{"id":9094,"date":"2019-05-03T12:12:42","date_gmt":"2019-05-03T05:12:42","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=9094"},"modified":"2019-05-05T12:15:52","modified_gmt":"2019-05-05T05:15:52","slug":"thuoc-chong-viem-khong-steroid-nsaid-va-cac-bien-chung-nhiem-trung-nghiem-trong","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/thuoc-chong-viem-khong-steroid-nsaid-va-cac-bien-chung-nhiem-trung-nghiem-trong\/","title":{"rendered":"Thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID) v\u00e0 c\u00e1c bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng"},"content":{"rendered":"<p>Th\u00e1ng 6\/2018, <strong>sau khi nh\u1eadn \u0111\u01b0\u1ee3c c\u00e1c b\u00e1o c\u00e1o v\u1ec1 c\u00e1c bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID)<\/strong> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong h\u1ea1 s\u1ed1t v\u00e0 gi\u1ea3m \u0111au, C\u01a1 quan An to\u00e0n Thu\u1ed1c v\u00e0 S\u1ea3n ph\u1ea9m y t\u1ebf Ph\u00e1p (ANSM) \u0111\u00e3 y\u00eau c\u1ea7u c\u00e1c trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c khu v\u1ef1c Tours v\u00e0 Marseille th\u1ef1c hi\u1ec7n m\u1ed9t cu\u1ed9c kh\u1ea3o s\u00e1t qu\u1ed1c gia v\u1ec1 hai thu\u1ed1c NSAID \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nhi\u1ec1u nh\u1ea5t trong c\u00e1c ch\u1ec9 \u0111\u1ecbnh tr\u00ean l\u00e0 ibuprofen v\u00e0 ketoprofen.<\/p>\n<p>K\u1ebft lu\u1eadn c\u1ee7a cu\u1ed9c kh\u1ea3o s\u00e1t n\u00e0y g\u1ee3i \u00fd kh\u1ea3 n\u0103ng c\u1ee7a c\u00e1c NSAID trong l\u00e0m n\u1eb7ng th\u00eam t\u00ecnh tr\u1ea1ng nhi\u1ec5m tr\u00f9ng. ANSM \u0111\u00e3 g\u1eedi k\u1ebft qu\u1ea3 t\u1edbi c\u00e1c \u0111\u1ed1i t\u00e1c \u1edf ch\u00e2u \u00c2u \u0111\u1ec3 c\u00f3 m\u1ed9t ph\u00e2n t\u00edch chung trong th\u1eddi gian t\u1edbi.<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID) nh\u01b0 ibuprofen v\u00e0 ketoprofen \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn trong c\u00e1c b\u00e1o c\u00e1o c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c v\u1ec1 c\u00e1c bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng.<\/p>\n<p>C\u00e1c trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c khu v\u1ef1c t\u1ea1i Tours v\u00e0 Marseille \u0111\u00e3 th\u1ef1c hi\u1ec7n m\u1ed9t nghi\u00ean c\u1ee9u kh\u1ea3o s\u00e1t nguy c\u01a1 xu\u1ea5t hi\u1ec7n bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng NSAID \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em b\u1eb1ng c\u00e1ch t\u1eadp trung v\u00e0o hai NSAID \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong s\u1ed1t v\u00e0 \u0111au nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u1ea5tl\u00e0ibuprofen v\u00e0 ketoprofen.<\/p>\n<h2>M\u1ee5c Ti\u00eau<\/h2>\n<p>M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng c\u00f3 li\u00ean quan v\u1edbi vi\u1ec7c d\u00f9ng thu\u1ed1c NSAID hay ch\u1ec9 ph\u1ea3n \u00e1nh s\u1ef1 ti\u1ebfn tri\u1ec3n b\u1ec7nh l\u00fd nhi\u1ec5m tr\u00f9ng ban \u0111\u1ea7u.<\/p>\n<h2>K\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u<\/h2>\n<p>Trong t\u1ea5t c\u1ea3 b\u00e1o c\u00e1o t\u1eeb n\u0103m 2000,c\u00f3 337 tr\u01b0\u1eddng h\u1ee3p bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng s\u1eed d\u1ee5ng ibuprofen v\u00e0 49 tr\u01b0\u1eddng h\u1ee3p s\u1eed d\u1ee5ng ketoprofen \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn theo c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng nh\u1ea5t \u1edf tr\u1ebb em v\u00e0 ng\u01b0\u1eddi l\u1edbn kh\u00f4ng c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 v\u00e0 b\u1ec7nh m\u1eafc k\u00e8m. \u0110\u00e2y l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p c\u00f3 nhi\u1ec5m khu\u1ea9n n\u1eb7ng \u1edf da v\u00e0 m\u00f4 m\u1ec1m (vi\u00eam da c\u01a1 \u0111\u1ecba, vi\u00eam c\u00e2n m\u1ea1c ho\u1ea1i t\u1eed\u2026), nhi\u1ec5m khu\u1ea9n huy\u1ebft, nhi\u1ec5m khu\u1ea9n m\u00e0ng ph\u1ed5i (\u00e1p xe ph\u1ed5i, vi\u00eam m\u00e0ng ph\u1ed5i), nhi\u1ec5m khu\u1ea9n th\u1ea7n kinh (vi\u00eam m\u00e0ng n\u00e3o m\u1ee7, \u00e1p xe n\u00e3o) ho\u1eb7c tai-m\u0169i-h\u1ecdng c\u00f3 bi\u1ebfn ch\u1ee9ng (vi\u00eam m\u00f4 t\u1ebf b\u00e0o, vi\u00eam tai gi\u1eefa,\u2026) d\u1eabn \u0111\u1ebfn nh\u1eadp vi\u1ec7n, \u0111\u1ec3 l\u1ea1i di ch\u1ee9ng ho\u1eb7c t\u1eed vong.<\/p>\n<p>Nh\u1eefng bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng n\u00e0y (ch\u1ee7 y\u1ebfu l\u00e0 do li\u00ean c\u1ea7u ho\u1eb7c ph\u1ebf c\u1ea7u) \u0111\u00e3 quan s\u00e1t th\u1ea5y sau m\u1ed9t kho\u1ea3ng th\u1eddi gian ng\u1eafn (t\u1eeb 2 \u0111\u1ebfn 3 ng\u00e0y) khi ph\u1ed1i h\u1ee3p NSAID v\u1edbi li\u1ec7u tr\u00ecnh kh\u00e1ng sinh. C\u00e1c bi\u1ebfn ch\u1ee9ng x\u1ea3y ra khi ibuprofen ho\u1eb7c ketoprofen c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 \u0111\u01a1n k\u00ea khi b\u1ecb s\u1ed1t c\u0169ng nh\u01b0 trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p t\u1ed5n th\u01b0\u01a1ng da d\u1ea1ng vi\u00eam l\u00e0nh t\u00ednh (ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7, v\u1ebft c\u00f4n tr\u00f9ng c\u1eafn\u2026), bi\u1ec3u hi\u1ec7n tr\u00ean \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p (ho, vi\u00eam ph\u1ed5i,\u2026) ho\u1eb7c tai-m\u0169i-h\u1ecdng(kh\u00f3 nu\u1ed1t, vi\u00eam amidan, vi\u00eam tai gi\u1eefa).<\/p>\n<p>Ph\u00e2n t\u00edch c\u00e1c b\u00e1o c\u00e1o ca c\u0169ng nh\u01b0 ph\u00e2n t\u00edch d\u1eef li\u1ec7u y v\u0103n (nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m v\u00e0 nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5) cho th\u1ea5y c\u00e1c b\u1ec7nh l\u00fd nhi\u1ec5m tr\u00f9ng,\u0111\u1eb7c bi\u1ec7t do li\u00ean c\u1ea7u khu\u1ea9n c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n n\u1eb7ng th\u00eam khi s\u1eed d\u1ee5ng NSAID.<\/p>\n<p>Nghi\u00ean c\u1ee9u n\u00e0y c\u0169ng ch\u1ee9ng minh c\u00f3 s\u1ef1 s\u1eed d\u1ee5ng NSAID k\u00e9o d\u00e0i v\u1edbi c\u00e1c ca m\u1eafc th\u1ee7y \u0111\u00e2u, ANSM nh\u1eafc nh\u1edf r\u1eb1ng NSAID g\u00e2y ra c\u00e1c bi\u1ebfn ch\u1ee9ng da do vi khu\u1ea9n nghi\u00eam tr\u1ecdng (vi\u00eam c\u00e2n m\u1ea1c ho\u1ea1i t\u1eed) tr\u00ean b\u1ec7nh nh\u00e2n \u0111ang m\u1eafc th\u1ee7y \u0111\u1eadu v\u00e0 c\u1ea7n tr\u00e1nh s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u00e0y.<\/p>\n<p>Trong giai \u0111o\u1ea1n n\u00e0y, ANSM mong mu\u1ed1n c\u1ea3nh b\u00e1o cho nh\u00e2n vi\u00ean y t\u1ebf, b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c b\u1eadc ph\u1ee5 huynh v\u1ec1 nguy c\u01a1 bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng da nghi\u00eam tr\u1ecdng c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng h\u1eadu qu\u1ea3 n\u1eb7ng n\u1ec1 cho s\u1ee9c kh\u1ecfe c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<h2>ANSM th\u00f4ng b\u00e1o cho b\u1ec7nh nh\u00e2n v\u00e0 nh\u00e2n vi\u00ean y t\u1ebf:<\/h2>\n<p>1. \u01afu ti\u00ean s\u1eed d\u1ee5ng paracetamol trong tr\u01b0\u1eddng h\u1ee3p \u0111au ho\u1eb7c s\u1ed1t, \u0111\u1eb7c bi\u1ec7t v\u1edbi t\u00ecnh tr\u1ea1ng nhi\u1ec5m tr\u00f9ng th\u00f4ng th\u01b0\u1eddng nh\u01b0 vi\u00eam amidan, vi\u00eam m\u0169i h\u1ecdng, vi\u00eam tai, vi\u00eam ph\u1ed5i, t\u1ed5n th\u01b0\u01a1ng da ho\u1eb7c th\u1ee7y \u0111\u1eadu, \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c kh\u00f4ng c\u1ea7n k\u00ea \u0111\u01a1n.<\/p>\n<p>2. C\u00e1c nguy\u00ean t\u1eafc s\u1eed d\u1ee5ng t\u1ed1t NSAID trong qu\u1ea3n l\u00fd \u0111au v\u00e0 s\u1ed1t:<\/p>\n<p>K\u00ea \u0111\u01a1n v\u00e0 s\u1eed d\u1ee5ng NSAID v\u1edbi li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t<br \/>\nNg\u1eebng thu\u1ed1c khi kh\u00f4ng c\u00f2n tri\u1ec7u ch\u1ee9ng<br \/>\nTr\u00e1nh s\u1eed d\u1ee5ng NSAID trong tr\u01b0\u1eddng h\u1ee3p th\u1ee7y \u0111\u1eadu<br \/>\nKh\u00f4ng d\u00f9ng thu\u1ed1c qu\u00e1 3 ng\u00e0y \u0111\u1ec3 h\u1ea1 s\u1ed1t<br \/>\nKh\u00f4ng d\u00f9ng thu\u1ed1c qu\u00e1 5 ng\u00e0y \u0111\u1ec3 gi\u1ea3m \u0111au.<br \/>\nKh\u00f4ng s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi 2 NSAID.<\/p>\n<p>Ngu\u1ed3n: <a href=\"https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Anti-inflammatoires-non-steroidiens-AINS-et-complications-infectieuses-graves-Point-d-Information\" rel=\"noopener\">https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Anti-inflammatoires-non-steroidiens-AINS-et-complications-infectieuses-graves-Point-d-Information<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: V\u0169 \u0110\u1ee9c Ho\u00e0n &#8211; D\u01b0\u01a1ng Kh\u00e1nh Linh &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Th\u00e1ng 6\/2018, sau khi nh\u1eadn \u0111\u01b0\u1ee3c c\u00e1c b\u00e1o c\u00e1o v\u1ec1 c\u00e1c bi\u1ebfn ch\u1ee9ng nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid (NSAID) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong h\u1ea1 s\u1ed1t v\u00e0 gi\u1ea3m \u0111au, C\u01a1 quan An to\u00e0n Thu\u1ed1c v\u00e0 S\u1ea3n ph\u1ea9m y t\u1ebf Ph\u00e1p (ANSM) \u0111\u00e3 y\u00eau c\u1ea7u c\u00e1c trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c [&#8230;]\n","protected":false},"author":1,"featured_media":9095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9094","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=9094"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/9094\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/9095"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=9094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=9094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=9094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}