{"id":122082,"date":"2025-06-05T16:43:14","date_gmt":"2025-06-05T09:43:14","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122082"},"modified":"2025-12-23T15:22:54","modified_gmt":"2025-12-23T08:22:54","slug":"xaravix-10","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/xaravix-10\/","title":{"rendered":"XARAVIX 10"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>XARAVIX 10 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang &#8211; Chi nh\u00e1nh nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m DHG t\u1ea1i H\u1eadu Giang, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35983-22.<\/strong><\/p>\n<h2>XARAVIX 10 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>XARAVIX 10<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Th\u00e0nh ph\u1ea7n ch\u00ednh: <strong>Rivaroxaban<\/strong> 10mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: V\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<li>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-35983-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 14 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_122083\" aria-describedby=\"caption-attachment-122083\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122083\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-10.jpg\" alt=\"XARAVIX 10 \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-10.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-10-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-10-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/xaravix-10-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122083\" class=\"wp-caption-text\">XARAVIX 10 \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c XARAVIX 10<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Rivaroxaban l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf tr\u1ef1c ti\u1ebfp, ch\u1ecdn l\u1ecdc cao y\u1ebfu t\u1ed1 Xa (FXa) qua \u0111\u01b0\u1eddng u\u1ed1ng. FXa \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u, tr\u1ef1c ti\u1ebfp chuy\u1ec3n prothrombin th\u00e0nh thrombin, d\u1eabn \u0111\u1ebfn s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng. Rivaroxaban \u1ee9c ch\u1ebf ho\u1ea1t t\u00ednh c\u1ee7a FXa, t\u1eeb \u0111\u00f3 k\u00ecm h\u00e3m qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Rivaroxaban h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a sau 2-4 gi\u1edd. V\u1edbi vi\u00ean 10mg, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng cao (80-100%) v\u00e0 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n.<\/li>\n<li>Ph\u00e2n b\u1ed1: G\u1eafn k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (kho\u1ea3ng 92-95%), ch\u1ee7 y\u1ebfu l\u00e0 albumin. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh kho\u1ea3ng 50L.<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 Th\u1ea3i tr\u1eeb: Kho\u1ea3ng 2\/3 li\u1ec1u \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a t\u1ea1i gan (qua CYP 3A4, CYP 2J2 v\u00e0 c\u01a1 ch\u1ebf kh\u00f4ng ph\u1ee5 thu\u1ed9c CYP), sau \u0111\u00f3 th\u1ea3i tr\u1eeb qua th\u1eadn v\u00e0 ph\u00e2n. 1\/3 li\u1ec1u c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb tr\u1ef1c ti\u1ebfp qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 5-9 gi\u1edd \u1edf ng\u01b0\u1eddi tr\u1ebb v\u00e0 11-13 gi\u1edd \u1edf ng\u01b0\u1eddi gi\u00e0.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c XARAVIX 10 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>D\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n: D\u00e0nh cho b\u1ec7nh nh\u00e2n b\u1ecb rung nh\u0129 kh\u00f4ng do b\u1ec7nh l\u00fd van tim, c\u00f3 \u00edt nh\u1ea5t m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 nh\u01b0 suy tim, t\u0103ng huy\u1ebft \u00e1p, tr\u00ean 75 tu\u1ed5i, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, ti\u1ec1n s\u1eed \u0111\u1ed9t qu\u1ef5 ho\u1eb7c c\u01a1n tho\u00e1ng thi\u1ebfu m\u00e1u n\u00e3o.<\/li>\n<li>Ph\u00f2ng ng\u1eeba thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch (VTE): Sau c\u00e1c ph\u1eabu thu\u1eadt l\u1edbn nh\u01b0 thay th\u1ebf kh\u1edbp h\u00e1ng ho\u1eb7c kh\u1edbp g\u1ed1i.<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t: Huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u (DVT) v\u00e0 thuy\u00ean t\u1eafc ph\u1ed5i (PE).<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c XARAVIX 10<\/h2>\n<ul>\n<li>D\u1ef1 ph\u00f2ng \u0111\u1ed9t qu\u1ef5 v\u00e0 thuy\u00ean t\u1eafc m\u1ea1ch to\u00e0n th\u00e2n \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129: Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 20mg m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n (li\u1ec1u t\u1ed1i \u0111a).<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t DVT v\u00e0 PE:\n<ul>\n<li>Giai \u0111o\u1ea1n kh\u1edfi \u0111\u1ea7u (3 tu\u1ea7n \u0111\u1ea7u): 15mg hai l\u1ea7n m\u1ed7i ng\u00e0y.<\/li>\n<li>Giai \u0111o\u1ea1n duy tr\u00ec (t\u1eeb ng\u00e0y 22 tr\u1edf \u0111i): 20mg m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n.<\/li>\n<li>D\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t k\u00e9o d\u00e0i (sau \u00edt nh\u1ea5t 6 th\u00e1ng \u0111i\u1ec1u tr\u1ecb): 10mg ho\u1eb7c 20mg m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<li>Ph\u00f2ng ng\u1eeba VTE sau ph\u1eabu thu\u1eadt thay kh\u1edbp h\u00e1ng\/g\u1ed1i: 10mg m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n, b\u1eaft \u0111\u1ea7u sau 6-10 gi\u1edd h\u1eadu ph\u1eabu khi \u0111\u00e3 c\u1ea7m m\u00e1u. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb l\u00e0 5 tu\u1ea7n cho kh\u1edbp h\u00e1ng v\u00e0 2 tu\u1ea7n cho kh\u1edbp g\u1ed1i.<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c XARAVIX 10<\/h2>\n<ul>\n<li>U\u1ed1ng thu\u1ed1c b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/li>\n<li>N\u00ean u\u1ed1ng thu\u1ed1c c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/li>\n<li>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f3 nu\u1ed1t, c\u00f3 th\u1ec3 nghi\u1ec1n vi\u00ean<strong> XARAVIX 10mg<\/strong> v\u00e0 tr\u1ed9n v\u1edbi n\u01b0\u1edbc ho\u1eb7c th\u1ee9c \u0103n m\u1ec1m (nh\u01b0 n\u01b0\u1edbc t\u00e1o) ngay tr\u01b0\u1edbc khi d\u00f9ng.<\/li>\n<li>Vi\u00ean nghi\u1ec1n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng qua \u1ed1ng th\u00f4ng d\u1ea1 d\u00e0y, sau \u0111\u00f3 c\u1ea7n tr\u00e1ng l\u1ea1i \u1ed1ng b\u1eb1ng n\u01b0\u1edbc.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c XARAVIX 10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi Rivaroxaban ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>\u0110ang ch\u1ea3y m\u00e1u li\u00ean quan l\u00e2m s\u00e0ng (v\u00ed d\u1ee5: ch\u1ea3y m\u00e1u n\u1ed9i s\u1ecd, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a).<\/li>\n<li>\u0110ang \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c (ngo\u1ea1i tr\u1eeb giai \u0111o\u1ea1n chuy\u1ec3n thu\u1ed1c ho\u1eb7c khi d\u00f9ng Heparin kh\u00f4ng ph\u00e2n \u0111o\u1ea1n (UFH) \u0111\u1ec3 duy tr\u00ec th\u00f4ng \u1ed1ng).<\/li>\n<li>Ti\u1ec1n s\u1eed huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn h\u1ed9i ch\u1ee9ng kh\u00e1ng Phospholipid.<\/li>\n<li>B\u1ec7nh gan \u0111i k\u00e8m r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u v\u00e0 nguy c\u01a1 ch\u1ea3y m\u00e1u li\u00ean quan l\u00e2m s\u00e0ng, bao g\u1ed3m x\u01a1 gan Child-Pugh B v\u00e0 C.<\/li>\n<li>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa.<\/li>\n<li>C\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 nguy c\u01a1 xu\u1ea5t huy\u1ebft cao nh\u01b0 lo\u00e9t ti\u00eau h\u00f3a ti\u1ebfn tri\u1ec3n, ung th\u01b0 d\u1ec5 ch\u1ea3y m\u00e1u, ch\u1ea5n th\u01b0\u01a1ng s\u1ecd n\u00e3o\/c\u1ed9t s\u1ed1ng, ho\u1eb7c v\u1eeba ph\u1eabu thu\u1eadt m\u1eaft, th\u1ea7n kinh, c\u1ed9t s\u1ed1ng.<\/li>\n<li>B\u1ec7nh nh\u00e2n thay van \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 qua da ho\u1eb7c c\u00f3 van tim nh\u00e2n t\u1ea1o.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 15ml\/ph\u00fat.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c XARAVIX 10<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Nguy c\u01a1 xu\u1ea5t huy\u1ebft: C\u1ea7n theo d\u00f5i c\u1ea9n th\u1eadn c\u00e1c d\u1ea5u hi\u1ec7u ch\u1ea3y m\u00e1u. Ng\u1eebng d\u00f9ng thu\u1ed1c n\u1ebfu xu\u1ea5t huy\u1ebft x\u1ea3y ra. Th\u1eadn tr\u1ecdng v\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ch\u1ea3y m\u00e1u cao (r\u1ed1i lo\u1ea1n \u0111\u00f4ng m\u00e1u, t\u0103ng huy\u1ebft \u00e1p kh\u00f4ng ki\u1ec3m so\u00e1t, lo\u00e9t ti\u00eau h\u00f3a, ph\u1eabu thu\u1eadt g\u1ea7n \u0111\u00e2y, v.v.).<\/li>\n<li>Suy th\u1eadn: Th\u1eadn tr\u1ecdng v\u1edbi b\u1ec7nh nh\u00e2n suy th\u1eadn trung b\u00ecnh (CrCl 30-49ml\/ph\u00fat) v\u00e0 n\u1eb7ng (CrCl 15-29ml\/ph\u00fat). Kh\u00f4ng khuy\u1ebfn c\u00e1o cho b\u1ec7nh nh\u00e2n CrCl &lt; 15ml\/ph\u00fat.<\/li>\n<li>Ph\u1eabu thu\u1eadt v\u00e0 can thi\u1ec7p: C\u1ea7n th\u1eadn tr\u1ecdng khi g\u00e2y t\u00ea tr\u1ee5c th\u1ea7n kinh (ngo\u00e0i m\u00e0ng c\u1ee9ng\/t\u1ee7y s\u1ed1ng) do nguy c\u01a1 h\u00ecnh th\u00e0nh kh\u1ed1i m\u00e1u t\u1ee5. C\u1ea7n ng\u1eebng thu\u1ed1c tr\u01b0\u1edbc ph\u1eabu thu\u1eadt theo h\u01b0\u1edbng d\u1eabn.<\/li>\n<li>Ph\u1ee5 n\u1eef \u1edf \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n: Ch\u1ec9 s\u1eed d\u1ee5ng khi c\u00f3 bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3.<\/li>\n<li>Kh\u00f4ng dung n\u1ea1p lactose: Thu\u1ed1c c\u00f3 ch\u1ee9a lactose, kh\u00f4ng ph\u00f9 h\u1ee3p cho b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu Lapp lactase ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t hay g\u1eb7p (\u2265 1\/10): Thi\u1ebfu m\u00e1u.<\/li>\n<li>Hay g\u1eb7p (\u2265 1\/100 t\u1edbi &lt; 1\/10): Ch\u1ea3y m\u00e1u (bao g\u1ed3m ch\u1ea3y m\u00e1u n\u01b0\u1edbu r\u0103ng, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, ch\u1ea3y m\u00e1u m\u0169i, ho ra m\u00e1u, xu\u1ea5t huy\u1ebft d\u01b0\u1edbi da), \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, h\u1ea1 huy\u1ebft \u00e1p, t\u1ee5 m\u00e1u, \u0111au d\u1ea1 d\u00e0y ru\u1ed9t, kh\u00f3 ti\u00eau, bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, n\u00f4n, s\u1ed1t, ph\u00f9 ngo\u1ea1i vi, gi\u1ea3m s\u1ee9c l\u1ef1c, c\u1ea3m gi\u00e1c kh\u00f4ng kh\u1ecfe, t\u0103ng n\u1ed3ng \u0111\u1ed9 transaminase.<\/li>\n<li>\u00cdt g\u1eb7p (\u2265 1\/1.000 t\u1edbi &lt; 1\/100): T\u0103ng ti\u1ec3u c\u1ea7u, nh\u1ecbp tim nhanh, ch\u1ea3y m\u00e1u n\u00e3o\/n\u1ed9i s\u1ecd, ng\u1ea5t, kh\u00f4 mi\u1ec7ng, v\u00e0ng da, gi\u1ea3m ch\u1ee9c n\u0103ng gan, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, vi\u00eam da d\u1ecb \u1ee9ng, t\u1ee5 m\u00e1u kh\u1edbp, xu\u1ea5t huy\u1ebft c\u01a1, suy th\u1eadn (bao g\u1ed3m t\u0103ng creatinin m\u00e1u, ur\u00ea m\u00e1u), ng\u1ee9a, ph\u00e1t ban, b\u1ea7m t\u00edm, m\u00e0y \u0111ay, ch\u1ea3y m\u00e1u h\u1eadu ph\u1eabu.<\/li>\n<li>Hi\u1ebfm g\u1eb7p (\u2265 1\/10.000 t\u1edbi &lt; 1\/1.000): V\u00e0ng da, vi\u00eam gan (bao g\u1ed3m t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o gan).<\/li>\n<li>R\u1ea5t hi\u1ebfm g\u1eb7p (&lt; 1\/10.000): Ph\u1ea3n v\u1ec7, s\u1ed1c ph\u1ea3n v\u1ec7, h\u1ed9i ch\u1ee9ng Stevens-Johnson\/Ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec.<\/li>\n<li>Ch\u01b0a r\u00f5 t\u1ea7n su\u1ea5t: Suy th\u1eadn c\u1ea5p th\u1ee9 ph\u00e1t do xu\u1ea5t huy\u1ebft.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>XARAVIX 10mg c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1c, l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 ho\u1eb7c t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c, ho\u1eb7c t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u:<\/p>\n<ul>\n<li>T\u0103ng n\u1ed3ng \u0111\u1ed9 Rivaroxaban:\n<ul>\n<li>Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u1ed3ng th\u1eddi: Thu\u1ed1c ch\u1ed1ng n\u1ea5m nh\u00f3m azole (ketoconazole, itraconazole, voriconazole, posaconazole) v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf protease HIV (ritonavir) do t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Rivaroxaban v\u00e0 nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/li>\n<li>Th\u1eadn tr\u1ecdng: Clarithromycin, Erythromycin, Fluconazole c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Rivaroxaban nh\u01b0ng th\u01b0\u1eddng kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng.<\/li>\n<\/ul>\n<\/li>\n<li>Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Rivaroxaban: Tr\u00e1nh d\u00f9ng \u0111\u1ed3ng th\u1eddi: Thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng m\u1ea1nh CYP 3A4 v\u00e0 P-gp nh\u01b0 Rifampicin, Phenytoin, Carbamazepine, Phenobarbitone, St. John\u2019s Wort c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 Rivaroxaban, gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>T\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u:\n<ul>\n<li>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi: C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng kh\u00e1c (Enoxaparin, Warfarin), NSAIDs, thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u (Acetylsalicylic acid, Clopidogrel), SSRIs\/SNRIs.<\/li>\n<li>Khi chuy\u1ec3n \u0111\u1ed5i t\u1eeb VKA (v\u00ed d\u1ee5 Warfarin) sang XARAVIX, ch\u1ec9 s\u1ed1 INR c\u00f3 th\u1ec3 t\u0103ng gi\u1ea3 v\u00e0 kh\u00f4ng ph\u1ea3n \u00e1nh \u0111\u00fang t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111\u00f4ng c\u1ee7a Rivaroxaban. C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Qu\u00e1 li\u1ec1u: C\u00e1c tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u hi\u1ebfm g\u1eb7p, th\u01b0\u1eddng kh\u00f4ng g\u00e2y bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng \u1edf li\u1ec1u d\u01b0\u1edbi 600mg.<\/li>\n<li>X\u1eed tr\u00ed: Kh\u00f4ng c\u00f3 ch\u1ea5t gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho Rivaroxaban. C\u00f3 th\u1ec3 s\u1eed d\u1ee5ng than ho\u1ea1t t\u00ednh \u0111\u1ec3 gi\u1ea3m h\u1ea5p thu. X\u1eed tr\u00ed ch\u1ea3y m\u00e1u bao g\u1ed3m t\u1ea1m ng\u1eebng thu\u1ed1c, \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng (\u00e9p c\u01a1 h\u1ecdc, c\u1ea7m m\u00e1u ph\u1eabu thu\u1eadt, truy\u1ec1n d\u1ecbch, s\u1ea3n ph\u1ea9m m\u00e1u, ti\u1ec3u c\u1ea7u). Trong tr\u01b0\u1eddng h\u1ee3p nghi\u00eam tr\u1ecdng, c\u00f3 th\u1ec3 xem x\u00e9t c\u00e1c ch\u1ea5t \u0111\u1ea3o chi\u1ec1u ti\u1ec1n \u0111\u00f4ng m\u00e1u (PCC, APCC, r-FVIIa) nh\u01b0ng kinh nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f2n h\u1ea1n ch\u1ebf.<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c XARAVIX 10<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/thuoc-xelostad-10mg-stella\/\">Thu\u1ed1c Xelostad 10mg Stella<\/a>, s\u1ea3n xu\u1ea5t b\u1edfi Chi nh\u00e1nh C\u00f4ng ty TNHH LD Stella Vi\u1ec7t Nam, ch\u1ee9a th\u00e0nh ph\u1ea7n Rivaroxaban h\u00e0m l\u01b0\u1ee3ng 10mg, l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb v\u00e0 d\u1ef1 ph\u00f2ng huy\u1ebft kh\u1ed1i.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Yimeng Gao, Hongzhong Jin. Rivaroxaban for treatment of livedoid vasculopathy: A systematic review, truy c\u1eadp ng\u00e0y 05 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34197012\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34197012\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c XARAVIX 10 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c H\u1eadu Giang &#8211; Chi nh\u00e1nh nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m DHG t\u1ea1i H\u1eadu Giang, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35983-22.<\/p>\n","protected":false},"author":1,"featured_media":122084,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122082","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122082"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122084"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122082"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122082"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}