Ciclosporin l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf calcineurin \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ph\u00e1c \u0111\u1ed3 \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n sau gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean th\u1ebf gi\u1edbi ch\u1ec9 ra \u0111\u1ed9c t\u00ednh th\u1eadn c\u1ee7a CSA kh\u00f4ng nh\u1eefng l\u00e0m x\u1ea5u \u0111i t\u00ecnh tr\u1ea1ng tr\u00ean l\u00e2m s\u00e0ng m\u00e0 c\u00f2n li\u00ean quan \u0111\u1ebfn t\u0103ng nguy c\u01a1 b\u1ec7nh th\u1eadn m\u1ea1n v\u00e0 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n. \u1ede Vi\u1ec7t Nam, c\u00e1c nghi\u00ean c\u1ee9u t\u1ed5ng k\u1ebft v\u1ec1 TDM, t\u00ecm hi\u1ec3u \u0111\u1ed9c t\u00ednh th\u1eadn c\u1ee7a CSA c\u00f2n r\u1ea5t h\u1ea1n ch\u1ebf. V\u00ec v\u1eady, nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u1eb1m g\u00f3p ph\u1ea7n gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n
K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u ghi nh\u1eadn \u0111\u1eb7c \u0111i\u1ec3m n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y c\u1ee7a ciclosporin \u0111ang c\u00f3 xu h\u01b0\u1edbng th\u1ea5p, kho\u1ea3ng bi\u1ebfn thi\u00ean r\u1ed9ng, trong \u0111\u00f3 m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 n\u1ed3ng \u0111\u1ed9 v\u01b0\u1ee3t ng\u01b0\u1ee1ng khuy\u1ebfn c\u00e1o. B\u00ean c\u1ea1nh \u0111\u00f3, t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn l\u00e0 50,7 %, ph\u1ea7n l\u1edbn \u1edf m\u1ee9c \u0111\u1ed9 nguy c\u01a1. C\u00e1c y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn bao g\u1ed3m n\u1ed3ng \u0111\u1ed9 trung b\u00ecnh ciclosporin cao v\u00e0 c\u00f3 s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi amphotericin B. Ch\u00ednh v\u00ec v\u1eady,\u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u00f9ng k\u00e8m c\u00e1c thu\u1ed1c c\u00f3 nguy c\u01a1 \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn, n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y c\u1ee7a ciclosporin c\u0169ng nh\u01b0 ch\u1ee9c n\u0103ng th\u1eadn c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n
K\u1ebft qu\u1ea3 thu \u0111\u01b0\u1ee3cg\u00f3p ph\u1ea7n \u0111\u1ecbnh h\u01b0\u1edbng cho c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc, d\u01b0\u1ee3c l\u1ef1c h\u1ecdc ti\u1ebfp theo v\u00e0 vi\u1ec7c x\u00e2y d\u1ef1ng quy tr\u00ecnh gi\u00e1m s\u00e1t \u0111i\u1ec1u tr\u1ecb chu\u1ea9n \u0111\u1ed1i v\u1edbi ciclosporin tr\u00ean b\u1ec7nh nh\u00e2n gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ed3ng lo\u00e0i t\u1ea1i Vi\u1ec7n Huy\u1ebft h\u1ecdc – Truy\u1ec1n m\u00e1u Trung \u01b0\u01a1ng trong t\u01b0\u01a1ng lai.<\/p>\n
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“Ph\u00e2n t\u00edch k\u1ebft qu\u1ea3 gi\u00e1m s\u00e1t n\u1ed3ng \u0111\u1ed9 ciclosporin v\u00e0 \u0111\u1ed9c t\u00ednh th\u1eadn tr\u00ean b\u1ec7nh nh\u00e2n gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ed3ng lo\u00e0i t\u1ea1i Vi\u1ec7n Huy\u1ebft h\u1ecdc – Truy\u1ec1n m\u00e1u Trung \u01b0\u01a1ng”. Ciclosporin l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf calcineurin \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ph\u00e1c \u0111\u1ed3 \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n sau gh\u00e9p t\u1ebf […]\n","protected":false},"author":1,"featured_media":7631,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7630","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=7630"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7630\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/7631"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=7630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=7630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=7630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}