{"id":8711,"date":"2019-04-30T15:02:31","date_gmt":"2019-04-30T08:02:31","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=8711"},"modified":"2019-07-05T16:11:16","modified_gmt":"2019-07-05T09:11:16","slug":"vitamin-b12-muc-do-tac-dong-den-su-moi-mat-do-dieu-tiet-den-dau","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/vitamin-b12-muc-do-tac-dong-den-su-moi-mat-do-dieu-tiet-den-dau\/","title":{"rendered":"Vitamin B12 \u2013 M\u1ee9c \u0111\u1ed9 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn s\u1ef1 m\u1ecfi m\u1eaft do \u0111i\u1ec1u ti\u1ebft \u0111\u1ebfn \u0111\u00e2u?"},"content":{"rendered":"

– Vitamin B12<\/strong> l\u00e0 m\u1ed9t ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong nhi\u1ec1u l\u0129nh v\u1ef1c, trong \u0111\u00f3 c\u00f3 ng\u00e0nh ch\u0103n nu\u00f4i v\u00e0 ng\u00e0nh y t\u1ebf. Thu\u1eadt ng\u1eef Vitamin B12 d\u00f9ng \u0111\u1ec3 ch\u1ec9 m\u1ed9t nh\u00f3m h\u1ee3p ch\u1ea5t ch\u1ee9a coban hay c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 nh\u00f3m cobalamin (g\u1ed3m Cyanocobalamin, Methylcobalamin, Adenosylcobalamin v\u00e0 Hydroxocobalamin). Trong ng\u00e0nh y t\u1ebf, Vitamin B12 d\u1ea1ng d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng ho\u1eb7c ti\u00eam b\u1eafp \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t cho r\u1ea5t nhi\u1ec1u ch\u1ec9 \u0111\u1ecbnh v\u00e0 m\u1ed9t trong c\u00e1c ch\u1ec9 \u0111\u1ecbnh \u0111\u00e1ng ch\u00fa \u00fd li\u00ean quan \u0111\u1ebfn m\u1eaft l\u00e0 \u201c\u0110i\u1ec1u tr\u1ecb gi\u1ea3m th\u1ecb l\u1ef1c do thu\u1ed1c l\u00e1 v\u00e0 b\u1ec7nh teo d\u00e2y th\u1ea7n kinh th\u1ecb gi\u00e1c c\u00f3 di truy\u1ec1n Leber\u201d d\u00e0nh cho ho\u1ea1t ch\u1ea5t Hydroxocobalamin (nh\u01b0ng ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi ho\u1ea1t ch\u1ea5t Cyanocobalamin tr\u00ean b\u1ec7nh Leber do \u0111\u00e2y l\u00e0 m\u1ed9t d\u1ea1ng b\u1ec7nh r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a cyanid).<\/p>\n

$\"Vitamin_B12\"$ <\/p>\n

– Khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng ho\u1eb7c ti\u00eam b\u1eafp, Vitamin B12 c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 n\u00ean m\u1ed9t s\u1ed1 nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ngh\u0129 \u0111\u1ebfn vi\u1ec7c th\u1eed nghi\u1ec7m s\u1eed d\u1ee5ng Vitamin B12 d\u1ea1ng nh\u1ecf m\u1eaft tr\u1ef1c ti\u1ebfp \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng l\u00ean m\u1eaft ng\u01b0\u1eddi. N\u0103m 1987, hai nh\u00e0 khoa h\u1ecdc ng\u01b0\u1eddi Nh\u1eadt B\u1ea3n \u0111\u00e3 ti\u1ebfn h\u00e0nh nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng c\u1ee7a Methylcobalamin l\u00ean s\u1ef1 r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ti\u1ebft c\u1ee7a m\u1eaft do nh\u00ecn g\u1ea7n qu\u00e1 nhi\u1ec1u, d\u1ef1a tr\u00ean vi\u1ec7c \u0111\u00e1nh gi\u00e1 dao \u0111\u1ed9ng nh\u1ecf c\u1ee7a s\u1ef1 \u0111i\u1ec1u ti\u1ebft. Nghi\u00ean c\u1ee9u c\u1ee7a h\u1ecd \u0111\u00e3 ch\u1ec9 ra 2 \u0111i\u1ec3m \u0111\u00e1ng ch\u00fa \u00fd:<\/p>\n

+ Kh\u00f3 ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c s\u1ef1 c\u1ea3i thi\u1ec7n cho t\u00ecnh tr\u1ea1ng suy gi\u1ea3m kh\u1ea3 n\u0103ng \u0111i\u1ec1u ti\u1ebft do nh\u00ecn g\u1ea7n nhi\u1ec1u tr\u00ean nh\u00f3m b\u1ec7nh nh\u00e2n d\u00f9ng ch\u1ebf ph\u1ea9m ch\u1ee9a Methylcobalamin. (Hi\u1ec3u n\u00f4m na l\u00e0 kh\u00f4ng r\u00f5 t\u00e1c d\u1ee5ng ch\u1ed1ng m\u1ecfi m\u1eaft \u0111\u1ebfn \u0111\u00e2u khi nh\u1ecf m\u1eaft ch\u1ebf ph\u1ea9m ch\u1ee9a Methylcobalamin)
\n+ Bi\u00ean \u0111\u1ed9 dao \u0111\u1ed9ng nh\u1ecf c\u1ee7a s\u1ef1 \u0111i\u1ec1u ti\u1ebft cao h\u01a1n \u1edf nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c (Placebo \u2013 d\u1ecbch cho d\u1ec5 hi\u1ec3u l\u00e0 \u0111\u01b0a b\u1ec7nh nh\u00e2n 1 l\u1ecd kh\u00f4ng ch\u1ee9a Methylcobalamin nh\u01b0ng v\u1eabn b\u1ea3o \u0111\u00e2y l\u00e0 l\u1ecd c\u00f3 ch\u1ee9a ho\u1ea1t ch\u1ea5t n\u00e0y) so v\u1edbi nh\u00f3m kh\u00f4ng d\u00f9ng g\u00ec. (Hi\u1ec3u t\u1ea1m l\u00e0 d\u00f9ng thu\u1ed1c \u201c\u1ea3o\u201d hay thu\u1ed1c th\u1eadt v\u1eabn \u0111\u1ee1 h\u01a1n l\u00e0 kh\u00f4ng d\u00f9ng g\u00ec).<\/p>\n

– V\u1eady t\u00e1c \u0111\u1ed9ng c\u1ee7a nh\u00f3m Vitamin B12 n\u00e0y trong th\u1ef1c t\u1ebf s\u1eed d\u1ee5ng th\u00ec sao? Ch\u00fang ta ph\u1ea3i th\u1eeba nh\u1eadn r\u1eb1ng v\u1edbi t\u1ea7n su\u1ea5t l\u00e0m vi\u1ec7c v\u1edbi m\u00e1y t\u00ednh hay h\u1ecdc t\u1eadp k\u00e9o d\u00e0i th\u00ec vi\u1ec7c d\u00f9ng \u0111\u01a1n \u0111\u1ed9c thu\u1ed1c ch\u1ee9a Vitamin B12 \u0111\u1ec3 nh\u1ecf m\u1eaft kh\u00f4ng c\u1ea3i thi\u1ec7n nhi\u1ec1u, t\u00ecnh tr\u1ea1ng m\u1ecfi m\u1eaft v\u1eabn di\u1ec5n ra nh\u01b0ng \u0111a s\u1ed1 ng\u01b0\u1eddi s\u1eed d\u1ee5ng \u0111\u1ec1u c\u1ea3m th\u1ea5y c\u00f3 \u201c\u0111\u1ee1 h\u01a1n m\u1ed9t ch\u00fat\u201d. Sau khi \u0111\u00e3 s\u1eed d\u1ee5ng th\u00ec b\u1ec7nh nh\u00e2n t\u1ea1i vi\u1ec7n c\u1ee7a ad th\u01b0\u1eddng b\u1ed3i th\u00eam m\u1ed9t c\u00e2u: \u201cch\u1eb3ng kh\u00e1c g\u00ec nh\u1ecf n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd\u201d. Quay l\u1ea1i, nghi\u00ean c\u1ee9u c\u1ee7a hai t\u00e1c gi\u1ea3 tr\u00ean c\u0169ng c\u00f3 \u0111\u1ec1 c\u1eadp hi\u1ec7u \u1ee9ng \u201cgi\u1ea3 d\u01b0\u1ee3c\u201d c\u1ee7a ho\u1ea1t ch\u1ea5t Methylcobalamin, hi\u1ec3u \u0111\u01a1n gi\u1ea3n l\u00e0 k\u1ec3 c\u1ea3 c\u00f3 cho b\u1ec7nh nh\u00e2n nh\u1ecf n\u01b0\u1edbc c\u1ea5t m\u00e0 b\u1ea3o b\u1ec7nh nh\u00e2n \u0111\u00e2y l\u00e0 thu\u1ed1c \u201cx\u1ecbn\u201d th\u00ec b\u1ec7nh nh\u00e2n c\u0169ng c\u1ea3m th\u1ea5y \u201cc\u00f3 t\u00e1c d\u1ee5ng\u201d.<\/p>\n

– Vi\u1ec7c kh\u00f4ng c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u d\u00e0nh cho vitamin B12 v\u1edbi t\u00e1c d\u1ee5ng ch\u1ed1ng m\u1ecfi m\u1eaft \u0111\u00e3 h\u1ea1n ch\u1ebf vi\u1ec7c \u0111\u00e1nh gi\u00e1 m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n ho\u1ea1t ch\u1ea5t n\u00e0y. Do v\u1eady, t\u00e1c d\u1ee5ng c\u1ee7a Vitamin B12 l\u00ean s\u1ef1 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng \u0111i\u1ec1u ti\u1ebft m\u1eaft cho \u0111\u1ebfn nay c\u00f3 th\u1ec3 t\u1ea1m n\u00f3i l\u00e0 ch\u01b0a th\u1ef1c s\u1ef1 r\u00f5 r\u00e0ng nh\u01b0ng t\u00e2m l\u00fd ng\u01b0\u1eddi b\u1ec7nh khi \u0111\u1ebfn kh\u00e1m \u0111\u1ec1u mong c\u00f3 1 lo\u1ea1i thu\u1ed1c g\u00ec \u0111\u00f3 \u0111\u1ec3 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng c\u1ee7a m\u00ecnh, ch\u00ednh t\u00e2m l\u00fd \u0111\u00f3 c\u0169ng \u0111\u00e3 g\u00f3p ph\u1ea7n khi\u1ebfn thu\u1ed1c \u201cc\u00f3 t\u00e1c d\u1ee5ng\u201d. Ch\u1ec9 c\u00f3 \u0111i\u1ec1u, \u0111\u1ec3 c\u00f3 t\u00e1c \u0111\u1ed9ng hi\u1ec7u qu\u1ea3 l\u00ean vi\u1ec7c gi\u1ea3m t\u00ecnh tr\u1ea1ng m\u1ecfi m\u1eaft th\u00ec c\u1ea7n ph\u1ea3i l\u00e0m nhi\u1ec1u vi\u1ec7c k\u1ebft h\u1ee3p ch\u1ee9 kh\u00f4ng th\u1ec3 ch\u1ec9 d\u00f9ng thu\u1ed1c \u0111\u01a1n thu\u1ea7n, m\u00e0 l\u1ea1i c\u00f2n ch\u1ec9 d\u00f9ng \u0111\u01a1n \u0111\u1ed9c 1 lo\u1ea1i thu\u1ed1c.<\/p>\n

– Trong c\u00e1c b\u00e0i sau, s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a Vitamin B12 c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c s\u1ebd \u0111\u01b0\u1ee3c b\u00e0n lu\u1eadn s\u00e2u h\u01a1n. \u0110\u1ec3 k\u1ebft th\u00fac b\u00e0i vi\u1ebft, ad xin li\u1ec7t ra m\u1ed9t s\u1ed1 l\u01b0u \u00fd khi s\u1eed d\u1ee5ng ch\u1ebf ph\u1ea9m nh\u1ecf m\u1eaft c\u00f3 ch\u1ee9a Vitamin B12:<\/p>\n

+ Vitamin B12 c\u00f3 \u0111\u1ed9 b\u1ec1n k\u1ec3 c\u1ea3 v\u1edbi nhi\u1ec7t \u0111\u1ed9 cao khi \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf \u1edf pH 4-6 (m\u00f4i tr\u01b0\u1eddng acid). Nh\u01b0ng khi chuy\u1ec3n sang m\u00f4i tr\u01b0\u1eddng pH cao (m\u00f4i tr\u01b0\u1eddng ki\u1ec1m hay c\u00f2n g\u1ecdi l\u00e0 m\u00f4i tr\u01b0\u1eddng \u201cx\u00e0 ph\u00f2ng\u201d) ho\u1eb7c ti\u1ebfp x\u00fac v\u1edbi \u00e1nh s\u00e1ng m\u1eb7t tr\u1eddi, Vitamin B12 r\u1ea5t d\u1ec5 b\u1ecb ph\u00e2n h\u1ee7y v\u00e0 tr\u1edf n\u00ean m\u1ea5t t\u00e1c d\u1ee5ng. D\u00f9 c\u00e1c h\u00e3ng \u0111\u00e3 b\u00e0o ch\u1ebf \u0111\u1ec3 ho\u1ea1t ch\u1ea5t kh\u00f3 b\u1ecb ph\u00e2n h\u1ee7y h\u01a1n nh\u01b0ng ch\u00fang ta v\u1eabn n\u00ean c\u1ea5t l\u1ecd thu\u1ed1c \u1edf c\u00e1c ch\u1ed7 tr\u00e1nh \u00e1nh s\u00e1ng.
\n+ Kh\u00f4ng nh\u1ecf \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ebf ph\u1ea9m c\u00f3 ch\u1ee9a Vitamin C do s\u1ef1 t\u01b0\u01a1ng t\u00e1c h\u00f3a h\u1ecdc l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ed9 b\u1ec1n c\u1ee7a Vitamin B12.
\n+ D\u1ea1ng Vitamin B12 hay d\u00f9ng trong nh\u00e3n khoa l\u00e0 Cyanocobalamin, c\u00f3 m\u00e0u \u0111\u1ecf \u0111\u1eb7c tr\u01b0ng n\u00ean c\u00e1c b\u1ea1n \u0111\u1eebng lo thu\u1ed1c b\u1ecb h\u1ecfng. N\u1ebfu thu\u1ed1c b\u1ecb h\u1ecfng th\u00ec m\u00e0u \u0111\u1ecf s\u1ebd gi\u1ea3m \u0111i nhi\u1ec1u ho\u1eb7c bi\u1ebfn m\u1ea5t.<\/p>\n

Nh\u00e0 thu\u1ed1c chuy\u00ean khoa m\u1eaft HD H\u00e0 N\u1ed9i c\u00f3 b\u00e1n thu\u1ed1c:<\/p>\n

+ Sancoba<\/a> 0.02% 5ml (ch\u1ee9a Cyanocobalamin 0.02%) do h\u00e3ng Santen c\u1ee7a Nh\u1eadt s\u1ea3n xu\u1ea5t v\u1edbi ch\u1ec9 \u0111\u1ecbnh: \u201cC\u1ea3i thi\u1ec7n s\u1ef1 dao \u0111\u1ed9ng v\u1ec1 \u0111i\u1ec1u ti\u1ebft trong ch\u1ee9ng m\u1ecfi m\u1eaft do \u0111i\u1ec1u ti\u1ebft\u201d. Gi\u00e1 b\u00e1n: 50.000\u0111. Gi\u00e1 nh\u1eadp (gi\u00e1 tr\u00fang th\u1ea7u to\u00e0n qu\u1ed1c): 47.376\u0111.<\/p>\n