{"id":122200,"date":"2025-06-06T09:33:04","date_gmt":"2025-06-06T02:33:04","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122200"},"modified":"2025-07-24T13:13:11","modified_gmt":"2025-07-24T06:13:11","slug":"vik-1-inj","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/vik-1-inj\/","title":{"rendered":"Vik 1 inj."},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Vik 1 inj. \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Dai Han Pharm. Co., Ltd. c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 880110792024 (S\u0110K c\u0169: VN-21634-18)<\/strong><\/p>\n<h2>Vik 1 inj. l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>\u1ed1ng Vik 1 inj.<\/strong> c\u00f3 ch\u1ee9a: Phytonadione 10mg\/ml<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Dung d\u1ecbch ti\u00eam<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 880110792024 (S\u0110K c\u0169: VN-21634-18)<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 \u1ed0ng x 1ml<\/p>\n<p>Xu\u1ea5t x\u1ee9: H\u00e0n Qu\u1ed1c<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Vik 1 inj.<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Vitamin K1 \u0111\u00f3ng vai tr\u00f2 thi\u1ebft y\u1ebfu trong chu\u1ed7i ph\u1ea3n \u1ee9ng c\u1ee7a h\u1ec7 enzym gan gi\u00fap s\u1ea3n sinh c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u quan tr\u1ecdng nh\u01b0 y\u1ebfu t\u1ed1 II (prothrombin), VII, IX, X, c\u0169ng nh\u01b0 protein C v\u00e0 protein S. Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng d\u1ea1ng coumarin (nh\u01b0 warfarin) l\u00e0m gi\u00e1n \u0111o\u1ea1n ho\u1ea1t \u0111\u1ed9ng n\u00e0y th\u00f4ng qua \u1ee9c ch\u1ebf c\u1ea1nh tranh, do \u0111\u00f3 b\u1ed5 sung vitamin K1 li\u1ec1u cao c\u00f3 th\u1ec3 ph\u1ee5c h\u1ed3i qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u. \u0110\u00e2y ch\u00ednh l\u00e0 c\u01a1 s\u1edf \u0111\u1ec3 d\u00f9ng vitamin K1 nh\u01b0 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u ho\u1eb7c xu\u1ea5t huy\u1ebft li\u00ean quan \u0111\u1ebfn thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng coumarin.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>Sau khi ti\u00eam b\u1eafp, vitamin K1 \u0111\u1ea1t sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 50%, tuy nhi\u00ean kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o ti\u00eam b\u1eafp \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 xu\u1ea5t huy\u1ebft cao do nguy c\u01a1 t\u1ee5 m\u00e1u t\u1ea1i ch\u1ed7. N\u1ed3ng \u0111\u1ed9 vitamin K1 trong huy\u1ebft t\u01b0\u01a1ng sau ti\u00eam b\u1eafp c\u00f3 s\u1ef1 dao \u0111\u1ed9ng l\u1edbn gi\u1eefa c\u00e1c c\u00e1 th\u1ec3.<button class=\"rank-math-content-ai-tooltip\">R\u00fat g\u1ecdn b\u1eb1ng AI<\/button><\/p>\n<p>Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 x\u1ea5p x\u1ec9 5 l\u00edt, ch\u1ee7 y\u1ebfu t\u1eadp trung t\u1ea1i gan nh\u01b0ng d\u1ef1 tr\u1eef trong c\u01a1 th\u1ec3 kh\u00f4ng l\u00e2u. Vitamin K1 kh\u00f3 qua h\u00e0ng r\u00e0o nhau thai nh\u01b0ng c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. Th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng t\u1eeb 1,5 \u0111\u1ebfn 3 gi\u1edd. Sau chuy\u1ec3n h\u00f3a, thu\u1ed1c li\u00ean h\u1ee3p v\u1edbi acid glucuronic r\u1ed3i \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua m\u1eadt v\u00e0 n\u01b0\u1edbc ti\u1ec3u.<button class=\"rank-math-content-ai-tooltip\">R\u00fat g\u1ecdn b\u1eb1ng AI<\/button><\/p>\n<h2>Thu\u1ed1c Vik 1 inj. \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Phytonadion \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng nh\u00f3m coumarin (nh\u01b0 warfarin) trong c\u00e1c t\u00ecnh hu\u1ed1ng ch\u1ea3y m\u00e1u ho\u1eb7c c\u00f3 nguy c\u01a1 xu\u1ea5t huy\u1ebft nghi\u00eam tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t khi c\u00f3 gi\u1ea3m prothrombin ho\u1eb7c y\u1ebfu t\u1ed1 VII trong m\u00e1u.<\/p>\n<figure id=\"attachment_122204\" aria-describedby=\"caption-attachment-122204\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122204\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Vik-1-inj.jpg\" alt=\"Vik 1 inj.\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Vik-1-inj.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Vik-1-inj-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Vik-1-inj-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/Vik-1-inj-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122204\" class=\"wp-caption-text\">Thu\u1ed1c Vik 1 inj. l\u00e0 dung d\u1ecbch ti\u00eam c\u00f3 ch\u1ee9a ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 phytonadion gi\u00fap ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u do thi\u1ebfu vitamin K, do Dai Han Pharm. Co., Ltd. s\u1ea3n xu\u1ea5t<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<h4>Ng\u01b0\u1eddi l\u1edbn<\/h4>\n<ul>\n<li>Ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng, \u0111e d\u1ecda t\u00ednh m\u1ea1ng do thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng coumarin:<\/li>\n<\/ul>\n<p>Ng\u01b0ng ngay thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng v\u00e0 ti\u00eam ch\u1eadm vitamin K1 (5\u201310 mg), ph\u1ed1i h\u1ee3p v\u1edbi PCC (ph\u1ee9c h\u1ee3p prothrombin c\u00f4 \u0111\u1eb7c). N\u1ebfu PCC kh\u00f4ng s\u1eb5n c\u00f3, c\u00f3 th\u1ec3 thay b\u1eb1ng FFP (huy\u1ebft t\u01b0\u01a1ng t\u01b0\u01a1i \u0111\u00f4ng l\u1ea1nh). Theo d\u00f5i INR sau 3 gi\u1edd, c\u00f3 th\u1ec3 l\u1eb7p li\u1ec1u n\u1ebfu ch\u01b0a \u0111\u00e1p \u1ee9ng. T\u1ed5ng li\u1ec1u kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 40 mg trong 24 gi\u1edd.<\/p>\n<table style=\"width: 102.097%;\">\n<tbody>\n<tr>\n<td style=\"text-align: center; width: 24.3144%;\"><b>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng<\/b><\/td>\n<td style=\"text-align: center; width: 31.6271%;\"><b>T\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng<\/b><\/td>\n<td style=\"text-align: center; width: 23.5832%;\"><b>Li\u1ec1u vitamin K (IV)<\/b><\/td>\n<td style=\"text-align: center; width: 36.9325%;\"><b>K\u00e8m theo<\/b><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 24.3144%;\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/td>\n<td style=\"text-align: center; width: 31.6271%;\"><span style=\"font-weight: 400;\">Ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng<\/span><\/td>\n<td style=\"text-align: center; width: 23.5832%;\"><span style=\"font-weight: 400;\">5 mg<\/span><\/td>\n<td style=\"text-align: center; width: 36.9325%;\"><span style=\"font-weight: 400;\">PCC ho\u1eb7c FFP<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center; width: 24.3144%;\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/td>\n<td style=\"text-align: center; width: 31.6271%;\"><span style=\"font-weight: 400;\">Nguy c\u01a1 \u0111e d\u1ecda t\u00ednh m\u1ea1ng<\/span><\/td>\n<td style=\"text-align: center; width: 23.5832%;\"><span style=\"font-weight: 400;\">5\u201310 mg<\/span><\/td>\n<td style=\"text-align: center; width: 36.9325%;\"><span style=\"font-weight: 400;\">PCC ho\u1eb7c FFP<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li>\nXu\u1ea5t huy\u1ebft nh\u1eb9 ho\u1eb7c kh\u00f4ng tri\u1ec7u ch\u1ee9ng v\u1edbi INR cao:<\/li>\n<\/ul>\n<p>Li\u1ec1u vitamin K1 t\u1eeb 0,5\u20131 mg (INR 5\u20139) v\u00e0 1 mg (INR &gt;9), d\u00f9ng \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch.<\/p>\n<ul>\n<li>Chu\u1ea9n b\u1ecb ph\u1eabu thu\u1eadt kh\u1ea9n c\u1ea5p (c\u00f3 th\u1ec3 tr\u00ec ho\u00e3n 6\u201312h):<\/li>\n<\/ul>\n<p>Ti\u00eam IV 5 mg vitamin K1. N\u1ebfu c\u1ea7n ph\u1eabu thu\u1eadt ngay, c\u00f3 th\u1ec3 d\u00f9ng th\u00eam PCC v\u00e0 \u0111\u00e1nh gi\u00e1 INR tr\u01b0\u1edbc m\u1ed5.<\/p>\n<ul>\n<li>\u0110\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c (kh\u00f4ng ph\u1ea3i warfarin):<\/li>\n<\/ul>\n<p>Th\u00f4ng tin v\u1ec1 s\u1eed d\u1ee5ng vitamin K c\u00f2n h\u1ea1n ch\u1ebf, v\u00ec th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a c\u00e1c thu\u1ed1c n\u00e0y kh\u00e1c nhau (nh\u01b0 acenocoumarol, phenprocoumon). Li\u1ec1u c\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh t\u01b0\u01a1ng \u1ee9ng.<\/p>\n<h4>Ng\u01b0\u1eddi cao tu\u1ed5i<\/h4>\n<p>Nh\u1ea1y c\u1ea3m h\u01a1n v\u1edbi vitamin K1, n\u00ean d\u00f9ng li\u1ec1u \u1edf gi\u1edbi h\u1ea1n th\u1ea5p c\u1ee7a khuy\u1ebfn ngh\u1ecb.<\/p>\n<h4>Tr\u1ebb em (1\u201318 tu\u1ed5i)<\/h4>\n<p>Tr\u01b0\u1edbc khi d\u00f9ng c\u1ea7n \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng \u0111\u00f4ng m\u00e1u.<\/p>\n<ul>\n<li>D\u00f9ng cho tr\u1ebb b\u1ecb gi\u1ea3m h\u1ea5p thu vitamin K, suy dinh d\u01b0\u1ee1ng n\u1eb7ng k\u00e8m d\u00f9ng kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, b\u1ec7nh gan ho\u1eb7c \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi warfarin.<\/li>\n<li>Tr\u1ebb \u0111ang d\u00f9ng warfarin c\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb v\u00e0 nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng hi\u1ec7u qu\u1ea3 thu\u1ed1c trong 2\u20133 tu\u1ea7n sau khi d\u00f9ng vitamin K.<\/li>\n<li>T\u00e1c d\u1ee5ng c\u1ee7a vitamin K th\u01b0\u1eddng b\u1eaft \u0111\u1ea7u sau 4\u20136 gi\u1edd n\u00ean trong tr\u01b0\u1eddng h\u1ee3p xu\u1ea5t huy\u1ebft n\u1eb7ng, c\u1ea7n ph\u1ed1i h\u1ee3p truy\u1ec1n y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u.<\/li>\n<\/ul>\n<p>Li\u1ec1u khuy\u1ebfn ngh\u1ecb:<\/p>\n<table style=\"width: 100.83%;\">\n<tbody>\n<tr>\n<td style=\"width: 35.1882%; text-align: center;\"><b>\u0110\u1ed1i t\u01b0\u1ee3ng<\/b><\/td>\n<td style=\"width: 23.7316%; text-align: center;\"><b>Li\u1ec1u vitamin K1 (IV)<\/b><\/td>\n<td style=\"width: 44.8445%; text-align: center;\"><b>Ghi ch\u00fa<\/b><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 35.1882%; text-align: center;\"><span style=\"font-weight: 400;\">Xu\u1ea5t huy\u1ebft nghi\u00eam tr\u1ecdng<\/span><\/td>\n<td style=\"width: 23.7316%; text-align: center;\"><span style=\"font-weight: 400;\">5 mg<\/span><\/td>\n<td style=\"width: 44.8445%; text-align: center;\"><span style=\"font-weight: 400;\">K\u00e8m PCC ho\u1eb7c FFP n\u1ebfu c\u1ea7n<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 35.1882%; text-align: center;\"><span style=\"font-weight: 400;\">Kh\u00f4ng tri\u1ec7u ch\u1ee9ng, INR t\u0103ng nh\u1eb9<\/span><\/td>\n<td style=\"width: 23.7316%; text-align: center;\"><span style=\"font-weight: 400;\">30 mcg\/kg<\/span><\/td>\n<td style=\"width: 44.8445%; text-align: center;\"><span style=\"font-weight: 400;\">Theo d\u00f5i INR sau 2\u20136 gi\u1edd<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 35.1882%; text-align: center;\"><span style=\"font-weight: 400;\">Tr\u1ebb s\u01a1 sinh, tr\u1ebb &lt; 1 tu\u1ed5i<\/span><\/td>\n<td style=\"width: 23.7316%; text-align: center;\"><span style=\"font-weight: 400;\">Kh\u00f4ng d\u00f9ng d\u1ea1ng n\u00e0y<\/span><\/td>\n<td style=\"width: 44.8445%; text-align: center;\"><span style=\"font-weight: 400;\">D\u00f9ng ch\u1ebf ph\u1ea9m 2 mg\/0,2 ml ph\u00f9 h\u1ee3p<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>Pha lo\u00e3ng phytonadion v\u1edbi dung d\u1ecbch NaCl 0,9% ho\u1eb7c dextrose 5% \u0111\u1ec3 truy\u1ec1n t\u0129nh m\u1ea1ch ngay sau khi pha. Kh\u00f4ng n\u00ean tr\u1ed9n thu\u1ed1c v\u1edbi c\u00e1c dung d\u1ecbch ti\u00eam truy\u1ec1n kh\u00e1c. C\u00f3 th\u1ec3 ti\u00eam \u1edf ph\u1ea7n d\u01b0\u1edbi c\u1ee7a h\u1ec7 th\u1ed1ng truy\u1ec1n d\u1ecbch n\u1ebfu c\u1ea7n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Vik 1 inj. trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Phytonadione c\u00f3 trong Vik 1 inj.<\/p>\n<p>N\u1ebfu ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng b\u1ecb xu\u1ea5t huy\u1ebft cao kh\u00f4ng n\u00ean d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam b\u1eafp<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Ng\u01b0\u1eddi thi\u1ebfu men G6PD d\u1ec5 b\u1ecb tan m\u00e1u khi d\u00f9ng phytonadion.<\/li>\n<li>B\u1ec7nh nh\u00e2n gan n\u1eb7ng d\u00f9ng li\u1ec1u cao c\u00f3 th\u1ec3 b\u1ecb t\u1ed5n th\u01b0\u01a1ng gan th\u00eam.<\/li>\n<li>Kh\u00f4ng d\u00f9ng qu\u00e1 5 mg cho tr\u1ebb s\u01a1 sinh do h\u1ec7 enzyme gan ch\u01b0a ho\u00e0n ch\u1ec9nh.<\/li>\n<li>Trong xu\u1ea5t huy\u1ebft n\u1eb7ng, c\u00f3 th\u1ec3 c\u1ea7n truy\u1ec1n m\u00e1u ho\u1eb7c c\u00e1c ch\u1ebf ph\u1ea9m m\u00e1u.<\/li>\n<li>Nguy c\u01a1 huy\u1ebft kh\u1ed1i t\u0103ng n\u1ebfu s\u1eed d\u1ee5ng vitamin K \u0111\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e0 kh\u00f4ng \u0111\u00e1nh gi\u00e1 nguy c\u01a1 \u2013 l\u1ee3i \u00edch c\u1ea9n th\u1eadn.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Ph\u1ea3n \u1ee9ng to\u00e0n th\u00e2n khi ti\u00eam t\u0129nh m\u1ea1ch: \u0111\u1ecf b\u1eebng, t\u1ee5t huy\u1ebft \u00e1p, ch\u00f3ng m\u1eb7t, cho\u00e1ng, ph\u1ea3n v\u1ec7, th\u1eadm ch\u00ed t\u1eed vong.<\/li>\n<li>C\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed5i v\u1ecb gi\u00e1c, k\u00edch \u1ee9ng da v\u00e0 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/li>\n<li>D\u1ea1ng dung d\u1ecbch c\u00f3 th\u1ec3 g\u00e2y ph\u1ed3ng r\u1ed9p da.<\/li>\n<li>Li\u1ec1u cao (&gt;25 mg) l\u00e0m t\u0103ng bilirubin huy\u1ebft \u1edf tr\u1ebb s\u01a1 sinh ho\u1eb7c sinh non.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Kh\u00f4ng n\u00ean pha tr\u1ed9n phytonadion v\u1edbi b\u1ea5t k\u1ef3 dung d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch n\u00e0o kh\u00e1c \u0111\u1ec3 tr\u00e1nh nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c v\u00e0 bi\u1ebfn \u0111\u1ed5i h\u00f3a h\u1ecdc b\u1ea5t l\u1ee3i.<\/li>\n<li>Phytonadion (vitamin K1) c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ed1i kh\u00e1ng v\u1edbi t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng nh\u00f3m coumarin. C\u00e1c thu\u1ed1c n\u00e0y \u1ee9c ch\u1ebf enzyme epoxide reductase, m\u1ed9t th\u00e0nh ph\u1ea7n thi\u1ebft y\u1ebfu trong chu tr\u00ecnh ho\u1ea1t h\u00f3a vitamin K, t\u1eeb \u0111\u00f3 l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng carboxyl h\u00f3a c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u ph\u1ee5 thu\u1ed9c vitamin K. Khi d\u00f9ng \u0111\u1ed3ng th\u1eddi, phytonadion c\u00f3 th\u1ec3 l\u00e0m \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng m\u00e1u, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Ngo\u00e0i ra, aspirin v\u00e0 c\u00e1c d\u1eabn xu\u1ea5t c\u1ee7a acid salicylic c\u0169ng c\u00f3 th\u1ec3 c\u1ea3n tr\u1edf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 enzyme carboxylase reductase, d\u1eabn \u0111\u1ebfn gi\u1ea3m hi\u1ec7u l\u1ef1c sinh l\u00fd c\u1ee7a vitamin K.<\/li>\n<li>M\u1ed9t s\u1ed1 kh\u00e1ng sinh cephalosporin mang nh\u00f3m N-methylthiotetrazole (NMTT) c\u0169ng c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a vitamin K th\u00f4ng qua \u1ee9c ch\u1ebf enzyme vitamin K epoxide reductase.<\/li>\n<li>D\u00f9ng phytonadion c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh nh\u01b0 phenytoin ho\u1eb7c phenobarbital c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a vitamin K1. H\u01a1n n\u1eefa, khi m\u1eb9 s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1ed1ng co gi\u1eadt ho\u1eb7c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb lao (nh\u01b0 rifampicin, isoniazid) trong th\u1eddi k\u1ef3 mang thai, tr\u1ebb s\u01a1 sinh c\u00f3 nguy c\u01a1 thi\u1ebfu h\u1ee5t vitamin K ngay t\u1eeb nh\u1eefng ng\u00e0y \u0111\u1ea7u sau sinh, g\u00e2y ch\u1ea3y m\u00e1u. D\u00f9 c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5, \u0111\u00e2y l\u00e0 m\u1ed9t t\u01b0\u01a1ng t\u00e1c c\u1ea7n l\u01b0u \u00fd trong l\u00e2m s\u00e0ng.<\/li>\n<li>Do kh\u1ea3 n\u0103ng \u0111\u1ed1i kh\u00e1ng v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u00f3m coumarin, vitamin K1 c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u1ee3p l\u00fd.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<ul>\n<li>Ph\u1ee5 n\u1eef mang thai:vHi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 ch\u1ee9ng minh t\u00ednh an to\u00e0n c\u1ee7a phytonadion khi d\u00f9ng trong thai k\u1ef3. Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c cho ph\u1ee5 n\u1eef mang thai c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u1ef9 l\u01b0\u1ee1ng gi\u1eefa l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb v\u00e0 nguy c\u01a1 ti\u1ec1m \u1ea9n \u0111\u1ed1i v\u1edbi thai nhi. Phytonadion kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn kh\u00edch d\u00f9ng v\u1edbi m\u1ee5c \u0111\u00edch ph\u00f2ng ng\u1eeba thi\u1ebfu m\u00e1u cho tr\u1ebb s\u01a1 sinh trong thai k\u1ef3.<\/li>\n<li>Ph\u1ee5 n\u1eef cho con b\u00fa: Vitamin K1 c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf v\u00e0o s\u1eefa m\u1eb9. Tuy nhi\u00ean, phytonadion kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u1edf ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa \u0111\u1ec3 ng\u0103n ng\u1eeba t\u00ecnh tr\u1ea1ng xu\u1ea5t huy\u1ebft \u1edf tr\u1ebb s\u01a1 sinh, do ch\u01b0a c\u00f3 \u0111\u1ee7 b\u1eb1ng ch\u1ee9ng x\u00e1c l\u1eadp hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n trong nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng phytonadion c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng ph\u1ee5 nh\u01b0 h\u1ea1 huy\u1ebft \u00e1p, ch\u00f3ng m\u1eb7t, cho\u00e1ng v\u00e1ng, l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng t\u1eadp trung v\u00e0 ph\u1ea3n x\u1ea1. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c n\u00ean tr\u00e1nh tham gia v\u00e0o c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o cao nh\u01b0 l\u00e1i xe ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Vi\u1ec7c d\u00f9ng li\u1ec1u l\u1edbn phytonadion c\u00f3 th\u1ec3 l\u00e0m m\u1ea5t t\u00e1c d\u1ee5ng t\u1ea1m th\u1eddi c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1ng vitamin K nh\u01b0 warfarin, do \u0111\u00f3 c\u00f3 th\u1ec3 c\u1ea7n t\u0103ng li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng ho\u1eb7c l\u1ef1a ch\u1ecdn s\u1eed d\u1ee5ng m\u1ed9t ch\u1ea5t ch\u1ed1ng \u0111\u00f4ng kh\u00e1c kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng, nh\u01b0 heparin.<\/p>\n<p>M\u1eb7c d\u00f9 ch\u01b0a ghi nh\u1eadn bi\u1ec3u hi\u1ec7n qu\u00e1 li\u1ec1u r\u00f5 r\u00e0ng \u1edf ng\u01b0\u1eddi l\u1edbn, nh\u01b0ng \u1edf tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb nh\u1ecf, vi\u1ec7c d\u00f9ng qu\u00e1 li\u1ec1u vitamin K1 \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 n\u1ed5i m\u1ea9n, t\u0103ng men gan, t\u0103ng bilirubin huy\u1ebft, \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, ph\u00e2n m\u1ec1m, k\u00edch th\u00edch, m\u1ec7t m\u1ecfi ho\u1eb7c ph\u00e1t ban da. H\u1ea7u h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y th\u01b0\u1eddng nh\u1eb9 v\u00e0 c\u00f3 th\u1ec3 t\u1ef1 h\u1ed3i ph\u1ee5c m\u00e0 kh\u00f4ng c\u1ea7n can thi\u1ec7p y t\u1ebf \u0111\u1eb7c hi\u1ec7u.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef Vik 1 inj. \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Vik 1 inj. trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Vik 1 inj. khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Vik 1 inj. gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Vik 1 inj. hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Vik 1 inj. c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Vik 1 inj. t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Vik 1 inj. nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/phytok-20mg-ml\/\">Phytok 20mg\/ml<\/a> c\u00f3 th\u00e0nh ph\u1ea7n Phytomenadion 20 mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m CPC1 H\u00e0 N\u1ed9i, ch\u1ec9 \u0111\u1ecbnh cho tr\u01b0\u1eddng h\u1ee3p thi\u1ebfu vitamin K<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>T\u1edd H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Vik 1 inj. \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf ph\u00ea duy\u1ec7t. Xem v\u00e0 t\u1ea3i v\u1ec1 b\u1ea3n PDF \u0111\u1ea7y \u0111\u1ee7 <a href=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/To-huong-dan-su-dung-Vik-1-inj.pdf\">t\u1ea1i \u0111\u00e2y<\/a>. Truy c\u1eadp ng\u00e0y 4 th\u00e1ng 6 n\u0103m 2025 t\u1eeb:<a href=\"https:\/\/drugbank.vn\/thuoc\/Vik-1-inj-&amp;VN-21634-18\" rel=\"noopener\"> https:\/\/drugbank.vn\/thuoc\/Vik-1-inj-&amp;VN-21634-18<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Vik 1 inj. l\u00e0 dung d\u1ecbch ti\u00eam c\u00f3 ch\u1ee9a ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 phytonadion gi\u00fap ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u do thi\u1ebfu vitamin K, do Dai Han Pharm. Co., Ltd. s\u1ea3n xu\u1ea5t<\/p>\n","protected":false},"author":1,"featured_media":122202,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122200","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122200"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122202"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122200"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122200"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}