H\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang (PCOS) l\u00e0 r\u1ed1i lo\u1ea1n n\u1ed9i ti\u1ebft th\u01b0\u1eddng g\u1eb7p nh\u1ea5t \u1edf ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n v\u00e0 c\u0169ng l\u00e0 nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn nh\u1ea5t g\u00e2y v\u00f4 sinh do chu k\u1ef3 kh\u00f4ng ph\u00f3ng no\u00e3n. \u0110i\u1ec1u tr\u1ecb v\u00f4 sinh \u1edf ph\u1ee5 n\u1eef h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang t\u1eadp trung ch\u1ee7 y\u1ebfu v\u00e0o g\u00e2y ph\u00f3ng no\u00e3n. Nhi\u1ec1u ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u01b0a ra v\u1edbi t\u1ef7 l\u1ec7 th\u00e0nh c\u00f4ng r\u1ea5t \u0111a d\u1ea1ng, trong \u0111\u00f3 th\u01b0\u1eddng d\u00f9ng nh\u1ea5t l\u00e0 Clomiphene Citrate. Clomiphene Citrate l\u00e0 m\u1ed9t ch\u1ea5t \u0111i\u1ec1u ph\u1ed1i ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 estrogen b\u1eb1ng c\u00e1ch c\u1ea1nh tranh g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 estrogen nh\u00e2n t\u1ebf b\u00e0o. Khi estrogen gi\u1ea3m s\u1ebd l\u00e0m t\u0103ng ti\u1ebft hormone h\u01b0\u1edbng sinh d\u1ee5c FSH, l\u00e0m t\u0103ng s\u1ed1 l\u01b0\u1ee3ng nang no\u00e3n ph\u00e1t tri\u1ec3n. Clomiphene Citrate c\u0169ng c\u00f3 t\u00e1c \u0111\u1ed9ng kh\u00e1ng estrogen \u1edf n\u1ed9i m\u1ea1c t\u1eed cung v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ea3n xu\u1ea5t ch\u1ea5t nh\u1ea7y c\u1ed5 t\u1eed cung, \u0111\u01b0\u1ee3c cho l\u00e0 hai trong nh\u1eefng y\u1ebfu t\u1ed1 khi\u1ebfn cho t\u1ef7 l\u1ec7 mang thai th\u1ea5p m\u1eb7c d\u00f9 t\u1ef7 l\u1ec7 ph\u00f3ng no\u00e3n cao.<\/p>\n
Letrozole c\u0169ng l\u00e0 s\u1ef1 l\u1ef1a ch\u1ecdn ph\u1ed5 bi\u1ebfn kh\u00e1c \u0111\u1ec3 g\u00e2y ph\u00f3ng no\u00e3n. V\u1edbi c\u01a1 ch\u1ebf kh\u00e1c Clomiphene Citrate, Letrozole ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc aromatase, ng\u0103n ch\u1eb7n chuy\u1ec3n h\u00f3a androgen th\u00e0nh estrogen, vi\u1ec7c \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh estrogen s\u1ebd l\u00e0m gi\u1ea3m ph\u1ea3n h\u1ed3i \u00e2m l\u00ean h\u1ea1 \u0111\u1ed3i tuy\u1ebfn y\u00ean, t\u1eeb \u0111\u00f3 t\u0103ng ti\u1ebft FSH. C\u00f3 m\u1ed9t c\u01a1 ch\u1ebf kh\u00e1c c\u0169ng \u0111\u01b0\u1ee3c s\u1ef1 \u0111\u1ed3ng thu\u1eadn cao, cho r\u1eb1ng Letrozole l\u00e0m t\u0103ng t\u00ednh nh\u1ea1y c\u1ee7a nang no\u00e3n v\u1edbi FSH, t\u0103ng t\u1ea1m th\u1eddi androgen trong bu\u1ed3ng tr\u1ee9ng. Ngo\u00e0i ra, Letrozole c\u0169ng c\u00f3 l\u1ee3i h\u01a1n Clomiphene Citrate do kh\u00f4ng \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 estrogen \u1edf m\u00f4 \u0111\u00edch ngo\u1ea1i vi v\u00e0 trung t\u00e2m, v\u00e0 c\u01a1 ch\u1ebf ph\u1ea3n h\u1ed3i \u00e2m \u0111\u01b0\u1ee3c duy tr\u00ec nguy\u00ean v\u1eb9n.<\/p>\n
Do Letrozole v\u00e0 Clomiphene Citrate c\u00f3 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng kh\u00e1c nhau, nhi\u1ec1u chuy\u00ean gia cho r\u1eb1ng n\u1ebfu k\u1ebft h\u1ee3p s\u1ebd c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 ph\u00f3ng no\u00e3n h\u01a1n l\u00e0 s\u1eed d\u1ee5ng \u0111\u01a1n tr\u1ecb li\u1ec7u Letrozole. Nghi\u00ean c\u1ee9u c\u1ee7a t\u00e1c gi\u1ea3 Mejia v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u01b0\u1ee3c \u0111\u0103ng tr\u00ean Hi\u1ec7p h\u1ed9i Y h\u1ecdc sinh s\u1ea3n Hoa K\u1ef3 (American Society for Reproductive Medince – ASRM) v\u00e0o th\u00e1ng 11\/2018 \u0111\u00e3 kh\u1eb3ng \u0111\u1ecbnh, k\u1ebft h\u1ee3p Letrozole v\u00e0 Clomiphene Citrate l\u00e0m t\u0103ng t\u1ef7 l\u1ec7 ph\u00f3ng no\u00e3n so v\u1edbi \u0111\u01a1n tr\u1ecb li\u1ec7u Letrozole \u1edf ph\u1ee5 n\u1eef h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang v\u00f4 sinh. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean 70 b\u1ec7nh nh\u00e2n trong \u0111\u1ed9 tu\u1ed5i t\u1eeb 18-40 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n v\u00f4 sinh v\u00e0 h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang theo ti\u00eau chu\u1ea9n Rotterdam v\u00e0 kh\u00f4ng t\u1ed3n t\u1ea1i b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n g\u00e2y v\u00f4 sinh kh\u00e1c. Nh\u1eefng ph\u1ee5 n\u1eef tham gia \u0111\u01b0\u1ee3c chia ng\u1eabu nhi\u00ean th\u00e0nh hai nh\u00f3m s\u1eed d\u1ee5ng \u0111\u01a1n tr\u1ecb li\u1ec7u 2,5 mg Letrozole ho\u1eb7c k\u1ebft h\u1ee3p 2,5 mg Letrozole c\u00f9ng v\u1edbi 50 mg Clomiphene Citrate m\u1ed7i ng\u00e0y trong 3-7 ng\u00e0y cho m\u1ed7i chu tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n
Qua ph\u00e2n t\u00edch, nh\u1eefng ph\u1ee5 n\u1eef s\u1eed d\u1ee5ng li\u1ec1u k\u1ebft h\u1ee3p c\u00f3 t\u1ef7 l\u1ec7 ph\u00f3ng no\u00e3n cao h\u01a1n so v\u1edbi nh\u1eefng ph\u1ee5 n\u1eef s\u1eed d\u1ee5ng li\u1ec1u \u0111\u01a1n \u0111\u1ed9c (27\/35 ph\u1ee5 n\u1eef s\u1eed d\u1ee5ng li\u1ec1u k\u1ebft h\u1ee3p [77%] so v\u1edbi 15\/35 ph\u1ee5 n\u1eef s\u1eed d\u1ee5ng li\u1ec1u \u0111\u01a1n \u0111\u1ed9c [43%]). \u1ede c\u1ea3 hai nh\u00f3m ph\u00e1c \u0111\u1ed3 kh\u00f4ng xu\u1ea5t hi\u1ec7n bi\u1ebfn c\u1ed1 nghi\u00eam tr\u1ecdng hay \u0111a thai. Ngo\u00e0i ra, kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u00e1c d\u1ee5ng ph\u1ee5 \u1edf hai nh\u00f3m nh\u01b0 \u0111au \u0111\u1ea7u, m\u1ec7t m\u1ecfi, \u0111au b\u1ee5ng, \u0111au l\u01b0ng.<\/p>\n
Nghi\u00ean c\u1ee9u tr\u00ean cho th\u1ea5y Letrozole v\u00e0 Clomiphene Citrate \u01b0u vi\u1ec7t h\u01a1n \u0111\u1ec3 g\u00e2y ph\u00f3ng no\u00e3n trong \u0111i\u1ec1u tr\u1ecb v\u00f4 sinh \u1edf ph\u1ee5 n\u1eef h\u1ed9i ch\u1ee9ng bu\u1ed3ng ch\u1ee9ng \u0111a nang. \u0110\u00e2y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c cho l\u00e0 m\u1ed9t ti\u1ebfn b\u1ed9 m\u1edbi cho k\u1ebft qu\u1ea3 cao trong \u0111i\u1ec1u tr\u1ecb v\u00f4 sinh hi\u1ec7u qu\u1ea3, \u00edt nguy c\u01a1, chi ph\u00ed th\u1ea5p.<\/p>\n
Ngu\u1ed3n: Mejia, Rachel B., et al. “A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome.” Fertility and sterility (2019).<\/p>\n
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So s\u00e1nh gi\u1eefa \u0111\u01a1n tr\u1ecb li\u1ec7u Letrozole v\u00e0 k\u1ebft h\u1ee3p Letrozole v\u1edbi Clomiphene Citrate \u0111\u1ec3 g\u00e2y ph\u00f3ng no\u00e3n \u1edf b\u1ec7nh nh\u00e2n v\u00f4 sinh c\u00f3 h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang. H\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang (PCOS) l\u00e0 r\u1ed1i lo\u1ea1n n\u1ed9i ti\u1ebft th\u01b0\u1eddng g\u1eb7p nh\u1ea5t \u1edf ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n v\u00e0 c\u0169ng […]\n","protected":false},"author":1,"featured_media":9391,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=9390"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9390\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/9391"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=9390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=9390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=9390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}