{"id":121205,"date":"2025-05-29T22:24:35","date_gmt":"2025-05-29T15:24:35","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=121205"},"modified":"2025-07-24T13:13:22","modified_gmt":"2025-07-24T06:13:22","slug":"lenvimon-4","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/lenvimon-4\/","title":{"rendered":"LENVIMON &#8211; 4"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c LENVIMON &#8211; 4 \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd b\u1edfi Prospera Life Sciences private limited \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam <\/strong><\/p>\n<h2>LENVIMON &#8211; 4 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i LENVIMON &#8211; 4 c\u00f3 ch\u1ee9a: Lenvatinib 4mg<\/p>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: \u0110ang c\u1eadp nh\u1eadt<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 30 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: Xem tr\u00ean bao b\u00ec<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c LENVIMON &#8211; 4<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Lenvatinib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf tyrosine kinase \u0111a m\u1ee5c ti\u00eau, \u1ee9c ch\u1ebf c\u00e1c th\u1ee5 th\u1ec3 VEGFR1-3, FGFR1-4, PDGFR\u03b1, KIT v\u00e0 RET. Qua vi\u1ec7c ch\u1eb7n c\u00e1c t\u00edn hi\u1ec7u n\u00e0y, thu\u1ed1c l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n m\u1ea1ch m\u00e1u nu\u00f4i kh\u1ed1i u, k\u00ecm h\u00e3m t\u0103ng sinh t\u1ebf b\u00e0o ung th\u01b0, t\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh. Lenvatinib c\u00f2n th\u1ec3 hi\u1ec7n hi\u1ec7u qu\u1ea3 ch\u1ed1ng kh\u1ed1i u m\u1ea1nh h\u01a1n khi ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c mi\u1ec5n d\u1ecbch (kh\u00e1ng PD-1) ho\u1eb7c everolimus (\u1ee9c ch\u1ebf mTOR).<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh \u0111\u1ea1t trong v\u00f2ng 1\u20134 gi\u1edd. Th\u1ee9c \u0103n gi\u00e0u ch\u1ea5t b\u00e9o kh\u00f4ng l\u00e0m thay \u0111\u1ed5i sinh kh\u1ea3 d\u1ee5ng nh\u01b0ng l\u00e0m ch\u1eadm t\u1ed1c \u0111\u1ed9 h\u1ea5p thu.<\/li>\n<li>Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh ~97 L; g\u1eafn k\u1ebft protein huy\u1ebft t\u01b0\u01a1ng &gt;97%.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Qua CYP3A, aldehyde oxidase v\u00e0 m\u1ed9t ph\u1ea7n nh\u1ecf kh\u00f4ng qua enzym.<\/li>\n<li>Th\u1ea3i tr\u1eeb: 64% th\u1ea3i qua ph\u00e2n, 25% qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i ~28 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c LENVIMON &#8211; 4 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Ung th\u01b0 tuy\u1ebfn gi\u00e1p bi\u1ec7t h\u00f3a &#8211; DTC<\/li>\n<\/ul>\n<p>LENVIMON &#8211; 4 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u1edbn m\u1eafc ung th\u01b0 tuy\u1ebfn gi\u00e1p bi\u1ec7t h\u00f3a ti\u1ebfn tri\u1ec3n, t\u00e1i ph\u00e1t t\u1ea1i ch\u1ed7 ho\u1eb7c \u0111\u00e3 di c\u0103n, kh\u00f4ng c\u00f2n \u0111\u00e1p \u1ee9ng v\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng iod ph\u00f3ng x\u1ea1.<\/p>\n<ul>\n<li>Ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o th\u1eadn &#8211; RCC<\/li>\n<\/ul>\n<p>\u0110i\u1ec1u tr\u1ecb ban \u0111\u1ea7u: Ph\u1ed1i h\u1ee3p lenvatinib v\u1edbi pembrolizumab gi\u00fap ki\u1ec3m so\u00e1t RCC ti\u1ebfn tri\u1ec3n \u1edf ng\u01b0\u1eddi l\u1edbn ch\u01b0a t\u1eebng \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Sau \u0111i\u1ec1u tr\u1ecb kh\u00e1ng sinh m\u1ea1ch: D\u00f9ng ph\u1ed1i h\u1ee3p lenvatinib v\u1edbi everolimus cho b\u1ec7nh nh\u00e2n RCC ti\u1ebfn tri\u1ec3n \u0111\u00e3 qua \u00edt nh\u1ea5t m\u1ed9t li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng h\u00ecnh th\u00e0nh m\u1ea1ch.<\/p>\n<ul>\n<li>Ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o gan &#8211; HCC<\/li>\n<\/ul>\n<p>LENVIMON &#8211; 4 l\u00e0 l\u1ef1a ch\u1ecdn kh\u1edfi \u0111\u1ea7u cho ng\u01b0\u1eddi b\u1ec7nh b\u1ecb HCC kh\u00f4ng c\u00f2n ch\u1ec9 \u0111\u1ecbnh ph\u1eabu thu\u1eadt tri\u1ec7t c\u0103n.<\/p>\n<ul>\n<li>Ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung &#8211; EC<\/li>\n<\/ul>\n<p>Ph\u1ed1i h\u1ee3p LENVIMON &#8211; 4 v\u00e0 pembrolizumab \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi l\u1edbn m\u1eafc ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung ti\u1ebfn tri\u1ec3n, c\u00f3 ki\u1ec3u gen pMMR v\u00e0 kh\u00f4ng thu\u1ed9c nh\u00f3m MSI-H, \u0111\u00e3 th\u1ea5t b\u1ea1i v\u1edbi h\u00f3a tr\u1ecb to\u00e0n th\u00e2n tr\u01b0\u1edbc \u0111\u00f3 v\u00e0 kh\u00f4ng ph\u00f9 h\u1ee3p cho \u0111i\u1ec1u tr\u1ecb tri\u1ec7t c\u0103n b\u1eb1ng ph\u1eabu thu\u1eadt ho\u1eb7c x\u1ea1 tr\u1ecb.<\/p>\n<figure id=\"attachment_121208\" aria-describedby=\"caption-attachment-121208\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-121208\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/LENVIMON-4.jpg\" alt=\"LENVIMON - 4\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/LENVIMON-4.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/LENVIMON-4-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/LENVIMON-4-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/LENVIMON-4-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-121208\" class=\"wp-caption-text\">Thu\u1ed1c LENVIMON &#8211; 4 (lenvatinib) l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb nh\u1eafm tr\u00fang \u0111\u00edch, gi\u00fap \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u nu\u00f4i d\u01b0\u1ee1ng t\u1ebf b\u00e0o ung th\u01b0.<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<ul>\n<li>Ung th\u01b0 tuy\u1ebfn gi\u00e1p bi\u1ec7t h\u00f3a<\/li>\n<\/ul>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o: 24 mg u\u1ed1ng m\u1ed7i ng\u00e0y, duy tr\u00ec \u0111\u1ebfn khi b\u1ec7nh ti\u1ebfn tri\u1ec3n ho\u1eb7c x\u1ea3y ra \u0111\u1ed9c t\u00ednh kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t.<\/p>\n<ul>\n<li>Ung th\u01b0 t\u1ebf b\u00e0o th\u1eadn<\/li>\n<\/ul>\n<p>Ch\u01b0a \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3: 20 mg lenvatinib m\u1ed7i ng\u00e0y + pembrolizumab 200 mg ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed7i 3 tu\u1ea7n.<\/p>\n<p>\u0110\u00e3 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc: 18 mg lenvatinib + 5 mg everolimus u\u1ed1ng m\u1ed7i ng\u00e0y.<\/p>\n<ul>\n<li>Ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o gan<\/li>\n<\/ul>\n<p>Li\u1ec1u t\u00f9y theo c\u00e2n n\u1eb7ng:<\/p>\n<p>\u226560 kg: 12 mg\/ng\u00e0y<\/p>\n<p>&lt;60 kg: 8 mg\/ng\u00e0y<\/p>\n<ul>\n<li>Ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung<\/li>\n<\/ul>\n<p>20 mg lenvatinib\/ng\u00e0y + pembrolizumab 200 mg truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed7i 3 tu\u1ea7n.<\/p>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>D\u00f9ng m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n, v\u00e0o th\u1eddi \u0111i\u1ec3m c\u1ed1 \u0111\u1ecbnh, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o b\u1eefa \u0103n.<\/p>\n<p>N\u1ebfu b\u1ecf l\u1ee1 li\u1ec1u v\u00e0 ch\u01b0a qu\u00e1 12 gi\u1edd, u\u1ed1ng b\u1ed5 sung ngay. N\u1ebfu qu\u00e1 12 gi\u1edd, b\u1ecf qua li\u1ec1u \u0111\u00f3.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c LENVIMON &#8211; 4 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Lenvatinib v\u00e0 nh\u1eefng t\u00e1 d\u01b0\u1ee3c c\u00f3 trong LENVIMON &#8211; 4<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>C\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u00f9y theo m\u1ee9c \u0111\u1ed9 suy ch\u1ee9c n\u0103ng th\u1eadn ho\u1eb7c gan.<\/li>\n<li>Th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 n\u1ebfu b\u1ea1n g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng \u1edf v\u00f9ng mi\u1ec7ng nh\u01b0 \u0111au, s\u01b0ng, t\u00ea, n\u1eb7ng h\u00e0m, lo\u00e9t, lung lay r\u0103ng, v\u00ec LENVIMON &#8211; 4 c\u00f3 th\u1ec3 g\u00e2y ho\u1ea1i t\u1eed x\u01b0\u01a1ng h\u00e0m<\/li>\n<li>N\u1ebfu c\u1ea7n ph\u1eabu thu\u1eadt nha khoa, h\u00e3y cho b\u00e1c s\u0129 bi\u1ebft b\u1ea1n \u0111ang d\u00f9ng LENVIMON &#8211; 4, \u0111\u1eb7c bi\u1ec7t n\u1ebfu \u0111ang ho\u1eb7c \u0111\u00e3 t\u1eebng s\u1eed d\u1ee5ng bisphosphonate \u2013 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng ho\u1eb7c \u1ee9c ch\u1ebf t\u1ea1o m\u1ea1ch trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/li>\n<li>C\u1ea7n \u0111\u00e1nh gi\u00e1 huy\u1ebft \u00e1p, ch\u1ee9c n\u0103ng gan \u2013 th\u1eadn, n\u1ed3ng \u0111\u1ed9 natri v\u00e0 hormone TSH trong m\u00e1u tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Nhi\u1ec5m tr\u00f9ng: Nhi\u1ec5m tr\u00f9ng ti\u1ec3u, \u00e1p xe t\u1ea7ng sinh m\u00f4n.<\/li>\n<li>H\u1ec7 m\u00e1u v\u00e0 b\u1ea1ch huy\u1ebft: Gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, gi\u1ea3m lympho, nh\u1ed3i m\u00e1u l\u00e1ch.<\/li>\n<li>N\u1ed9i ti\u1ebft: Suy gi\u00e1p, t\u0103ng hormone TSH, suy tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn.<\/li>\n<li>Chuy\u1ec3n h\u00f3a \u2013 dinh d\u01b0\u1ee1ng: Gi\u1ea3m calci, kali, magnesi, albumin m\u00e1u; t\u0103ng cholesterol; ch\u00e1n \u0103n, s\u1ee5t c\u00e2n, m\u1ea5t n\u01b0\u1edbc.<\/li>\n<li>T\u00e2m th\u1ea7n \u2013 th\u1ea7n kinh: M\u1ea5t ng\u1ee7, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, \u0111\u1ed9t qu\u1ef5, thi\u1ebfu m\u00e1u n\u00e3o tho\u00e1ng qua, h\u1ed9i ch\u1ee9ng n\u00e3o c\u00f3 h\u1ed3i ph\u1ee5c sau (PRES).<\/li>\n<li>Tim m\u1ea1ch: Nh\u1ed3i m\u00e1u c\u01a1 tim, suy tim, k\u00e9o d\u00e0i QT, gi\u1ea3m ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u.<\/li>\n<li>M\u1ea1ch m\u00e1u: T\u0103ng huy\u1ebft \u00e1p, xu\u1ea5t huy\u1ebft, t\u1ee5t huy\u1ebft \u00e1p, ph\u00ecnh ho\u1eb7c b\u00f3c t\u00e1ch \u0111\u1ed9ng m\u1ea1ch.<\/li>\n<li>H\u00f4 h\u1ea5p: Kh\u00e0n ti\u1ebfng, thuy\u00ean t\u1eafc ph\u1ed5i, tr\u00e0n kh\u00ed m\u00e0ng ph\u1ed5i.<\/li>\n<li>Ti\u00eau h\u00f3a: Ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, n\u00f4n, bu\u1ed3n n\u00f4n, vi\u00eam mi\u1ec7ng, \u0111au mi\u1ec7ng, t\u00e1o b\u00f3n, kh\u00f3 ti\u00eau, kh\u00f4 mi\u1ec7ng, t\u0103ng amylase\/lipase, \u0111\u1ea7y h\u01a1i, vi\u00eam t\u1ee5y, vi\u00eam \u0111\u1ea1i tr\u00e0ng, th\u1ee7ng ti\u00eau h\u00f3a, r\u00f2 h\u1eadu m\u00f4n.<\/li>\n<li>Gan \u2013 m\u1eadt: T\u0103ng men gan (AST, ALT, GGT, phosphatase ki\u1ec1m), bilirubin; gi\u1ea3m albumin m\u00e1u; r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan, vi\u00eam gan, suy gan, b\u1ec7nh n\u00e3o gan, vi\u00eam t\u00fai m\u1eadt.<\/li>\n<li>Da \u2013 m\u00f4 d\u01b0\u1edbi da: H\u1ed9i ch\u1ee9ng tay ch\u00e2n, ph\u00e1t ban, r\u1ee5ng t\u00f3c, d\u00e0y s\u1eebng.<\/li>\n<li>C\u01a1 \u2013 x\u01b0\u01a1ng \u2013 kh\u1edbp: \u0110au l\u01b0ng, \u0111au c\u01a1, \u0111au kh\u1edbp, \u0111au chi, ho\u1ea1i t\u1eed x\u01b0\u01a1ng h\u00e0m.<\/li>\n<li>Th\u1eadn \u2013 ti\u1ebft ni\u1ec7u: Protein ni\u1ec7u, t\u0103ng creatinin, t\u0103ng ure m\u00e1u, suy th\u1eadn, h\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0, t\u1ed5n th\u01b0\u01a1ng th\u1eadn.<\/li>\n<li>To\u00e0n th\u00e2n: M\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, ph\u00f9 ngo\u1ea1i bi\u00ean, kh\u00f3 ch\u1ecbu, ch\u1eadm l\u00e0nh v\u1ebft th\u01b0\u01a1ng, r\u00f2 kh\u00f4ng thu\u1ed9c h\u1ec7 ti\u00eau h\u00f3a.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>LENVIMON &#8211; 4 c\u00f3 kh\u1ea3 n\u0103ng k\u00e9o d\u00e0i kho\u1ea3ng QT. C\u1ea7n tr\u00e1nh ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c c\u0169ng g\u00e2y k\u00e9o d\u00e0i QT ho\u1eb7c l\u00e0m r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i.<\/p>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<ul>\n<li>Lenvatinib \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 \u0111\u1ed9c t\u00ednh v\u1edbi ph\u00f4i thai v\u00e0 c\u00f3 th\u1ec3 g\u00e2y qu\u00e1i thai \u1edf \u0111\u1ed9ng v\u1eadt. Kh\u00f4ng s\u1eed d\u1ee5ng LENVIMON &#8211; 4 cho ph\u1ee5 n\u1eef c\u00f3 thai tr\u1eeb khi l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1. N\u00ean t\u01b0 v\u1ea5n tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 \u00edt nh\u1ea5t v\u00e0i tu\u1ea7n sau khi ng\u1eebng thu\u1ed1c.<\/li>\n<li>Hi\u1ec7n ch\u01b0a r\u00f5 lenvatinib c\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 \u1edf ng\u01b0\u1eddi hay kh\u00f4ng. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y lenvatinib v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa v\u1edbi n\u1ed3ng \u0111\u1ed9 cao h\u01a1n so v\u1edbi n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng m\u1eb9. C\u1ee5 th\u1ec3, \u1edf chu\u1ed9t Sprague Dawley \u0111ang cho con b\u00fa, sau khi d\u00f9ng lenvatinib \u0111\u00e1nh d\u1ea5u ph\u00f3ng x\u1ea1, m\u1ee9c \u0111\u1ed9 ph\u01a1i nhi\u1ec5m qua s\u1eefa (t\u00ednh theo AUC) cao g\u1ea5p \u0111\u00f4i so v\u1edbi huy\u1ebft t\u01b0\u01a1ng.<\/li>\n<li>Do nguy c\u01a1 ti\u1ec1m \u1ea9n g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng cho tr\u1ebb s\u01a1 sinh, ph\u1ee5 n\u1eef n\u00ean ng\u01b0ng cho con b\u00fa trong th\u1eddi gian s\u1eed d\u1ee5ng LENVIMON &#8211; 4 v\u00e0 duy tr\u00ec vi\u1ec7c n\u00e0y \u00edt nh\u1ea5t m\u1ed9t tu\u1ea7n sau li\u1ec1u cu\u1ed1i c\u00f9ng.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 b\u00e1o c\u00e1o hay nghi\u00ean c\u1ee9u v\u1ec1 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 t\u1eadp trung do \u0111\u00f3 nh\u1eefng ng\u01b0\u1eddi \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n giao th\u00f4ng v\u00e0 m\u00e1y m\u00f3c c\u1ea7n l\u01b0u \u00fd theo d\u00f5i tri\u1ec7u ch\u1ee9ng g\u1eb7p ph\u1ea3i khi d\u00f9ng thu\u1ed1c tr\u01b0\u1edbc khi tham gia c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 an to\u00e0n.<\/p>\n<p>N\u1ebfu th\u1ea5y m\u1ec7t m\u1ecfi th\u00ec d\u1eebng ngay c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y l\u1ea1i<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Lenvatinib c\u00f3 \u00e1i l\u1ef1c cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, do \u0111\u00f3 kh\u00f4ng lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 b\u1eb1ng l\u1ecdc m\u00e1u. Qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong do suy \u0111a c\u01a1 quan.<\/p>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef LENVIMON &#8211; 4 \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 LENVIMON &#8211; 4 trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng LENVIMON &#8211; 4 khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>Thu\u1ed1c LENVIMON &#8211; 4 gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>LENVIMON &#8211; 4 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i nhi\u1ec1u nh\u00e0 thu\u1ed1c tr\u00ean to\u00e0n qu\u1ed1c v\u1edbi gi\u00e1 dao \u0111\u1ed9ng kh\u00e1c nhau nh\u01b0ng kh\u00f4ng qu\u00e1 nhi\u1ec1u. Ch\u00fang t\u00f4i s\u1ebd th\u01b0\u1eddng xuy\u00ean c\u1eadp nh\u1eadt m\u1ee9c gi\u00e1 ngay \u0111\u1ea7u trang \u0111\u1ec3 b\u1ea1n \u0111\u1ecdc tham kh\u1ea3o.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p LENVIMON &#8211; 4 t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi LENVIMON &#8211; 4 nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/nexavar-200\/\">Nexavar 200mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Lenvatinib h\u00e0m l\u01b0\u1ee3ng 10mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Everest Pharmaceuticals \u2013 Bangladesh, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 nh\u01b0 gan, th\u1eadn, tuy\u1ebfn gi\u00e1p<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/lenvaxen-10\/\">Lenvaxen 10<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Sorafenib v\u1edbi h\u00e0m l\u01b0\u1ee3ng 200mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Bayer Pharma AG \u2013 \u0110\u1ee8C, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i ung th\u01b0 nh\u01b0 gan, th\u1eadn, tuy\u1ebfn gi\u00e1p.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Suyama K, Iwase H (2018). Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers. Cancer Control. Truy c\u1eadp ng\u00e0y 29 th\u00e1ng 5 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6056795\/\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6056795\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"color: #d83131;\"><strong>CH\u00daNG T\u00d4I KH\u00d4NG KINH DOANH S\u1ea2N PH\u1ea8M, B\u00c0I VI\u1ebeT CH\u1ec8 MANG T\u00cdNH CH\u1ea4T THAM KH\u1ea2O V\u00c0 CUNG C\u1ea4P TH\u00d4NG TIN CHO KH\u00c1CH H\u00c0NG T\u00ccM HI\u1ec2U<\/strong><\/span><\/p>\n<p>Thu\u1ed1c LENVIMON &#8211; 4 (lenvatinib) l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb nh\u1eafm tr\u00fang \u0111\u00edch, gi\u00fap \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u nu\u00f4i d\u01b0\u1ee1ng t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":1,"featured_media":121207,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-121205","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/121205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=121205"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/121207"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=121205"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=121205"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=121205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}