{"id":8990,"date":"2019-05-03T12:33:50","date_gmt":"2019-05-03T05:33:50","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=8990"},"modified":"2019-06-23T12:15:27","modified_gmt":"2019-06-23T05:15:27","slug":"dung-khang-histamine-h1-va-nhom-diazepam-de-gay-ngu-co-khac-gi-nhau-khong","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/dung-khang-histamine-h1-va-nhom-diazepam-de-gay-ngu-co-khac-gi-nhau-khong\/","title":{"rendered":"D\u00f9ng kh\u00e1ng histamine H1 v\u00e0 nh\u00f3m diazepam \u0111\u1ec3 g\u00e2y ng\u1ee7 c\u00f3 kh\u00e1c g\u00ec nhau kh\u00f4ng?"},"content":{"rendered":"

\u0110\u00e2y l\u00e0 m\u1ed9t c\u00e2u h\u1ecfi c\u00f3 v\u1ebb r\u1ea5t nh\u1eb9 nh\u00e0ng nh\u01b0ng l\u1ea1i r\u1ea5t kh\u1ee7ng khi\u1ebfp cho ng\u01b0\u1eddi ph\u1ea3i gi\u1ea3i \u0111\u00e1p v\u00ec ch\u1eafc ch\u1eafn ng\u01b0\u1eddi h\u1ecfi kh\u00f4ng mong \u0111\u1ee3i c\u00e2u tr\u1ea3 l\u1eddi theo ki\u1ec3u yes\/no, right\/wrong v\u00ec v\u1eady c\u0169ng nh\u01b0 m\u1ecdi lo\u1ea1i thu\u1ed1c kh\u00e1c tr\u01b0\u1edbc khi n\u00f3i v\u1ec1 thu\u1ed1c ch\u00fang ta h\u00e3y xem x\u00e9t ng\u1ee7 l\u00e0 g\u00ec? th\u1ee9c l\u00e0 g\u00ec?<\/p>\n

\"g\u00e2y<\/p>\n

Tr\u01b0\u1edbc h\u1ebft kh\u00f4ng th\u1ec3 tr\u00e1nh kh\u1ecfi vi\u1ec7c ph\u1ea3i n\u00f3i t\u1edbi c\u1ea5u tr\u00fac l\u01b0\u1edbi c\u1ee7a n\u00e3o (Reticular Formation) \u0111\u00e2y l\u00e0 ph\u1ea7n quan tr\u1ecdng v\u00ec t\u1ed5 ch\u1ee9c n\u00e0y l\u00e0m nhi\u1ec7m v\u1ee5 t\u00edch h\u1ee3p (integration) t\u1ea5t c\u1ea3 nh\u1eefng ch\u1ee9c n\u0103ng ri\u00eang r\u1ebd c\u1ee7a n\u1ea3o nh\u01b0 v\u1eadn \u0111\u1ed9ng ,c\u1ea3m gi\u00e1c, c\u1ea3m x\u00fac, k\u1ec3 c\u1ea3 ph\u1ed1i h\u1ee3p gi\u1eefa h\u1ec7 th\u1ea7n kinh t\u1ef1 \u0111\u1ed9ng(autonomous nervous system) nh\u01b0ng \u1edf \u0111\u00e2y h\u00e3y t\u1ea1m ch\u1ec9 n\u00f3i v\u1ec1 th\u1ee9c\/ ng\u1ee7. C\u1ea5u tr\u00fac l\u01b0\u1edbi \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh nh\u01b0 l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng nhi\u1ec1u nh\u00e2n x\u00e1m \u0111\u01b0\u1ee3c n\u1ed1i k\u1ebft v\u1edbi nhau b\u1edfi nh\u1eefng neuron c\u00f3 tr\u1ee5c ng\u1eafn \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o lo\u1ea1i neuron h\u00ecnh th\u00e1p. h1. S\u1ef1 t\u1ed5 h\u1ee3p n\u00e0y t\u1ea1o th\u00e0nh hai pathway r\u00f5 r\u1ec7t.<\/p>\n

1.acivating pathway bao g\u1ed3m hai nh\u00e1nh k\u00edch th\u00edch v\u1ecf n\u00e3o v\u1edbi t\u1ea5t c\u1ea3 monoamines c\u1ee7a n\u00e3o v\u00e0 Acetylcholine h2 c\u00e1c nh\u00e2n x\u00e1m v\u00e0 neurotransmitters c\u0169ng \u0111\u01b0\u1ee3c ch\u00fa th\u00edch trong h\u00ecnh n\u00e0y. H\u00ecnh 3 ch\u00fa th\u00edch v\u1ec1 nh\u00e2n TMN (tuberomamillary nucleus) n\u01a1i t\u1ed5ng h\u1ee3p duy nh\u1ea5t histamine c\u1ee7a n\u00e3o, t\u1eeb nh\u00e2n n\u00e0y histamine \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp n\u00e3o nh\u01b0 m\u1ed9t neurotransmitter k\u00edch th\u00edch th\u1ee5 th\u1ec3 H1.<\/p>\n

2. inhibitory pathway kh\u1edfi \u0111\u1ea7u t\u1eeb nh\u00e2n VPLO (ventolateral preoptic nucleus) \u0111\u00e2y c\u0169ng l\u00e0 n\u01a1i duy nh\u1ea5t t\u1ed5ng h\u1ee3p v\u00e0 ph\u00e2n ph\u1ed1i GABA (gamma aminobutyric acid) h4 nh\u00e2n x\u00e1m n\u00e0y ch\u1ecbu s\u1ef1 chi ph\u1ed1i c\u1ee7a melatonine t\u1eeb tuy\u1ebfn T\u00f9ng (Pineal gland-Epiphysis) h5.
\nMelatonine \u0111i\u1ec1u khi\u1ec3n VPLO theo chu k\u1ef3 ng\u00e0y \u0111\u00eam (Circadian rythm). Khi VPLO \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ed9ng n\u00f3 \u1ee9c ch\u1ebf to\u00e0n th\u1ec3 c\u00e1c \u0111\u01b0\u1eddng k\u00edch th\u00edch trong m\u1ed9t kho\u1ea3ng th\u1eddi gian \u0111\u1ec3 t\u1ea1o ra gi\u1ea5c ng\u1ee7 non-REMS (rapid eyes movement sleep) GABA \u1ee9c ch\u1ebf ng\u1eafn h\u01a1n v\u00e0 th\u00e0nh t\u1eebng \u0111\u1ee3t tr\u00ean nh\u00e2n LH (lateral hypothalamus) ,t\u1ea1i \u0111\u00e2y t\u1ed5ng h\u1ee3p Orexin (c\u00f2n g\u1ecdi l\u00e0 hypocretin) ch\u1ea5t n\u00e0y t\u00e1i ho\u1ea1t t\u1ea1o ra gi\u1ea5c ng\u1ee7 REMS.<\/p>\n

Nh\u01b0 v\u1eady c\u00f3 m\u1ed9t s\u1ef1 kh\u00e1c bi\u1ec7t r\u00f5 r\u1ec7t gi\u1eefa vi\u1ec7c kh\u1edfi \u0111\u1ed9ng \u0111\u01b0\u1eddng GABAergic trong s\u1ef1 t\u1ea1o ra gi\u1ea5c ng\u1ee7 \u0111\u00f3 l\u00e0 \u1ee9c ch\u1ebf to\u00e0n b\u1ed9 \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n Monoaminergic & Ach trong ch\u1ec9 v\u00f4 hi\u1ec7u h\u00f3a \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n histaminergic. N\u00ean nh\u1edb r\u1eb1ng c\u00e1c synapse c\u1ee7a v\u00f9ng CA1 t\u1ea1i Hippocampus c\u00f3 li\u00ean quan \u0111\u1ebfn tr\u00ed nh\u1edb \u0111\u01b0\u1ee3c tinh l\u1ecdc v\u00e0 c\u1ee7ng c\u1ed1 trong giai \u0111\u1ea1n 3&4 c\u1ee7a non-REMS. B\u1ea3ng li\u1ec7t k\u00ea c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 d\u00f9ng trong m\u1ea5t ng\u1ee7<\/a> nh\u01b0 trong b\u1ea3ng \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y v\u1edbi m\u1ed9t gi\u1ea3 \u0111\u1ecbnh c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng \u0111\u00e3 bi\u1ebft nh\u1eefng \u0111i\u1ec1u t\u1ed1i thi\u1ec3u \u0111\u00e3 tr\u00ecnh b\u00e0y \u1edf tr\u00ean. \u0110\u00f3 l\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t trong \u0111\u00e0o t\u1ea1o Y khoa c\u1ee7a ta v\u00e0 c\u1ee7a ng\u01b0\u1eddi ta. Em kh\u00f4ng th\u1ec3 g\u1ecdi l\u00e0 nh\u00f3m diazepam m\u00e0 ph\u1ea3i g\u1ecdi \u0111\u00fang l\u00e0 nh\u00f3m Benzodiazepine.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u0110\u00e2y l\u00e0 m\u1ed9t c\u00e2u h\u1ecfi c\u00f3 v\u1ebb r\u1ea5t nh\u1eb9 nh\u00e0ng nh\u01b0ng l\u1ea1i r\u1ea5t kh\u1ee7ng khi\u1ebfp cho ng\u01b0\u1eddi ph\u1ea3i gi\u1ea3i \u0111\u00e1p v\u00ec ch\u1eafc ch\u1eafn ng\u01b0\u1eddi h\u1ecfi kh\u00f4ng mong \u0111\u1ee3i c\u00e2u tr\u1ea3 l\u1eddi theo ki\u1ec3u yes\/no, right\/wrong v\u00ec v\u1eady c\u0169ng nh\u01b0 m\u1ecdi lo\u1ea1i thu\u1ed1c kh\u00e1c tr\u01b0\u1edbc khi n\u00f3i v\u1ec1 thu\u1ed1c ch\u00fang ta h\u00e3y xem x\u00e9t ng\u1ee7 l\u00e0 […]\n","protected":false},"author":1,"featured_media":8992,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8990","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=8990"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8990\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/8992"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=8990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=8990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=8990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}