{"id":6887,"date":"2019-04-08T08:42:48","date_gmt":"2019-04-08T01:42:48","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=6887"},"modified":"2019-04-13T08:53:19","modified_gmt":"2019-04-13T01:53:19","slug":"fda-chap-thuan-lieu-phap-dieu-tri-loang-xuong-dau-tien-bang-cach-tang-tao-xuong","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/fda-chap-thuan-lieu-phap-dieu-tri-loang-xuong-dau-tien-bang-cach-tang-tao-xuong\/","title":{"rendered":"FDA ch\u1ea5p thu\u1eadn li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng \u0111\u1ea7u ti\u00ean b\u1eb1ng c\u00e1ch t\u0103ng t\u1ea1o x\u01b0\u01a1ng"},"content":{"rendered":"<p>Ng\u00e0y 09\/04\/2019, <strong>C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 \u0111\u00e3 ch\u1ea5p thu\u1eadn Evenity (romosozumab-aqqg) cho ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef sau m\u00e3n kinh c\u00f3 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao<\/strong> (ti\u1ec1n s\u1eed g\u00e3y x\u01b0\u01a1ng ho\u1eb7c nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng, ho\u1eb7c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u00e3 th\u1ea5t b\u1ea1i hay kh\u00f4ng dung n\u1ea1p v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng kh\u00e1c).<\/p>\n<p>Evenity l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng c\u1ee7a protein sclerostin v\u00e0 ho\u1ea1t \u0111\u1ed9ng ch\u1ee7 y\u1ebfu b\u1eb1ng c\u00e1ch t\u0103ng s\u1ef1 h\u00ecnh th\u00e0nh x\u01b0\u01a1ng m\u1edbi.<\/p>\n<p>M\u1ed9t li\u1ec1u \u0111i\u1ec1u tr\u1ecb bao g\u1ed3m hai m\u0169i ti\u00eam, m\u1ed7i th\u00e1ng m\u1ed9t l\u1ea7n.<br \/>\nHi\u1ec7u l\u1ef1c t\u1ea1o x\u01b0\u01a1ng c\u1ee7a Evenity gi\u1ea3m sau 12 li\u1ec1u, do \u0111\u00f3 kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng h\u01a1n 12 li\u1ec1u.<br \/>\nN\u1ebfu c\u1ea7n ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng sau 12 li\u1ec1u, b\u1ec7nh nh\u00e2n n\u00ean b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c li\u1ec7u ph\u00e1p l\u00e0m gi\u1ea3m ph\u00e2n hu\u1ef7 x\u01b0\u01a1ng.<\/p>\n<p>An to\u00e0n v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng th\u00f4ng qua 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng bao g\u1ed3m h\u01a1n 11.000 ph\u1ee5 n\u1eef m\u1eafc lo\u00e3ng x\u01b0\u01a1ng sau m\u00e3n kinh.<\/p>\n<p>Th\u1eed nghi\u1ec7m 1 so s\u00e1nh v\u1edbi gi\u1ea3 d\u01b0\u1ee3c: M\u1ed9t n\u0103m \u0111i\u1ec1u tr\u1ecb v\u1edbi Evenity l\u00e0m gi\u1ea3m 73% nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng m\u1edbi \u1edf c\u1ed9t s\u1ed1ng; l\u1ee3i \u00edch \u0111\u01b0\u1ee3c ghi nh\u1eadn duy tr\u00ec \u1edf n\u0103m th\u1ee9 2 khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb v\u1edbi denosumab.<br \/>\nTh\u1eed nghi\u1ec7m 2 so s\u00e1nh v\u1edbi ho\u1ea1t ch\u1ea5t: m\u1ed9t n\u0103m \u0111i\u1ec1u tr\u1ecb v\u1edbi Evenity ti\u1ebfp n\u1ed1i m\u1ed9t n\u0103m \u0111i\u1ec1u tr\u1ecb v\u1edbi alendronate l\u00e0m gi\u1ea3m 50% nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng m\u1edbi \u1edf c\u1ed9t s\u1ed1ng so v\u1edbi hai n\u0103m ch\u1ec9 d\u00f9ng alendronate. Nguy c\u01a1 c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn gi\u1ea3m \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i x\u01b0\u01a1ng kh\u00e1c c\u1ed9t s\u1ed1ng.<\/p>\n<p>Tuy nhi\u00ean, c\u1ea3nh b\u00e1o \u0111\u00f3ng khung c\u1ee7a Evenity l\u00e0 thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5 v\u00e0 t\u1eed vong do tim m\u1ea1ch.<\/p>\n<p>Do \u0111\u00f3, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim ho\u1eb7c \u0111\u1ed9t qu\u1ef5.<br \/>\nFDA khuy\u1ebfn c\u00e1o n\u00ean c\u00e2n nh\u1eafc gi\u1eefa l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 tim m\u1ea1ch.<\/p>\n<p>C\u00e1c t\u00e1c \u0111\u1ed9ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a Evenity bao g\u1ed3m \u0111au kh\u1edbp, \u0111au \u0111\u1ea7u v\u00e0 ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7 ti\u00eam.<\/p>\n<p>T\u00e0i li\u1ec7u tham kh\u1ea3o FDA approves new treatment for osteoporosis in postmenopausal women at high risk of fracture [new release]. Silver Spring, MD 20993, April 9, 2019. Link <a href=\"https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm635653.htm\" rel=\"noopener\">https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm635653.htm<\/a> . Truy c\u1eadp: 11\/4\/2019.<\/p>\n<p>T\u1ed5ng h\u1ee3p : Nguy\u1ec5n Phan H\u01b0ng \u2013 SV D16, \u0110H Hutech<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ng\u00e0y 09\/04\/2019, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 \u0111\u00e3 ch\u1ea5p thu\u1eadn Evenity (romosozumab-aqqg) cho ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef sau m\u00e3n kinh c\u00f3 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng cao (ti\u1ec1n s\u1eed g\u00e3y x\u01b0\u01a1ng ho\u1eb7c nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng, ho\u1eb7c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u00e3 th\u1ea5t b\u1ea1i hay [&#8230;]\n","protected":false},"author":1,"featured_media":6888,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=6887"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6887\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/6888"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=6887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=6887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=6887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}