{"id":7623,"date":"2019-04-15T16:39:20","date_gmt":"2019-04-15T09:39:20","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=7623"},"modified":"2019-04-18T16:52:29","modified_gmt":"2019-04-18T09:52:29","slug":"hoi-dap-tuong-tac-colchicine-va-statin","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/hoi-dap-tuong-tac-colchicine-va-statin\/","title":{"rendered":"H\u1ecfi \u2013 \u0110\u00e1p: T\u01b0\u01a1ng t\u00e1c colchicine v\u00e0 statin"},"content":{"rendered":"<p>D\u01b0\u1ee3c s\u0129 tr\u1ea3 l\u1eddi: Th\u1ea1c s\u0129 D\u01b0\u1ee3c s\u0129 Nguy\u1ec5n Th\u1ebf Anh (gi\u1ea3ng vi\u00ean Khoa D\u01b0\u1ee3c \u2013 \u0110\u1ea1i h\u1ecdc Y khoa Ph\u1ea1m Ng\u1ecdc Th\u1ea1ch, DSLS \u2013 Khoa D\u01b0\u1ee3c, BV Nguy\u1ec5n Tri Ph\u01b0\u01a1ng.<\/p>\n<h2>C\u00e2u h\u1ecfi:<\/h2>\n<p><strong>Colchicin<\/strong> t\u01b0\u01a1ng t\u00e1c nghi\u00eam tr\u1ecdng v\u1edbi nh\u00f3m statin nh\u01b0ng b\u1ec7nh nh\u00e2n b\u1ecb Gout ph\u1ea3i d\u00f9ng Colchicin th\u01b0\u1eddng xuy\u00ean, \u0111\u1ed3ng th\u1eddi b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh tim m\u1ea1ch n\u00ean kh\u00f4ng th\u1ec3 b\u1ecf Statin. N\u1ebfu gi\u1ea3m li\u1ec1u Statin th\u00ec c\u00f3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 tr\u00ean tim m\u1ea1ch hay kh\u00f4ng ?<\/p>\n<h2>Tr\u1ea3 l\u1eddi:<\/h2>\n<p>V\u1ec1 ph\u1ed1i h\u1ee3p Colchicin v\u00e0 Statin theo H\u1ed9i tim m\u1ea1ch Hoa K\u1ef3 (AHA) 2016 khuy\u1ebfn c\u00e1o nh\u01b0 sau:<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi Colchicine v\u00e0 rosuvastatin\/ fluvastatin\/ lovastain\/ pitavastatin\/ pravastatin l\u00e0 h\u1ee3p l\u00fd khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/p>\n<p>Gi\u1ea3m li\u1ec1u c\u1ea7n xem x\u00e9t v\u1edbi atorvastatin, simvastatin v\u00e0 lovastatin v\u00ec t\u01b0\u01a1ng t\u00e1c thu\u1ed1c Colchicin v\u00e0 c\u00e1c statin n\u00e0y c\u00f3 th\u1ec3 x\u1ea3y ra th\u00f4ng c\u1ea3 enzym chuy\u1ec3n h\u00f3a CYP3A4 v\u00e0 k\u00eanh v\u1eadn chuy\u1ec3n P-glycoprotein.<\/p>\n<p>Colchicin s\u1eed d\u1ee5ng li\u1ec1u n\u1ea1p (0,6mg \u2013 1,2mg) v\u00e0 li\u1ec1u duy tr\u00ec (0,3 \u2013 0,6 mg\/ng\u00e0y) khi k\u1ebft h\u1ee3p v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4\/ P-glycoprotein.<\/p>\n<p>Colchicin n\u00ean \u0111\u01b0\u1ee3c gi\u1ea3m li\u1ec1u khi s\u1eed d\u1ee5ng chung Statin tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p>Theo d\u00f5i d\u1ea5u hi\u1ec7u, tri\u1ec7u ch\u1ee9ng v\u1ec1 t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean c\u01a1 khi ph\u1ed1i h\u1ee3p thu\u1ed1c.<\/p>\n<h2>K\u1ebeT LU\u1eacN:<\/h2>\n<p>N\u1ebfu s\u1eed d\u1ee5ng chung Colchicin v\u00e0 Statin c\u00e2n nh\u1eafc l\u1ef1a ch\u1ecdn Statin \u00edt t\u01b0\u01a1ng t\u00e1c thu\u1ed1c rosuvastatin\/ fluvastatin\/ lovastain\/ pitavastatin\/ pravastatin) ho\u1eb7c gi\u1ea3m li\u1ec1u Statin ( atorvastatin, simvastatin, lovastatin). Lu\u00f4n theo d\u00f5i t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean c\u01a1.<\/p>\n<h2>T\u00c0I LI\u1ec6U THAM KH\u1ea2O:<\/h2>\n<p>American Heart Association (2016), Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease. Link:\u00a0<a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIR.0000000000000456\" rel=\"noopener\">https:\/\/www.ahajournals.org\/doi\/10.1161\/CIR.0000000000000456<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>D\u01b0\u1ee3c s\u0129 tr\u1ea3 l\u1eddi: Th\u1ea1c s\u0129 D\u01b0\u1ee3c s\u0129 Nguy\u1ec5n Th\u1ebf Anh (gi\u1ea3ng vi\u00ean Khoa D\u01b0\u1ee3c \u2013 \u0110\u1ea1i h\u1ecdc Y khoa Ph\u1ea1m Ng\u1ecdc Th\u1ea1ch, DSLS \u2013 Khoa D\u01b0\u1ee3c, BV Nguy\u1ec5n Tri Ph\u01b0\u01a1ng. C\u00e2u h\u1ecfi: Colchicin t\u01b0\u01a1ng t\u00e1c nghi\u00eam tr\u1ecdng v\u1edbi nh\u00f3m statin nh\u01b0ng b\u1ec7nh nh\u00e2n b\u1ecb Gout ph\u1ea3i d\u00f9ng Colchicin th\u01b0\u1eddng xuy\u00ean, \u0111\u1ed3ng th\u1eddi b\u1ec7nh nh\u00e2n [&#8230;]\n","protected":false},"author":1,"featured_media":7624,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7623","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=7623"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7623\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/7624"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=7623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=7623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=7623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}