{"id":8677,"date":"2019-04-28T10:40:40","date_gmt":"2019-04-28T03:40:40","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=8677"},"modified":"2019-04-30T10:50:47","modified_gmt":"2019-04-30T03:50:47","slug":"hydrochlorothiazid-va-nguy-co-ung-thu-da-khong-hac-to","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/hydrochlorothiazid-va-nguy-co-ung-thu-da-khong-hac-to\/","title":{"rendered":"Hydrochlorothiazid v\u00e0 nguy c\u01a1 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1"},"content":{"rendered":"

Medsafe (New Zealand): Hydrochlorothiazid v\u00e0 nguy c\u01a1 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1<\/h2>\n

C\u00f3 hai nghi\u00ean c\u1ee9u \u1edf \u0110an M\u1ea1ch cho th\u1ea5y m\u1ed1i li\u00ean quan gi\u1eefa hydrochlorothiazid v\u00e0 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1, \u0111\u1eb7c bi\u1ec7t l\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y (SCC) v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y \u1edf m\u00f4i v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o \u0111\u00e1y (BCC). Tr\u01b0\u1edbc Medsafe, c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd y t\u1ebf \u1edf Canada, M\u1ef9, Singapore, Anh … \u0111\u1ec1u \u0111\u00e3 \u0111\u01b0a ra c\u1ea3nh b\u00e1o v\u1ec1 nguy c\u01a1 n\u00e0y<\/p>\n

Th\u00f4ng tin chung<\/h2>\n

Hydrochlorothiazid l\u00e0 thu\u1ed1c ch\u1ec9 \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n \u1edf New Zealand, d\u00f9ng k\u00e8m v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c nh\u01b0 cilazapril, quinapril, losartan, amilorid. Nh\u1eefng thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00e0 ph\u00f9.<\/p>\n

C\u00f3 hai nghi\u00ean c\u1ee9u \u1edf \u0110an M\u1ea1ch cho th\u1ea5y m\u1ed1i li\u00ean quan gi\u1eefa hydrochlorothiazid v\u00e0 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1, \u0111\u1eb7c bi\u1ec7t l\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y (SCC) v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y \u1edf m\u00f4i v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o \u0111\u00e1y (BCC).<\/p>\n

S\u1ea3n ph\u1ea9m b\u1ecb \u1ea3nh h\u01b0\u1edfng<\/h2>\n\n\n\n\n\n\n\n
Thu\u1ed1c<\/td>\nBi\u1ec7t d\u01b0\u1ee3c<\/td>\n<\/tr>\n
Vi\u00ean n\u00e9n\u00a0 cilazapiril\/hydrochlorothiazid (5mg\/12.5mg)<\/td>\nApo-Cilazapril\/ Hydrochlorothiazide<\/td>\n<\/tr>\n
Vi\u00ean n\u00e9n quinapril\/hydrochlorothiazid (10mg\/12.5mg v\u00e0 20mg\/12.5mg)<\/td>\nAccuretic<\/td>\n<\/tr>\n
Vi\u00ean n\u00e9n losartan\/hydrochlorothiazid (50mg\/12.5mg)<\/td>\nHyzaar, Arrow-Losartan & Hydrochlorothiazide<\/td>\n<\/tr>\n
Vi\u00ean n\u00e9n amilorid\/hydrochlorothiazid (5mg\/50mg)<\/td>\nModuretic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

H\u00ecnh \u1ea3nh 1 s\u1ed1 s\u1ea3n ph\u1ea9m b\u1ecb \u1ea3nh h\u01b0\u1edfng:<\/p>\n

\"hyzaar\"
H\u00ecnh \u1ea3nh: thu\u1ed1c hyzaar<\/figcaption><\/figure>\n
\"Accuretic\"
H\u00ecnh \u1ea3nh: thu\u1ed1c Accuretic<\/figcaption><\/figure>\n
\"Moduretic\"
H\u00ecnh \u1ea3nh: thu\u1ed1c Moduretic<\/figcaption><\/figure>\n

Khuy\u1ebfn c\u00e1o cho ng\u01b0\u1eddi d\u00f9ng<\/h2>\n

M\u1ed1i li\u00ean quan gi\u1eefa hydrochlorothiazid v\u00e0 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c ch\u1ee9a hydrochlorothiazid trong th\u1eddi gian d\u00e0i.<\/p>\n

Kh\u00f4ng t\u1ef1 \u00fd ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ee9a hydrochlorothiazid n\u1ebfu kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129. L\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb c\u00f3 \u00fd ngh\u0129a h\u01a1n nhi\u1ec1u so v\u1edbi nguy c\u01a1 nh\u1ecf ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1.<\/p>\n

Ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1 g\u1ed3m ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o \u0111\u00e1y (BCC) v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y (SCC). BCC v\u00e0 SCC c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng \u0111i\u1ec1u tr\u1ecb n\u1ebfu \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n s\u1edbm.<\/p>\n

Hydrochlorothiazid c\u00f3 th\u1ec3 l\u00e0m t\u0103ng m\u1ee9c \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a da \u0111\u1ed1i v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi v\u00e0 tia UV. H\u1ea1n ch\u1ebf th\u1eddi gian ti\u1ebfp x\u00fac da tr\u1ef1c ti\u1ebfp v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi ho\u1eb7c t\u1eafm n\u1eafng nh\u00e2n t\u1ea1o, \u0111\u1ea3m b\u1ea3o trang b\u1ecb kem ch\u1ed1ng n\u1eafng (SPF t\u1eeb 30 tr\u1edf l\u00ean, thoa tr\u00ean da v\u00e0 m\u00f4i) v\u00e0 qu\u1ea7n \u00e1o ch\u1ed1ng n\u1eafng khi ra ngo\u00e0i.<\/p>\n

Ki\u1ec3m tra da v\u00e0 m\u00f4i th\u01b0\u1eddng xuy\u00ean, trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u1ef9 n\u1ebfu nh\u1eadn th\u1ea5y b\u1ea5t k\u00ec \u0111\u1ed1m, c\u1ee5c, n\u1ed1t ru\u1ed3i, v\u1ebft lo\u00e9t n\u00e0o thay \u0111\u1ed5i\/m\u1edbi xu\u1ea5t hi\u1ec7n.<\/p>\n

Th\u00f4ng tin cho c\u00e1n b\u1ed9 y t\u1ebf<\/h2>\n

Hai nghi\u00ean c\u1ee9u ki\u1ec3m so\u00e1t tr\u01b0\u1eddng h\u1ee3p g\u1ea7n \u0111\u00e2y \u1edf \u0110an M\u1ea1ch ph\u00e1t hi\u1ec7n t\u0103ng nguy c\u01a1 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1 (BCC, SCC v\u00e0 SCC \u1edf m\u00f4i) khi ti\u1ebfp x\u00fac v\u1edbi hydrochlorothiazid. Nguy c\u01a1 t\u0103ng khi t\u0103ng li\u1ec1u t\u00edch l\u0169y.<\/p>\n

C\u01a1 ch\u1ebf c\u1ee7a vi\u1ec7c hydrochlorothiazid l\u00e0m t\u0103ng m\u1ee9c \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a da v\u1edbi \u00e1nh s\u00e1ng v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c t\u00ecm ra.<\/p>\n

B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao ph\u00e1t tri\u1ec3n ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1 (VD: b\u1ec7nh nh\u00e2n c\u00f3 da s\u00e1ng m\u00e0u, ti\u1ec1n s\u1eed b\u1ea3n th\u00e2n\/gia \u0111\u00ecnh ung th\u01b0 da, \u0111ang \u0111i\u1ec1u tr\u1ecb \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch) c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p b\u1ea3o v\u1ec7 da trong m\u1ecdi tr\u01b0\u1eddng h\u1ee3p.<\/p>\n

Th\u00f4ng b\u00e1o cho b\u1ec7nh nh\u00e2n v\u1ec1 nguy c\u01a1 n\u00e0y v\u00e0 khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n h\u1ea1n ch\u1ebf ti\u1ebfp x\u00fac v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi hay tia UV v\u00e0 th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p ch\u1ed1ng n\u1eafng \u0111\u1ea7y \u0111\u1ee7.<\/p>\n

Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ee9a hydrochlorothiazid c\u1ea7n ki\u1ec3m tra da v\u00e0 m\u00f4i th\u01b0\u1eddng xuy\u00ean, b\u00e1o c\u00e1o b\u1ea5t k\u1ef3 t\u1ed5n th\u01b0\u01a1ng da hay n\u1ed1t ru\u1ed3i thay \u0111\u1ed5i\/m\u1edbi xu\u1ea5t hi\u1ec7n.<\/p>\n

Th\u1ea3o lu\u1eadn k\u1ef9 nh\u1eefng l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 khi \u0111i\u1ec1u tr\u1ecb hydrochlorothiazid tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 tr\u1ea3i qua ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1, c\u00e2n nh\u1eafc c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb kh\u00e1c.<\/p>\n

Th\u00f4ng tin chi ti\u1ebft<\/h2>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u kh\u00f4ng t\u00ecm th\u1ea5y m\u1ed1i li\u00ean quan t\u01b0\u01a1ng t\u1ef1 gi\u1eefa nguy c\u01a1 m\u1eafc ung th\u01b0 da BCC, SCC v\u00e0 SCC \u1edf m\u00f4i v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00e1c nh\u01b0 bendroflumethiazid, furosemid, c\u00e1c thu\u1ed1c ch\u1eb9n k\u00eanh calci, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3.<\/p>\n

T\u1ec9 l\u1ec7 m\u1eafc BCC v\u00e0 SCC \u1edf New Zealand hi\u1ec7n ch\u01b0a r\u00f5. C\u00e1c s\u1ed1 li\u1ec7u \u0111\u00e3 c\u00f4ng b\u1ed1 cho th\u1ea5y, \u1edf m\u1ed9t s\u1ed1 n\u01a1i tr\u00ean th\u1ebf gi\u1edbi, nguy c\u01a1 m\u1eafc BCC trong su\u1ed1t cu\u1ed9c \u0111\u1eddi \u01b0\u1edbc t\u00ednh 30%. Ngo\u00e0i ra, t\u1ea1i \u00dac, n\u01a1i c\u00f3 chung v\u0129 \u0111\u1ed9 v\u1edbi New Zealand, t\u1ef7 l\u1ec7 m\u1eafc SCC tr\u00ean da h\u00e0ng n\u0103m \u1edf nam v\u00e0 n\u1eef x\u1ea5p x\u1ec9 1035 v\u00e0 472 tr\u00ean 100.000 tr\u01b0\u1eddng h\u1ee3p.<\/p>\n

Ngu\u1ed3n: https:\/\/www.medsafe.govt.nz\/safety\/Alerts\/Hydrochlorothiazide.asp<\/a><\/p>\n

B\u00e0i d\u1ecbch \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i tr\u00ean website Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia, Vi\u1ec7t Nam.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Medsafe (New Zealand): Hydrochlorothiazid v\u00e0 nguy c\u01a1 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1 C\u00f3 hai nghi\u00ean c\u1ee9u \u1edf \u0110an M\u1ea1ch cho th\u1ea5y m\u1ed1i li\u00ean quan gi\u1eefa hydrochlorothiazid v\u00e0 ung th\u01b0 da kh\u00f4ng h\u1eafc t\u1ed1, \u0111\u1eb7c bi\u1ec7t l\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y (SCC) v\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y \u1edf m\u00f4i […]\n","protected":false},"author":1,"featured_media":8678,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=8677"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8677\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/8678"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=8677"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=8677"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=8677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}