Tofacitinib<\/strong> l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam kh\u1edbp v\u1ea9y n\u1ebfn ho\u1eb7c vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng m\u1ee9c \u0111\u1ed9 t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c. Thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 methotrexate.<\/p>\n Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111ang di\u1ec5n ra, \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u00e0nh b\u1edfi Pfizer, \u0111\u00e3 ph\u00e1t hi\u1ec7n nguy c\u01a1 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng trong ph\u1ed5i v\u00e0 t\u1eed vong khi d\u00f9ng thu\u1ed1c v\u1edbi li\u1ec1u cao 10 mg, hai l\u1ea7n m\u1ed9t ng\u00e0y. B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng 10 mg tofacitinib hai l\u1ea7n m\u1ed9t ng\u00e0y hi\u1ec7n \u0111ang chuy\u1ec3n sang li\u1ec1u th\u1ea5p h\u01a1n, \u1edf li\u1ec1u cho ph\u00e9p l\u00e0 5 mg hai l\u1ea7n m\u1ed9t ng\u00e0y.<\/p>\n M\u1ee5c \u0111\u00edch c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng n\u00e0y l\u00e0 \u0111\u00e1nh gi\u00e1 th\u00eam v\u1ec1 t\u00ednh an to\u00e0n c\u1ee7a tofacitinib \u1edf ch\u1ebf \u0111\u1ed9 li\u1ec1u 2 l\u1ea7n\/ng\u00e0y (5 mg hai l\u1ea7n m\u1ed9t ng\u00e0y v\u00e0 10 mg hai l\u1ea7n m\u1ed9t ng\u00e0y) khi d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t lo\u1ea1i thu\u1ed1c kh\u00e1c (methotrexate). Th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch, ung th\u01b0 v\u00e0 nhi\u1ec5m tr\u00f9ng c\u01a1 h\u1ed9i \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p.<\/p>\n Pfizer \u0111ang ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m \u1edf nhi\u1ec1u qu\u1ed1c gia, bao g\u1ed3m c\u1ea3 Canada. Th\u1eed nghi\u1ec7m bao g\u1ed3m nh\u1eefng b\u1ec7nh nh\u00e2n \u00edt nh\u1ea5t 50 tu\u1ed5i v\u00e0 c\u00f3 \u00edt nh\u1ea5t m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch.<\/p>\n Pfizer \u0111ang ti\u1ebfn h\u00e0nh c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng kh\u00e1c \u1edf Canada li\u00ean quan \u0111\u1ebfn tofacitinib \u1edf ch\u1ebf \u0111\u1ed9 li\u1ec1u 10 mg hai l\u1ea7n m\u1ed9t ng\u00e0y. B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 y\u00eau c\u1ea7u ho\u00e3n tuy\u1ec3n d\u1ee5ng \u1edf m\u1ed9t th\u1eed nghi\u1ec7m nhi khoa s\u1eed d\u1ee5ng li\u1ec1u n\u00e0y, v\u00e0 \u0111\u00e3 y\u00eau c\u1ea7u c\u00e1c chuy\u00ean gia nghi\u00ean c\u1ee9u c\u1ee7a c\u00e1c th\u1eed nghi\u1ec7m kh\u00e1c th\u00f4ng b\u00e1o cho nh\u1eefng ng\u01b0\u1eddi tham gia v\u00e0 \u0111\u1ea3m b\u1ea3o th\u1ecfa thu\u1eadn c\u1ee7a h\u1ecd \u0111\u1ec3 ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u. B\u1ed9 Y t\u1ebf Canada \u0111ang h\u1ee3p t\u00e1c v\u1edbi Pfizer \u0111\u1ec3 theo d\u00f5i t\u00ecnh h\u00ecnh ch\u1eb7t ch\u1ebd v\u00e0 ti\u1ebfp t\u1ee5c \u0111\u00e1nh gi\u00e1 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng n\u00e0y.<\/p>\n B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 kh\u00f4ng cho ph\u00e9p d\u00f9ng li\u1ec1u cao 10 mg hai l\u1ea7n m\u1ed9t ng\u00e0y cho b\u1ec7nh vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p ho\u1eb7c vi\u00eam kh\u1edbp v\u1ea9y n\u1ebfn; Li\u1ec1u n\u00e0y ch\u1ec9 \u0111\u01b0\u1ee3c ph\u00e9p ch\u1ec9 \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng, th\u00f4ng tin k\u00ea \u0111\u01a1n c\u1ee7a Canada khuy\u1ebfn c\u00e1o r\u1eb1ng b\u1ec7nh nh\u00e2n n\u00ean s\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb duy tr\u00ec, \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 x\u1ea3y ra ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i.<\/p>\n B\u1ed9 Y t\u1ebf Canada \u0111ang h\u1ee3p t\u00e1c v\u1edbi Pfizer \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 th\u00f4ng tin an to\u00e0n c\u00f3 s\u1eb5n cho tofacitinib v\u00e0 s\u1ebd th\u00f4ng b\u00e1o cho c\u00f4ng ch\u00fang v\u1ec1 b\u1ea5t k\u1ef3 ph\u00e1t hi\u1ec7n an to\u00e0n m\u1edbi n\u00e0o khi c\u1ea7n, sau khi ho\u00e0n th\u00e0nh \u0111\u00e1nh gi\u00e1.<\/p>\n Th\u00f4ng tin cho b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng tofacitinib:<\/p>\n Kh\u00f4ng \u0111\u01b0\u1ee3c ng\u01b0ng thu\u1ed1c ho\u1eb7c gi\u1ea3m li\u1ec1u tofacitinib m\u00e0 kh\u00f4ng tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129.<\/p>\n Li\u00ean h\u1ec7 v\u1edbi c\u00e1n b\u1ed9 y t\u1ebf nagy l\u1eadp t\u1ee9c n\u1ebfu b\u1ea1n g\u1eb7p ph\u1ea3i c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a c\u1ee5c m\u00e1u \u0111\u00f4ng trong ph\u1ed5i, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111au ng\u1ef1c \u0111\u1ed9t ng\u1ed9t ho\u1eb7c kh\u00f3 th\u1edf, ho ra m\u00e1u, \u0111\u1ed5 m\u1ed3 h\u00f4i qu\u00e1 nhi\u1ec1u, da s\u1ea1m m\u00e0u ho\u1eb7c h\u01a1i xanh ho\u1eb7c b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng n\u00e0o kh\u00e1c.<\/p>\n Th\u00f4ng tin cho c\u00e1n b\u1ed9 y t\u1ebf:<\/p>\n Th\u1ef1c hi\u1ec7n theo c\u00e1c khuy\u1ebfn c\u00e1o trong chuy\u00ean lu\u1eadn s\u1ea3n ph\u1ea9m tofacitinib \u1ee9ng v\u1edbi t\u1eebng t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u1ee5 th\u1ec3.<\/p>\n Theo d\u00f5i b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a t\u1eafc m\u1ea1ch ph\u1ed5i, v\u00e0 khuy\u00ean h\u1ecd n\u00ean \u0111i kh\u00e1m ngay l\u1eadp t\u1ee9c n\u1ebfu h\u1ecd g\u1eb7p ph\u1ea3i c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u00f3.<\/p>\n