{"id":8455,"date":"2019-04-23T19:10:21","date_gmt":"2019-04-23T12:10:21","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=8455"},"modified":"2019-04-27T19:22:14","modified_gmt":"2019-04-27T12:22:14","slug":"pregabalin-gabapentin-va-nguy-co-lam-dung-va-le-thuoc-thuoc","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/pregabalin-gabapentin-va-nguy-co-lam-dung-va-le-thuoc-thuoc\/","title":{"rendered":"Pregabalin &#8211; gabapentin v\u00e0 nguy c\u01a1 l\u1ea1m d\u1ee5ng v\u00e0 l\u1ec7 thu\u1ed9c thu\u1ed1c"},"content":{"rendered":"<h2>MHRA (ANH): Pregabalin &#8211; gabapentin v\u00e0 nguy c\u01a1 l\u1ea1m d\u1ee5ng v\u00e0 l\u1ec7 thu\u1ed9c thu\u1ed1c<\/h2>\n<p>Ng\u00e0y 01\/4\/2019, MHRA c\u00f4ng b\u1ed1 nh\u1eefng thay \u0111\u1ed5i trong vi\u1ec7c qu\u1ea3n l\u00fd pregabalin v\u00e0 gabapentin, hai thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i theo \u0110\u1ea1o lu\u1eadt l\u1ea1m d\u1ee5ng thu\u1ed1c 1971 v\u00e0 \u0111\u01b0\u1ee3c coi l\u00e0 ch\u1ea5t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t lo\u1ea1i C. C\u1ea7n ph\u1ea3i \u0111\u00e1nh gi\u00e1 ti\u1ec1n s\u1eed l\u1ea1m d\u1ee5ng thu\u1ed1c c\u1ee7a b\u1ec7nh nh\u00e2n tr\u01b0\u1edbc khi k\u00ea \u0111\u01a1n, theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed9c thu\u1ed1c tr\u00ean b\u1ec7nh nh\u00e2n.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8456 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin.jpg\" alt=\"Pregabalin\" width=\"450\" height=\"450\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin-280x280.jpg 280w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin-400x400.jpg 400w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin-350x350.jpg 350w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Pregabalin-100x100.jpg 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n<h2>Th\u00f4ng tin chung<\/h2>\n<p>Gabapentin (Neurontin) \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u01a1n tr\u1ecb li\u1ec7u ho\u1eb7c h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb cho \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 hay \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 to\u00e0n th\u1ec3 h\u00f3a th\u1ee9 ph\u00e1t; ngo\u00e0i ra thu\u1ed1c c\u00f2n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho \u0111au d\u00e2y th\u1ea7n kinh ngo\u1ea1i bi\u00ean nh\u01b0 bi\u1ebfn ch\u1ee9ng vi\u00eam d\u00e2y th\u1ea7n kinh ngo\u1ea1i vi trong \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, \u0111au d\u00e2y th\u1ea7n kinh sau zona.<\/p>\n<figure id=\"attachment_8459\" aria-describedby=\"caption-attachment-8459\" style=\"width: 450px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8459\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin.jpg\" alt=\"Neurontin\" width=\"450\" height=\"450\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin-280x280.jpg 280w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin-400x400.jpg 400w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin-350x350.jpg 350w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/Neurontin-100x100.jpg 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-8459\" class=\"wp-caption-text\">H\u00ecnh \u1ea3nh: thu\u1ed1c Neurontin<\/figcaption><\/figure>\n<p>Pregabalin (Lyrica) \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb cho \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9\/\u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 to\u00e0n th\u1ec3 h\u00f3a th\u1ee9 ph\u00e1t; ngo\u00e0i ra thu\u1ed1c c\u00f2n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho \u0111au th\u1ea7n kinh ngo\u1ea1i vi\/trung \u01b0\u01a1ng v\u00e0 r\u1ed1i lo\u1ea1n lo \u00e2u lan t\u1ecfa.<\/p>\n<figure id=\"attachment_8458\" aria-describedby=\"caption-attachment-8458\" style=\"width: 450px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8458\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica.jpg\" alt=\"lyrica\" width=\"450\" height=\"450\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica-280x280.jpg 280w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica-400x400.jpg 400w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica-350x350.jpg 350w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/04\/lyrica-100x100.jpg 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-8458\" class=\"wp-caption-text\">H\u00ecnh \u1ea3nh: lyrica<\/figcaption><\/figure>\n<h2>Quy \u0111\u1ecbnh m\u1edbi v\u1ec1 pregabalin v\u00e0 gabapentin<\/h2>\n<p>T\u1eeb 1\/4\/2019, pregabalin v\u00e0 gabapentin \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 ch\u1ea5t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t lo\u1ea1i C (theo \u0110\u1ea1o lu\u1eadt l\u1ea1m d\u1ee5ng thu\u1ed1c n\u0103m 1971) v\u00e0 x\u1ebfp v\u00e0o B\u1ea3ng 3 theo Quy \u0111\u1ecbnh l\u1ea1m d\u1ee5ng thu\u1ed1c n\u0103m 2001 (s\u1eeda \u0111\u1ed5i) \u1edf Anh.<\/p>\n<p>Theo \u0111\u00f3, vi\u1ec7c m\u1ed9t ng\u01b0\u1eddi s\u1edf h\u1eefu pregabalin v\u00e0 gabapentin m\u00e0 kh\u00f4ng c\u00f3 \u0111\u01a1n thu\u1ed1c hay khi m\u1ed9t b\u1ec7nh nh\u00e2n cung c\u1ea5p ho\u1eb7c b\u00e1n ch\u00fang cho ng\u01b0\u1eddi kh\u00e1c l\u00e0 b\u1ea5t h\u1ee3p ph\u00e1p.<\/p>\n<h2>Nguy c\u01a1 l\u1ea1m d\u1ee5ng v\u00e0 l\u1ec7 thu\u1ed9c thu\u1ed1c<\/h2>\n<p>Th\u00f4ng tin s\u1ea3n ph\u1ea9m c\u1ee7a pregabalin v\u00e0 gabapentin \u0111\u00e3 c\u00f3 nh\u1eefng c\u1ea3nh b\u00e1o v\u1ec1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed9c thu\u1ed1c. C\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 ti\u1ec1n s\u1eed l\u1ea1m d\u1ee5ng thu\u1ed1c c\u1ee7a b\u1ec7nh nh\u00e2n m\u1ed9t c\u00e1ch c\u1ea9n th\u1eadn v\u00e0 theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed9c thu\u1ed1c tr\u00ean b\u1ec7nh nh\u00e2n nh\u01b0 h\u00e0nh vi t\u00ecm ki\u1ebfm thu\u1ed1c, t\u0103ng li\u1ec1u d\u00f9ng v\u00e0 t\u0103ng dung n\u1ea1p thu\u1ed1c.<\/p>\n<p>C\u1ea7n th\u00f4ng tin cho b\u1ec7nh nh\u00e2n v\u1ec1 l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 khi s\u1eed d\u1ee5ng pregabalin v\u00e0 gabapentin b\u1eb1ng c\u00e1ch cung c\u1ea5p t\u1edd r\u01a1i Th\u00f4ng tin b\u1ec7nh nh\u00e2n khi ph\u00e1t thu\u1ed1c. Ng\u01b0\u1eddi k\u00ea \u0111\u01a1n c\u1ea7n n\u1eafm r\u00f5 t\u1ea5t c\u1ea3 m\u1ecdi lo\u1ea1i thu\u1ed1c (k\u1ec3 c\u1ea3 thu\u1ed1c kh\u00f4ng qua k\u00ea \u0111\u01a1n v\u00e0 thu\u1ed1c s\u1eed d\u1ee5ng v\u1edbi ch\u1ec9 \u0111\u1ecbnh ch\u01b0a \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p) m\u00e0 b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m thi\u1ec3u v\u00e0 h\u1ea1n ch\u1ebf t\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/p>\n<h2>Khuy\u1ebfn c\u00e1o cho c\u00e1n b\u1ed9 y t\u1ebf<\/h2>\n<p>\u0110\u00e1nh gi\u00e1 ti\u1ec1n s\u1eed l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed9c thu\u1ed1c c\u1ee7a b\u1ec7nh nh\u00e2n m\u1ed9t c\u00e1ch c\u1ea9n th\u1eadn tr\u01b0\u1edbc khi k\u00ea \u0111\u01a1n pregabalin v\u00e0 gabapentin<br \/>\nTheo d\u00f5i nh\u1eefng d\u1ea5u hi\u1ec7u c\u1ee7a l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed1c thu\u1ed1c tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng pregabalin v\u00e0 gabapentin<br \/>\n\u0110\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n nh\u1eadn th\u1ee9c \u0111\u01b0\u1ee3c nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u1ee7a hai thu\u1ed1c tr\u00ean v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c, \u0111\u1eb7c bi\u1ec7t l\u00e0 thu\u1ed1c gi\u1ea3m \u0111au opioid v\u00e0 \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n: g\u00e2y tr\u1ea7m c\u1ea3m th\u1ea7n kinh trung \u01b0\u01a1ng, c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<br \/>\nB\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a pregabalin v\u00e0 gabapentin, trong \u0111\u00f3 c\u00f3 c\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u1ea1m dung\/l\u1ec7 thu\u1ed9c thu\u1ed1c.<\/p>\n<h2>Tr\u00e1ch nhi\u1ec7m c\u1ee7a d\u01b0\u1ee3c s\u1ef9<\/h2>\n<p>D\u01b0\u1ee3c s\u1ef9 c\u1ea7n ph\u00e1t thu\u1ed1c trong v\u00f2ng 28 ng\u00e0y sau khi k\u00ea \u0111\u01a1n. Nh\u00e0 thu\u1ed1c c\u1ea7n l\u00e0m bi\u1ebfn t\u00ednh thu\u1ed1c tr\u01b0\u1edbc khi v\u1ee9t b\u1ecf.<\/p>\n<h2>C\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u1ea1m d\u1ee5ng\/l\u1ec7 thu\u1ed9c thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf Anh<\/h2>\n<p>T\u00ednh \u0111\u1ebfn 10\/4\/2019, MHRA \u0111\u00e3 nh\u1eadn \u0111\u01b0\u1ee3c 113 b\u00e1o c\u00e1o v\u1ec1 l\u1ea1m d\u1ee5ng v\u00e0 98 b\u00e1o c\u00e1o v\u1ec1 l\u1ec7 thu\u1ed9c \u0111\u1ed1i v\u1edbi pregabalin, 11 b\u00e1o c\u00e1o v\u1ec1 l\u1ea1m d\u1ee5ng v\u00e0 9 b\u00e1o c\u00e1o v\u1ec1 l\u1ec7 thu\u1ed9c \u0111\u1ed1i v\u1edbi gabapentin.<\/p>\n<p>Gabapentin v\u00e0 pregabalin c\u00f3 th\u1ec3 g\u00e2y tr\u1ea7m c\u1ea3m th\u1ea7n kinh trung \u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn bu\u1ed3n ng\u1ee7, \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p c\u00f3 kh\u1ea3 n\u0103ng \u0111e d\u1ecda t\u00ednh m\u1ea1ng, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c gi\u1ea3m \u0111au opioid v\u00e0 \u0111\u1ed3 u\u1ed1ng c\u00f3 c\u1ed3n.<\/p>\n<p>Ngu\u1ed3n: <a href=\"https:\/\/www.gov.uk\/drug-safety-update\/pregabalin-lyrica-gabapentin-neurontin-and-risk-of-abuse-and-dependence-new-scheduling-requirements-from-1-april\" rel=\"noopener\">https:\/\/www.gov.uk\/drug-safety-update\/pregabalin-lyrica-gabapentin-neurontin-and-risk-of-abuse-and-dependence-new-scheduling-requirements-from-1-april<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: \u0110\u1ed7 Thu Thanh \u2013 Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fay &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MHRA (ANH): Pregabalin &#8211; gabapentin v\u00e0 nguy c\u01a1 l\u1ea1m d\u1ee5ng v\u00e0 l\u1ec7 thu\u1ed9c thu\u1ed1c Ng\u00e0y 01\/4\/2019, MHRA c\u00f4ng b\u1ed1 nh\u1eefng thay \u0111\u1ed5i trong vi\u1ec7c qu\u1ea3n l\u00fd pregabalin v\u00e0 gabapentin, hai thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i theo \u0110\u1ea1o lu\u1eadt l\u1ea1m d\u1ee5ng thu\u1ed1c 1971 v\u00e0 \u0111\u01b0\u1ee3c coi l\u00e0 ch\u1ea5t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t lo\u1ea1i C. C\u1ea7n ph\u1ea3i \u0111\u00e1nh [&#8230;]\n","protected":false},"author":1,"featured_media":8457,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8455","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=8455"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/8455\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/8457"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=8455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=8455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=8455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}