{"id":9496,"date":"2019-05-11T01:13:14","date_gmt":"2019-05-10T18:13:14","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=9496"},"modified":"2019-05-14T01:17:33","modified_gmt":"2019-05-13T18:17:33","slug":"su-dung-thuoc-chong-roi-loan-tam-than-o-benh-nhan-suy-giam-chuc-nang-gan","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/su-dung-thuoc-chong-roi-loan-tam-than-o-benh-nhan-suy-giam-chuc-nang-gan\/","title":{"rendered":"S\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan"},"content":{"rendered":"

Khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan<\/h2>\n
T\u00e1c gi\u1ea3:<\/p>\n
\n
Nguy\u1ec5n Th\u00e0nh H\u1ea3i1,<\/li>\n
Nguy\u1ec5n Th\u1ecb Thanh Tuy\u1ec1n2<\/li>\n
Ch\u00fa th\u00edch: 1 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc D\u01b0\u1ee3c H\u00e0 N\u1ed9i 2 B\u1ec7nh vi\u1ec7n T\u00e2m th\u1ea7n Trung \u01b0\u01a1ng 1
\nE-mail: haint@hup.edu.vn.<\/li>\n<\/ol>\n
Summary<\/h2>\n
Taking chronic liver diseases alter the kinetics of drugs, and despite dosage adjustment was based on ChildPugh scores, no recommendations and\/or algorithms of reference are available to facilitate dosage regimens, recommendations on dosage adjustment of antipsychotics for patients with liver funtion mpairments were proposed.
\nA literature review was presented on dose adjustment of the drugs from the hospital guide included in the list of the summary of product characteristics; AHFS 2018 and Mausley guidelines in Psychiatry 13th; the review articles from the last 10 years in Medline database for each drug related to patients with impaired liver function. recommendations for dosage adjustment of 27 antipsychotics were tabulated. For clinical management. the proposed recommendations included: 9 antipsychotics (33.3 %) contraindicated for patients with severe hepatic impairment (Child-Pugh C): 6
\nantipsychotics (22.2 %) contraindicated for chronic liver diseases at all levels; 6 antipsychotics (22.2 %) were contraindicated for patients with hepatic impairment at all levels; 2 antipsychotics (7.4 %) should be used with caution and 4 antipsychotics (14.8 %) without adjustment required. The dosage adjustment of antipsychotics for the practical management of patients with chronic liver disease were presented.
\nKeywords: Chronic liver diseases, antipsychotics, dosage regimens.<\/p>\n
$\"gan\"$ <\/p>\n
\u0110\u1eb7t v\u1ea5n \u0111\u1ec1<\/h2>\n
Gan \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a h\u1ea7u h\u1ebft c\u00e1c lo\u1ea1i thu\u1ed1c th\u00f4ng qua qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t v\u00e0 b\u00e0i ti\u1ebft m\u1eadt. Suy gi\u1ea3m ch\u1ee9c n\u0103ng gan d\u1eabn \u0111\u1ebfn: Gi\u1ea3m l\u01b0u l\u01b0\u1ee3ng m\u00e1u qua t\u0129nh m\u1ea1ch c\u1eeda (QH), \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u c\u1ee7a c\u00e1c thu\u1ed1c c\u00f3 h\u1ec7 s\u1ed1 chi\u1ebft xu\u1ea5t qua gan cao (EH); Gi\u1ea3m t\u1ed5ng h\u1ee3p protein huy\u1ebft t\u01b0\u01a1ng (albumin v\u00e0 alpha-glycoprotein), l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 \u1edf d\u1ea1ng t\u1ef1 do c\u1ee7a thu\u1ed1c; \u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c c\u00f2n ho\u1ea1t t\u00ednh trong huy\u1ebft t\u01b0\u01a1ng; T\u1eeb \u0111\u00f3, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 tr\u00ean l\u00e2m s\u00e0ng v\u00e0\/ho\u1eb7c \u0111\u1ed9c t\u00ednh c\u1ee7a thu\u1ed1c [1].<\/p>\n
Cho \u0111\u1ebfn nay, v\u1eabn ch\u01b0a c\u00f3 ch\u1ec9 s\u1ed1 n\u00e0o \u0111\u00e1nh gi\u00e1 ch\u00ednh x\u00e1c t\u00ecnh tr\u1ea1ng v\u00e0 m\u1ee9c \u0111\u1ed9 t\u1ed5n th\u01b0\u01a1ng gan gi\u1ed1ng nh\u01b0<\/p>\n
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Khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan T\u00e1c gi\u1ea3: Nguy\u1ec5n Th\u00e0nh H\u1ea3i1, Nguy\u1ec5n Th\u1ecb Thanh Tuy\u1ec1n2 Ch\u00fa th\u00edch: 1 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc D\u01b0\u1ee3c H\u00e0 N\u1ed9i 2 B\u1ec7nh vi\u1ec7n T\u00e2m th\u1ea7n Trung \u01b0\u01a1ng 1 E-mail: haint@hup.edu.vn. Summary Taking chronic liver diseases alter the kinetics of […]\n","protected":false},"author":1,"featured_media":9498,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9496","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9496","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=9496"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9496\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/9498"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=9496"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=9496"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=9496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}