{"id":105596,"date":"2024-11-26T16:29:15","date_gmt":"2024-11-26T09:29:15","guid":{"rendered":"https:\/\/vnras.com\/drug\/?post_type=product&p=105596"},"modified":"2025-07-24T13:22:55","modified_gmt":"2025-07-24T06:22:55","slug":"trajenta-duo-25mg-1000mg","status":"publish","type":"product","link":"https:\/\/vnras.com\/drug\/trajenta-duo-25mg-1000mg\/","title":{"rendered":"Trajenta Duo 2,5mg\/1000mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH & Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 400110085623.<\/strong><\/p>\n

<\/p>\n

Trajenta Duo 2,5mg\/1000mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Th\u00e0nh ph\u1ea7n<\/h3>\n
Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n
\n
Linagliptin 2,5mg<\/li>\n
Metformin hydrochloride 1000mg<\/li>\n
T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n
Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: 400110085623<\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd x 14 vi\u00ean<\/p>\n
Xu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
Trajenta Duo 2,5mg\/1000mg ho\u1ea1t \u0111\u1ed9ng th\u00f4ng qua s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai th\u00e0nh ph\u1ea7n ch\u00ednh, Linagliptin v\u00e0 Metformin, \u0111\u1ec3 c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.
\nLinagliptin, m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf DPP-4, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch b\u1ea3o v\u1ec7 c\u00e1c hormone incretin t\u1ef1 nhi\u00ean c\u1ee7a c\u01a1 th\u1ec3 kh\u1ecfi b\u1ecb ph\u00e2n h\u1ee7y. C\u00e1c hormone n\u00e0y, bao g\u1ed3m GLP-1 v\u00e0 GIP, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u b\u1eb1ng c\u00e1ch k\u00edch th\u00edch tuy\u1ebfn t\u1ee5y ti\u1ebft insulin khi c\u1ea7n thi\u1ebft v\u00e0 \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf s\u1ea3n xu\u1ea5t glucose \u1edf gan. Khi Linagliptin \u1ee9c ch\u1ebf enzyme DPP-4, c\u00e1c hormone incretin \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n l\u00e2u h\u01a1n, t\u1eeb \u0111\u00f3 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng c\u1ee7a ch\u00fang trong vi\u1ec7c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n
Trong khi \u0111\u00f3, Metformin, m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m biguanid, ho\u1ea1t \u0111\u1ed9ng theo nhi\u1ec1u c\u01a1 ch\u1ebf \u0111\u1ec3 gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u. Metformin gi\u00fap gi\u1ea3m s\u1ea3n xu\u1ea5t glucose \u1edf gan, t\u0103ng kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng glucose \u1edf c\u00e1c m\u00f4 ngo\u1ea1i bi\u00ean, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u01a1, v\u00e0 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh h\u1ea5p thu glucose \u1edf ru\u1ed9t.<\/p>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n\n\n\n\n\n\n\n\n\n\n
Th\u00f4ng s\u1ed1<\/strong><\/td>\n Linagliptin<\/strong><\/td>\n Metformin<\/strong><\/td>\n<\/tr>\n
H\u1ea5p thu<\/td>\n Tmax: 1,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: ~30%. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3.<\/td>\n Tmax: 2,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: 50-60%. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu (~40% Cmax, ~25% AUC).<\/td>\n<\/tr>\n
Ph\u00e2n b\u1ed1<\/td>\n Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: ~1110L. Li\u00ean k\u1ebft protein ph\u1ee5 thu\u1ed9c n\u1ed3ng \u0111\u1ed9 (99% \u1edf 1nmol\/L, gi\u1ea3m khi n\u1ed3ng \u0111\u1ed9 >30nmol\/L).<\/td>\n Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: 63-276L. G\u1eafn kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng; ph\u00e2n b\u1ed1 v\u00e0o h\u1ed3ng c\u1ea7u.<\/td>\n<\/tr>\n
Chuy\u1ec3n h\u00f3a<\/td>\n Chuy\u1ec3n h\u00f3a \u00edt; ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/td>\n Kh\u00f4ng chuy\u1ec3n h\u00f3a. \u0110\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u.<\/td>\n<\/tr>\n
Th\u1ea3i tr\u1eeb<\/td>\n Th\u1eddi gian b\u00e1n th\u1ea3i: >100 gi\u1edd (pha cu\u1ed1i). Ch\u1ee7 y\u1ebfu qua ph\u00e2n (80%), n\u01b0\u1edbc ti\u1ec3u (5%).<\/td>\n Th\u1eddi gian b\u00e1n th\u1ea3i bi\u1ec3u ki\u1ebfn: ~6,5 gi\u1edd. Th\u1ea3i tr\u1eeb qua th\u1eadn (l\u1ecdc c\u1ea7u th\u1eadn v\u00e0 b\u00e0i ti\u1ebft \u1ed1ng th\u1eadn).<\/td>\n<\/tr>\n
Suy th\u1eadn<\/td>\n Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy th\u1eadn. N\u1ed3ng \u0111\u1ed9 t\u0103ng nh\u1eb9 \u1edf suy th\u1eadn trung b\u00ecnh (~1,7 l\u1ea7n) v\u00e0 n\u1eb7ng (~1,4 l\u1ea7n).<\/td>\n Khi suy th\u1eadn, thanh th\u1ea3i gi\u1ea3m t\u1ef7 l\u1ec7 v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinine, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.<\/td>\n<\/tr>\n
Suy gan<\/td>\n Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. AUC v\u00e0 Cmax t\u01b0\u01a1ng t\u1ef1 \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy gan (Child-Pugh nh\u1eb9, trung b\u00ecnh, n\u1eb7ng).<\/td>\n Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u.<\/td>\n<\/tr>\n
Tr\u1ebb em<\/td>\n Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7.<\/td>\n N\u1ed3ng \u0111\u1ed9 Cmax v\u00e0 AUC gi\u1ea3m \u1edf tr\u1ebb em (~33% v\u00e0 ~40% so v\u1edbi ng\u01b0\u1eddi l\u1edbn); \u00edt \u00fd ngh\u0129a l\u00e2m s\u00e0ng do li\u1ec1u \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u01b0\u1eddng huy\u1ebft.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
Trajenta Duo 2,5mg\/1000mg<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh nh\u01b0 m\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng type 2 (khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng m\u00e1u) cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n
\n
B\u1ec7nh nh\u00e2n \u0111\u00e3 d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u v\u1edbi Metformin nh\u01b0ng \u0111\u01b0\u1eddng m\u00e1u v\u1eabn cao.<\/li>\n
B\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng Linagliptin v\u00e0 Metformin ri\u00eang l\u1ebb nh\u01b0ng c\u1ea7n t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/li>\n
B\u1ec7nh nh\u00e2n c\u1ea7n k\u1ebft h\u1ee3p v\u1edbi sulfonylurea \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft t\u1ed1i \u01b0u.<\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n
Li\u1ec1u khuy\u1ebfn c\u00e1o: Li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng l\u00e0 1 vi\u00ean ch\u1ee9a 2,5mg Linagliptin v\u00e0 500mg, 850mg ho\u1eb7c 1000mg Metformin, u\u1ed1ng 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n
\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u Trajenta Duo 2,5mg\/1000mg: B\u00e1c s\u0129 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n.<\/p>\n
Li\u1ec1u t\u1ed1i \u0111a: Li\u1ec1u d\u00f9ng h\u00e0ng ng\u00e0y kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 5mg Linagliptin v\u00e0 2000mg Metformin.<\/p>\n
N\u00ean u\u1ed1ng Trajenta Duo 2,5mg\/1000mg c\u00f9ng b\u1eefa \u0103n \u0111\u1ec3 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean d\u1ea1 d\u00e0y c\u1ee7a\u00a0 Metformin<\/p>\n
$\"Thu\u1ed1c$
Thu\u1ed1c Trajenta Duo 2.5mg\/1000mg d\u00f9ng cho \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o?<\/figcaption><\/figure>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Trajenta Duo 2,5mg\/1000mg 14 vi\u00ean trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
Thu\u1ed1c Trajenta Duo<\/strong> 2.5mg\/1000mg kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n
\n
Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/li>\n
\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng kh\u00f4ng ki\u1ec3m so\u00e1t: nhi\u1ec5m toan ceton ho\u1eb7c ti\u1ec1n h\u00f4n m\u00ea<\/li>\n
V\u1ea5n \u0111\u1ec1 v\u1ec1 r\u01b0\u1ee3u (nghi\u1ec7n r\u01b0\u1ee3u ho\u1eb7c ng\u1ed9 \u0111\u1ed9c c\u1ea5p t\u00ednh)<\/li>\n
Ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn n\u1eb7ng ho\u1eb7c c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u1ecb gi\u1ea3m s\u00fat \u0111\u00e1ng k\u1ec3<\/li>\n
Ng\u01b0\u1eddi b\u1ec7nh b\u1ecb suy gan<\/li>\n
T\u00ecnh tr\u1ea1ng c\u1ea5p t\u00ednh nh\u01b0 m\u1ea5t n\u01b0\u1edbc nghi\u00eam tr\u1ecdng, nhi\u1ec5m tr\u00f9ng n\u1eb7ng, s\u1ed1c ho\u1eb7c v\u1eeba th\u1ef1c hi\u1ec7n th\u1ee7 thu\u1eadt ch\u1ee5p X-quang s\u1eed d\u1ee5ng ch\u1ea5t c\u1ea3n quang<\/li>\n
Thi\u1ebfu oxy do m\u1eafc c\u00e1c b\u1ec7nh nh\u01b0 suy tim n\u1eb7ng, suy h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh, ho\u1eb7c v\u1eeba tr\u1ea3i qua c\u01a1n \u0111au tim.<\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n
Th\u1eadn tr\u1ecdng<\/h2>\n
Khi k\u1ebft h\u1ee3p Trajenta Duo 2,5mg\/1000mg v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u0103ng cao, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, suy nh\u01b0\u1ee3c ho\u1eb7c suy th\u1eadn.<\/p>\n
Nguy c\u01a1 nhi\u1ec5m toan lactic: Bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi suy th\u1eadn ho\u1eb7c suy tim. Tri\u1ec7u ch\u1ee9ng ban \u0111\u1ea7u th\u01b0\u1eddng kh\u00f4ng r\u00f5 r\u00e0ng, khi n\u1eb7ng c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<\/p>\n
Vi\u00eam t\u1ee5y: Hi\u1ebfm g\u1eb7p nh\u01b0ng c\u00f3 th\u1ec3 x\u1ea3y ra. N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u \u0111au b\u1ee5ng d\u1eef d\u1ed9i, c\u1ea7n ng\u1eebng thu\u1ed1c ngay.<\/p>\n
Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng: C\u00f3 th\u1ec3 x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0 s\u1ed1c, ph\u00f9 m\u1ea1ch.<\/p>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/h3>\n
Khi s\u1eed d\u1ee5ng Trajenta Duo 2,5mg\/1000mg, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 g\u1eb7p m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 t\u00f9y thu\u1ed9c v\u00e0o t\u1eebng c\u00e1 nh\u00e2n v\u00e0 c\u00e1ch ph\u1ed1i h\u1ee3p thu\u1ed1c.<\/p>\n
\n
Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi metformin: C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t bao g\u1ed3m ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, n\u00f4n v\u00e0 gi\u1ea3m c\u1ea3m gi\u00e1c th\u00e8m \u0103n. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u1ef1 h\u1ebft sau m\u1ed9t th\u1eddi gian.<\/li>\n
Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi sulfonylurea: Nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3 so v\u1edbi khi ch\u1ec9 s\u1eed d\u1ee5ng metformin.<\/li>\n
Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi insulin: Nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u0169ng t\u0103ng l\u00ean, tuy nhi\u00ean kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 so v\u1edbi khi s\u1eed d\u1ee5ng insulin k\u1ebft h\u1ee3p v\u1edbi gi\u1ea3 d\u01b0\u1ee3c.<\/li>\n<\/ul>\n
C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i bao g\u1ed3m:<\/p>\n
\n
Vi\u00eam t\u1ee5y: \u0110\u00e2y l\u00e0 m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 hi\u1ebfm g\u1eb7p v\u00e0 c\u1ea7n theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 \u0111au b\u1ee5ng d\u1eef d\u1ed9i, n\u00f4n m\u1eeda.<\/li>\n
Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nh\u01b0 ph\u00e1t ban, ng\u1ee9a, ph\u00f9 m\u1ea1ch.<\/li>\n
R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan: T\u0103ng men gan.<\/li>\n
Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 vitamin B12: C\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn thi\u1ebfu m\u00e1u.<\/li>\n<\/ul>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h3>\n
Linagliptin<\/h4>\n
\u00cdt t\u01b0\u01a1ng t\u00e1c: Linagliptin n\u00f3i chung t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c r\u1ea5t \u00edt. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 b\u1ea1n c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng linagliptin k\u1ebft h\u1ee3p v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c kh\u00e1c m\u00e0 kh\u00f4ng qu\u00e1 lo l\u1eafng v\u1ec1 c\u00e1c t\u01b0\u01a1ng t\u00e1c nghi\u00eam tr\u1ecdng.<\/p>\n
C\u1ea3m \u1ee9ng enzyme: Tuy nhi\u00ean, khi k\u1ebft h\u1ee3p linagliptin v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c enzyme chuy\u1ec3n h\u00f3a thu\u1ed1c (nh\u01b0 rifampicin), hi\u1ec7u qu\u1ea3 c\u1ee7a linagliptin c\u00f3 th\u1ec3 gi\u1ea3m \u0111i. \u0110i\u1ec1u n\u00e0y l\u00e0 do c\u00e1c enzyme n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 linagliptin trong m\u00e1u.<\/p>\n
Sulphonylureas: Linagliptin (5mg) kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Glibenclamid, AUC v\u00e0 Cmax gi\u1ea3m 14% kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c sulphonylurea kh\u00e1c (glipizide, tolbutamide) c\u0169ng th\u1ea5p.<\/p>\n
Thiazolidinediones: Linagliptin (10mg\/ng\u00e0y) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pioglitazone (45mg\/ng\u00e0y) v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3, cho th\u1ea5y kh\u00f4ng \u1ee9c ch\u1ebf CYP2C8 ho\u1eb7c CYP3A4 in vivo.<\/p>\n
Ritonavir l\u00e0m t\u0103ng AUC (2 l\u1ea7n) v\u00e0 Cmax (3 l\u1ea7n) c\u1ee7a linagliptin, nh\u01b0ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u khi d\u00f9ng chung v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf P-glycoprotein ho\u1eb7c CYP3A4.<\/p>\n
Rifampicin gi\u1ea3m AUC (39,6%) v\u00e0 Cmax (43,8%) c\u1ee7a linagliptin, nh\u01b0ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u1eabn \u0111\u1ea1t \u0111\u01b0\u1ee3c.<\/p>\n
Simvastatin: Linagliptin (10mg\/ng\u00e0y) t\u0103ng nh\u1eb9 AUC (34%) v\u00e0 Cmax (10%) c\u1ee7a simvastatin nh\u01b0ng kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n
Thu\u1ed1c tr\u00e1nh thai: Linagliptin (5mg) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a levonorgestrel v\u00e0 ethinylestradiol.<\/p>\n
Metformin<\/h4>\n
Toan lactic: Metformin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic, \u0111\u1eb7c bi\u1ec7t khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c nh\u01b0 suy th\u1eadn, suy gan, ti\u00eau th\u1ee5 r\u01b0\u1ee3u, ho\u1eb7c khi c\u01a1 th\u1ec3 b\u1ecb m\u1ea5t n\u01b0\u1edbc.<\/p>\n
Iod c\u1ea3n quang: Ng\u1eebng metformin tr\u01b0\u1edbc v\u00e0 sau khi d\u00f9ng iod c\u1ea3n quang 48 gi\u1edd \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 suy th\u1eadn v\u00e0 nhi\u1ec5m toan acid lactic.<\/p>\n
Thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase: C\u00e1c thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a, khi k\u1ebft h\u1ee3p v\u1edbi metformin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng th\u00eam nguy c\u01a1 nhi\u1ec5m toan lactic.<\/p>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/h3>\n
Thai k\u1ef3: Ch\u01b0a c\u00f3 \u0111\u1ee7 b\u1eb1ng ch\u1ee9ng v\u1ec1 \u0111\u1ed9 an to\u00e0n c\u1ee7a Trajenta Duo 2,5mg\/1000mg 14 vi\u00ean<\/strong> khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y m\u1ed9t s\u1ed1 lo ng\u1ea1i v\u1ec1 kh\u1ea3 n\u0103ng g\u00e2y qu\u00e1i thai \u1edf li\u1ec1u cao. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho thai nhi, ph\u1ee5 n\u1eef mang thai n\u00ean s\u1eed d\u1ee5ng insulin \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n
Cho con b\u00fa: C\u1ea3 Metformin v\u00e0 Linagliptin (hai th\u00e0nh ph\u1ea7n c\u1ee7a Trajenta Duo 2,5mg\/1000mg) \u0111\u1ec1u c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9, do \u0111\u00f3 kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Trajenta Duo trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n
Trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u Trajenta Duo 2,5mg\/1000mg v\u00e0 xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng, h\u00e3y g\u1ecdi ngay s\u1ed1 \u0111i\u1ec7n tho\u1ea1i c\u1ea5p c\u1ee9u ho\u1eb7c \u0111\u1ebfn b\u1ec7nh vi\u1ec7n g\u1ea7n nh\u1ea5t.<\/p>\n
Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n
Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n
Tr\u01b0\u1eddng h\u1ee3p thu\u1ed1c Trajenta Duo 2,5mg\/1000mg.. t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c Trajenta Duo 2,5mg\/1000mg nh\u01b0:<\/p>\n
Thu\u1ed1c Glyxambi 25mg\/5mg<\/a> (Boehringer Ingelheim, 1.385.000 VN\u0110\/h\u1ed9p) v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 empagliflozin v\u00e0 linagliptin, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2 \u1edf ng\u01b0\u1eddi l\u1edbn th\u00f4ng qua t\u0103ng b\u00e0i ti\u1ebft \u0111\u01b0\u1eddng qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 t\u0103ng s\u1ea3n xu\u1ea5t insulin.<\/p>\n
Thu\u1ed1c Glucophage 1000mg<\/a> (Merck Sante s.a.s \u2013 Ph\u00e1p, 200.000 VN\u0110\/h\u1ed9p) v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 metformin hydrochloride, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2 b\u1eb1ng c\u00e1ch gi\u1ea3m s\u1ea3n xu\u1ea5t glucose \u1edf gan, t\u0103ng s\u1eed d\u1ee5ng glucose \u1edf t\u1ebf b\u00e0o v\u00e0 gi\u1ea3m h\u1ea5p thu glucose \u1edf ru\u1ed9t.<\/p>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
\n
Rodolfo Guardado-Mendoza, Sara Stephania Salazar-L\u00f3pez v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 kh\u00e1c. (Th\u00e1ng 3 n\u0103m 2020). The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial. Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 11 n\u0103m 2024, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/31887309\/\u00a0<\/a><\/li>\n
Stuart A Ross v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 kh\u00e1c. (Ng\u00e0y 29 th\u00e1ng 9 n\u0103m 2016). Linagliptin plus metformin in patients with newly diagnosed type 2 diabetes and marked hyperglycemia. Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 11 n\u0103m 2024, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/27684308\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Thu\u1ed1c Trajenta Duo 2.5mg\/1000mg l\u00e0 thu\u1ed1c k\u1ebft h\u1ee3p hai th\u00e0nh ph\u1ea7n ch\u00ednh Linagliptin v\u00e0 Metformin gi\u00fap h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 duy tr\u00ec m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft \u1ed5n \u0111\u1ecbnh \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2<\/p>\n","protected":false},"author":1,"featured_media":105598,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-105596","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/105596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=105596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/105598"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=105596"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=105596"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=105596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Th\u00f4ng s\u1ed1<\/strong><\/td>\n	Linagliptin<\/strong><\/td>\n	Metformin<\/strong><\/td>\n<\/tr>\n
H\u1ea5p thu<\/td>\n	Tmax: 1,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: ~30%. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3.<\/td>\n	Tmax: 2,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: 50-60%. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu (~40% Cmax, ~25% AUC).<\/td>\n<\/tr>\n
Ph\u00e2n b\u1ed1<\/td>\n	Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: ~1110L. Li\u00ean k\u1ebft protein ph\u1ee5 thu\u1ed9c n\u1ed3ng \u0111\u1ed9 (99% \u1edf 1nmol\/L, gi\u1ea3m khi n\u1ed3ng \u0111\u1ed9 >30nmol\/L).<\/td>\n	Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1: 63-276L. G\u1eafn kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng; ph\u00e2n b\u1ed1 v\u00e0o h\u1ed3ng c\u1ea7u.<\/td>\n<\/tr>\n
Chuy\u1ec3n h\u00f3a<\/td>\n	Chuy\u1ec3n h\u00f3a \u00edt; ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/td>\n	Kh\u00f4ng chuy\u1ec3n h\u00f3a. \u0110\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u.<\/td>\n<\/tr>\n
Th\u1ea3i tr\u1eeb<\/td>\n	Th\u1eddi gian b\u00e1n th\u1ea3i: >100 gi\u1edd (pha cu\u1ed1i). Ch\u1ee7 y\u1ebfu qua ph\u00e2n (80%), n\u01b0\u1edbc ti\u1ec3u (5%).<\/td>\n	Th\u1eddi gian b\u00e1n th\u1ea3i bi\u1ec3u ki\u1ebfn: ~6,5 gi\u1edd. Th\u1ea3i tr\u1eeb qua th\u1eadn (l\u1ecdc c\u1ea7u th\u1eadn v\u00e0 b\u00e0i ti\u1ebft \u1ed1ng th\u1eadn).<\/td>\n<\/tr>\n
Suy th\u1eadn<\/td>\n	Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy th\u1eadn. N\u1ed3ng \u0111\u1ed9 t\u0103ng nh\u1eb9 \u1edf suy th\u1eadn trung b\u00ecnh (~1,7 l\u1ea7n) v\u00e0 n\u1eb7ng (~1,4 l\u1ea7n).<\/td>\n	Khi suy th\u1eadn, thanh th\u1ea3i gi\u1ea3m t\u1ef7 l\u1ec7 v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinine, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.<\/td>\n<\/tr>\n
Suy gan<\/td>\n	Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. AUC v\u00e0 Cmax t\u01b0\u01a1ng t\u1ef1 \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy gan (Child-Pugh nh\u1eb9, trung b\u00ecnh, n\u1eb7ng).<\/td>\n	Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u.<\/td>\n<\/tr>\n
Tr\u1ebb em<\/td>\n	Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7.<\/td>\n	N\u1ed3ng \u0111\u1ed9 Cmax v\u00e0 AUC gi\u1ea3m \u1edf tr\u1ebb em (~33% v\u00e0 ~40% so v\u1edbi ng\u01b0\u1eddi l\u1edbn); \u00edt \u00fd ngh\u0129a l\u00e2m s\u00e0ng do li\u1ec1u \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u01b0\u1eddng huy\u1ebft.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n Trajenta Duo 2,5mg\/1000mg<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh nh\u01b0 m\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng type 2 (khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng m\u00e1u) cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n \n B\u1ec7nh nh\u00e2n \u0111\u00e3 d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u v\u1edbi Metformin nh\u01b0ng \u0111\u01b0\u1eddng m\u00e1u v\u1eabn cao.<\/li>\n B\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng Linagliptin v\u00e0 Metformin ri\u00eang l\u1ebb nh\u01b0ng c\u1ea7n t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/li>\n B\u1ec7nh nh\u00e2n c\u1ea7n k\u1ebft h\u1ee3p v\u1edbi sulfonylurea \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft t\u1ed1i \u01b0u.<\/li>\n<\/ul>\n Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n Li\u1ec1u khuy\u1ebfn c\u00e1o: Li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng l\u00e0 1 vi\u00ean ch\u1ee9a 2,5mg Linagliptin v\u00e0 500mg, 850mg ho\u1eb7c 1000mg Metformin, u\u1ed1ng 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u Trajenta Duo 2,5mg\/1000mg: B\u00e1c s\u0129 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n.<\/p>\n Li\u1ec1u t\u1ed1i \u0111a: Li\u1ec1u d\u00f9ng h\u00e0ng ng\u00e0y kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 5mg Linagliptin v\u00e0 2000mg Metformin.<\/p>\n N\u00ean u\u1ed1ng Trajenta Duo 2,5mg\/1000mg c\u00f9ng b\u1eefa \u0103n \u0111\u1ec3 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean d\u1ea1 d\u00e0y c\u1ee7a\u00a0 Metformin<\/p>\n $\"Thu\u1ed1c$ Thu\u1ed1c Trajenta Duo 2.5mg\/1000mg d\u00f9ng cho \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o?<\/figcaption><\/figure>\n Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Trajenta Duo 2,5mg\/1000mg 14 vi\u00ean trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n Thu\u1ed1c Trajenta Duo<\/strong> 2.5mg\/1000mg kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n \n Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/li>\n \u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng kh\u00f4ng ki\u1ec3m so\u00e1t: nhi\u1ec5m toan ceton ho\u1eb7c ti\u1ec1n h\u00f4n m\u00ea<\/li>\n V\u1ea5n \u0111\u1ec1 v\u1ec1 r\u01b0\u1ee3u (nghi\u1ec7n r\u01b0\u1ee3u ho\u1eb7c ng\u1ed9 \u0111\u1ed9c c\u1ea5p t\u00ednh)<\/li>\n Ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn n\u1eb7ng ho\u1eb7c c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u1ecb gi\u1ea3m s\u00fat \u0111\u00e1ng k\u1ec3<\/li>\n Ng\u01b0\u1eddi b\u1ec7nh b\u1ecb suy gan<\/li>\n T\u00ecnh tr\u1ea1ng c\u1ea5p t\u00ednh nh\u01b0 m\u1ea5t n\u01b0\u1edbc nghi\u00eam tr\u1ecdng, nhi\u1ec5m tr\u00f9ng n\u1eb7ng, s\u1ed1c ho\u1eb7c v\u1eeba th\u1ef1c hi\u1ec7n th\u1ee7 thu\u1eadt ch\u1ee5p X-quang s\u1eed d\u1ee5ng ch\u1ea5t c\u1ea3n quang<\/li>\n Thi\u1ebfu oxy do m\u1eafc c\u00e1c b\u1ec7nh nh\u01b0 suy tim n\u1eb7ng, suy h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh, ho\u1eb7c v\u1eeba tr\u1ea3i qua c\u01a1n \u0111au tim.<\/li>\n<\/ul>\n L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n Th\u1eadn tr\u1ecdng<\/h2>\n Khi k\u1ebft h\u1ee3p Trajenta Duo 2,5mg\/1000mg v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u0103ng cao, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, suy nh\u01b0\u1ee3c ho\u1eb7c suy th\u1eadn.<\/p>\n Nguy c\u01a1 nhi\u1ec5m toan lactic: Bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi suy th\u1eadn ho\u1eb7c suy tim. Tri\u1ec7u ch\u1ee9ng ban \u0111\u1ea7u th\u01b0\u1eddng kh\u00f4ng r\u00f5 r\u00e0ng, khi n\u1eb7ng c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<\/p>\n Vi\u00eam t\u1ee5y: Hi\u1ebfm g\u1eb7p nh\u01b0ng c\u00f3 th\u1ec3 x\u1ea3y ra. N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u \u0111au b\u1ee5ng d\u1eef d\u1ed9i, c\u1ea7n ng\u1eebng thu\u1ed1c ngay.<\/p>\n Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng: C\u00f3 th\u1ec3 x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0 s\u1ed1c, ph\u00f9 m\u1ea1ch.<\/p>\n T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/h3>\n Khi s\u1eed d\u1ee5ng Trajenta Duo 2,5mg\/1000mg, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 g\u1eb7p m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 t\u00f9y thu\u1ed9c v\u00e0o t\u1eebng c\u00e1 nh\u00e2n v\u00e0 c\u00e1ch ph\u1ed1i h\u1ee3p thu\u1ed1c.<\/p>\n \n Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi metformin: C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t bao g\u1ed3m ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, n\u00f4n v\u00e0 gi\u1ea3m c\u1ea3m gi\u00e1c th\u00e8m \u0103n. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u1ef1 h\u1ebft sau m\u1ed9t th\u1eddi gian.<\/li>\n Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi sulfonylurea: Nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3 so v\u1edbi khi ch\u1ec9 s\u1eed d\u1ee5ng metformin.<\/li>\n Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi insulin: Nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u0169ng t\u0103ng l\u00ean, tuy nhi\u00ean kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 so v\u1edbi khi s\u1eed d\u1ee5ng insulin k\u1ebft h\u1ee3p v\u1edbi gi\u1ea3 d\u01b0\u1ee3c.<\/li>\n<\/ul>\n C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i bao g\u1ed3m:<\/p>\n \n Vi\u00eam t\u1ee5y: \u0110\u00e2y l\u00e0 m\u1ed9t t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng v\u00e0 hi\u1ebfm g\u1eb7p v\u00e0 c\u1ea7n theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 \u0111au b\u1ee5ng d\u1eef d\u1ed9i, n\u00f4n m\u1eeda.<\/li>\n Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nh\u01b0 ph\u00e1t ban, ng\u1ee9a, ph\u00f9 m\u1ea1ch.<\/li>\n R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan: T\u0103ng men gan.<\/li>\n Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 vitamin B12: C\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn thi\u1ebfu m\u00e1u.<\/li>\n<\/ul>\n T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h3>\n Linagliptin<\/h4>\n \u00cdt t\u01b0\u01a1ng t\u00e1c: Linagliptin n\u00f3i chung t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c r\u1ea5t \u00edt. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 b\u1ea1n c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng linagliptin k\u1ebft h\u1ee3p v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c kh\u00e1c m\u00e0 kh\u00f4ng qu\u00e1 lo l\u1eafng v\u1ec1 c\u00e1c t\u01b0\u01a1ng t\u00e1c nghi\u00eam tr\u1ecdng.<\/p>\n C\u1ea3m \u1ee9ng enzyme: Tuy nhi\u00ean, khi k\u1ebft h\u1ee3p linagliptin v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c enzyme chuy\u1ec3n h\u00f3a thu\u1ed1c (nh\u01b0 rifampicin), hi\u1ec7u qu\u1ea3 c\u1ee7a linagliptin c\u00f3 th\u1ec3 gi\u1ea3m \u0111i. \u0110i\u1ec1u n\u00e0y l\u00e0 do c\u00e1c enzyme n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 linagliptin trong m\u00e1u.<\/p>\n Sulphonylureas: Linagliptin (5mg) kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Glibenclamid, AUC v\u00e0 Cmax gi\u1ea3m 14% kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c sulphonylurea kh\u00e1c (glipizide, tolbutamide) c\u0169ng th\u1ea5p.<\/p>\n Thiazolidinediones: Linagliptin (10mg\/ng\u00e0y) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pioglitazone (45mg\/ng\u00e0y) v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3, cho th\u1ea5y kh\u00f4ng \u1ee9c ch\u1ebf CYP2C8 ho\u1eb7c CYP3A4 in vivo.<\/p>\n Ritonavir l\u00e0m t\u0103ng AUC (2 l\u1ea7n) v\u00e0 Cmax (3 l\u1ea7n) c\u1ee7a linagliptin, nh\u01b0ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u khi d\u00f9ng chung v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf P-glycoprotein ho\u1eb7c CYP3A4.<\/p>\n Rifampicin gi\u1ea3m AUC (39,6%) v\u00e0 Cmax (43,8%) c\u1ee7a linagliptin, nh\u01b0ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u1eabn \u0111\u1ea1t \u0111\u01b0\u1ee3c.<\/p>\n Simvastatin: Linagliptin (10mg\/ng\u00e0y) t\u0103ng nh\u1eb9 AUC (34%) v\u00e0 Cmax (10%) c\u1ee7a simvastatin nh\u01b0ng kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n Thu\u1ed1c tr\u00e1nh thai: Linagliptin (5mg) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a levonorgestrel v\u00e0 ethinylestradiol.<\/p>\n Metformin<\/h4>\n Toan lactic: Metformin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic, \u0111\u1eb7c bi\u1ec7t khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c nh\u01b0 suy th\u1eadn, suy gan, ti\u00eau th\u1ee5 r\u01b0\u1ee3u, ho\u1eb7c khi c\u01a1 th\u1ec3 b\u1ecb m\u1ea5t n\u01b0\u1edbc.<\/p>\n Iod c\u1ea3n quang: Ng\u1eebng metformin tr\u01b0\u1edbc v\u00e0 sau khi d\u00f9ng iod c\u1ea3n quang 48 gi\u1edd \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 suy th\u1eadn v\u00e0 nhi\u1ec5m toan acid lactic.<\/p>\n Thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase: C\u00e1c thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 toan chuy\u1ec3n h\u00f3a, khi k\u1ebft h\u1ee3p v\u1edbi metformin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng th\u00eam nguy c\u01a1 nhi\u1ec5m toan lactic.<\/p>\n L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/h3>\n Thai k\u1ef3: Ch\u01b0a c\u00f3 \u0111\u1ee7 b\u1eb1ng ch\u1ee9ng v\u1ec1 \u0111\u1ed9 an to\u00e0n c\u1ee7a Trajenta Duo 2,5mg\/1000mg 14 vi\u00ean<\/strong> khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y m\u1ed9t s\u1ed1 lo ng\u1ea1i v\u1ec1 kh\u1ea3 n\u0103ng g\u00e2y qu\u00e1i thai \u1edf li\u1ec1u cao. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n cho thai nhi, ph\u1ee5 n\u1eef mang thai n\u00ean s\u1eed d\u1ee5ng insulin \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n Cho con b\u00fa: C\u1ea3 Metformin v\u00e0 Linagliptin (hai th\u00e0nh ph\u1ea7n c\u1ee7a Trajenta Duo 2,5mg\/1000mg) \u0111\u1ec1u c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9, do \u0111\u00f3 kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Trajenta Duo trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/p>\n Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n Trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u Trajenta Duo 2,5mg\/1000mg v\u00e0 xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng, h\u00e3y g\u1ecdi ngay s\u1ed1 \u0111i\u1ec7n tho\u1ea1i c\u1ea5p c\u1ee9u ho\u1eb7c \u0111\u1ebfn b\u1ec7nh vi\u1ec7n g\u1ea7n nh\u1ea5t.<\/p>\n Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/h2>\n Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n Tr\u01b0\u1eddng h\u1ee3p thu\u1ed1c Trajenta Duo 2,5mg\/1000mg.. t\u1ea1m th\u1eddi h\u1ebft h\u00e0ng, qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi thu\u1ed1c Trajenta Duo 2,5mg\/1000mg nh\u01b0:<\/p>\n Thu\u1ed1c Glyxambi 25mg\/5mg<\/a> (Boehringer Ingelheim, 1.385.000 VN\u0110\/h\u1ed9p) v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 empagliflozin v\u00e0 linagliptin, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2 \u1edf ng\u01b0\u1eddi l\u1edbn th\u00f4ng qua t\u0103ng b\u00e0i ti\u1ebft \u0111\u01b0\u1eddng qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 t\u0103ng s\u1ea3n xu\u1ea5t insulin.<\/p>\n Thu\u1ed1c Glucophage 1000mg<\/a> (Merck Sante s.a.s \u2013 Ph\u00e1p, 200.000 VN\u0110\/h\u1ed9p) v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 metformin hydrochloride, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2 b\u1eb1ng c\u00e1ch gi\u1ea3m s\u1ea3n xu\u1ea5t glucose \u1edf gan, t\u0103ng s\u1eed d\u1ee5ng glucose \u1edf t\u1ebf b\u00e0o v\u00e0 gi\u1ea3m h\u1ea5p thu glucose \u1edf ru\u1ed9t.<\/p>\n T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n \n Rodolfo Guardado-Mendoza, Sara Stephania Salazar-L\u00f3pez v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 kh\u00e1c. (Th\u00e1ng 3 n\u0103m 2020). The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial. Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 11 n\u0103m 2024, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/31887309\/\u00a0<\/a><\/li>\n Stuart A Ross v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 kh\u00e1c. (Ng\u00e0y 29 th\u00e1ng 9 n\u0103m 2016). Linagliptin plus metformin in patients with newly diagnosed type 2 diabetes and marked hyperglycemia. Truy c\u1eadp ng\u00e0y 26 th\u00e1ng 11 n\u0103m 2024, t\u1eeb https:\/\/pubmed.ncbi.nlm.nih.gov\/27684308\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":" Thu\u1ed1c Trajenta Duo 2.5mg\/1000mg l\u00e0 thu\u1ed1c k\u1ebft h\u1ee3p hai th\u00e0nh ph\u1ea7n ch\u00ednh Linagliptin v\u00e0 Metformin gi\u00fap h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 duy tr\u00ec m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft \u1ed5n \u0111\u1ecbnh \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng type 2<\/p>\n","protected":false},"author":1,"featured_media":105598,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-105596","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product\/105596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=105596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/105598"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=105596"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_cat?post=105596"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/product_tag?post=105596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Tr\u00ecnh b\u00e0y<\/h3>\nS\u0110K: 400110085623<\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd x 14 vi\u00ean<\/p>\nXu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h3>\n

Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: 400110085623<\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd x 14 vi\u00ean<\/p>\n
Xu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n