{"id":119957,"date":"2025-05-23T10:34:11","date_gmt":"2025-05-23T03:34:11","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=119957"},"modified":"2025-07-24T13:13:31","modified_gmt":"2025-07-24T06:13:31","slug":"pprunitil","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/pprunitil\/","title":{"rendered":"Prunitil 40mg\/12.5mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Prunitil \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Kh\u00e1nh H\u00f2a c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35733-22<\/strong><\/p>\n<h2>Prunitil l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Trong m\u1ed7i <strong>vi\u00ean n\u00e9n Prunitil<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n<ul>\n<li>Telmisartan \u2026\u2026\u2026\u2026\u2026\u2026\u2026.40mg<\/li>\n<li>Hydrochlorothiazide \u2026\u2026\u202612,5mg<\/li>\n<li>C\u00e1c t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 vi\u00ean.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VD-35733-22<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 20 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<p>H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Prunitil<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<ul>\n<li>Telmisartan<\/li>\n<\/ul>\n<p>L\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 Angiotensin II lo\u1ea1i AT1, Telmisartan ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng g\u00e2y co m\u1ea1ch v\u00e0 ti\u1ebft aldosteron c\u1ee7a Angiotensin II, t\u1eeb \u0111\u00f3 l\u00e0m gi\u00e3n m\u1ea1ch v\u00e0 gi\u1ea3m huy\u1ebft \u00e1p.<br \/>\nKh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn bradykinin nh\u01b0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, do \u0111\u00f3 tr\u00e1nh \u0111\u01b0\u1ee3c t\u00e1c d\u1ee5ng ph\u1ee5 ho dai d\u1eb3ng. Thu\u1ed1c \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t, th\u00edch h\u1ee3p cho b\u1ec7nh nh\u00e2n kh\u00f4ng d\u00f9ng \u0111\u01b0\u1ee3c ACEI. Hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p k\u00e9o d\u00e0i \u0111\u1ebfn 24 gi\u1edd v\u00e0 kh\u00f4ng g\u00e2y ph\u1ea3n \u1ee9ng d\u1ed9i khi ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t.<\/p>\n<ul>\n<li>Hydroclorothiazid<\/li>\n<\/ul>\n<p>Thu\u1ed9c nh\u00f3m thiazid, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng l\u1ee3i ti\u1ec3u b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu Na\u207a v\u00e0 Cl\u207b \u1edf \u1ed1ng l\u01b0\u1ee3n xa, l\u00e0m t\u0103ng th\u1ea3i natri, clorid, kali v\u00e0 n\u01b0\u1edbc. K\u1ebft qu\u1ea3 l\u00e0 gi\u1ea3m th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng v\u00e0 gi\u1ea3m s\u1ee9c c\u1ea3n ngo\u1ea1i vi, d\u1eabn \u0111\u1ebfn h\u1ea1 huy\u1ebft \u00e1p.<br \/>\nT\u00e1c d\u1ee5ng l\u1ee3i ti\u1ec3u kh\u1edfi ph\u00e1t trong 2 gi\u1edd, \u0111\u1ea1t \u0111\u1ec9nh sau 4 gi\u1edd v\u00e0 k\u00e9o d\u00e0i 6\u201312 gi\u1edd. Ngo\u00e0i ra, thu\u1ed1c c\u00f2n gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00e1c khi s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<h4>H\u1ea5p thu<\/h4>\n<p>Telmisartan: H\u1ea5p thu nhanh, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong 0,5 \u2013 1 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 42%. Th\u1ee9c \u0103n \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Hydroclorothiazid: H\u1ea5p thu t\u01b0\u01a1ng \u0111\u1ed1i nhanh, \u0111\u1ea1t \u0111\u1ec9nh sau 1\u20133 gi\u1edd, sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 60%. C\u00f3 th\u1ec3 gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n suy tim.<\/p>\n<h4>Ph\u00e2n b\u1ed1<\/h4>\n<p>Telmisartan: G\u1eafn m\u1ea1nh v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng (&gt;99%), ch\u1ee7 y\u1ebfu l\u00e0 albumin. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn (~500 L).<\/p>\n<p>Hydroclorothiazid: G\u1eafn k\u1ebft protein kho\u1ea3ng 68%, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 t\u1eeb 0,83\u20131,14 L\/kg. Thu\u1ed1c qua nhau thai v\u00e0 t\u1eadp trung trong thai nhi.<\/p>\n<h4>Chuy\u1ec3n h\u00f3a<\/h4>\n<p>Telmisartan: Chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu th\u00e0nh d\u1ea1ng kh\u00f4ng ho\u1ea1t t\u00ednh (Acylglucuronid). Kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi enzym CYP450.<\/p>\n<p>Hydroclorothiazid: Kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a.<\/p>\n<h4>Th\u1ea3i tr\u1eeb<\/h4>\n<p>Telmisartan: Th\u1ea3i ch\u1ee7 y\u1ebfu qua m\u1eadt v\u00e0o ph\u00e2n (97%), \u00edt qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i &gt;20 gi\u1edd.<\/p>\n<p>Hydroclorothiazid: Th\u1ea3i tr\u1eeb qua th\u1eadn ch\u1ee7 y\u1ebfu \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n, ~60% li\u1ec1u trong 48 gi\u1edd. Th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 10\u201315 gi\u1edd, k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi suy th\u1eadn.<\/p>\n<h2>Thu\u1ed1c Prunitil \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>\u0110\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p ch\u01b0a \u0111\u1ea1t ki\u1ec3m so\u00e1t \u0111\u1ea7y \u0111\u1ee7 v\u1edbi Telmisartan \u0111\u01a1n \u0111\u1ed9c.<\/li>\n<li>H\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p trong tr\u01b0\u1eddng h\u1ee3p t\u0103ng huy\u1ebft \u00e1p nguy\u00ean ph\u00e1t.<\/li>\n<\/ul>\n<figure id=\"attachment_119968\" aria-describedby=\"caption-attachment-119968\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-119968\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/Prunitil.jpg\" alt=\"Prunitil\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/Prunitil.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/Prunitil-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/Prunitil-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/Prunitil-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-119968\" class=\"wp-caption-text\">Thu\u1ed1c Prunitil 40mg\/12.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n \u1edfn g\u01b0\u1eddi tr\u01b0\u1eddng th\u00e0nh khi s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u01a1n tr\u1ecb li\u1ec7u nh\u01b0ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p<\/figcaption><\/figure>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<ul>\n<li>Li\u1ec1u khuy\u1ebfn c\u00e1o th\u00f4ng th\u01b0\u1eddng l\u00e0 1 vi\u00ean Prunitil m\u1ed7i ng\u00e0y.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy th\u1eadn: Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 30 mL\/ph\u00fat) do th\u00e0nh ph\u1ea7n Hydroclorothiazid. C\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3 n\u1ebfu d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<\/li>\n<li>B\u1ec7nh nh\u00e2n suy gan: Kh\u00f4ng s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng. V\u1edbi tr\u01b0\u1eddng h\u1ee3p suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u 1 vi\u00ean\/ng\u00e0y v\u00e0 c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd.<\/li>\n<li>Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u theo tu\u1ed5i.<\/li>\n<li>Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean d\u01b0\u1edbi 18 tu\u1ed5i: Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3.<\/li>\n<\/ul>\n<h3>C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n<p>D\u00f9ng <strong>vi\u00ean u\u1ed1ng Prunitil<\/strong> theo \u0111\u01b0\u1eddng u\u1ed1ng, tr\u01b0\u1edbc ho\u1eb7c sau b\u1eefa \u0103n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Prunitil trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>D\u1ecb \u1ee9ng v\u1edbi Telmisartan, Hydroclorothiazid, c\u00e1c sulfonamid ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u00f3 trong Prunitil.<\/li>\n<li>Ph\u1ee5 n\u1eef mang thai \u1edf tam c\u00e1 nguy\u1ec7t th\u1ee9 hai v\u00e0 ba, c\u0169ng nh\u01b0 trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/li>\n<li>B\u1ec7nh nh\u00e2n b\u1ecb t\u1eafc m\u1eadt ho\u1eb7c \u1ee9 m\u1eadt.<\/li>\n<li>Suy gan n\u1eb7ng ho\u1eb7c suy th\u1eadn n\u1eb7ng (ClCr &lt; 30 mL\/ph\u00fat).<\/li>\n<li>R\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i nh\u01b0 h\u1ea1 kali m\u00e1u, t\u0103ng canxi m\u00e1u.<\/li>\n<li>Kh\u00f4ng ph\u1ed1i h\u1ee3p v\u1edbi Aliskiren \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn n\u1eb7ng (GFR &lt; 60 mL\/ph\u00fat\/1,73m\u00b2).<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>B\u1ec7nh nh\u00e2n suy gan kh\u00f4ng d\u00f9ng n\u1ebfu b\u1ecb \u1ee9 m\u1eadt, r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng m\u1eadt, suy gan n\u1eb7ng; Th\u1eadn tr\u1ecdng v\u1edbi b\u1ec7nh gan \u0111ang ti\u1ebfn tri\u1ec3n (nguy c\u01a1 h\u00f4n m\u00ea gan).; Gi\u1edbi h\u1ea1n li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan nh\u1eb9-v\u1eeba.<\/li>\n<li>T\u0103ng huy\u1ebft \u00e1p do h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn: Nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p v\u00e0 suy th\u1eadn cao.<\/li>\n<li>Suy th\u1eadn\/gh\u00e9p th\u1eadn: Kh\u00f4ng d\u00f9ng n\u1ebfu ClCr &lt; 30 mL\/ph\u00fat; Thi\u1ebfu d\u1eef li\u1ec7u tr\u00ean ng\u01b0\u1eddi gh\u00e9p th\u1eadn ho\u1eb7c suy th\u1eadn n\u1eb7ng; C\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn, kali, acid uric.<\/li>\n<li>H\u1ea1 huy\u1ebft \u00e1p: Nguy c\u01a1 sau li\u1ec1u \u0111\u1ea7u n\u1ebfu b\u1ec7nh nh\u00e2n m\u1ea5t n\u01b0\u1edbc\/natri, ti\u00eau ch\u1ea3y, n\u00f4n.<\/li>\n<li>Phong t\u1ecfa k\u00e9p RAAS: Kh\u00f4ng n\u00ean k\u1ebft h\u1ee3p ACEi, ARB, Aliskiren \u2192 t\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p, t\u0103ng kali, suy th\u1eadn.<\/li>\n<li>T\u0103ng aldosterone nguy\u00ean ph\u00e1t: Kh\u00f4ng hi\u1ec7u qu\u1ea3, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng.<\/li>\n<li>H\u1eb9p van tim, b\u1ec7nh c\u01a1 tim ph\u00ec \u0111\u1ea1i: Th\u1eadn tr\u1ecdng do nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p.<\/li>\n<li>Chuy\u1ec3n h\u00f3a &#8211; n\u1ed9i ti\u1ebft:<\/li>\n<li>Thiazid c\u00f3 th\u1ec3 t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, cholesterol, triglycerid, ur\u00ea m\u00e1u; g\u00e2y Gout.<\/li>\n<li>C\u00f3 th\u1ec3 k\u00edch ho\u1ea1t \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ti\u1ec1m \u1ea9n.<\/li>\n<li>M\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i:<\/li>\n<li>Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean natri, kali, magie, canxi.<\/li>\n<li>H\u1ea1 kali m\u00e1u (nh\u1ea5t l\u00e0 khi d\u00f9ng c\u00f9ng corticoid, ACTH).<\/li>\n<li>T\u0103ng kali m\u00e1u n\u1ebfu c\u00f3 suy th\u1eadn, suy tim ho\u1eb7c d\u00f9ng th\u00eam thu\u1ed1c gi\u1eef kali.<\/li>\n<li>H\u1ea1 natri, h\u1ea1 clorua m\u00e1u, ki\u1ec1m chuy\u1ec3n h\u00f3a, h\u1ea1 magie, t\u0103ng canxi c\u00f3 th\u1ec3 x\u1ea3y ra.<\/li>\n<li>Kh\u00e1c bi\u1ec7t ch\u1ee7ng t\u1ed9c: Telmisartan \u00edt hi\u1ec7u qu\u1ea3 h\u01a1n \u1edf b\u1ec7nh nh\u00e2n da \u0111en.<\/li>\n<li>T\u0103ng nh\u00e3n \u00e1p g\u00f3c \u0111\u00f3ng: Hydroclorothiazid c\u00f3 th\u1ec3 g\u00e2y c\u1eadn th\u1ecb c\u1ea5p v\u00e0 t\u0103ng nh\u00e3n \u00e1p.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>Th\u01b0\u1eddn g\u1eb7p: ch\u00f3ng m\u1eb7t<\/li>\n<li>Kh\u00f4ng th\u01b0\u1eddng g\u1eb7p: lo\u1ea1n nh\u1ecbp tim, lo l\u1eafng, gi\u1ea3m kali huy\u1ebft, kh\u00f3 th\u1edf, t\u1ee5t huy\u1ebft \u00e1p, ti\u00eau ch\u1ea3y, \u0111\u1ea7y h\u01a1i, mi\u1ec7ng kh\u00f4, \u0111au l\u01b0ng, c\u01a1, ng\u1ef1c, t\u0103ng acid uric huy\u1ebft,&#8230;<\/li>\n<li>\u00cdt g\u1eb7p: Vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p (ph\u1ebf qu\u1ea3n, h\u1ecdng, xoang); suy h\u00f4 h\u1ea5p; ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7, tr\u1ea7m c\u1ea3m, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan, \u0111au b\u1ee5ng, r\u1ed3i lo\u1ea1n ti\u00eau ho\u00e1, n\u00f4n, \u0111au kh\u1edbp, c\u01a1, ch\u00e2n tay,&#8230;<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Lithi: Telmisartan ho\u1eb7c Hydroclorothiazid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft thanh, g\u00e2y nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c nh\u01b0 run tay, l\u00fa l\u1eabn ho\u1eb7c suy th\u1eadn. C\u1ea7n theo d\u00f5i s\u00e1t n\u1ed3ng \u0111\u1ed9 lithi n\u1ebfu b\u1eaft bu\u1ed9c ph\u1ed1i h\u1ee3p<\/li>\n<li>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng kali huy\u1ebft: Thu\u1ed1c l\u1ee3i ti\u1ec3u quai, corticoid, thu\u1ed1c nhu\u1eadn tr\u00e0ng, amphotericin B&#8230; c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 h\u1ea1 kali khi d\u00f9ng k\u00e8m. Trong khi \u0111\u00f3, thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali, b\u1ed5 sung kali, cyclosporin, heparin, ho\u1eb7c mu\u1ed1i ch\u1ee9a kali l\u1ea1i l\u00e0m t\u0103ng nguy c\u01a1 t\u0103ng kali m\u00e1u. N\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p ho\u1eb7c gi\u00e1m s\u00e1t \u0111i\u1ec7n gi\u1ea3i m\u00e1u th\u01b0\u1eddng xuy\u00ean.<\/li>\n<li>Digoxin: Telmisartan c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh v\u00e0 \u0111\u00e1y c\u1ee7a digoxin trong m\u00e1u, d\u1eabn \u0111\u1ebfn nguy c\u01a1 nhi\u1ec5m \u0111\u1ed9c. C\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 digoxin khi c\u00f3 thay \u0111\u1ed5i v\u1ec1 li\u1ec1u Telmisartan.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp v\u00e0 glycosid tim (nh\u01b0 amiodarone, sotalol, quinidine, digitalis&#8230;): S\u1ef1 thay \u0111\u1ed5i \u0111i\u1ec7n gi\u1ea3i do Hydroclorothiazid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp, \u0111\u1eb7c bi\u1ec7t l\u00e0 xo\u1eafn \u0111\u1ec9nh. C\u1ea7n theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 \u0111i\u1ec7n gi\u1ea3i \u0111\u1ecbnh k\u1ef3.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng: Hydroclorothiazid c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a insulin v\u00e0 thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft u\u1ed1ng. C\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng khi d\u00f9ng chung.<\/li>\n<li>Metformin: Nguy c\u01a1 nhi\u1ec5m toan lactic t\u0103ng l\u00ean khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi Hydroclorothiazid, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn. C\u1ea7n \u0111\u00e1nh gi\u00e1 nguy c\u01a1 tr\u01b0\u1edbc khi ph\u1ed1i h\u1ee3p.<\/li>\n<li>NSAIDs (thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid): L\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 \u00e1p c\u1ee7a Telmisartan v\u00e0 Hydroclorothiazid, \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 suy th\u1eadn c\u1ea5p, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c m\u1ea5t n\u01b0\u1edbc.<\/li>\n<li>Nh\u1ef1a g\u1eafn acid m\u1eadt (cholestyramin, colestipol): Gi\u1ea3m h\u1ea5p thu Hydroclorothiazid n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi. N\u00ean c\u00e1ch kho\u1ea3ng v\u00e0i gi\u1edd gi\u1eefa hai thu\u1ed1c \u0111\u1ec3 h\u1ea1n ch\u1ebf t\u01b0\u01a1ng t\u00e1c.<\/li>\n<li>R\u01b0\u1ee3u, thu\u1ed1c ng\u1ee7, barbiturat: T\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng. C\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/li>\n<li>Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb gout (allopurinol, probenecid&#8230;): Hydroclorothiazid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng acid uric m\u00e1u, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb gout. C\u1ea7n theo d\u00f5i v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u n\u1ebfu c\u1ea7n.<\/li>\n<li>Canxi v\u00e0 vitamin D: Hydroclorothiazid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng calci huy\u1ebft b\u1eb1ng c\u00e1ch gi\u1ea3m th\u1ea3i calci qua th\u1eadn. C\u1ea7n theo d\u00f5i calci m\u00e1u n\u1ebfu ph\u1ed1i h\u1ee3p.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<h4>Ph\u1ee5 n\u1eef mang thai<\/h4>\n<ul>\n<li>Telmisartan: C\u00e1c th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 cho th\u1ea5y kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c cho thai nhi, m\u1eb7c d\u00f9 ch\u01b0a ghi nh\u1eadn r\u00f5 r\u00e0ng nguy c\u01a1 g\u00e2y qu\u00e1i thai tr\u00ean ng\u01b0\u1eddi. Tuy nhi\u00ean, \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n, thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong ba th\u00e1ng \u0111\u1ea7u c\u1ee7a thai k\u1ef3. Trong tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c ph\u1ea3i \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p, n\u00ean c\u00e2n nh\u1eafc thay th\u1ebf b\u1eb1ng li\u1ec7u ph\u00e1p an to\u00e0n h\u01a1n tr\u01b0\u1edbc khi c\u00f3 k\u1ebf ho\u1ea1ch mang thai.<\/li>\n<li>Vi\u1ec7c ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng thu\u1ed1c trong qu\u00fd hai v\u00e0 ba c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng nh\u01b0 thi\u1ec3u \u1ed1i, r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n h\u1ed9p s\u1ecd, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn thai nhi, ho\u1eb7c h\u1ea1 huy\u1ebft \u00e1p v\u00e0 t\u0103ng kali m\u00e1u \u1edf tr\u1ebb s\u01a1 sinh. N\u1ebfu thai ph\u1ee5 \u0111\u00e3 ti\u1ebfp x\u00fac v\u1edbi Telmisartan t\u1eeb qu\u00fd hai, c\u1ea7n \u0111\u01b0\u1ee3c si\u00eau \u00e2m \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 ph\u00e1t tri\u1ec3n s\u1ecd n\u00e3o c\u1ee7a thai. Ph\u1ee5 n\u1eef ph\u00e1t hi\u1ec7n mang thai trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb n\u00ean ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c.<\/li>\n<li>Hydroclorothiazid: D\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 \u0111\u1ed9 an to\u00e0n khi d\u00f9ng trong thai k\u1ef3 c\u00f2n h\u1ea1n ch\u1ebf. Thu\u1ed1c c\u00f3 th\u1ec3 \u0111i qua nhau thai v\u00e0 c\u00f3 m\u1eb7t trong tu\u1ea7n ho\u00e0n thai nhi, t\u1eeb \u0111\u00f3 g\u00e2y ra m\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i, gi\u1ea3m ti\u1ec3u c\u1ea7u, ho\u1eb7c v\u00e0ng da s\u01a1 sinh. \u0110\u1eb7c bi\u1ec7t, thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p do thai k\u1ef3, ph\u00f9 do thai ngh\u00e9n ho\u1eb7c ti\u1ec1n s\u1ea3n gi\u1eadt v\u00ec nguy c\u01a1 l\u00e0m gi\u1ea3m l\u01b0u l\u01b0\u1ee3ng m\u00e1u qua nhau thai m\u00e0 kh\u00f4ng \u0111em l\u1ea1i l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb r\u00f5 r\u1ec7t. Vi\u1ec7c s\u1eed d\u1ee5ng ch\u1ec9 n\u00ean c\u00e2n nh\u1eafc khi kh\u00f4ng c\u00f3 l\u1ef1a ch\u1ecdn thay th\u1ebf an to\u00e0n h\u01a1n.<\/li>\n<\/ul>\n<h4>Ph\u1ee5 n\u1eef cho con b\u00fa<\/h4>\n<p>Telmisartan kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa, \u0111\u1eb7c bi\u1ec7t l\u00e0 v\u1edbi tr\u1ebb s\u01a1 sinh ho\u1eb7c sinh non, do ch\u01b0a x\u00e1c \u0111\u1ecbnh r\u00f5 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. Hydroclorothiazid c\u00f3 th\u1ec3 ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u1edbi l\u01b0\u1ee3ng nh\u1ecf, tuy nhi\u00ean li\u1ec1u cao c\u00f3 nguy c\u01a1 \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft s\u1eefa. N\u1ebfu c\u1ea7n s\u1eed d\u1ee5ng thu\u1ed1c trong giai \u0111o\u1ea1n cho con b\u00fa, n\u00ean d\u00f9ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 v\u00e0 theo d\u00f5i tr\u1ebb k\u1ef9 l\u01b0\u1ee1ng.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c Prunitil c\u00f3 th\u1ec3 l\u00e0m xu\u1ea5t hi\u1ec7n c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 ch\u00f3ng m\u1eb7t ho\u1eb7c c\u1ea3m gi\u00e1c bu\u1ed3n ng\u1ee7 \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, t\u1eeb \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 kh\u1ea3 n\u0103ng ph\u1ea3n \u1ee9ng khi \u0111i\u1ec1u khi\u1ec3n ph\u01b0\u01a1ng ti\u1ec7n giao th\u00f4ng ho\u1eb7c m\u00e1y m\u00f3c. Do \u0111\u00f3, ng\u01b0\u1eddi d\u00f9ng n\u00ean th\u1eadn tr\u1ecdng v\u00e0 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u00e1 nh\u00e2n tr\u01b0\u1edbc khi tham gia v\u00e0o c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ea7n s\u1ef1 t\u1eadp trung cao.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Bi\u1ec3u hi\u1ec7n qu\u00e1 li\u1ec1u l\u00e0 t\u1ea5t c\u1ea3 c\u00e1c d\u1ea5u hi\u1ec7u qu\u00e1 li\u1ec1u c\u1ee7a 2 ho\u1ea1t ch\u1ea5t th\u00e0nh ph\u1ea7n bao g\u1ed3m:<\/p>\n<ul>\n<li>Telmisartan: H\u1ea1 huy\u1ebft \u00e1p, ch\u00f3ng m\u1eb7t, ch\u1eadm nh\u1ecbp tim.<\/li>\n<li>Hydroclorothiazid: M\u1ea5t c\u00e2n b\u1eb1ng n\u01b0\u1edbc \u2013 \u0111i\u1ec7n gi\u1ea3i do l\u1ee3i ti\u1ec3u m\u1ea1nh, c\u00f3 th\u1ec3 g\u00e2y lo\u1ea1n nh\u1ecbp n\u1ebfu k\u1ebft h\u1ee3p v\u1edbi Digitalis.<\/li>\n<\/ul>\n<p>X\u1eed tr\u00ed:<\/p>\n<ul>\n<li>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 theo d\u00f5i huy\u1ebft \u00e1p, \u0111i\u1ec7n gi\u1ea3i.<\/li>\n<li>C\u00f3 th\u1ec3 r\u1eeda d\u1ea1 d\u00e0y, g\u00e2y n\u00f4n s\u1edbm ho\u1eb7c d\u00f9ng than ho\u1ea1t \u0111\u1ec3 h\u1ea5p ph\u1ee5 thu\u1ed1c n\u1ebfu m\u1edbi d\u00f9ng.<\/li>\n<li>Theo d\u00f5i tim m\u1ea1ch v\u00e0 b\u00f9 d\u1ecbch, \u0111i\u1ec7n gi\u1ea3i khi c\u1ea7n.<\/li>\n<\/ul>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<ul>\n<li>Gi\u1eef Prunitil \u1edf n\u01a1i kh\u00f4 r\u00e1o, tho\u00e1ng m\u00e1t (&lt;30\u2103), tr\u00e1nh \u00e1nh n\u1eafng qu\u00e1 m\u1ea1nh t\u1eeb m\u1eb7t tr\u1eddi<\/li>\n<li>Kh\u00f4ng \u0111\u1ec3 Prunitil trong t\u1ea7m v\u1edbi tr\u1ebb em<\/li>\n<li>Kh\u00f4ng s\u1eed d\u1ee5ng Prunitil khi qu\u00e1 h\u1ea1n cho ph\u00e9p<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Prunitil gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Prunitil hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Prunitil c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p Prunitil t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Prunitil nh\u01b0:<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/aprovel-300mg\/\">Aprovel 300mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Irbesartan v\u1edbi h\u00e0m l\u01b0\u1ee3ng 300mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Sanofi Winthrop Industrie c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p><a href=\"https:\/\/vnras.com\/drug\/captazib-25-25\/\">Captazib 25\/25<\/a> c\u00f3 th\u00e0nh ph\u1ea7n l\u00e0 Captopril 25mg v\u00e0 Hydrochlorothiazide 25mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Tipharco, c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Schmieder RE (2004). Telmisartan\/hydrochlorothiazide combination therapy in the treatment of essential hypertension. Expert Opin Pharmacother. Truy c\u1eadp ng\u00e0y 23 th\u00e1ng 5 n\u0103m 2025 t\u1eeb: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15500377\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15500377\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">Thu\u1ed1c Prunitil 40mg\/12.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n \u1edfn g\u01b0\u1eddi tr\u01b0\u1eddng th\u00e0nh khi s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u01a1n tr\u1ecb li\u1ec7u nh\u01b0ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p<\/span><\/p>\n","protected":false},"author":1,"featured_media":119958,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-119957","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/119957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=119957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/119958"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=119957"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=119957"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=119957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}