{"id":6975,"date":"2019-04-07T10:49:02","date_gmt":"2019-04-07T03:49:02","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=6975"},"modified":"2019-04-14T18:32:30","modified_gmt":"2019-04-14T11:32:30","slug":"cac-tac-dung-khong-mong-muon-tren-than-kinh-trung-uong-cua-cac-khang-sinh-cephalosporin","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/cac-tac-dung-khong-mong-muon-tren-than-kinh-trung-uong-cua-cac-khang-sinh-cephalosporin\/","title":{"rendered":"C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n tr\u00ean th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a c\u00e1c kh\u00e1ng sinh cephalosporin"},"content":{"rendered":"<h2>\u0110i\u1ec3m b\u00e0i T\u1ea1p ch\u00ed BIP Occitanie 2019: C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n tr\u00ean th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a c\u00e1c kh\u00e1ng sinh cephalosporin<\/h2>\n<p><strong>Nh\u00f3m kh\u00e1ng sinh cephalosporin <\/strong>l\u00e0 m\u1ed9t trong nh\u1eefng nh\u00f3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t. B\u00ean c\u1ea1nh nh\u1eefng l\u1ee3i \u00edch m\u00e0 nh\u00f3m thu\u1ed1c n\u00e0y mang l\u1ea1i trong \u0111i\u1ec1u tr\u1ecb, c\u00e1c ph\u1ea3n \u1ee9ng tr\u00ean t\u00e2m th\u1ea7n kinh c\u00f3 li\u00ean quan t\u1edbi nh\u00f3m cephalosporin l\u00e0 nh\u1eefng ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i d\u00f9 \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn nh\u1eefng l\u1ea1i \u00edt \u0111\u01b0\u1ee3c \u0111\u1ec3 \u00fd \u0111\u1ebfn trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng. Ph\u1ea7n l\u1edbn c\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y \u0111\u01b0\u1ee3c ghi nh\u1eadn th\u00f4ng qua c\u00e1c b\u00e1o c\u00e1o ca \u0111\u01a1n l\u1ebb, do \u0111\u00f3 t\u1ef7 l\u1ec7 \u01b0\u1edbc t\u00ednh c\u0169ng nh\u01b0 hi\u1ec3u bi\u1ebft v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i n\u00e0y c\u1ee7a thu\u1ed1c c\u00f2n h\u1ea1n ch\u1ebf.<\/p>\n<p>Nh\u00f3m kh\u00e1ng sinh <strong>cephalosporin<\/strong> l\u00e0 m\u1ed9t trong nh\u1eefng nh\u00f3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t. cephalosporin d\u00f9 \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn nh\u1eefng l\u1ea1i \u00edt \u0111\u01b0\u1ee3c \u0111\u1ec3 \u00fd \u0111\u1ebfn trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng. Ph\u1ea7n l\u1edbn c\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y \u0111\u01b0\u1ee3c ghi nh\u1eadn th\u00f4ng qua c\u00e1c b\u00e1o c\u00e1o ca \u0111\u01a1n l\u1ebb, do \u0111\u00f3 t\u1ef7 l\u1ec7 \u01b0\u1edbc t\u00ednh c\u0169ng nh\u01b0 hi\u1ec3u bi\u1ebft v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i n\u00e0y c\u1ee7a thu\u1ed1c c\u00f2n h\u1ea1n ch\u1ebf.<\/p>\n<p>Trung t\u00e2m c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c \u1edf Marseille, Toulouse, Amiens v\u00e0 Lyon \u0111\u00e3 th\u1ed1ng k\u00ea c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i ghi nh\u1eadn \u0111\u01b0\u1ee3c trong d\u1eef li\u1ec7u qu\u1ed1c gia v\u1ec1 c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c t\u1eeb n\u0103m 1987 \u0111\u1ebfn n\u0103m 2017. Theo \u0111\u00f3, trong v\u00f2ng 30 n\u0103m, 511 tr\u01b0\u1eddng h\u1ee3p g\u1eb7p c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng (vi\u1ebft t\u1eaft l\u00e0 SAE) \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch. Nh\u1eefng thu\u1ed1c nghi ng\u1edd g\u00e2y ra ph\u1ea3n \u1ee9ng nhi\u1ec1u nh\u1ea5t l\u00e0 kh\u00e1ng sinh cefepim (bi\u1ec7t d\u01b0\u1ee3c Axepim\u00ae, chi\u1ebfm t\u1ec9 l\u1ec7 33%), ceftriaxon (bi\u1ec7t d\u01b0\u1ee3c Rocephine\u00ae v\u00e0 c\u00e1c thu\u1ed1c generic, 30%), ceftazidim (bi\u1ec7t d\u01b0\u1ee3c Fortum\u00ae v\u00e0 c\u00e1c thu\u1ed1c generic, 20%), cefotaxim (bi\u1ec7t d\u01b0\u1ee3c Cefoxidine\u00ae v\u00e0 Texodil\u00ae, 9%) v\u00e0 cefazolin (bi\u1ec7t d\u01b0\u1ee3c Cefazoline\u00ae). Trong s\u1ed1 \u0111\u00f3, 9 tr\u00ean 10 tr\u01b0\u1eddng h\u1ee3p xu\u1ea5t hi\u1ec7n c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng l\u00e0 tr\u00ean b\u1ec7nh s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch. Ti\u1ec1n s\u1eed m\u1eafc c\u00e1c b\u1ec7nh l\u00fd v\u1ec1 th\u1ea7n kinh ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c tr\u00ean 1\/4 s\u1ed1 b\u1ec7nh nh\u00e2n. C\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 b\u1ec7nh l\u00fd n\u00e3o (30%), r\u1ed1i lo\u1ea1n \u00fd th\u1ee9c (19%), co gi\u1eadt (15%), co c\u1ee9ng c\u01a1 (9%), t\u00ecnh tr\u1ea1ng \u0111\u1ed9ng kinh n\u1eb7ng (9%), h\u00f4n m\u00ea (6%) v\u00e0 \u1ea3o gi\u00e1c (4%). Trung b\u00ecnh c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i xu\u1ea5t hi\u1ec7n sau 8 ng\u00e0y t\u1eeb l\u00fac b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c v\u00e0 k\u00e9o d\u00e0i trung b\u00ecnh trong 6 ng\u00e0y. Khi ti\u1ebfn h\u00e0nh \u0111\u1ecbnh l\u01b0\u1ee3ng m\u00e1u, n\u1ed3ng \u0111\u1ed9 kh\u00e1ng sinh trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y cao h\u01a1n m\u1ee9c b\u00ecnh th\u01b0\u1eddng trong 2\/3 s\u1ed1 tr\u01b0\u1eddng h\u1ee3p. \u0110i\u1ec7n n\u00e3o \u0111\u1ed3 cho th\u1ea5y c\u00f3 b\u1ea5t th\u01b0\u1eddng \u1edf 8 tr\u00ean 10 b\u1ec7nh nh\u00e2n.<\/p>\n<p>C\u01a1 ch\u1ebf c\u1ee7a c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng n\u00e0y \u0111\u01b0\u1ee3c d\u1ef1 \u0111o\u00e1n c\u00f3 li\u00ean quan \u0111\u1ebfn t\u00e1c d\u1ee5ng tr\u00ean d\u1eabn truy\u1ec1n th\u1ea7n kinh trung \u01b0\u01a1ng v\u1edbi vi\u1ec7c ho\u1ea1t h\u00f3a glutamat (acid amin d\u1eabn truy\u1ec1n th\u1ea7n kinh k\u00edch th\u00edch) v\u00e0 \u1ee9c ch\u1ebf GABA (ch\u1ea5t \u1ee9c ch\u1ebf d\u1eabn truy\u1ec1n th\u1ea7n kinh c\u1ed9t s\u1ed1ng).<\/p>\n<p>M\u1ed9t trong nh\u1eefng nguy\u00ean t\u1eafc c\u1ea7n nh\u1edb: tr\u01b0\u1edbc m\u1ecdi t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd, c\u1ea7n c\u00f3 \u0111\u01b0\u1ee3c ph\u1ea3n x\u1ea1 nghi ng\u1edd c\u1ea3 nh\u1eefng nguy\u00ean nh\u00e2n li\u00ean quan \u0111\u1ebfn thu\u1ed1c hay bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb. C\u00e2u h\u1ecfi n\u00ean \u0111\u01b0\u1ee3c \u0111\u1eb7t ra l\u00e0 &#8220;T\u00ecnh tr\u1ea1ng n\u00e0y c\u00f3 ph\u1ea3i do thu\u1ed1c g\u00e2y ra hay kh\u00f4ng?&#8221;. Do \u0111\u00f3 tr\u01b0\u1edbc m\u1ecdi tri\u1ec7u ch\u1ee9ng tr\u00ean th\u1ea7n kinh ho\u1eb7c t\u00e2m th\u1ea7n \u1edf b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng cephalosporin, cephalosporin c\u00f3 th\u1ec3 l\u00e0 y\u1ebfu t\u1ed1 nghi ng\u1edd \u0111\u1ea7u ti\u00ean. \u0110\u00e2y l\u00e0 m\u1ed9t \u0111\u1ed9ng th\u00e1i c\u1ea3nh gi\u00e1c h\u1ee3p l\u00fd \u0111\u1ec3 tr\u00e1nh \u0111\u01b0\u1ee3c c\u00e1c x\u00e9t nghi\u1ec7m kh\u00f4ng c\u1ea7n thi\u1ebft, t\u1ed1n k\u00e9m v\u00e0 nguy hi\u1ec3m trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p.<\/p>\n<p>Ngu\u1ed3n: T\u00ean b\u00e0i g\u1ed1c: Ne pas oublier les e\ufb00ets ind\u00e9sirables centraux des c\u00e9phalosporines : une \u00e9tude fran\u00e7aise de PharmacoVigilance &#8211; T\u1ea1p ch\u00ed BIP Occitanie 2019;26(1):10. Link:\u00a0<a href=\"https:\/\/www.rfcrpv.fr\/cephalosporines-effets-indesirables-neurologiques-psychiatriques\/\" rel=\"noopener\">https:\/\/www.rfcrpv.fr\/cephalosporines-effets-indesirables-neurologiques-psychiatriques\/<\/a><\/p>\n<p>T\u00e1c gi\u1ea3: GS Jean-Louis Montastruc<\/p>\n<p>Ng\u01b0\u1eddi d\u1ecbch: V\u0169 \u0110\u1ee9c Ho\u00e0n \u2013 D\u01b0\u01a1ng Kh\u00e1nh Linh &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0110i\u1ec3m b\u00e0i T\u1ea1p ch\u00ed BIP Occitanie 2019: C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n tr\u00ean th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a c\u00e1c kh\u00e1ng sinh cephalosporin Nh\u00f3m kh\u00e1ng sinh cephalosporin l\u00e0 m\u1ed9t trong nh\u1eefng nh\u00f3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t. B\u00ean c\u1ea1nh nh\u1eefng l\u1ee3i \u00edch m\u00e0 nh\u00f3m thu\u1ed1c n\u00e0y mang l\u1ea1i trong \u0111i\u1ec1u tr\u1ecb, c\u00e1c ph\u1ea3n \u1ee9ng [&#8230;]\n","protected":false},"author":1,"featured_media":6976,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=6975"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6975\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/6976"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=6975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=6975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=6975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}