{"id":119346,"date":"2025-05-17T17:04:36","date_gmt":"2025-05-17T10:04:36","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=119346"},"modified":"2025-12-23T13:29:44","modified_gmt":"2025-12-23T06:29:44","slug":"chalkas-2","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/chalkas-2\/","title":{"rendered":"CHALKAS-2"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/vnras.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>CHALKAS-2 \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C PH\u1ea8M \u0110\u1ea0T VI PH\u00da, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110228124.<\/strong><\/p>\n<h2>CHALKAS-2 l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Thu\u1ed1c <strong>CHALKAS-2<\/strong> ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Ho\u1ea1t ch\u1ea5t: <strong>Eszopiclone<\/strong> 2mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: Cellulose vi tinh th\u1ec3 M112, dicalci phosphat khan, carmellose calci, silicon dioxyd, magnesi stearat,<\/li>\n<\/ul>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110228124<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_119347\" aria-describedby=\"caption-attachment-119347\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-119347\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/CHALKAS-2.jpg\" alt=\"CHALKAS-2 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng m\u1ea5t ng\u1ee7\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/CHALKAS-2.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/CHALKAS-2-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/CHALKAS-2-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/05\/CHALKAS-2-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-119347\" class=\"wp-caption-text\">CHALKAS-2 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng m\u1ea5t ng\u1ee7<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c CHALKAS-2<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<ul>\n<li>Nh\u00f3m d\u01b0\u1ee3c l\u00fd: Thu\u1ed1c an th\u1ea7n g\u00e2y ng\u1ee7, c\u00f3 li\u00ean quan \u0111\u1ebfn benzodiazepin.<\/li>\n<li>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: C\u01a1 ch\u1ebf ch\u00ednh x\u00e1c c\u1ee7a eszopiclone trong vi\u1ec7c g\u00e2y ng\u1ee7 ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ea7y \u0111\u1ee7. Tuy nhi\u00ean, ng\u01b0\u1eddi ta cho r\u1eb1ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c c\u00f3 li\u00ean quan \u0111\u1ebfn t\u01b0\u01a1ng t\u00e1c c\u1ee7a n\u00f3 v\u1edbi ph\u1ee9c h\u1ee3p th\u1ee5 th\u1ec3 GABA t\u1ea1i v\u1ecb tr\u00ed g\u1eafn benzodiazepin. Eszopiclone kh\u00f4ng c\u00f3 c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc li\u00ean quan \u0111\u1ebfn c\u00e1c nh\u00f3m thu\u1ed1c ng\u1ee7 kh\u00e1c nh\u01b0 pyrazolopyrimidin, imidazopyridin, benzodiazepin, ho\u1eb7c barbiturat.<\/li>\n<\/ul>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: Eszopiclone \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng sau khi u\u1ed1ng, v\u1edbi th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng (Tmax) kho\u1ea3ng 1 gi\u1edd. Th\u1ee9c \u0103n gi\u00e0u ch\u1ea5t b\u00e9o c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh h\u1ea5p thu, l\u00e0m tr\u00ec ho\u00e3n Tmax kho\u1ea3ng 1 gi\u1edd v\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a (Cmax) kho\u1ea3ng 21%, nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu (AUC).<\/li>\n<li>Ph\u00e2n b\u1ed1: T\u1ef7 l\u1ec7 g\u1eafn k\u1ebft c\u1ee7a eszopiclone v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng n\u1eb1m trong kho\u1ea3ng 52-59%.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Eszopiclone \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan th\u00f4ng qua c\u00e1c qu\u00e1 tr\u00ecnh oxy h\u00f3a v\u00e0 demethyl h\u00f3a. C\u00e1c enzym CYP3A4 v\u00e0 CYP2E1 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh n\u00e0y.<\/li>\n<li>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a eszopiclone (T1\/2) l\u00e0 kho\u1ea3ng 6 gi\u1edd. Kho\u1ea3ng 75% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a, v\u00e0 d\u01b0\u1edbi 10% \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c kh\u00f4ng thay \u0111\u1ed5i.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c CHALKAS-2 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Eszopiclone \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng m\u1ea5t ng\u1ee7, gi\u00fap gi\u1ea3m th\u1eddi gian \u0111i v\u00e0o gi\u1ea5c ng\u1ee7 v\u00e0 duy tr\u00ec gi\u1ea5c ng\u1ee7.<\/li>\n<li>Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng k\u00e9o d\u00e0i \u0111\u1ebfn 6 th\u00e1ng.<\/li>\n<li>C\u00e1c \u0111\u00e1nh gi\u00e1 ch\u00ednh th\u1ee9c v\u1ec1 th\u1eddi gian \u0111i v\u00e0o gi\u1ea5c ng\u1ee7 v\u00e0 kh\u1ea3 n\u0103ng duy tr\u00ec gi\u1ea5c ng\u1ee7 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u1edf tu\u1ea7n th\u1ee9 4 trong nghi\u00ean c\u1ee9u 6 tu\u1ea7n (tr\u00ean ng\u01b0\u1eddi l\u1edbn), giai \u0111o\u1ea1n cu\u1ed1i c\u1ee7a nghi\u00ean c\u1ee9u 2 tu\u1ea7n (tr\u00ean ng\u01b0\u1eddi cao tu\u1ed5i) v\u00e0 6 th\u00e1ng (tr\u00ean ng\u01b0\u1eddi l\u1edbn).<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c CHALKAS-2<\/h2>\n<ul>\n<li>Ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh: Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o l\u00e0 1mg, c\u00f3 th\u1ec3 t\u0103ng l\u00ean 2mg ho\u1eb7c 3mg t\u00f9y theo ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng. Tuy nhi\u00ean, \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, li\u1ec1u 2mg ho\u1eb7c 3mg c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 suy gi\u1ea3m kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0o bu\u1ed5i s\u00e1ng h\u00f4m sau.\u00a0 T\u1ed5ng li\u1ec1u eszopiclone kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 3mg m\u1ed7i ng\u00e0y v\u00e0 n\u00ean u\u1ed1ng ngay tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/li>\n<li>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:\n<ul>\n<li>Kh\u00f4ng d\u00f9ng qu\u00e1 2mg \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy nh\u01b0\u1ee3c ho\u1eb7c b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i.<\/li>\n<li>T\u1ed5ng li\u1ec1u kh\u00f4ng qu\u00e1 2mg khi d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4.<\/li>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng: C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u khi d\u00f9ng k\u1ebft h\u1ee3p \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5.<\/li>\n<li>S\u1eed d\u1ee5ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n: D\u00f9ng c\u00f9ng ho\u1eb7c ngay sau b\u1eefa \u0103n ch\u00ednh gi\u00e0u ch\u1ea5t b\u00e9o c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm h\u1ea5p thu v\u00e0 gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c l\u00ean th\u1eddi gian \u0111i v\u00e0o gi\u1ea5c ng\u1ee7.<\/li>\n<\/ul>\n<\/li>\n<li>\u0110\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 suy gi\u1ea3m ch\u1ee9c n\u0103ng t\u00e2m th\u1ea7n v\u00e0o ng\u00e0y h\u00f4m sau, eszopiclone n\u00ean \u0111\u01b0\u1ee3c u\u1ed1ng ngay tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/li>\n<\/ul>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c CHALKAS-2 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi b\u1ecb d\u1ecb \u1ee9ng v\u1edbi eszopiclone ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o kh\u00e1c c\u1ee7a thu\u1ed1c.<\/li>\n<li>Kh\u00f4ng d\u00f9ng cho ng\u01b0\u1eddi \u0111\u00e3 t\u1eebng c\u00f3 c\u00e1c h\u00e0nh vi ph\u1ee9c t\u1ea1p khi ng\u1ee7 sau khi s\u1eed d\u1ee5ng eszopiclone.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c CHALKAS-2<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>C\u00e1c h\u00e0nh vi ph\u1ee9c t\u1ea1p khi ng\u1ee7:\n<ul>\n<li>Eszopiclone c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c h\u00e0nh vi b\u1ea5t th\u01b0\u1eddng trong khi ng\u1ee7, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111i b\u1ed9, l\u00e1i xe, \u0103n u\u1ed1ng, g\u1ecdi \u0111i\u1ec7n tho\u1ea1i ho\u1eb7c quan h\u1ec7 t\u00ecnh d\u1ee5c m\u00e0 ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng nh\u1eadn th\u1ee9c \u0111\u01b0\u1ee3c. C\u00e1c h\u00e0nh vi n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nguy c\u01a1 t\u1ef1 g\u00e2y th\u01b0\u01a1ng t\u00edch ho\u1eb7c g\u00e2y th\u01b0\u01a1ng t\u00edch cho ng\u01b0\u1eddi kh\u00e1c.<\/li>\n<li>N\u1ebfu x\u1ea3y ra b\u1ea5t k\u1ef3 h\u00e0nh vi ph\u1ee9c t\u1ea1p n\u00e0o khi ng\u1ee7, c\u1ea7n ng\u1eebng d\u00f9ng eszopiclone ngay l\u1eadp t\u1ee9c.<\/li>\n<\/ul>\n<\/li>\n<li>\u1ee8c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 suy gi\u1ea3m ch\u1ee9c n\u0103ng ban ng\u00e0y:\n<ul>\n<li>Eszopiclone c\u00f3 th\u1ec3 g\u00e2y \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn bu\u1ed3n ng\u1ee7 v\u00e0 suy gi\u1ea3m kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng v\u00e0o ban ng\u00e0y, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi d\u00f9ng li\u1ec1u cao.<\/li>\n<li>Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n th\u1eadn tr\u1ecdng khi th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng \u0111\u00f2i h\u1ecfi s\u1ef1 t\u1ec9nh t\u00e1o tinh th\u1ea7n, ch\u1eb3ng h\u1ea1n nh\u01b0 l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/li>\n<li>Nguy c\u01a1 t\u00e9 ng\u00e3 c\u00f3 th\u1ec3 t\u0103ng l\u00ean \u1edf ng\u01b0\u1eddi cao tu\u1ed5i do t\u00e1c d\u1ee5ng n\u00e0y c\u1ee7a thu\u1ed1c.<\/li>\n<\/ul>\n<\/li>\n<li>T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c:\n<ul>\n<li>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi eszopiclone v\u1edbi r\u01b0\u1ee3u, benzodiazepin, opioid ho\u1eb7c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 t\u0103ng nguy c\u01a1 x\u1ea3y ra c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/li>\n<li>C\u1ea7n c\u00e2n nh\u1eafc \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng khi d\u00f9ng eszopiclone c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/li>\n<li>Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u1ed3ng th\u1eddi eszopiclone v\u1edbi c\u00e1c thu\u1ed1c an th\u1ea7n ho\u1eb7c thu\u1ed1c ng\u1ee7 kh\u00e1c.<\/li>\n<\/ul>\n<\/li>\n<li>Nguy c\u01a1 suy gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng t\u00e2m th\u1ea7n v\u00e0o ng\u00e0y h\u00f4m sau: Nguy c\u01a1 n\u00e0y t\u0103ng l\u00ean n\u1ebfu d\u00f9ng eszopiclone v\u1edbi li\u1ec1u cao h\u01a1n khuy\u1ebfn c\u00e1o, khi kh\u00f4ng ng\u1ee7 \u0111\u1ee7 gi\u1ea5c ho\u1eb7c khi d\u00f9ng c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 eszopiclone trong m\u00e1u.<\/li>\n<li>\u0110\u00e1nh gi\u00e1 c\u00e1c b\u1ec7nh l\u00fd \u0111\u1ed3ng th\u1eddi:\n<ul>\n<li>R\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 c\u00f3 th\u1ec3 l\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a m\u1ed9t b\u1ec7nh l\u00fd t\u00e2m th\u1ea7n ho\u1eb7c th\u1ec3 ch\u1ea5t kh\u00e1c.<\/li>\n<li>N\u1ebfu t\u00ecnh tr\u1ea1ng m\u1ea5t ng\u1ee7 kh\u00f4ng c\u1ea3i thi\u1ec7n sau 7-10 ng\u00e0y \u0111i\u1ec1u tr\u1ecb, c\u1ea7n \u0111\u00e1nh gi\u00e1 l\u1ea1i c\u00e1c nguy\u00ean nh\u00e2n ti\u1ec1m \u1ea9n.<\/li>\n<li>N\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u b\u1ea5t th\u01b0\u1eddng nh\u01b0 thay \u0111\u1ed5i trong suy ngh\u0129 ho\u1eb7c h\u00e0nh vi, c\u1ea7n ng\u1eebng thu\u1ed1c v\u00e0 t\u00ecm ki\u1ebfm s\u1ef1 t\u01b0 v\u1ea5n y t\u1ebf.<\/li>\n<\/ul>\n<\/li>\n<li>Ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 nghi\u00eam tr\u1ecdng v\u00e0 ph\u00f9 m\u1ea1ch:\n<ul>\n<li>M\u1eb7c d\u00f9 hi\u1ebfm g\u1eb7p, eszopiclone c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng nghi\u00eam tr\u1ecdng, ch\u1eb3ng h\u1ea1n nh\u01b0 ph\u00f9 m\u1ea1ch (s\u01b0ng ph\u00f9 \u1edf m\u1eb7t, l\u01b0\u1ee1i, h\u1ecdng), c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng.<\/li>\n<li>N\u1ebfu x\u1ea3y ra ph\u1ea3n \u1ee9ng ph\u00f9 m\u1ea1ch, kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng l\u1ea1i eszopiclone.<\/li>\n<\/ul>\n<\/li>\n<li>Thay \u0111\u1ed5i suy ngh\u0129 v\u00e0 h\u00e0nh vi:\n<ul>\n<li>Eszopiclone c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c thay \u0111\u1ed5i trong suy ngh\u0129 v\u00e0 h\u00e0nh vi, bao g\u1ed3m gi\u1ea3m \u1ee9c ch\u1ebf, h\u00e0nh vi k\u1ef3 l\u1ea1, k\u00edch \u0111\u1ed9ng, \u1ea3o gi\u00e1c v\u00e0 r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c.<\/li>\n<li>Thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam t\u00ecnh tr\u1ea1ng tr\u1ea7m c\u1ea3m v\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 c\u00f3 \u00fd ngh\u0129 t\u1ef1 t\u1eed.<\/li>\n<li>N\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 thay \u0111\u1ed5i b\u1ea5t th\u01b0\u1eddng n\u00e0o trong suy ngh\u0129 ho\u1eb7c h\u00e0nh vi, c\u1ea7n th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 ngay l\u1eadp t\u1ee9c.<\/li>\n<\/ul>\n<\/li>\n<li>Hi\u1ec7u \u1ee9ng cai thu\u1ed1c: Ng\u1eebng \u0111\u1ed9t ng\u1ed9t ho\u1eb7c gi\u1ea3m li\u1ec1u nhanh ch\u00f3ng eszopiclone c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng cai thu\u1ed1c t\u01b0\u01a1ng t\u1ef1 nh\u01b0 khi ng\u1eebng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<h4>Th\u01b0\u1eddng g\u1eb7p<\/h4>\n<ul>\n<li>\u0110au ng\u1ef1c.<\/li>\n<li>\u0110au n\u1eeda \u0111\u1ea7u.<\/li>\n<li>Ph\u00f9 m\u1ea1ch ngo\u1ea1i bi\u00ean.<\/li>\n<\/ul>\n<h4>\u00cdt g\u1eb7p<\/h4>\n<ul>\n<li>To\u00e0n th\u00e2n: C\u00e1c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, vi\u00eam m\u00f4 t\u1ebf b\u00e0o, ph\u00f9 m\u1eb7t, s\u1ed1t, h\u00f4i mi\u1ec7ng, \u0111\u1ed9t qu\u1ef5, sa ru\u1ed9t, kh\u00f3 ch\u1ecbu, c\u1ee9ng c\u1ed5, t\u0103ng nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng.<\/li>\n<li>Tim m\u1ea1ch: T\u0103ng huy\u1ebft \u00e1p.<\/li>\n<li>Ti\u00eau h\u00f3a: Ch\u00e1n \u0103n, s\u1ecfi m\u1eadt, t\u0103ng c\u1ea3m gi\u00e1c th\u00e8m \u0103n, xu\u1ea5t hi\u1ec7n m\u00e1u \u0111en trong ph\u00e2n, lo\u00e9t mi\u1ec7ng, kh\u00e1t n\u01b0\u1edbc, vi\u00eam lo\u00e9t mi\u1ec7ng.<\/li>\n<li>Thi\u1ebfu m\u00e1u, b\u1ec7nh h\u1ea1ch b\u1ea1ch huy\u1ebft.<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: T\u0103ng cholesterol m\u00e1u, t\u0103ng c\u00e2n ho\u1eb7c gi\u1ea3m c\u00e2n.<\/li>\n<li>C\u01a1 x\u01b0\u01a1ng: Vi\u00eam kh\u1edbp, vi\u00eam t\u00fai thanh m\u1ea1c, c\u00e1c r\u1ed1i lo\u1ea1n kh\u1edbp x\u01b0\u01a1ng (nh\u01b0 s\u01b0ng, c\u1ee9ng v\u00e0 \u0111au kh\u1edbp), chu\u1ed9t r\u00fat \u1edf ch\u00e2n, nh\u01b0\u1ee3c c\u01a1, co gi\u1eadt c\u01a1.<\/li>\n<li>H\u1ec7 th\u1ea7n kinh: K\u00edch \u0111\u1ed9ng, th\u1edd \u01a1, m\u1ea5t \u0111i\u1ec1u h\u00f2a, thay \u0111\u1ed5i c\u1ea3m x\u00fac, c\u00f3 c\u00e1c \u00fd t\u01b0\u1edfng ch\u1ed1ng \u0111\u1ed1i, t\u0103ng tr\u01b0\u01a1ng l\u1ef1c c\u01a1, gi\u1ea3m c\u1ea3m gi\u00e1c, m\u1ea5t ng\u1ee7, suy gi\u1ea3m tr\u00ed nh\u1edb, r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n, rung gi\u1eadt nh\u00e3n c\u1ea7u, d\u1ecb c\u1ea3m, gi\u1ea3m ph\u1ea3n x\u1ea1, c\u00f3 c\u00e1c suy ngh\u0129 b\u1ea5t th\u01b0\u1eddng, ch\u00f3ng m\u1eb7t.<\/li>\n<li>H\u00f4 h\u1ea5p: Vi\u00eam thanh qu\u1ea3n, hen suy\u1ec5n, kh\u00f3 th\u1edf, vi\u00eam ph\u1ebf qu\u1ea3n, ch\u1ea3y m\u00e1u cam.<\/li>\n<li>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: M\u1ee5n tr\u1ee9ng c\u00e1, r\u1ee5ng t\u00f3c, vi\u00eam da ti\u1ebfp x\u00fac, kh\u00f4 da, eczema, thay \u0111\u1ed5i m\u00e0u da, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i, n\u1ed5i m\u1ec1 \u0111ay.<\/li>\n<li>C\u00e1c gi\u00e1c quan: Vi\u00eam k\u1ebft m\u1ea1c, vi\u00eam tai gi\u1eefa, \u00f9 tai, kh\u00f4 m\u1eaft, \u0111au tai.<\/li>\n<li>Sinh d\u1ee5c &#8211; ti\u1ebft ni\u1ec7u: M\u1ea5t kinh nguy\u1ec7t, \u1ee9 s\u1eefa, u v\u00fa, \u0111au ng\u1ef1c, ti\u1ec3u kh\u00f3, ch\u1ea3y s\u1eefa \u1edf n\u1eef gi\u1edbi, ti\u1ec3u ra m\u00e1u, s\u1ecfi th\u1eadn, \u0111au th\u1eadn, vi\u00eam tuy\u1ebfn v\u00fa, rong kinh, xu\u1ea5t huy\u1ebft t\u1eed cung, ti\u1ec3u nhi\u1ec1u, kh\u00f3 ti\u1ec3u, \u0111\u00e1i d\u1ea7m, xu\u1ea5t huy\u1ebft \u00e2m \u0111\u1ea1o, vi\u00eam \u00e2m \u0111\u1ea1o.<\/li>\n<\/ul>\n<h4>Hi\u1ebfm g\u1eb7p<\/h4>\n<ul>\n<li>Tim m\u1ea1ch: Vi\u00eam t\u1eafc t\u0129nh m\u1ea1ch.<\/li>\n<li>Ti\u00eau h\u00f3a: Xu\u1ea5t huy\u1ebft tr\u1ef1c tr\u00e0ng, vi\u00eam \u0111\u1ea1i tr\u00e0ng, vi\u00eam d\u1ea1 d\u00e0y, kh\u00f3 nu\u1ed1t, vi\u00eam d\u1ea1 d\u00e0y, vi\u00eam gan.<\/li>\n<li>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: M\u1ea5t n\u01b0\u1edbc, b\u1ec7nh g\u00fat, t\u0103ng lipid m\u00e1u, gi\u1ea3m kali m\u00e1u.<\/li>\n<li>C\u01a1 x\u01b0\u01a1ng: B\u1ec7nh c\u01a1, vi\u00eam kh\u1edbp, run.<\/li>\n<li>H\u1ec7 th\u1ea7n kinh: D\u00e1ng \u0111i b\u1ea5t th\u01b0\u1eddng, t\u0103ng \u0111\u1ed9ng, t\u0103ng c\u1ea3m gi\u00e1c, gi\u1ea3m ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng, vi\u00eam d\u00e2y th\u1ea7n kinh, b\u1ec7nh th\u1ea7n kinh, cho\u00e1ng v\u00e1ng, run.<\/li>\n<li>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: r\u1eadm l\u00f4ng, nhi\u1ec5m virus Herpes.<\/li>\n<li>C\u00e1c gi\u00e1c quan: T\u0103ng th\u00ednh l\u1ef1c, vi\u00eam m\u1ed1ng m\u1eaft, gi\u00e3n \u0111\u1ed3ng t\u1eed, s\u1ee3 \u00e1nh s\u00e1ng.<\/li>\n<li>Sinh d\u1ee5c &#8211; ti\u1ebft ni\u1ec7u: Gi\u1ea3m l\u01b0\u1ee3ng n\u01b0\u1edbc ti\u1ec3u, vi\u00eam b\u1ec3 th\u1eadn, vi\u00eam ni\u1ec7u \u0111\u1ea1o.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Ethanol: L\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf l\u00ean h\u1ec7 th\u1ea7n kinh v\u1eadn \u0111\u1ed9ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi eszopiclone.<\/li>\n<li>Olanzapin: Khi d\u00f9ng chung, eszopiclone v\u00e0 olanzapin c\u00f3 th\u1ec3 g\u00e2y ra t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc, l\u00e0m gi\u1ea3m ch\u1ec9 s\u1ed1 DSST. N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a (Cmax) c\u1ee7a c\u1ea3 hai thu\u1ed1c \u0111\u1ec1u gi\u1ea3m.<\/li>\n<li>Lorazepam: D\u00f9ng \u0111\u1ed3ng th\u1eddi eszopiclone v\u00e0 lorazepam li\u1ec1u \u0111\u01a1n kh\u00f4ng th\u1ea5y c\u00f3 t\u01b0\u01a1ng t\u00e1c \u0111\u00e1ng k\u1ec3 v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc ho\u1eb7c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc.<\/li>\n<li>Paroxetin: T\u01b0\u01a1ng t\u1ef1 nh\u01b0 lorazepam, d\u00f9ng li\u1ec1u \u0111\u01a1n eszopiclone c\u00f9ng paroxetin kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng ho\u1eb7c d\u01b0\u1ee3c l\u1ef1c r\u00f5 r\u1ec7t. Tuy nhi\u00ean, kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c khi d\u00f9ng k\u00e9o d\u00e0i.<\/li>\n<li>C\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 (v\u00ed d\u1ee5: Rifampicin) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 eszopiclone v\u00e0 do \u0111\u00f3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/li>\n<li>C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 (v\u00ed d\u1ee5: Ketoconazol, itraconazol, clarithromycin, ritonavir, nelfinavir) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 eszopiclone. C\u1ea7n c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u eszopiclone khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4.<\/li>\n<li>Digoxin: Eszopiclone kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a digoxin khi d\u00f9ng chung.<\/li>\n<li>Warfarin: T\u01b0\u01a1ng t\u1ef1, eszopiclone kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc ho\u1eb7c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc c\u1ee7a warfarin.<\/li>\n<li>Thu\u1ed1c g\u1eafn k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng: Eszopiclone c\u00f3 t\u1ef7 l\u1ec7 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u1edf m\u1ee9c trung b\u00ecnh (52-59%). Do \u0111\u00f3, d\u1ef1 ki\u1ebfn kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn s\u1ef1 ph\u00e2n b\u1ed1 c\u1ee7a eszopiclone khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c c\u00f3 t\u1ef7 l\u1ec7 g\u1eafn k\u1ebft protein cao.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<ul>\n<li>Hi\u1ec7n t\u1ea1i, ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng eszopiclone \u1edf ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa.<\/li>\n<li>Ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng eszopiclone \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y khi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb l\u1edbn h\u01a1n nguy c\u01a1 ti\u1ec1m \u1ea9n cho thai nhi ho\u1eb7c tr\u1ebb s\u01a1 sinh.<\/li>\n<\/ul>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>N\u1ebfu x\u1ea3y ra qu\u00e1 li\u1ec1u, ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u01b0a \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf ngay l\u1eadp t\u1ee9c \u0111\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u1ee3ng t\u1ef1 thu\u1ed1c CHALKAS-2<\/h2>\n<p><a href=\"https:\/\/vnras.com\/drug\/neuractin\/\">Neuractin<\/a> c\u00f3 th\u00e0nh ph\u1ea7n Eszopiclone 2mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m SaVi \u2013 VI\u1ec6T NAM, \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng m\u1ea5t ng\u1ee7.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Susanne R\u00f6sner, Christian Englbrecht, Renate Wehrle, G\u00f6ran Hajak, Michael Soyka. Eszopiclone for insomnia, truy c\u1eadp ng\u00e0y 17 th\u00e1ng 05 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30303519\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30303519\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c CHALKAS-2 c\u00f3 th\u00e0nh ph\u1ea7n Eszopiclone 2mg, s\u1ea3n xu\u1ea5t b\u1edfi C\u00d4NG TY C\u1ed4 PH\u1ea6N D\u01af\u1ee2C PH\u1ea8M \u0110\u1ea0T VI PH\u00da, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng m\u1ea5t ng\u1ee7, gi\u00fap gi\u1ea3m th\u1eddi gian \u0111i v\u00e0o gi\u1ea5c ng\u1ee7 v\u00e0 duy tr\u00ec gi\u1ea5c ng\u1ee7.<\/p>\n","protected":false},"author":1,"featured_media":119349,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-119346","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/119346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=119346"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/119349"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=119346"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=119346"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=119346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}