{"id":5969,"date":"2019-04-02T15:20:55","date_gmt":"2019-04-02T08:20:55","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5969"},"modified":"2019-04-02T15:20:55","modified_gmt":"2019-04-02T08:20:55","slug":"tac-dong-cua-progesterone-dat-am-dao-len-cac-chi-so-doppler","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/tac-dong-cua-progesterone-dat-am-dao-len-cac-chi-so-doppler\/","title":{"rendered":"T\u00e1c \u0111\u1ed9ng c\u1ee7a Progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o l\u00ean c\u00e1c ch\u1ec9 s\u1ed1 Doppler"},"content":{"rendered":"

T\u00e1c \u0111\u1ed9ng c\u1ee7a Progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o l\u00ean c\u00e1c ch\u1ec9 s\u1ed1 Doppler \u0111\u1ed9ng m\u1ea1ch t\u1eed cung, \u0111\u1ed9ng m\u1ea1ch r\u1ed1n v\u00e0 \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa<\/h2>\n

M\u1ed7i n\u0103m, c\u00f3 g\u1ea7n 13 tri\u1ec7u tr\u1ebb sinh non tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Theo t\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi, sinh non v\u1eabn thu\u1ed9c nh\u00f3m n\u0103m nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y t\u1eed vong s\u01a1 sinh hi\u1ec7n nay.<\/p>\n

Trong nh\u1eefng bi\u1ec7n ph\u00e1p d\u1ef1 ph\u00f2ng sinh non \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng tr\u00ean l\u00e2m s\u00e0ng, progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o hi\u1ec7n \u0111ang gi\u1eef vai tr\u00f2 quan tr\u1ecdng. K\u1ebft qu\u1ea3 t\u1eeb nh\u1eefng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean c\u00f3 nh\u00f3m ch\u1ee9ng cho th\u1ea5y r\u1eb1ng progesterone c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m co th\u1eaft t\u1eed cung v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 sinh s\u1edbm \u1edf nh\u1eefng thai k\u1ef3 nguy c\u01a1 cao. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a progesterone trong d\u1ef1 ph\u00f2ng sinh non c\u00f3 li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng duy tr\u00ec l\u01b0u l\u01b0\u1ee3ng tu\u1ea7n ho\u00e0n b\u00e1nh nhau, gi\u1ea3m kh\u00e1ng tr\u1edf \u0111\u1ed9ng m\u1ea1ch c\u1ee7a tu\u1ea7n ho\u00e0n nhau thai. \u0110\u00e3 c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a progesterone trong ba th\u00e1ng \u0111\u1ea7u thai k\u1ef3, tuy nhi\u00ean ch\u01b0a c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u th\u1ef1c hi\u1ec7n tr\u00ean giai \u0111o\u1ea1n sau c\u1ee7a thai. K\u1ebft h\u1ee3p v\u1edbi vai tr\u00f2 c\u1ee7a c\u00e1c ch\u1ec9 s\u1ed1 doppler trong \u0111\u00e1nh gi\u00e1 s\u1ee9c kho\u1ebb thai, m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 t\u00e1c \u0111\u1ed9ng c\u1ee7a progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o trong tam c\u00e1 nguy\u1ec7t hai v\u00e0 ba c\u1ee7a thai k\u1ef3 l\u00ean \u0111\u1ed9ng m\u1ea1ch t\u1eed cung, \u0111\u1ed9ng m\u1ea1ch r\u1ed1n v\u00e0 \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa qua si\u00eau \u00e2m doppler \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh.<\/p>\n

\u0110\u00e2y l\u00e0 nghi\u00ean c\u1ee9u \u0111o\u00e0n h\u1ec7 h\u1ed3i c\u1ee9u th\u1ef1c hi\u1ec7n tr\u00ean t\u1ed5ng s\u1ed1 80 thai ph\u1ee5 \u1edf tu\u1ed5i thai t\u1eeb 18 \u0111\u1ebfn 34 tu\u1ea7n, \u0111\u01a1n thai c\u00f3 nguy c\u01a1 sinh non (c\u00f3 ti\u1ec1n s\u1eed sinh non v\u00e0\/ho\u1eb7c chi\u1ec1u d\u00e0i k\u00eanh c\u1ed5 t\u1eed cung < 25 mm \u1edf l\u1ea7n mang thai n\u00e0y). Si\u00eau \u00e2m doppler \u0111\u00e1nh gi\u00e1 c\u00e1c th\u00f4ng s\u1ed1 tr\u00ean m\u1ea1ch m\u00e1u r\u1ed1n, t\u1eed cung v\u00e0 n\u00e3o gi\u1eefa v\u00e0o th\u1eddi \u0111i\u1ec3m tr\u01b0\u1edbc v\u00e0 sau m\u1ed9t tu\u1ea7n \u0111\u1eb7t progesterone \u00e2m \u0111\u1ea1o v\u1edbi li\u1ec1u 200 mg ng\u00e0y 2 l\u1ea7n. K\u1ebft qu\u1ea3 ch\u00ednh bao g\u1ed3m so s\u00e1nh s\u1ef1 thay \u0111\u1ed5i c\u1ee7a ch\u1ec9 s\u1ed1 \u0111\u1eadp (PI) \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa (MCA) sau khi \u0111\u1eb7t progesterone. K\u1ebft qu\u1ea3 ph\u00e2n t\u00edch ph\u1ee5 bao g\u1ed3m s\u1ef1 thay \u0111\u1ed5i c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 doppler c\u1ee7a \u0111\u1ed9ng m\u1ea1ch t\u1eed cung v\u00e0 \u0111\u1ed9ng m\u1ea1ch r\u1ed1n.<\/p>\n

K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 ch\u1ec9 s\u1ed1 kh\u00e1ng tr\u1edf (RI) v\u00e0 ch\u1ec9 s\u1ed1 \u0111\u1eadp (PI) \u0111\u1ed9ng m\u1ea1ch r\u1ed1n, \u0111\u1ed9ng m\u1ea1ch t\u1eed cung v\u00e0 PI \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa.
\nK\u1ebft qu\u1ea3 c\u00e1c th\u00f4ng s\u1ed1 tr\u00ean si\u00eau \u00e2m doppler \u1edf th\u1eddi \u0111i\u1ec3m tr\u01b0\u1edbc v\u00e0 sau m\u1ed9t tu\u1ea7n \u0111\u1eb7t progesterone l\u1ea7n l\u01b0\u1ee3t nh\u01b0 sau:<\/p>\n\n\n\n\n\n\n\n\n
<\/td>\nTr\u01b0\u1edbc khi \u0111\u1eb7t P<\/td>\nSau 1 tu\u1ea7n \u0111\u1eb7t P<\/td>\nP<\/td>\n95% CI<\/td>\n<\/tr>\n
RI \u0111\u1ed9ng m\u1ea1ch r\u1ed1n<\/td>\n0,69 \u00b1 0,049<\/td>\n0,68 \u00b1 0,041<\/td>\n0,077<\/td>\n0,006 (-0,001 \u2013 0,012)<\/td>\n<\/tr>\n
PI \u0111\u1ed9ng m\u1ea1ch r\u1ed1n<\/td>\n0,14 \u00b1 0.118<\/td>\n1,11 \u00b1 0,016<\/td>\n0,053<\/td>\n0,02 (0,0027 \u2013 0,044)<\/td>\n<\/tr>\n
RI \u0111\u1ed9ng m\u1ea1ch t\u1eed cung<\/td>\n0,66 \u00b1 0,12<\/td>\n0,66 \u00b1 0,107<\/td>\n0,770<\/td>\n0,002 (-0,015 \u2013 0,02)<\/td>\n<\/tr>\n
PI \u0111\u1ed9ng m\u1ea1ch t\u1eed cung<\/td>\n1,00 \u00b1 0,26<\/td>\n1,016 \u00b1 0,24<\/td>\n0,531<\/td>\n-0,012 (-0,054 \u2013 0,082)<\/td>\n<\/tr>\n
PI \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa<\/td>\n1,27 \u00b1 0,18<\/td>\n1,26 \u00b1 0,23<\/td>\n0.553<\/td>\n0,006 (-0,028 \u2013 0,015)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

P: progesterone; RI: ch\u1ec9 s\u1ed1 kh\u00e1ng tr\u1edf, PI: ch\u1ec9 s\u1ed1 \u0111\u1eadp<\/p>\n

T\u1eeb k\u1ebft qu\u1ea3 ph\u00e2n t\u00edch tr\u00ean, nghi\u00ean c\u1ee9u k\u1ebft lu\u1eadn progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o kh\u00f4ng \u1ea3nh h\u01b0\u1edfng l\u00ean c\u00e1c ch\u1ec9 s\u1ed1 doppler \u0111\u1ed9ng m\u1ea1ch t\u1eed cung, \u0111\u1ed9ng m\u1ea1ch r\u1ed1n v\u00e0 \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa qua si\u00eau \u00e2m. \u0110\u00e2y \u0111\u01b0\u1ee3c xem l\u00e0 nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean \u0111\u00e1nh gi\u00e1 \u0111\u1ea7y \u0111\u1ee7 c\u00e1c th\u00f4ng s\u1ed1 doppler \u1edf tu\u1ea7n ho\u00e0n m\u1eb9 (\u0111\u1ed9ng m\u1ea1ch t\u1eed cung), tu\u1ea7n ho\u00e0n b\u00e1nh nhau (\u0111\u1ed9ng m\u1ea1ch r\u1ed1n) v\u00e0 tu\u1ea7n ho\u00e0n thai (\u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa) d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng c\u1ee7a progesterone. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y k\u1ebft lu\u1eadn ng\u01b0\u1ee3c l\u1ea1i v\u1edbi m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y, cho r\u1eb1ng progesterone l\u00e0m gi\u1ea3m ch\u1ec9 s\u1ed1 kh\u00e1ng tr\u1edf v\u00e0 ch\u1ec9 s\u1ed1 \u0111\u1eadp c\u1ee7a \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa. Nh\u00f3m t\u00e1c gi\u1ea3 nghi\u00ean c\u1ee9u c\u0169ng th\u1eeba nh\u1eadn r\u1eb1ng, h\u1ea1n ch\u1ebf c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 kh\u00f4ng theo d\u00f5i d\u00e0i h\u1ea1n \u1edf nh\u1eefng tr\u1ebb sinh ra t\u1eeb nghi\u00ean c\u1ee9u n\u00e0y, c\u0169ng nh\u01b0 kh\u00f4ng th\u1ec3 so s\u00e1nh gi\u1eefa nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng nghi\u00ean c\u1ee9u t\u01b0\u01a1ng \u0111\u1ed3ng trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng d\u00f9ng progesterone. T\u1eeb \u0111\u00f3, m\u1edf ra h\u01b0\u1edbng c\u1ea7n kh\u1ea3o s\u00e1t th\u00eam \u1ea3nh h\u01b0\u1edfng c\u1ee7a progesterone trong nh\u1eefng nghi\u00ean c\u1ee9u l\u1edbn h\u01a1n v\u00e0 theo d\u00f5i l\u00e2u d\u00e0i h\u01a1n.<\/p>\n

L\u01b0\u1ee3c d\u1ecbch t\u1eeb: The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study Original article \u2013 American Journal of perinatology \u2013 March 2019. Link\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30866028<\/a><\/p>\n

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T\u00e1c \u0111\u1ed9ng c\u1ee7a Progesterone \u0111\u1eb7t \u00e2m \u0111\u1ea1o l\u00ean c\u00e1c ch\u1ec9 s\u1ed1 Doppler \u0111\u1ed9ng m\u1ea1ch t\u1eed cung, \u0111\u1ed9ng m\u1ea1ch r\u1ed1n v\u00e0 \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa M\u1ed7i n\u0103m, c\u00f3 g\u1ea7n 13 tri\u1ec7u tr\u1ebb sinh non tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. Theo t\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi, sinh non v\u1eabn thu\u1ed9c nh\u00f3m n\u0103m nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y […]\n","protected":false},"author":1,"featured_media":5970,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5969"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5969\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5970"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}