{"id":7551,"date":"2019-04-14T10:47:36","date_gmt":"2019-04-14T03:47:36","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=7551"},"modified":"2019-04-17T10:52:46","modified_gmt":"2019-04-17T03:52:46","slug":"tap-chi-bip-occitanie-2019-mat-bach-cau-hat-muon-khi-su-dung-rituximab","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/tap-chi-bip-occitanie-2019-mat-bach-cau-hat-muon-khi-su-dung-rituximab\/","title":{"rendered":"T\u1ea1p ch\u00ed BIP Occitanie 2019: M\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t mu\u1ed9n khi s\u1eed d\u1ee5ng rituximab"},"content":{"rendered":"

Rituximab<\/strong> l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng kh\u00e1ng CD20 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau nh\u01b0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, b\u1ec7nh b\u1ea1ch c\u1ea7u th\u1ec3 lympho m\u1ea1n t\u00ednh, ung th\u01b0 h\u1ea1ch lympho kh\u00f4ng Hodgkin. Trong t\u1edd th\u00f4ng tin s\u1ea3n ph\u1ea9m, ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i tr\u00ean huy\u1ebft h\u1ecdc c\u1ee7a thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 nh\u01b0 sau: gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh mu\u1ed9n x\u1ea3y ra sau h\u01a1n 4 tu\u1ea7n t\u00ednh t\u1eeb l\u1ea7n truy\u1ec1n rituximab g\u1ea7n nh\u1ea5t.<\/p>\n

Trong t\u1edd th\u00f4ng tin s\u1ea3n ph\u1ea9m, ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i tr\u00ean huy\u1ebft h\u1ecdc c\u1ee7a thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 nh\u01b0 sau: gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh mu\u1ed9n x\u1ea3y ra sau h\u01a1n 4 tu\u1ea7n t\u00ednh t\u1eeb l\u1ea7n truy\u1ec1n rituximab g\u1ea7n nh\u1ea5t. Theo y v\u0103n, \u0111\u1ed9 tr\u1ec5 c\u1ee7a ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i n\u00e0y c\u00f3 th\u1ec3 dao \u0111\u1ed9ng t\u1eeb 56 \u0111\u1ebfn 175 ng\u00e0y (Expert Rev Hematol 2011, 4, 619). M\u1ed9t ph\u00e2n t\u00edch c\u00e1c b\u00e1o c\u00e1o \u0111\u01b0\u1ee3c g\u1eedi \u0111\u1ebfn c\u00e1c trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c khu v\u1ef1c v\u00e0 ghi nh\u1eadn trong c\u01a1 s\u1edf d\u1eef li\u1ec7u c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c qu\u1ed1c gia \u0111\u00e3 th\u1ed1ng k\u00ea 96 tr\u01b0\u1eddng h\u1ee3p m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t mu\u1ed9n do rituximab t\u1eeb th\u00e1ng 01\/2007 \u0111\u1ebfn th\u00e1ng 10\/2018 v\u1edbi th\u1eddi gian xu\u1ea5t hi\u1ec7n sau d\u00f9ng thu\u1ed1c trung b\u00ecnh l\u00e0 14 tu\u1ea7n. Kh\u00f4ng quan s\u00e1t \u0111\u01b0\u1ee3c m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa th\u1eddi gian tr\u1ec5 v\u00e0 \u0111\u1ed9 tu\u1ed5i, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb c\u0169ng nh\u01b0 vi\u1ec7c s\u1eed d\u1ee5ng c\u00f3 v\u00e0 kh\u00f4ng tu\u00e2n theo ch\u1ec9 \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p.<\/p>\n

Vi\u1ec7c m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t x\u1ea3y ra trong n\u0103m \u0111i\u1ec1u tr\u1ecb ti\u1ebfp theo c\u1ee7a rituximab \u0111\u1eb7t ra m\u1ed1i nghi ng\u1edd v\u1edbi thu\u1ed1c v\u1edbi kho\u1ea3ng th\u1eddi gian xu\u1ea5t hi\u1ec7n mu\u1ed9n h\u01a1n so v\u1edbi ghi nh\u1eadn trong th\u00f4ng tin s\u1ea3n ph\u1ea9m. C\u1ea7n thi\u1ebft l\u1eadp gi\u00e1m s\u00e1t l\u00e2u d\u00e0i tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n

T\u00ean b\u00e0i g\u1ed1c: Agranulocytoses tardives sous Rituximab : bien plus tardives que mentionn\u00e9es ! – T\u1ea1p ch\u00ed BIP Occitanie 2019;26(1):8.<\/p>\n

T\u00e1c gi\u1ea3: Florine Chollet, Pascale Palassin \u2013 Montpellier<\/p>\n

Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: D\u01b0\u1ee3c s\u0129 V\u0169 \u0110\u1ee9c Ho\u00e0n \u2013 Th\u1ea1c s\u0129 D\u01b0\u01a1ng Kh\u00e1nh Linh – Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia Vi\u1ec7t Nam.<\/p>\n

<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Rituximab l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng kh\u00e1ng CD20 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c nhau nh\u01b0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, b\u1ec7nh b\u1ea1ch c\u1ea7u th\u1ec3 lympho m\u1ea1n t\u00ednh, ung th\u01b0 h\u1ea1ch lympho kh\u00f4ng Hodgkin. Trong t\u1edd th\u00f4ng tin s\u1ea3n ph\u1ea9m, ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i tr\u00ean huy\u1ebft h\u1ecdc c\u1ee7a thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 […]\n","protected":false},"author":1,"featured_media":7552,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=7551"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/7551\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/7552"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=7551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=7551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=7551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}