{"id":8461,"date":"2019-04-23T19:22:37","date_gmt":"2019-04-23T12:22:37","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=8461"},"modified":"2019-04-27T19:37:26","modified_gmt":"2019-04-27T12:37:26","slug":"su-dung-thuoc-chong-dong-kinh-su-dung-trong-giai-doan-mang-thai","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/su-dung-thuoc-chong-dong-kinh-su-dung-trong-giai-doan-mang-thai\/","title":{"rendered":"S\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh s\u1eed d\u1ee5ng trong giai \u0111o\u1ea1n mang thai"},"content":{"rendered":"<h2>ANSM (Ph\u00e1p): Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh s\u1eed d\u1ee5ng trong giai \u0111o\u1ea1n mang thai v\u00e0 nguy c\u01a1 d\u1ecb t\u1eadt v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh<\/h2>\n<p>ANSM c\u00f4ng b\u1ed1 m\u1ed9t ph\u00e2n t\u00edch t\u1eeb ngu\u1ed3n d\u1eef li\u1ec7u c\u00f3 s\u1eb5n li\u00ean quan \u0111\u1ebfn nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh \u1edf tr\u1ebb em b\u1ecb ph\u01a1i nhi\u1ec5m v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh trong giai \u0111o\u1ea1n thai k\u1ef3.<\/p>\n<p>ANSM c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Ph\u00e1p b\u00ean c\u1ea1nh m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u00e3 c\u00f3 v\u1edbi thu\u1ed1c valproat.<\/p>\n<p>T\u1eeb k\u1ebft qu\u1ea3 ph\u00e2n t\u00edch n\u00e0y, ANSM \u0111\u00e3 quy\u1ebft \u0111\u1ecbnh tri\u1ec7u t\u1eadp \u1ee7y ban c\u00e1c chuy\u00ean gia \u0111\u1ed9c l\u1eadp (vi\u1ebft t\u1eaft CSST) v\u00e0o ng\u00e0y 14 th\u00e1ng 5 n\u0103m 2019 \u0111\u1ec3 \u0111\u1ec1 xu\u1ea5t c\u00e1c bi\u1ec7n ph\u00e1p b\u1ed5 sung \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 li\u00ean quan t\u1edbi vi\u1ec7c ph\u01a1i nhi\u1ec5m v\u1edbi thu\u1ed1c \u0111\u1ed9ng kinh khi \u1edf trong t\u1eed cung. \u1ee6y ban s\u1ebd ti\u1ebfn h\u00e0nh c\u00e1c bu\u1ed5i h\u1ecdp v\u00e0 s\u1ebd \u0111\u01b0\u1ee3c ph\u00e1t tr\u1ef1c tuy\u1ebfn tr\u00ean k\u00eanh Youtube ANSM.<\/p>\n<h2>Nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt<\/h2>\n<p>Trong d\u1eef li\u1ec7u y v\u0103n, ngo\u00e0i thu\u1ed1c valproat l\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh g\u00e2y d\u1ecb t\u1eadt nhi\u1ec1u nh\u1ea5t, n\u0103m ho\u1ea1t ch\u1ea5t kh\u00e1c c\u00f3 nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt cao b\u1edfi b\u00e1o c\u00e1o quan s\u00e1t trong d\u00e2n s\u1ed1 l\u00e0 topiramat, phenobarbital, primidon, carbamazepin v\u00e0 phenytoin.<\/p>\n<p>Ngo\u00e0i ra ANSM k\u00eau g\u1ecdi c\u1ea3nh gi\u00e1c trong vi\u1ec7c s\u1eed d\u1ee5ng pregabalin (bi\u1ec7t d\u01b0\u1ee3c Lyrica v\u00e0 c\u00e1c thu\u1ed1c generic) c\u00f3 nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt ti\u1ec1m t\u00e0ng v\u00e0 l\u01b0u \u00fd trong qu\u00e1 tr\u00ecnh k\u00ea \u0111\u01a1n t\u1ea1i Ph\u00e1p. Nghi\u00ean c\u1ee9u kh\u00f4ng cho th\u1ea5y s\u1ef1 gia t\u0103ng t\u1ea7n su\u1ea5t d\u1ecb t\u1eadt thai nhi \u0111\u1ed1i v\u1edbi lamotrigine v\u00e0 levetiracetam.<\/p>\n<h2>Nguy c\u01a1 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh<\/h2>\n<p>D\u1eef li\u1ec7u hi\u1ec7n t\u1ea1i kh\u00f4ng cho ph\u00e9p k\u1ebft lu\u1eadn r\u00f5 r\u00e0ng \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh.<\/p>\n<p>Cu\u1ed1i c\u00f9ng \u0111\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n v\u00e0 t\u1ed1i \u01b0u h\u00f3a vi\u1ec7c thu th\u1eadp th\u00f4ng tin, ANSM c\u00f9ng v\u1edbi APESAC (hi\u1ec7p h\u1ed9i ph\u1ee5 huynh c\u00f3 con \u1ea3nh h\u01b0\u1edfng b\u1edfi vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh) v\u00e0 trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c v\u00f9ng c\u1ee7a Ph\u00e1p m\u1ed9t bi\u1ec3u m\u1eabu b\u1ed5 sung cho b\u00e1o c\u00e1o c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c trong tr\u01b0\u1eddng h\u1ee3p tr\u1ebb ti\u1ebfp x\u00fac v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh trong giai \u0111o\u1ea1n thai k\u1ef3. Bi\u1ec3u m\u1eabu n\u00e0y c\u00f3 s\u1eb5n \u1edf trang web: signalement-sante.gouv.fr.<\/p>\n<p>ANSM th\u00f4ng b\u00e1o c\u00e1c chuy\u00ean gia y t\u1ebf r\u1eb1ng c\u01a1 quan y t\u1ebf c\u1ea5p cao (vi\u1ebft t\u1eaft HAS) \u0111\u00e3 c\u1eadp nh\u1eadt c\u00e1c khuy\u1ebfn c\u00e1o v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh d\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb b\u00e1o c\u00e1o n\u00e0y v\u00e0o cu\u1ed1i n\u0103m 2018.<\/p>\n<p>Ngu\u1ed3n: <a href=\"https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Antiepileptiques-au-cours-de-la-grossesse-Etat-actuel-des-connaissances-sur-les-risques-de-malformations-et-de-troubles-neuro-developpementaux\" rel=\"noopener\">https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Antiepileptiques-au-cours-de-la-grossesse-Etat-actuel-des-connaissances-sur-les-risques-de-malformations-et-de-troubles-neuro-developpementaux<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ANSM (Ph\u00e1p): Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh s\u1eed d\u1ee5ng trong giai \u0111o\u1ea1n mang thai v\u00e0 nguy c\u01a1 d\u1ecb t\u1eadt v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh ANSM c\u00f4ng b\u1ed1 m\u1ed9t ph\u00e2n t\u00edch t\u1eeb ngu\u1ed3n d\u1eef li\u1ec7u c\u00f3 s\u1eb5n li\u00ean quan \u0111\u1ebfn nguy c\u01a1 g\u00e2y d\u1ecb t\u1eadt v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh \u1edf tr\u1ebb em [&#8230;]\n","protected":false},"author":1,"featured_media":8467,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=8461"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8461\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/8467"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=8461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=8461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=8461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}