{"id":6834,"date":"2019-04-12T13:45:18","date_gmt":"2019-04-12T06:45:18","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=6834"},"modified":"2019-04-12T13:45:49","modified_gmt":"2019-04-12T06:45:49","slug":"he-vi-sinh-o-tinh-hoan-cua-nam-gioi-vo-tinh","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/he-vi-sinh-o-tinh-hoan-cua-nam-gioi-vo-tinh\/","title":{"rendered":"H\u1ec7 vi sinh \u1edf tinh ho\u00e0n c\u1ee7a nam gi\u1edbi v\u00f4 tinh"},"content":{"rendered":"

H\u1ec7 vi sinh \u1edf tinh ho\u00e0n c\u1ee7a nam gi\u1edbi v\u00f4 tinh – b\u1eb1ng ch\u1ee9ng \u0111\u1ea7u ti\u00ean v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a s\u1ef1 thay \u0111\u1ed5i vi m\u00f4i tr\u01b0\u1eddng<\/h2>\n

T\u00e1c gi\u1ea3: H\u1ed3 Lan Tr\u00e2m – Chuy\u00ean vi\u00ean ph\u00f4i h\u1ecdc – IVFMD T\u00e2n B\u00ecnh.<\/p>\n

Vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n ch\u1ea5t ti\u1ebft c\u1ee7a vi sinh v\u1eadt v\u00e0o vi m\u00f4i tr\u01b0\u1eddng ngo\u1ea1i b\u00e0o. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn m\u1ed9t s\u1ed1 qu\u00e1 tr\u00ecnh sinh l\u00fd bao g\u1ed3m vi\u1ec7c l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 testosterone (Markle v\u00e0 cs, 2013), estrogen (Baker v\u00e0 cs, 2017) v\u00e0 ph\u1ee9c h\u1ee3p vitamin B (Biesalski, 2016), \u0111i\u1ec1u n\u00e0y cho th\u1ea5y r\u1eb1ng vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt c\u00f3 th\u1ec3 c\u00f3 m\u1ed9t t\u00e1c \u0111\u1ed9ng kh\u00e1 l\u1edbn \u0111\u1ebfn s\u1ef1 sinh tinh.<\/p>\n

Nh\u00ecn chung, t\u00e1c \u0111\u1ed9ng c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt l\u00ean tinh ho\u00e0n c\u1ee7a ng\u01b0\u1eddi hi\u1ec7n nay v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c t\u00ecm hi\u1ec3u r\u00f5. B\u00ean c\u1ea1nh \u0111\u00f3, c\u00e1c nam gi\u1edbi b\u1ecb v\u00f4 tinh th\u01b0\u1eddng c\u00f3 nguy c\u01a1 cao m\u1eafc c\u00e1c b\u1ec7nh l\u00fd ung th\u01b0 c\u0169ng nh\u01b0 c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn tu\u1ed5i t\u00e1c nh\u01b0 b\u1ec7nh tim m\u1ea1ch, r\u1ed1i lo\u1ea1n bi\u1ebfn d\u01b0\u1ee1ng (Ventimiglia v\u00e0 cs, 2016), \u0111\u1ed3ng th\u1eddi m\u00f4 tinh ho\u00e0n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n tr\u1ebb v\u00f4 tinh c\u00f3 nhi\u1ec1u \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi m\u00f4 tinh ho\u00e0n \u0111\u00e3 b\u1ecb l\u00e3o h\u00f3a \u1edf nh\u1eefng nam gi\u1edbi l\u1edbn tu\u1ed5i (Yi-chao v\u00e0 cs, 2014). Ngo\u00e0i ra, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y c\u00f3 s\u1ef1 li\u00ean quan c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng ngo\u1ea1i b\u00e0o tinh ho\u00e0n \u0111\u1ebfn qu\u00e1 tr\u00ecnh t\u1ea1o tinh v\u00e0 t\u1eeb \u0111\u00f3 \u0111\u01b0a ra c\u01a1 s\u1edf r\u1eb1ng vi\u1ec7c ph\u1ee5c h\u1ed3i tr\u1ea1ng th\u00e1i b\u00ecnh th\u01b0\u1eddng c\u1ee7a m\u00f4 tinh ho\u00e0n b\u1ecb t\u1ed5n th\u01b0\u01a1ng th\u00f4ng qua vi\u1ec7c thay \u0111\u1ed5i th\u00e0nh ph\u1ea7n c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng ngo\u1ea1i b\u00e0o c\u00f3 th\u1ec3 l\u00e0 c\u01a1 s\u1edf quan tr\u1ecdng cho vi\u1ec7c ph\u1ee5c h\u1ed3i kh\u1ea3 n\u0103ng s\u1ea3n xu\u1ea5t c\u00e1c t\u1ebf b\u00e0o m\u1ea7m (Ogawa v\u00e0 cs, 2000; Ryu v\u00e0 cs, 2006; Zhang v\u00e0 cs, 2006). Do \u0111\u00f3, nghi\u00ean c\u1ee9u n\u00e0y s\u1ebd ph\u00e2n t\u00edch t\u00e1c \u0111\u1ed9ng c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt trong tinh ho\u00e0n ng\u01b0\u1eddi s\u1eed d\u1ee5ng c\u00e1c m\u1eabu m\u00f4 tinh ho\u00e0n sinh thi\u1ebft t\u1eeb c\u00e1c nam gi\u1edbi b\u1ecb v\u00f4 tinh kh\u00f4ng b\u1ebf t\u1eafc kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n (iNOA) c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng thu nh\u1eadn tinh tr\u00f9ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p microTESE r\u1ed3i t\u1eeb \u0111\u00f3 so s\u00e1nh v\u1edbi m\u1eabu m\u00f4 tinh ho\u00e0n c\u1ee7a ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng sinh s\u1ea3n b\u00ecnh th\u01b0\u1eddng.<\/p>\n

Thi\u1ebft k\u1ebf th\u00ed nghi\u1ec7m:<\/h2>\n

– So s\u00e1nh \u0111\u1ec3 t\u00ecm ra s\u1ef1 t\u00e1c \u0111\u1ed9ng c\u1ee7a vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt l\u00ean m\u00f4 sinh thi\u1ebft tinh ho\u00e0n \u1edf 3 nh\u00f3m: 5 nam gi\u1edbi m\u1eafc iNOA kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng thu nh\u1eadn tinh tr\u00f9ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p microTESE, 5 nam gi\u1edbi m\u1eafc iNOA c\u00f3 kh\u1ea3 n\u0103ng thu nh\u1eadn tinh tr\u00f9ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p microTESE, 5 nam gi\u1edbi c\u00f3 kh\u1ea3 n\u0103ng sinh tinh b\u00ecnh th\u01b0\u1eddng (nh\u00f3m \u0111\u1ed1i ch\u1ee9ng). C\u00e1c m\u1eabu m\u00f4 tinh ho\u00e0n s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i m\u00f4 h\u1ecdc v\u00e0 \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch qu\u1ea7n th\u1ec3 vi sinh v\u1eadt t\u1ed3n t\u1ea1i trong vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a m\u1eabu m\u00f4.<\/p>\n

– Ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3i tr\u00ecnh t\u1ef1 Massive ultra-deep pyrosequencing \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u1ecbnh danh qu\u1ea7n th\u1ec3 vi sinh v\u1eadt trong vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a m\u00f4 tinh ho\u00e0n. Vi\u1ec7c ph\u00e2n t\u00edch b\u1ed9 gen chuy\u00ean s\u00e2u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p QIIME (Quantitative Insights Into Microbial Ecology). T\u1ea3i l\u01b0\u1ee3ng vi sinh v\u1eadt trong m\u1eabu m\u00f4 s\u1ebd \u0111\u01b0\u1ee3c \u0111\u1ecbnh l\u01b0\u1ee3ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p gi\u1ecdt PCR k\u1ef9 thu\u1eadt s\u1ed1 (Digital droplet PCR).<\/p>\n

K\u1ebft qu\u1ea3: Nam gi\u1edbi thu\u1ed9c nh\u00f3m \u0111\u1ed1i ch\u1ee9ng c\u00f3 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf vi khu\u1ea9n trong tinh ho\u00e0n bao g\u1ed3m Actinobacteria, Bacteroidetes, Firmicutes Proteobacteria; \u1edf nh\u00f3m iNOA n\u00f3i chung c\u00f3 s\u1ef1 gia t\u0103ng h\u00e0m l\u01b0\u1ee3ng DNA vi khu\u1ea9n (P = 0,02) v\u00e0 gi\u1ea3m s\u1ef1 \u0111a d\u1ea1ng v\u1ec1 ch\u1ee7ng lo\u1ea1i do gi\u1ea3m \u0111\u00e1ng k\u1ec3 Bacteroidetes v\u00e0 Proteobacteria (P = 2\u00d710\u22125). C\u00e1c m\u1eabu thu nh\u1eadn tinh tr\u00f9ng th\u1ea5t b\u1ea1i b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p microTESE cho th\u1ea5y s\u1ef1 gi\u1ea3m \u0111\u00e1ng k\u1ec3 Firmicutes v\u00e0 Clostridia (P < 0,05), v\u1eafng m\u1eb7t ho\u00e0n to\u00e0n Peptoniphilus asaccharolyticus v\u00e0 t\u0103ng \u0111\u00e1ng k\u1ec3 Actinobacteria.<\/p>\n

K\u1ebft lu\u1eadn:<\/h2>\n

– \u0110\u00e2y l\u00e0 ph\u00e2n t\u00edch \u0111\u1ea7u ti\u00ean cho th\u1ea5y tinh ho\u00e0n ng\u01b0\u1eddi kh\u00f4ng ho\u00e0n to\u00e0n v\u00f4 tr\u00f9ng, \u0111\u1ed3ng th\u1eddi cho th\u1ea5y c\u00f3 s\u1ef1 t\u01b0\u01a1ng quan gi\u1eefa vi m\u00f4i tr\u01b0\u1eddng vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt v\u00e0 m\u1eabu m\u00f4 tinh ho\u00e0n, kh\u00f4ng bao g\u1ed3m c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb nhi\u1ec5m qu\u1ea7n th\u1ec3 vi khu\u1ea9n t\u1eeb c\u00e1c m\u00f4 kh\u00e1c v\u00e0 c\u00e1c c\u01a1 quan c\u1ee7a \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u.<\/p>\n

– Vi\u1ec7c thi\u1ebfu h\u1ee5t ho\u00e0n to\u00e0n t\u1ebf b\u00e0o m\u1ea7m xu\u1ea5t hi\u1ec7n \u0111\u1ed3ng th\u1eddi v\u1edbi vi\u1ec7c m\u1ea5t Clostridia trong qu\u1ea7n th\u1ec3 vi khu\u1ea9n, \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0m n\u1ec1n t\u1ea3ng cho c\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c trong t\u01b0\u01a1ng lai v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a Clostridia trong tinh d\u1ecbch ng\u01b0\u1eddi \u0111\u1ec3 l\u00e0m d\u1ea5u ch\u1ec9 ch\u1ea9n \u0111o\u00e1n kh\u1ea3 n\u0103ng thu nh\u1eadn tinh tr\u00f9ng.<\/p>\n

Ngu\u1ed3n: Testicular microbiome in azoospermic men-first evidence of the impact of an altered microenvironment. Human Reproduction, Vol.33, No.7 pp. 1212\u20131217, 2018, doi:10.1093\/humrep\/dey116 Link:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29850857<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

H\u1ec7 vi sinh \u1edf tinh ho\u00e0n c\u1ee7a nam gi\u1edbi v\u00f4 tinh – b\u1eb1ng ch\u1ee9ng \u0111\u1ea7u ti\u00ean v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a s\u1ef1 thay \u0111\u1ed5i vi m\u00f4i tr\u01b0\u1eddng T\u00e1c gi\u1ea3: H\u1ed3 Lan Tr\u00e2m – Chuy\u00ean vi\u00ean ph\u00f4i h\u1ecdc – IVFMD T\u00e2n B\u00ecnh. Vi m\u00f4i tr\u01b0\u1eddng c\u1ee7a vi sinh v\u1eadt \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n ch\u1ea5t […]\n","protected":false},"author":1,"featured_media":6835,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=6834"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6834\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/6835"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=6834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=6834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=6834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}