{"id":114907,"date":"2025-04-14T16:40:48","date_gmt":"2025-04-14T09:40:48","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&#038;p=114907"},"modified":"2025-07-24T13:16:42","modified_gmt":"2025-07-24T06:16:42","slug":"tripta-10mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/tripta-10mg\/","title":{"rendered":"Tripta 10mg"},"content":{"rendered":"<p>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 Ph\u1ea1m Chi\u1ebfn gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m <strong>thu\u1ed1c Tripta 10mg<\/strong> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Atlantic Pharma, \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m.<\/p>\n<h2>Tripta 10mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p>Thu\u1ed1c <strong>Tripta 10mg<\/strong> ch\u1ee9a:<\/p>\n<ul>\n<li>Amitriptyline HCl: 10mg<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<figure id=\"attachment_114917\" aria-describedby=\"caption-attachment-114917\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-114917\" src=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/04\/Tripta-10mg.jpg\" alt=\"Tripta 10mg\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/04\/Tripta-10mg.jpg 1200w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/04\/Tripta-10mg-600x400.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/04\/Tripta-10mg-768x512.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2025\/04\/Tripta-10mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-114917\" class=\"wp-caption-text\">Tripta 10mg \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m<\/figcaption><\/figure>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: \u0110ang c\u1eadp nh\u1eadt<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1000 vi\u00ean<\/p>\n<h2>Xu\u1ea5t x\u1ee9: Th\u00e1i Lan<\/h2>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Tripta 10mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Amitriptyline l\u00e0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng, \u0111\u1ed3ng th\u1eddi c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au. Thu\u1ed1c c\u00f3 \u0111\u1eb7c t\u00ednh an th\u1ea7n v\u00e0 kh\u00e1ng cholinergic m\u1ea1nh. C\u01a1 ch\u1ebf ch\u00ednh l\u00e0 \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu serotonin v\u00e0 noradrenaline t\u1ea1i synap th\u1ea7n kinh, gi\u00fap t\u0103ng ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh n\u00e0y trong n\u00e3o &#8211; y\u1ebfu t\u1ed1 quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m.<\/p>\n<p>Ngo\u00e0i ra, thu\u1ed1c c\u00f2n \u1ee9c ch\u1ebf c\u00e1c k\u00eanh ion (natri, kali, NMDA) \u1edf n\u00e3o v\u00e0 t\u1ee7y s\u1ed1ng, g\u00f3p ph\u1ea7n v\u00e0o hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au, \u0111\u1eb7c bi\u1ec7t trong \u0111au th\u1ea7n kinh, \u0111au \u0111\u1ea7u do c\u0103ng th\u1eb3ng v\u00e0 \u0111au n\u1eeda \u0111\u1ea7u.<\/p>\n<p>Amitriptyline c\u00f2n g\u1eafn k\u1ebft v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 muscarinic v\u00e0 histamine H1 v\u1edbi m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu: Sau khi u\u1ed1ng, amitriptyline h\u1ea5p thu ch\u1eadm nh\u01b0ng g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong m\u00e1u th\u01b0\u1eddng \u0111\u1ea1t sau 1 &#8211; 8 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 50%.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp c\u01a1 th\u1ec3 v\u00e0 g\u1eafn k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (95%). Amitriptyline v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 th\u1ec3 \u0111i qua nhau thai v\u00e0 b\u00e0i ti\u1ebft m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Thu\u1ed1c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu t\u1ea1i gan th\u00f4ng qua c\u00e1c enzyme CYP2C19, CYP3A4 v\u00e0 CYP2D6. Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 nortriptyline v\u1eabn c\u00f2n ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd. M\u1ed9t s\u1ed1 ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00e1c y\u1ebfu h\u01a1n v\u00e0 \u00edt \u0111\u1ed9c t\u00ednh h\u01a1n.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n h\u1ee7y trung b\u00ecnh kho\u1ea3ng 25 gi\u1edd. Ch\u1ee7 y\u1ebfu \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng \u0111\u00e3 chuy\u1ec3n h\u00f3a, l\u01b0\u1ee3ng b\u00e0i ti\u1ebft nguy\u00ean v\u1eb9n qua th\u1eadn kh\u00f4ng \u0111\u00e1ng k\u1ec3. N\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh trong m\u00e1u \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng m\u1ed9t tu\u1ea7n \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c.<\/p>\n<h2>Thu\u1ed1c Tripta 10mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<p>Tripta 10mg \u0111\u01b0\u1ee3c d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/p>\n<ul>\n<li>Tr\u1ea7m c\u1ea3m n\u1eb7ng<\/li>\n<li>\u0110au th\u1ea7n kinh<\/li>\n<li>Ph\u00f2ng ng\u1eeba \u0111au \u0111\u1ea7u do c\u0103ng th\u1eb3ng m\u1ea1n t\u00ednh v\u00e0 \u0111au n\u1eeda \u0111\u1ea7u<\/li>\n<\/ul>\n<p>\u1ede tr\u1ebb t\u1eeb 6 tu\u1ed5i tr\u1edf l\u00ean, thu\u1ed1c c\u00f3 th\u1ec3 d\u00f9ng \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i d\u1ea7m ban \u0111\u00eam khi kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c v\u00e0 \u0111\u00e3 lo\u1ea1i tr\u1eeb nguy\u00ean nh\u00e2n th\u1ef1c th\u1ec3.<\/p>\n<h2>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n<h3>Li\u1ec1u d\u00f9ng<\/h3>\n<h4>Tr\u1ea7m c\u1ea3m n\u1eb7ng<\/h4>\n<p>Ng\u01b0\u1eddi l\u1edbn: B\u1eaft \u0111\u1ea7u 25 mg x 2 l\u1ea7n\/ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng d\u1ea7n \u0111\u1ebfn t\u1ed1i \u0111a 150 mg\/ng\u00e0y n\u1ebfu c\u1ea7n. Duy tr\u00ec v\u1edbi li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 b\u1ec7nh nh\u00e2n tim m\u1ea1ch: B\u1eaft \u0111\u1ea7u 10 &#8211; 25 mg\/ng\u00e0y, c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ebfn 100 &#8211; 150 mg\/ng\u00e0y t\u00f9y \u0111\u00e1p \u1ee9ng.<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: T\u00e1c d\u1ee5ng th\u01b0\u1eddng b\u1eaft \u0111\u1ea7u t\u1eeb sau 2 &#8211; 4 tu\u1ea7n. N\u00ean duy tr\u00ec \u00edt nh\u1ea5t 6 th\u00e1ng sau h\u1ed3i ph\u1ee5c \u0111\u1ec3 tr\u00e1nh t\u00e1i ph\u00e1t.<\/p>\n<h4>\u0110au th\u1ea7n kinh v\u00e0 d\u1ef1 ph\u00f2ng \u0111au \u0111\u1ea7u m\u1ea1n<\/h4>\n<p>Ng\u01b0\u1eddi l\u1edbn: 25 &#8211; 75 mg\/ng\u00e0y, d\u00f9ng v\u00e0o bu\u1ed5i t\u1ed1i; c\u00f3 th\u1ec3 t\u0103ng m\u1ed7i 3 &#8211; 7 ng\u00e0y t\u00f9y \u0111\u00e1p \u1ee9ng. Tr\u00e1nh d\u00f9ng li\u1ec1u \u0111\u01a1n &gt;75 mg.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 b\u1ec7nh nh\u00e2n tim: B\u1eaft \u0111\u1ea7u t\u1eeb 10 &#8211; 25 mg bu\u1ed5i t\u1ed1i, th\u1eadn tr\u1ecdng v\u1edbi li\u1ec1u tr\u00ean 75 mg.<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb: T\u00f9y t\u00ecnh tr\u1ea1ng b\u1ec7nh. N\u00ean \u0111\u00e1nh gi\u00e1 l\u1ea1i \u0111\u1ecbnh k\u1ef3 \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh nhu c\u1ea7u ti\u1ebfp t\u1ee5c d\u00f9ng thu\u1ed1c.<\/p>\n<h4>\u0110\u00e1i d\u1ea7m ban \u0111\u00eam (tr\u1ebb \u22656 tu\u1ed5i)<\/h4>\n<p>Tr\u1ebb 6 &#8211; 10 tu\u1ed5i: 10 &#8211; 20 mg<\/p>\n<p>Tr\u1ebb \u226511 tu\u1ed5i: 25 &#8211; 50 mg<\/p>\n<p>D\u00f9ng tr\u01b0\u1edbc khi ng\u1ee7 1 &#8211; 1,5 gi\u1edd. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 3 th\u00e1ng, kh\u00e1m l\u1ea1i m\u1ed7i 3 th\u00e1ng n\u1ebfu c\u1ea7n \u0111i\u1ec1u tr\u1ecb ti\u1ebfp.<\/p>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p>D\u00f9ng thu\u1ed1c Tripta 10mg qua \u0111\u01b0\u1eddng u\u1ed1ng. Ng\u01b0ng thu\u1ed1c n\u00ean gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb trong v\u00e0i tu\u1ea7n.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng Tripta 10mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ng\u01b0\u1eddi t\u1eebng b\u1ecb d\u1ecb \u1ee9ng v\u1edbi th\u00e0nh ph\u1ea7n trong thu\u1ed1c.<\/p>\n<p>Nh\u1ed3i m\u00e1u c\u01a1 tim (th\u1eddi gian g\u1ea7n), block, r\u1ed1i lo\u1ea1n nh\u1ecbp tim, suy \u0111\u1ed9ng m\u1ea1ch v\u00e0nh.<\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi MAOI ho\u1eb7c trong v\u00f2ng 14 ng\u00e0y k\u1ec3 t\u1eeb khi ng\u1eebng MAOI.<\/p>\n<p>Ng\u01b0\u1eddi g\u1eb7p t\u00ecnh tr\u1ea1ng suy gan n\u1eb7ng.<\/p>\n<p>Tr\u1ebb em nh\u1ecf h\u01a1n 6 tu\u1ed5i.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>Khi b\u1ec7nh nh\u00e2n s\u1eafp ph\u1eabu thu\u1eadt, n\u00ean ng\u1eebng thu\u1ed1c v\u00e0i ng\u00e0y tr\u01b0\u1edbc \u0111\u00f3 n\u1ebfu c\u00f3 th\u1ec3. N\u1ebfu kh\u00f4ng, b\u00e1c s\u0129 g\u00e2y m\u00ea c\u1ea7n bi\u1ebft b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng amitriptyline.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng v\u1edbi ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9ng kinh, b\u00ed ti\u1ec3u, ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t, hoang t\u01b0\u1edfng, b\u1ec7nh tim gan ti\u1ebfn tri\u1ec3n, li\u1ec7t ru\u1ed9t ho\u1eb7c h\u1eb9p m\u00f4n v\u1ecb.<\/p>\n<p>Tr\u1ea7m c\u1ea3m l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng ngh\u0129 \u0111\u1ebfn ho\u1eb7c h\u00e0nh vi t\u1ef1 t\u1eed, \u0111\u1eb7c bi\u1ec7t trong nh\u1eefng tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb. C\u1ea7n theo d\u00f5i s\u00e1t, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi d\u01b0\u1edbi 25 tu\u1ed5i ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed h\u00e0nh vi t\u1ef1 t\u1eed.<\/p>\n<p>N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh chuy\u1ec3n sang h\u01b0ng c\u1ea3m, n\u00ean ng\u1eebng thu\u1ed1c.<\/p>\n<p>Ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t sau th\u1eddi gian d\u00f9ng d\u00e0i c\u00f3 th\u1ec3 g\u00e2y tri\u1ec7u ch\u1ee9ng nh\u01b0 c\u00e1u g\u1eaft, m\u1ea5t ng\u1ee7, \u0111au \u0111\u1ea7u.<\/p>\n<p>V\u1edbi \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i d\u1ea7m: N\u00ean ki\u1ec3m tra \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 lo\u1ea1i tr\u1eeb h\u1ed9i ch\u1ee9ng QT k\u00e9o d\u00e0i.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 g\u1eb7p \u1edf nhi\u1ec1u h\u1ec7 c\u01a1 quan. M\u1ed9t s\u1ed1 nh\u00f3m \u0111\u00e1ng l\u01b0u \u00fd g\u1ed3m:<\/p>\n<ul>\n<li>H\u1ec7 m\u00e1u: Hi\u1ebfm g\u1eb7p nh\u01b0 gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, suy t\u1ee7y.<\/li>\n<li>Mi\u1ec5n d\u1ecbch: C\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n v\u1ec7, ph\u00f9 m\u1ea1ch.<\/li>\n<li>T\u00e2m th\u1ea7n: Th\u01b0\u1eddng g\u1eb7p t\u00ecnh tr\u1ea1ng hung h\u0103ng, l\u00fa l\u1eabn, m\u1ea5t ng\u1ee7, lo \u00e2u, trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn \u1ea3o gi\u00e1c, h\u00e0nh vi t\u1ef1 s\u00e1t.<\/li>\n<li>Th\u1ea7n kinh: Bu\u1ed3n ng\u1ee7, run, \u0111au \u0111\u1ea7u, r\u1ed1i lo\u1ea1n th\u0103ng b\u1eb1ng. Hi\u1ebfm khi g\u00e2y co gi\u1eadt, r\u1ed1i lo\u1ea1n ngo\u1ea1i th\u00e1p.<\/li>\n<li>M\u1eaft: R\u1ed1i lo\u1ea1n \u0111i\u1ec1u ti\u1ebft, gi\u00e3n \u0111\u1ed3ng t\u1eed, hi\u1ebfm khi t\u0103ng nh\u00e3n \u00e1p c\u1ea5p.<\/li>\n<li>Tim m\u1ea1ch: \u0110\u00e1nh tr\u1ed1ng ng\u1ef1c, r\u1ed1i lo\u1ea1n nh\u1ecbp tim, t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng, r\u1ea5t hi\u1ebfm c\u00f3 th\u1ec3 g\u00e2y vi\u00eam c\u01a1 tim.<\/li>\n<li>H\u00f4 h\u1ea5p: Ngh\u1eb9t m\u0169i ph\u1ed5 bi\u1ebfn, hi\u1ebfm g\u1eb7p vi\u00eam ph\u1ed5i d\u1ecb \u1ee9ng.Ti\u00eau h\u00f3a: Kh\u00f4 mi\u1ec7ng, t\u00e1o b\u00f3n, bu\u1ed3n n\u00f4n l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng ph\u1ed5 bi\u1ebfn. Hi\u1ebfm g\u1eb7p li\u1ec7t ru\u1ed9t ho\u1eb7c v\u00e0ng da.<\/li>\n<li>Da: T\u0103ng ti\u1ebft m\u1ed3 h\u00f4i, n\u1ed5i m\u1ec1 \u0111ay, hi\u1ebfm g\u1eb7p r\u1ee5ng t\u00f3c, ph\u1ea3n \u1ee9ng DRESS.<\/li>\n<li>Ti\u1ebft ni\u1ec7u &#8211; sinh d\u1ee5c: R\u1ed1i lo\u1ea1n ti\u1ec3u ti\u1ec7n, r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng, ti\u1ebft s\u1eefa b\u1ea5t th\u01b0\u1eddng.<\/li>\n<li>To\u00e0n th\u00e2n: M\u1ec7t m\u1ecfi, kh\u00e1t n\u01b0\u1edbc, t\u0103ng ho\u1eb7c gi\u1ea3m c\u00e2n, r\u1ed1i lo\u1ea1n ECG.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<p>T\u01b0\u01a1ng t\u00e1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh: Kh\u00f4ng ph\u1ed1i h\u1ee3p amitriptyline v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf MAO (c\u1ea3 ch\u1ecdn l\u1ecdc v\u00e0 kh\u00f4ng ch\u1ecdn l\u1ecdc) do nguy c\u01a1 g\u00e2y h\u1ed9i ch\u1ee9ng serotonin nghi\u00eam tr\u1ecdng.<\/p>\n<p>T\u01b0\u01a1ng t\u00e1c c\u1ea7n th\u1eadn tr\u1ecdng, n\u00ean tr\u00e1nh d\u00f9ng chung:<\/p>\n<ul>\n<li>Thu\u1ed1c c\u01b0\u1eddng giao c\u1ea3m: Amitriptyline c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c nh\u01b0 adrenaline, noradrenaline, d\u1eabn \u0111\u1ebfn nguy c\u01a1 tim m\u1ea1ch.<\/li>\n<li>Thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p t\u00e1c d\u1ee5ng trung \u01b0\u01a1ng: C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u00e1c thu\u1ed1c nh\u01b0 clonidine, methyldopa, guanethidine.<\/li>\n<li>Thu\u1ed1c kh\u00e1ng cholinergic: L\u00e0m t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 li\u1ec7t ru\u1ed9t, b\u00ed ti\u1ec3u, t\u0103ng th\u00e2n nhi\u1ec7t.<\/li>\n<li>C\u00e1c thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT: Nguy c\u01a1 lo\u1ea1n nh\u1ecbp tim t\u0103ng khi d\u00f9ng k\u00e8m c\u00e1c thu\u1ed1c nh\u01b0 quinidine, sotalol, cisapride, pimozide\u2026<\/li>\n<li>Methadone ho\u1eb7c thu\u1ed1c l\u1ee3i ti\u1ec3u g\u00e2y h\u1ea1 kali: L\u00e0m t\u0103ng nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 tim m\u1ea1ch.<\/li>\n<li>Thioridazine, tramadol: T\u0103ng nguy c\u01a1 co gi\u1eadt, k\u00e9o d\u00e0i QT ho\u1eb7c h\u1ed9i ch\u1ee9ng serotonin.<\/li>\n<li>Thu\u1ed1c ch\u1ed1ng n\u1ea5m nh\u01b0 fluconazole, terbinafine: C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 amitriptyline trong m\u00e1u, g\u00e2y ng\u1ed9 \u0111\u1ed9c.<\/li>\n<li>Thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng: C\u00f3 th\u1ec3 t\u0103ng hi\u1ec7u l\u1ef1c an th\u1ea7n khi d\u00f9ng chung v\u1edbi r\u01b0\u1ee3u, barbiturat, thu\u1ed1c ng\u1ee7.<\/li>\n<\/ul>\n<p>\u1ea2nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c kh\u00e1c \u0111\u1ebfn amitriptyline:<\/p>\n<ul>\n<li>Amitriptyline b\u1ecb chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu b\u1edfi c\u00e1c enzym gan CYP2D6, CYP2C19 v\u00e0 m\u1ed9t ph\u1ea7n b\u1edfi CYP3A4, CYP1A2, CYP2C9.<\/li>\n<li>Ch\u1ea5t \u1ee9c ch\u1ebf CYP2D6 m\u1ea1nh nh\u01b0 fluoxetine, paroxetine, quinidine&#8230; c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 amitriptyline \u0111\u00e1ng k\u1ec3, c\u1ea7n theo d\u00f5i ho\u1eb7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u.<\/li>\n<li>Cimetidine, diltiazem, methylphenidate&#8230; c\u0169ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u.<\/li>\n<li>Fluvoxamine (\u1ee9c ch\u1ebf CYP1A2): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 amitriptyline, n\u00ean tr\u00e1nh k\u1ebft h\u1ee3p.<\/li>\n<li>C\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng enzym gan nh\u01b0 rifampicin, phenytoin, carbamazepine, barbiturat v\u00e0 c\u00e2y ban \u00c2u c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 amitriptyline, g\u00e2y gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/li>\n<li>Valproate v\u00e0 valpromide: L\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 amitriptyline, n\u00ean theo d\u00f5i l\u00e2m s\u00e0ng s\u00e1t.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa<\/h3>\n<p>Mang thai: D\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c d\u00f9ng amitriptyline khi mang thai c\u00f2n h\u1ea1n ch\u1ebf. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y thu\u1ed1c c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n. Ch\u1ec9 n\u00ean d\u00f9ng khi th\u1eadt s\u1ef1 c\u1ea7n, sau khi c\u00e2n nh\u1eafc l\u1ee3i \u00edch v\u00e0 r\u1ee7i ro.<\/p>\n<p>Cho con b\u00fa: Amitriptyline v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111i v\u00e0o s\u1eefa m\u1eb9 v\u1edbi l\u01b0\u1ee3ng nh\u1ecf. D\u00f9 nguy c\u01a1 cho tr\u1ebb ch\u01b0a r\u00f5, c\u1ea7n c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb cho m\u1eb9 v\u00e0 vi\u1ec7c ti\u1ebfp t\u1ee5c cho b\u00fa.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Amitriptyline g\u00e2y an th\u1ea7n, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 t\u1eadp trung. Ng\u01b0\u1eddi d\u00f9ng c\u1ea7n tr\u00e1nh l\u00e1i xe ho\u1eb7c \u0111i\u1ec1u khi\u1ec3n m\u00e1y m\u00f3c, \u0111\u1eb7c bi\u1ec7t khi u\u1ed1ng r\u01b0\u1ee3u ho\u1eb7c d\u00f9ng thu\u1ed1c h\u01b0\u1edbng th\u1ea7n k\u00e8m theo.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Tri\u1ec7u ch\u1ee9ng: Qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng kh\u00e1ng cholinergic (gi\u00e3n \u0111\u1ed3ng t\u1eed, tim \u0111\u1eadp nhanh, b\u00ed ti\u1ec3u), \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, co gi\u1eadt, h\u00f4n m\u00ea, lo\u1ea1n nh\u1ecbp tim n\u1eb7ng, h\u00f4 h\u1ea5p k\u00e9m, r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i, toan chuy\u1ec3n h\u00f3a. \u1ede tr\u1ebb em, qu\u00e1 li\u1ec1u \u0111\u1eb7c bi\u1ec7t nguy hi\u1ec3m v\u1edbi c\u00e1c bi\u1ec3u hi\u1ec7n th\u1ea7n kinh, h\u00f4 h\u1ea5p v\u00e0 tim m\u1ea1ch. T\u00ecnh tr\u1ea1ng l\u00fa l\u1eabn v\u00e0 \u1ea3o gi\u00e1c c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n khi h\u1ed3i ph\u1ee5c.<\/p>\n<p>X\u1eed tr\u00ed: Nh\u1eadp vi\u1ec7n n\u1ebfu c\u1ea7n, theo d\u00f5i v\u00e0 \u0111i\u1ec1u tr\u1ecb theo t\u00ecnh tr\u1ea1ng, tri\u1ec7u ch\u1ee9ng. Do qu\u00e1 li\u1ec1u th\u01b0\u1eddng l\u00e0 do c\u1ed1 \u00fd, c\u1ea7n \u0111\u00e1nh gi\u00e1 nguy c\u01a1 t\u1ef1 t\u1eed khi h\u1ed3i ph\u1ee5c.<\/p>\n<h2>Thu\u1ed1c Tripta 10mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n<p>Thu\u1ed1c\u00a0 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p thu\u1ed1c Tripta 10m t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng nh\u01b0:<\/p>\n<ul>\n<li><a href=\"https:\/\/vnras.com\/drug\/trimibelin-10mg\/\">Trimibelin 10mg<\/a> c\u00f3 th\u00e0nh ph\u1ea7n Amitriptyline, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m. Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH li\u00ean doanh Hasan-DERMAPHARM.<\/li>\n<li><a href=\"https:\/\/vnras.com\/drug\/amilavil-10mg\/\">Amilavil 10mg<\/a> thu\u1ed9c nh\u00f3m ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m v\u00e0 tr\u1ecb \u0111\u00e1i d\u1ea7m cho tr\u1ebb t\u1eeb 6 tu\u1ed5i. S\u1ea3n ph\u1ea9m c\u00f3 gi\u00e1 70.000 VND cho m\u1ed9t h\u1ed9p 4 v\u1ec9 x 15 vi\u00ean.<\/li>\n<\/ul>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<ol>\n<li>Amitriptyline 10 mg Film-Coated Tablets, EMC. Truy c\u1eadp ng\u00e0y 14 th\u00e1ng 4 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/10849\/smpc#gref\" rel=\"noopener\">https:\/\/www.medicines.org.uk\/emc\/product\/10849\/smpc#gref<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Tripta 10mg ch\u1ee9a Amitriptyline \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m, \u0111au th\u1ea7n kinh m\u00e3n t\u00ednh, \u0111au n\u1eeda \u0111\u1ea7u v\u00e0 r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7.<\/p>\n","protected":false},"author":1,"featured_media":114922,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-114907","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/114907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=114907"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/114922"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=114907"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=114907"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=114907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}