{"id":122072,"date":"2025-06-05T16:20:29","date_gmt":"2025-06-05T09:20:29","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=122072"},"modified":"2025-12-23T15:24:47","modified_gmt":"2025-12-23T08:24:47","slug":"wright-f","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/wright-f\/","title":{"rendered":"WRIGHT-F"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>WRIGHT-F \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-28488-17.<\/strong><\/p>\n<h2>WRIGHT-F l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>M\u1ed7i vi\u00ean n\u00e9n <strong>WRIGHT-F<\/strong> ch\u1ee9a:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t:<strong> Imidapril<\/strong> hydrochlorid 10mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: V\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-28488-17<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_122073\" aria-describedby=\"caption-attachment-122073\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-122073\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/wright-f-1.jpg\" alt=\"WRIGHT-F \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/wright-f-1.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/wright-f-1-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/wright-f-1-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/06\/wright-f-1-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-122073\" class=\"wp-caption-text\">WRIGHT-F \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c WRIGHT-F<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Imidapril hydrochlorid l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t. Sau khi u\u1ed1ng, thu\u1ed1c s\u1ebd \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n \u0111\u1ec3 t\u1ea1o th\u00e0nh imidaprilat, l\u00e0 d\u1ea1ng chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd. Imidaprilat c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf Enzym Chuy\u1ec3n Angiotensin (ACE). C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee5 th\u1ec3 nh\u01b0 sau:<\/p>\n<ul>\n<li>\u1ee8c ch\u1ebf ACE: Imidaprilat ng\u0103n c\u1ea3n s\u1ef1 chuy\u1ec3n \u0111\u1ed5i Angiotensin I th\u00e0nh Angiotensin II. Angiotensin II l\u00e0 m\u1ed9t ch\u1ea5t g\u00e2y co m\u1ea1ch m\u1ea1nh v\u00e0 k\u00edch th\u00edch tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn ti\u1ebft Aldosteron (m\u1ed9t hormone g\u00e2y gi\u1eef mu\u1ed1i v\u00e0 n\u01b0\u1edbc).<\/li>\n<li>Gi\u00e3n m\u1ea1ch: Khi Angiotensin II b\u1ecb gi\u1ea3m, m\u1ea1ch m\u00e1u ngo\u1ea1i bi\u00ean s\u1ebd gi\u00e3n ra, l\u00e0m gi\u1ea3m s\u1ee9c c\u1ea3n th\u00e0nh m\u1ea1ch v\u00e0 h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>T\u0103ng ho\u1ea1t \u0111\u1ed9ng h\u1ec7 Kallikrein-Kinin: \u1ee8c ch\u1ebf ACE c\u0169ng l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh tho\u00e1i h\u00f3a Bradykinin (m\u1ed9t ch\u1ea5t g\u00e2y gi\u00e3n m\u1ea1ch), d\u1eabn \u0111\u1ebfn t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch th\u00f4ng qua h\u1ec7 th\u1ed1ng prostaglandin.<\/li>\n<li>Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng nh\u1ecbp tim: Imidapril l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p \u1edf c\u00e1c t\u01b0 th\u1ebf ng\u1ed3i, n\u1eb1m ng\u1eeda v\u00e0 \u0111\u1ee9ng v\u1edbi m\u1ee9c \u0111\u1ed9 t\u01b0\u01a1ng t\u1ef1, kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim.<\/li>\n<li>Ki\u1ec3m so\u00e1t \u1ed5n \u0111\u1ecbnh: T\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p m\u1ea1nh nh\u1ea5t sau 6-8 gi\u1edd u\u1ed1ng thu\u1ed1c v\u00e0 \u0111\u01b0\u1ee3c duy tr\u00ec khi \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i. Ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t kh\u00f4ng l\u00e0m t\u0103ng nhanh huy\u1ebft \u00e1p tr\u1edf l\u1ea1i. Thu\u1ed1c c\u0169ng gi\u00fap t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u qua th\u1eadn m\u00e0 kh\u00f4ng l\u00e0m thay \u0111\u1ed5i t\u1ed1c \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn.<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu\n<ul>\n<li>WRIGHT-F 10mg \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh nh\u01b0ng kh\u00f4ng ho\u00e0n to\u00e0n, v\u1edbi sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 70%.<\/li>\n<li>N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a imidapril trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 2 gi\u1edd.<\/li>\n<li>Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 imidaprilat \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh (kho\u1ea3ng 15 ng\/ml) sau 6-8 gi\u1edd.<\/li>\n<li>S\u1ef1 h\u1ea5p thu thu\u1ed1c c\u00f3 th\u1ec3 gi\u1ea3m khi d\u00f9ng chung v\u1edbi th\u1ee9c \u0103n.<\/li>\n<\/ul>\n<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 Th\u1ea3i tr\u1eeb\n<ul>\n<li>Imidapril hydrochlorid \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu t\u1ea1i gan \u0111\u1ec3 t\u1ea1o ra 4 ch\u1ea5t chuy\u1ec3n h\u00f3a, trong \u0111\u00f3 imidaprilat l\u00e0 ch\u1ea5t duy nh\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/li>\n<li>Kho\u1ea3ng 25,5% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u trong v\u00f2ng 24 gi\u1edd. Ph\u1ea7n c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb qua ph\u00e2n.<\/li>\n<li>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a imidapril l\u00e0 kho\u1ea3ng 2 gi\u1edd, c\u00f2n c\u1ee7a imidaprilat l\u00e0 kho\u1ea3ng 8 gi\u1edd.<\/li>\n<\/ul>\n<\/li>\n<li>T\u00edch l\u0169y\n<ul>\n<li>N\u1ed3ng \u0111\u1ed9 imidaprilat trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau 3-5 ng\u00e0y d\u00f9ng thu\u1ed1c m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y v\u00e0 kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u t\u00edch l\u0169y thu\u1ed1c \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh.<\/li>\n<li>\u1ede b\u1ec7nh nh\u00e2n suy th\u1eadn, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a imidaprilat c\u00f3 th\u1ec3 t\u0103ng l\u00ean v\u00e0 th\u1eddi gian th\u1ea3i tr\u1eeb ch\u1eadm l\u1ea1i.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>Thu\u1ed1c WRIGHT-F \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>WRIGHT-F \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p \u1edf ng\u01b0\u1eddi l\u1edbn, bao g\u1ed3m c\u1ea3 t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n v\u00e0 t\u0103ng huy\u1ebft \u00e1p do nhu m\u00f4 th\u1eadn.<\/p>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c WRIGHT-F<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi l\u1edbn:\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 5mg x 1 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>N\u1ebfu huy\u1ebft \u00e1p ch\u01b0a \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1i \u01b0u sau 3 tu\u1ea7n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean 10mg\/ng\u00e0y.<\/li>\n<li>Li\u1ec1u t\u1ed1i \u0111a khuy\u1ebfn c\u00e1o l\u00e0 20mg\/ng\u00e0y, nh\u01b0ng ch\u1ec9 d\u00f9ng khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 th\u1ec3 ph\u1ed1i h\u1ee3p th\u00eam thu\u1ed1c l\u1ee3i ti\u1ec3u.<\/li>\n<\/ul>\n<\/li>\n<li>B\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i (\u2265 65 tu\u1ed5i):\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 2,5mg x 1 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>Li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u00e1p \u1ee9ng huy\u1ebft \u00e1p.<\/li>\n<li>Li\u1ec1u t\u1ed1i \u0111a khuy\u1ebfn c\u00e1o l\u00e0 10mg x 1 l\u1ea7n\/ng\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn:\n<ul>\n<li>Clcr 30-80 mL\/ph\u00fat: Gi\u1ea3m li\u1ec1u, kh\u1edfi \u0111\u1ea7u v\u1edbi 2,5mg\/ng\u00e0y.<\/li>\n<li>Clcr 10-29 mL\/ph\u00fat: Kh\u00f4ng n\u00ean d\u00f9ng do AUC (di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong n\u1ed3ng \u0111\u1ed9-th\u1eddi gian) t\u0103ng cao.<\/li>\n<li>Clcr &lt; 10 mL\/ph\u00fat: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<li>C\u1ea7n \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<\/li>\n<li>B\u1ec7nh nh\u00e2n suy gan:\n<ul>\n<li>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o: 2,5mg x 1 l\u1ea7n\/ng\u00e0y.<\/li>\n<li>C\u1ea7n th\u1eadn tr\u1ecdng khi ch\u1ec9 \u0111\u1ecbnh cho nh\u00f3m b\u1ec7nh nh\u00e2n n\u00e0y.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c WRIGHT-F<\/h2>\n<ul>\n<li>WRIGHT-F \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/li>\n<li>N\u00ean u\u1ed1ng thu\u1ed1c v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m trong ng\u00e0y, kho\u1ea3ng 15 ph\u00fat tr\u01b0\u1edbc b\u1eefa \u0103n, \u0111\u1ec3 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 t\u1ed1t nh\u1ea5t.<\/li>\n<li>Li\u1ec1u \u0111\u1ea7u ti\u00ean n\u00ean u\u1ed1ng tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c WRIGHT-F trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c ho\u1eb7c c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ACE kh\u00e1c.<\/li>\n<li>Ng\u01b0\u1eddi \u0111ang th\u1ea9m ph\u00e2n l\u1ecdc m\u00e1u v\u1edbi m\u00e0ng acrylonitril methallyl sulfonat natri (AN69).<\/li>\n<li>Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed ph\u00f9 ni\u00eam m\u1ea1c (ph\u00f9 m\u1ea1ch) do thu\u1ed1c \u1ee9c ch\u1ebf ACE, ph\u00f9 ni\u00eam m\u1ea1c di truy\u1ec1n, m\u1eafc ph\u1ea3i ho\u1eb7c t\u1ef1 ph\u00e1t.<\/li>\n<li>Ng\u01b0\u1eddi \u0111ang trong qu\u00e1 tr\u00ecnh th\u1ea9m t\u00e1ch b\u1eb1ng ch\u1ea5t h\u1ea5p ph\u1ee5 s\u1eed d\u1ee5ng dextran sulfat c\u1ed1 \u0111\u1ecbnh b\u1eb1ng cellulose, tryptophan c\u1ed1 \u0111\u1ecbnh b\u1eb1ng polyvinyl alcohol ho\u1eb7c polyethylene terephthalate.<\/li>\n<li>Ph\u1ee5 n\u1eef \u0111ang mang thai ho\u1eb7c c\u00f3 th\u1ec3 c\u00f3 thai (\u0111\u1eb7c bi\u1ec7t 3 th\u00e1ng gi\u1eefa v\u00e0 3 th\u00e1ng cu\u1ed1i thai k\u1ef3).<\/li>\n<li>B\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng \u0111ang \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi aliskiren fumarat (tr\u1eeb khi kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p b\u1eb1ng c\u00e1c thu\u1ed1c kh\u00e1c).<\/li>\n<li>Suy th\u1eadn n\u1eb7ng c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 th\u1ea9m ph\u00e2n m\u00e1u (\u0111\u1ed9 thanh th\u1ea3i creatinine huy\u1ebft thanh &lt; 10 ml\/ph\u00fat).<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c WRIGHT-F<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Ng\u01b0\u1eddi b\u1ecb t\u0103ng kali m\u00e1u: Tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 tr\u1ea7m tr\u1ecdng h\u01a1n, c\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 kali m\u00e1u c\u1ea9n th\u1eadn.<\/li>\n<li>Ch\u1eb9n k\u00e9p h\u1ec7 Renin-Angiotensin-Aldosteron (RAAS): Kh\u00f4ng khuy\u1ebfn c\u00e1o k\u1ebft h\u1ee3p thu\u1ed1c \u1ee9c ch\u1ebf ACE v\u1edbi ch\u1eb7n th\u1ee5 th\u1ec3 angiotensin II ho\u1eb7c aliskiren do t\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p, t\u0103ng kali m\u00e1u v\u00e0 gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<li>B\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng: Theo d\u00f5i ch\u1eb7t ch\u1ebd m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft, \u0111\u1eb7c bi\u1ec7t trong th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>H\u1eb9p van \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ho\u1eb7c h\u1eb9p van hai l\u00e1\/ph\u00ec \u0111\u1ea1i c\u01a1 tim: Th\u1eadn tr\u1ecdng khi ch\u1ec9 \u0111\u1ecbnh.<\/li>\n<li>Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh\/m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u: Hi\u1ebfm g\u1eb7p nh\u01b0ng c\u1ea7n theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1.<\/li>\n<li>Ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 trong qu\u00e1 tr\u00ecnh gi\u1ea3i m\u1eabn c\u1ea3m: Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf ACE.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy gan: Hi\u1ebfm g\u1eb7p v\u00e0ng da \u1ee9 m\u1eadt ho\u1eb7c vi\u00eam gan. Ng\u1eebng thu\u1ed1c n\u1ebfu c\u00f3 tri\u1ec7u ch\u1ee9ng v\u00e0ng da ho\u1eb7c enzym gan t\u0103ng cao.<\/li>\n<li>Lactose: Thu\u1ed1c ch\u1ee9a lactose, kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu Lapp lactase ho\u1eb7c k\u00e9m h\u1ea5p thu glucose-galactose.<\/li>\n<li>Ph\u1eabu thu\u1eadt: Kh\u00f4ng d\u00f9ng thu\u1ed1c 24 gi\u1edd tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddng g\u1eb7p (ADR &gt; 1\/100):\n<ul>\n<li>Th\u1eadn: T\u0103ng BUN v\u00e0 creatinin huy\u1ebft thanh.<\/li>\n<li>Th\u1ea7n kinh &#8211; T\u00e2m th\u1ea7n: Nh\u1ee9c \u0111\u1ea7u, m\u00ea s\u1ea3ng, cho\u00e1ng v\u00e1ng, ch\u00f3ng m\u1eb7t.<\/li>\n<li>Tim m\u1ea1ch: H\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>H\u00f4 h\u1ea5p: Ho, kh\u00f3 ch\u1ecbu c\u1ed5 h\u1ecdng.<\/li>\n<li>Gan: T\u0103ng SGOT v\u00e0 SGPT.<\/li>\n<li>Qu\u00e1 m\u1eabn c\u1ea3m: Ph\u00e1t ban, ng\u1ee9a.<\/li>\n<li>Kh\u00e1c: T\u0103ng kali huy\u1ebft.<\/li>\n<\/ul>\n<\/li>\n<li>\u00cdt g\u1eb7p (1\/1000 &lt; ADR &lt; 1\/100):\n<ul>\n<li>M\u00e1u: Gi\u1ea3m h\u1ed3ng c\u1ea7u, hemoglobin, hematocrit, ti\u1ec3u c\u1ea7u; T\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin.<\/li>\n<li>Th\u1eadn: Protein ni\u1ec7u.<\/li>\n<li>Th\u1ea7n kinh &#8211; T\u00e2m th\u1ea7n: Cho\u00e1ng v\u00e1ng khi \u0111\u1ee9ng d\u1eady, m\u1ea5t ng\u1ee7.<\/li>\n<li>Tim m\u1ea1ch: \u0110\u00e1nh tr\u1ed1ng ng\u1ef1c.<\/li>\n<li>Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, kh\u00f3 ch\u1ecbu \u1edf d\u1ea1 d\u00e0y, \u0111au b\u1ee5ng, ch\u00e1n \u0103n, ti\u00eau ch\u1ea3y.<\/li>\n<li>Gan: T\u0103ng phosphatase ki\u1ec1m v\u00e0 LDH, v\u00e0ng da.<\/li>\n<li>Kh\u00e1c: \u00d9 tai, v\u1ecb gi\u00e1c b\u1ea5t th\u01b0\u1eddng, kh\u00e1t, t\u0103ng creatinin phosphokinase (CPK), t\u1ee9c ng\u1ef1c, m\u1ec7t, ph\u00f9, \u0111\u1ecf n\u00f3ng m\u1eb7t, suy nh\u01b0\u1ee3c.<\/li>\n<\/ul>\n<\/li>\n<li>Hi\u1ebfm g\u1eb7p (1\/10.000 \u2264 ADR &lt; 1\/1.000):\n<ul>\n<li>Gi\u1ea3m b\u1ea1ch c\u1ea7u ngo\u1ea1i vi, thi\u1ebfu m\u00e1u, suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/li>\n<li>T\u0103ng enzym gan (ASAT, Amylase), gi\u1ea3m protein m\u00e1u.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p\n<ul>\n<li>Dextran cellulose sulfat (h\u1ea5p ph\u1ee5 LDL-cholesterol): G\u00e2y s\u1ed1c ph\u1ea3n v\u1ec7.<\/li>\n<li>M\u00e0ng acrylonitrile methallyl sulfonat natri (AN69) trong th\u1ea9m ph\u00e2n: G\u00e2y s\u1ed1c ph\u1ea3n v\u1ec7.<\/li>\n<\/ul>\n<\/li>\n<li>Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p\n<ul>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali (spironolactone, triamterene&#8230;), thu\u1ed1c b\u1ed5 sung kali, mu\u1ed1i ch\u1ee9a kali: T\u0103ng nguy c\u01a1 t\u0103ng kali huy\u1ebft.<\/li>\n<li>Aliskiren fumarate: T\u0103ng nguy c\u01a1 suy th\u1eadn, t\u0103ng kali m\u00e1u v\u00e0 h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u h\u1ea1 huy\u1ebft \u00e1p (trichlormethiazide, hydrochlorothiazide&#8230;): H\u1ea1 huy\u1ebft \u00e1p m\u1ea1nh sau khi kh\u1edfi \u0111\u1ea7u d\u00f9ng imidapril.<\/li>\n<li>Ch\u1ebf ph\u1ea9m ch\u1ee9a lithi (lithi carbonate): T\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c lithi.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (indomethacin): Gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a imidapril, t\u0103ng nguy c\u01a1 suy th\u1eadn v\u00e0 t\u0103ng kali m\u00e1u.<\/li>\n<li>Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c (nitrat&#8230;): T\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<li>Thu\u1ed1c l\u1ee3i ti\u1ec3u kh\u00f4ng gi\u1eef kali: Nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p \u0111\u1ed9t ng\u1ed9t v\u00e0\/ho\u1eb7c suy th\u1eadn c\u1ea5p.<\/li>\n<li>V\u00e0ng (d\u1ea1ng ti\u00eam): Ph\u1ea3n \u1ee9ng nitritoid (\u0111\u1ecf m\u1eb7t, bu\u1ed3n n\u00f4n, n\u00f4n, t\u1ee5t huy\u1ebft \u00e1p).<\/li>\n<li>Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng (insulin, sulphonamid): T\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng, thu\u1ed1c an th\u1ea7n: T\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p v\u00e0 nguy c\u01a1 h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf.<\/li>\n<li>Ch\u1ebf ph\u1ea9m ch\u1ee9a kallidinogenase: H\u1ea1 huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c.<\/li>\n<li>Rifampicin: L\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh c\u1ee7a imidapril v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh, c\u00f3 th\u1ec3 gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 \u00e1p.<\/li>\n<li>Ch\u1ea5t k\u00edch th\u00edch th\u1ea7n kinh giao c\u1ea3m: Gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh WRIGHT-F 10mg cho ph\u1ee5 n\u1eef mang thai ho\u1eb7c nghi ng\u1edd c\u00f3 thai do nguy c\u01a1 g\u00e2y thi\u1ec3u \u1ed1i, thai ch\u1ebft, h\u1ea1 huy\u1ebft \u00e1p, suy th\u1eadn, t\u0103ng kali m\u00e1u, gi\u1ea3m s\u1ea3n n\u00e3o \u1edf tr\u1ebb s\u01a1 sinh.<\/li>\n<li>Kh\u00f4ng d\u00f9ng WRIGHT-F 10mg trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Do t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t ho\u1eb7c cho\u00e1ng v\u00e1ng, ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<ul>\n<li>Tri\u1ec7u ch\u1ee9ng: H\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng, s\u1ed1c, s\u1eefng s\u1edd, nh\u1ecbp tim ch\u1eadm, r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i, suy th\u1eadn.<\/li>\n<li>X\u1eed tr\u00ed: Gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1ec7nh nh\u00e2n (t\u1ed1t nh\u1ea5t t\u1ea1i \u0111\u01a1n v\u1ecb ch\u0103m s\u00f3c \u0111\u1eb7c bi\u1ec7t), theo d\u00f5i \u0111i\u1ec7n gi\u1ea3i v\u00e0 creatinin huy\u1ebft thanh. Th\u1ef1c hi\u1ec7n r\u1eeda d\u1ea1 d\u00e0y, d\u00f9ng ch\u1ea5t h\u1ea5p ph\u1ee5 v\u00e0 natri sulfat trong v\u00f2ng 30 ph\u00fat sau khi u\u1ed1ng. N\u1ebfu h\u1ea1 huy\u1ebft \u00e1p, c\u1ea7n nhanh ch\u00f3ng b\u1ed5 sung mu\u1ed1i v\u00e0 d\u1ecbch. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng angiotensin II c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem x\u00e9t. \u0110\u1ed1i v\u1edbi nh\u1ecbp tim ch\u1eadm, d\u00f9ng atropin ho\u1eb7c c\u00e2n nh\u1eafc d\u00f9ng m\u00e1y t\u1ea1o nh\u1ecbp tim. Imidapril v\u00e0 imidaprilat c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u.<\/li>\n<\/ul>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c WRIGHT-F<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/tanatril\/\">Thu\u1ed1c Tanatril Tablets 10mg<\/a> thu\u1ed9c nh\u00f3m thu\u1ed1c h\u1ec7 tim m\u1ea1ch, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh ho\u1eb7c ch\u1ee9ng b\u1ec7nh li\u00ean quan \u0111\u1ebfn t\u0103ng huy\u1ebft \u00e1p, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1ea1i P.T Tanabe Indonesia \u2013M\u1ef9, s\u1ed1 \u0111\u0103ng k\u00ed t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-13230-11.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Dean M Robinson, Monique P Curran, Katherine A Lyseng-Williamson. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure, truy c\u1eadp ng\u00e0y 05 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17547476\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17547476\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c WRIGHT-F \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-28488-17, ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n.<\/p>\n","protected":false},"author":1,"featured_media":122074,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-122072","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/122072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=122072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/122074"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=122072"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=122072"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=122072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}