L\u00ea Th\u1ecb B\u00edch Ph\u01b0\u1ee3ng- Chuy\u00ean vi\u00ean ph\u00f4i h\u1ecdc- IVFMD Ph\u00fa Nhu\u1eadn<\/p>\n
PGT-A ng\u00e0y c\u00e0ng ph\u1ed5 bi\u1ebfn trong c\u00e1c chu k\u1ef3 th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m. V\u00e0o n\u0103m 2012, ASRM v\u00e0 SART \u0111\u01b0a ra khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng ICSI cho t\u1ea5t c\u1ea3 c\u00e1c chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb PGT v\u1edbi l\u00fd do h\u1ea1n ch\u1ebf \u0111a th\u1ee5 tinh c\u0169ng nh\u01b0 gi\u1ea3m s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a tinh tr\u00f9ng trong ZP khi h\u1ee3p t\u1eed ph\u00e1t tri\u1ec3n \u0111\u1ebfn giai \u0111o\u1ea1n ph\u00f4i. M\u1eb7c d\u00f9 \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb l\u00e0 v\u1eady, nh\u01b0ng m\u1ed9t s\u1ed1 ph\u00f2ng x\u00e9t nghi\u1ec7m v\u1eabn ch\u1ea5p nh\u1eadn sinh thi\u1ebft thu nh\u1eadn v\u1eadt li\u1ec7u di truy\u1ec1n t\u1eeb ph\u00f4i th\u1ee5 tinh b\u1eb1ng k\u1ef9 thu\u1eadt IVF \u0111\u1ec3 th\u1ef1c hi\u1ec7n PGT-A, \u0111i\u1ec1u n\u00e0y gi\u00fap gi\u1ea3m m\u1ed9t s\u1ed1 nguy c\u01a1 c\u0169ng nh\u01b0 gi\u1ea3m chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n. K\u1ef9 thu\u1eadt NGS ra \u0111\u1eddi cho ph\u00e9p ph\u00e2n t\u00edch di truy\u1ec1n v\u1edbi \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao h\u01a1n do \u0111\u00f3 k\u1ef9 thu\u1eadt n\u00e0y nh\u1ea1y h\u01a1n trong vi\u1ec7c ph\u00e1t hi\u1ec7n ph\u00f4i kh\u1ea3m. V\u00ec v\u1eady, nghi\u00ean c\u1ee9u n\u00e0y s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt NGS nh\u1eb1m \u0111\u00e1nh gi\u00e1 t\u1ec9 l\u1ec7 ph\u00f4i nguy\u00ean b\u1ed9i, l\u1ec7ch b\u1ed9i c\u0169ng nh\u01b0 t\u1ec9 l\u1ec7 ph\u00f4i kh\u1ea3m t\u1eeb nh\u1eefng ph\u00f4i IVF v\u00e0 ICSI \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 xem ph\u01b0\u01a1ng ph\u00e1p th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m c\u1ed5 \u0111i\u1ec3n v\u1edbi ICSI c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m PGT-A b\u1eb1ng NGS hay kh\u00f4ng.<\/p>\n
Nghi\u00ean c\u1ee9u h\u1ed3i c\u1ee9u tr\u00ean t\u1ea5t c\u1ea3 c\u00e1c chu k\u1ef3 th\u1ef1c hi\u1ec7n PGT-A t\u1eeb 7\/2015 \u0111\u1ebfn 9\/2017 t\u1ea1i m\u1ed9t trung t\u00e2m c\u1ee7a M\u1ef9. Katherine L. Palmerola v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 th\u1ef1c hi\u1ec7n nghi\u00ean c\u1ee9u tr\u00ean 302 chu k\u1ef3 PGT-A bao g\u1ed3m 251 ph\u00f4i IVF v\u00e0 724 ph\u00f4i ICSI. C\u00e1c ph\u00f4i n\u00e0y \u0111\u01b0\u1ee3c sinh thi\u1ebft l\u1edbp t\u1ebf b\u00e0o l\u00e1 nu\u00f4i \u1edf giai \u0111o\u1ea1n ph\u00f4i nang ng\u00e0y 5 ho\u1eb7c ng\u00e0y 6 v\u00e0 ph\u00e2n t\u00edch b\u1eb1ng k\u1ef9 thu\u1eadt NGS. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 k\u1ebft qu\u1ea3 PGT-A c\u1ee7a c\u00e1c ph\u00f4i t\u1eeb IVF hay ICSI v\u1ec1 t\u1ec9 l\u1ec7 ph\u00f4i nguy\u00ean b\u1ed9i (27,9% v\u1edbi 30%), t\u1ec9 l\u1ec7 l\u1ec7ch b\u1ed9i (45,1% v\u1edbi 43,1%). Tuy nhi\u00ean, t\u1ec9 l\u1ec7 ph\u00f4i kh\u1ea3m \u1edf nh\u00f3m IVF cao h\u01a1n nh\u00f3m ph\u00f4i ICSI (25,9% v\u1edbi 20,9%).<\/p>\n
Nh\u01b0 v\u1eady nghi\u00ean c\u1ee9u n\u00e0y cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ec9 l\u1ec7 ph\u00f4i nguy\u00ean b\u1ed9i, l\u1ec7ch b\u1ed9i nh\u01b0ng k\u1ef9 thu\u1eadt IVF cho t\u1ec9 l\u1ec7 ph\u00f4i kh\u1ea3m cao h\u01a1n so v\u1edbi k\u1ef9 thu\u1eadt ICSI. Nh\u01b0 v\u1eady t\u1ea1o ph\u00f4i b\u1eb1ng k\u1ef9 thu\u1eadt ICSI c\u00f3 th\u1ec3 th\u00edch h\u1ee3p h\u01a1n k\u1ef9 thu\u1eadt IVF \u0111\u1ed1i v\u1edbi nh\u1eefng chu k\u1ef3 th\u1ef1c hi\u1ec7n PGT-A.<\/p>\n
Ngu\u1ed3n: Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A). 10.1007\/s10815-018-1347-6.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30362056<\/a><\/p>\n <\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" L\u00ea Th\u1ecb B\u00edch Ph\u01b0\u1ee3ng- Chuy\u00ean vi\u00ean ph\u00f4i h\u1ecdc- IVFMD Ph\u00fa Nhu\u1eadn PGT-A ng\u00e0y c\u00e0ng ph\u1ed5 bi\u1ebfn trong c\u00e1c chu k\u1ef3 th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m. V\u00e0o n\u0103m 2012, ASRM v\u00e0 SART \u0111\u01b0a ra khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng ICSI cho t\u1ea5t c\u1ea3 c\u00e1c chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb PGT v\u1edbi l\u00fd do h\u1ea1n ch\u1ebf \u0111a th\u1ee5 tinh […]\n","protected":false},"author":1,"featured_media":6562,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=6561"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/6561\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/6562"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=6561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=6561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=6561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}