n\u1ed9i s\u1ecd, ng\u1ea5t, t\u1ee5 m\u00e1u kh\u1edbp, kh\u00f3 ch\u1ecbu, gi\u1ea3m ch\u1ee9c n\u0103ng gan, m\u00e0y \u0111ay.<\/li>\n<li>Hi\u1ebfm g\u1eb7p (1\/10000 &lt; ADR &lt; 1\/1000): Ph\u00f9 t\u1ea1i ch\u1ed7, gi\u1ea3 v\u00e0ng da, ph\u00ecnh m\u1ea1ch, t\u0103ng n\u1ed3ng \u0111\u1ed9 bilirubin li\u00ean h\u1ee3p, xu\u1ea5t huy\u1ebft c\u01a1.<\/li>\n<li>Kh\u00f4ng r\u00f5 t\u1ea7n su\u1ea5t: Ph\u00f9 m\u1ea1ch, ph\u00f9 do d\u1ecb \u1ee9ng.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:\n<ul>\n<li>T\u0103ng n\u1ed3ng \u0111\u1ed9 Rivaroxaban: D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP 3A4 v\u00e0 P-gp m\u1ea1nh (v\u00ed d\u1ee5: thu\u1ed1c kh\u00e1ng n\u1ea5m nh\u00f3m azole to\u00e0n th\u00e2n nh\u01b0 ketoconazole, itraconazole; thu\u1ed1c \u1ee9c ch\u1ebf protease HIV nh\u01b0 ritonavir) l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Rivaroxaban huy\u1ebft t\u01b0\u01a1ng v\u00e0 nguy c\u01a1 ch\u1ea3y m\u00e1u. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi.<\/li>\n<li>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP 3A4 v\u00e0 P-gp trung b\u00ecnh (clarithromycin, erythromycin, fluconazole) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Rivaroxaban nh\u01b0ng th\u01b0\u1eddng \u00edt c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/li>\n<li>Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Rivaroxaban: D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 v\u00e0 P-gp m\u1ea1nh (rifampicin, phenytoin, carbamazepin, phenobarbital, St. John&#8217;s Wort) l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Rivaroxaban huy\u1ebft t\u01b0\u01a1ng. C\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p.<\/li>\n<\/ul>\n<\/li>\n<li>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc: D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u00f4ng m\u00e1u (enoxaparin, NSAIDs, thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, warfarin) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u. C\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd.<\/li>\n<li>Th\u1ee9c \u0103n v\u00e0 th\u1ef1c ph\u1ea9m t\u1eeb s\u1eefa: Vi\u00ean n\u00e9n XARAVIX 15mg c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/li>\n<li>T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c th\u00f4ng s\u1ed1 x\u00e9t nghi\u1ec7m: C\u00e1c x\u00e9t nghi\u1ec7m \u0111\u00f4ng m\u00e1u (PT, aPTT, HepTest\u00ae) c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng.<\/li>\n<\/ul>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>C\u00e1c tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u (l\u00ean \u0111\u1ebfn 600mg) hi\u1ebfm khi g\u00e2y bi\u1ebfn ch\u1ee9ng ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng.<\/li>\n<li>Hi\u1ec7n ch\u01b0a c\u00f3 ch\u1ea5t gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u.<\/li>\n<li>X\u1eed tr\u00ed ch\u1ea3y m\u00e1u: T\u1ea1m ng\u1eebng ho\u1eb7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb, \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng (\u00e9p c\u01a1 h\u1ecdc, c\u1ea7m m\u00e1u ph\u1eabu thu\u1eadt, truy\u1ec1n d\u1ecbch, truy\u1ec1n m\u00e1u n\u1ebfu c\u1ea7n).<\/li>\n<li>Than ho\u1ea1t t\u00ednh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem x\u00e9t \u0111\u1ec3 gi\u1ea3m h\u1ea5p thu. Rivaroxaban g\u1eafn protein huy\u1ebft t\u01b0\u01a1ng cao n\u00ean kh\u00f3 th\u1ea9m t\u00e1ch.<\/li>\n<li>Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng protamine sulfate, vitamin K, hay c\u00e1c thu\u1ed1c ch\u1ed1ng ly gi\u1ea3i s\u1ee3i fibrin.<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c XARAVIX 15<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/rivarelta-10mg\/\">Thu\u1ed1c Rivarelta 10mg<\/a>, v\u1edbi h\u00e0m l\u01b0\u1ee3ng Rivaroxaban th\u1ea5p h\u01a1n l\u00e0 10mg, s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH sinh d\u01b0\u1ee3c ph\u1ea9m Hera, d\u00f9ng ph\u00f2ng ng\u1eeba thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Tomas Kvasnicka, Ivana Malikova, Zuzana Zenahlikova, Karol\u00edna Kettnerova, Radka Brzezkova, Tomas Zima, Jan Ulrych, Jan Briza, Ivan Netuka, Jan Kvasnicka. Rivaroxaban &#8211; Metabolism, Pharmacologic Properties and Drug Interactions, truy c\u1eadp ng\u00e0y 05 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28524005\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28524005\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c XARAVIX 15 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang &#8211; Chi nh\u00e1nh nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m DHG t\u1ea1i H\u1eadu Giang, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35984-22.<\/p>\n","protected":false},"author":1,"featured_media":122225,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122223","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122223"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122225"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122223"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122223"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}