{"id":5962,"date":"2019-04-02T14:46:37","date_gmt":"2019-04-02T07:46:37","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5962"},"modified":"2019-04-02T14:46:37","modified_gmt":"2019-04-02T07:46:37","slug":"chi-dau-sinh-hoc-protein-ve-nguy-co-sinh-non-o-thai-phu-bi-hoi-chung-buong-trung-da-nang","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/chi-dau-sinh-hoc-protein-ve-nguy-co-sinh-non-o-thai-phu-bi-hoi-chung-buong-trung-da-nang\/","title":{"rendered":"Ch\u1ec9 d\u1ea5u sinh h\u1ecdc protein v\u1ec1 nguy c\u01a1 sinh non \u1edf thai ph\u1ee5 b\u1ecb h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang"},"content":{"rendered":"<h2>Ch\u1ec9 d\u1ea5u sinh h\u1ecdc protein v\u1ec1 nguy c\u01a1 sinh non \u1edf thai ph\u1ee5 b\u1ecb h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang: M\u1ed9t T\u1ed5ng quan h\u1ec7 th\u1ed1ng v\u00e0 T\u00edch h\u1ee3p d\u1eef li\u1ec7u Ch\u1ec9 d\u1ea5u sinh h\u1ecdc.<\/h2>\n<p><strong>Thai ph\u1ee5 b\u1ecb h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang<\/strong> (PCOS) c\u00f3 nguy c\u01a1 sinh non cao \u00edt nh\u1ea5t 2 l\u1ea7n so v\u1edbi nh\u00f3m kh\u00f4ng b\u1ecb PCOS, theo m\u1ed9t t\u1ed5ng quan h\u1ec7 th\u1ed1ng n\u0103m 2011. Tr\u01b0\u1edbc \u0111\u00e2y, nguy c\u01a1 sinh non \u1edf b\u1ec7nh nh\u00e2n PCOS \u0111\u01b0\u1ee3c cho l\u00e0 do li\u00ean quan \u0111\u1ebfn v\u00f4 sinh v\u00e0 \u0111i\u1ec1u tr\u1ecb v\u00f4 sinh, l\u00e0m t\u0103ng t\u1ec9 l\u1ec7 \u0111a thai. Tuy nhi\u00ean, sau khi ph\u00e2n t\u00edch lo\u1ea1i b\u1ecf y\u1ebfu t\u1ed1 \u0111a thai, nguy c\u01a1 sinh non \u1edf b\u1ec7nh nh\u00e2n PCOS v\u1eabn t\u1ed3n t\u1ea1i.<\/p>\n<p>C\u01a1 ch\u1ebf sinh l\u00fd b\u1ec7nh li\u00ean quan \u0111\u1ebfn sinh non \u1edf b\u1ec7nh nh\u00e2n PCOS v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5, m\u1ed9t s\u1ed1 gi\u1ea3 thuy\u1ebft bao g\u1ed3m: t\u0103ng n\u1ed3ng \u0111\u1ed9 estrone, c\u01b0\u1eddng insulin m\u00e1u, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 t\u0103ng huy\u1ebft \u00e1p l\u00e0 c\u00e1c \u0111\u1ed3ng y\u1ebfu t\u1ed1.<\/p>\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ng\u01b0\u1eddi Anh \u0111\u00e3 ti\u1ebfn h\u00e0nh t\u00ecm ki\u1ebfm c\u00e1c d\u1eef li\u1ec7u v\u1ec1 c\u00e1c ch\u1ec9 d\u1ea5u sinh h\u1ecdc proteomic (ph\u00e2n t\u00edch c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng protein) trong n\u1ed7 l\u1ef1c x\u00e1c \u0111\u1ecbnh c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a sinh non \u1edf b\u1ec7nh nh\u00e2n PCOS. C\u00e1c t\u1eeb kho\u00e1 \u0111\u01b0\u1ee3c t\u00ecm ki\u1ebfm g\u1ed3m \u2018\u2018proteomics\u2019\u2019, \u2018\u2018proteomic\u2019\u2019, \u2018\u2018preterm labour\u2019\u2019, \u2018\u2018preterm birth\u2019\u2019, v\u00e0 \u2018\u2018PCOS\u2019\u2019 ho\u1eb7c \u2018\u2018polycystic ovary syndrome\u2019\u2019. Kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o ph\u00e2n t\u00edch c\u00e1c ch\u1ec9 d\u1ea5u sinh h\u1ecdc proteomic c\u1ee7a sinh non tr\u00ean b\u1ec7nh nh\u00e2n PCOS. Tuy nhi\u00ean, c\u00f3 m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u ph\u00e2n t\u00edch c\u00e1c ch\u1ec9 d\u1ea5u sinh h\u1ecdc proteomic tr\u00ean nh\u00f3m b\u1ec7nh nh\u00e2n sinh non v\u00e0 tr\u00ean nh\u00f3m PCOS ri\u00eang. Nh\u00f3m sinh non c\u00f3 9 nghi\u00ean c\u1ee9u ph\u00f9 h\u1ee3p ti\u00eau chu\u1ea9n l\u1ef1a ch\u1ecdn v\u1edbi 201 ch\u1ec9 d\u1ea5u sinh h\u1ecdc \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. Nh\u00f3m PCOS x\u00e1c \u0111\u1ecbnh th\u00eam \u0111\u01b0\u1ee3c 32 ch\u1ec9 d\u1ea5u sinh h\u1ecdc.<\/p>\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u00edch h\u1ee3p 2 nh\u00f3m nghi\u00ean c\u1ee9u tr\u00ean v\u00e0 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 6 ch\u1ec9 d\u1ea5u sinh h\u1ecdc chung m\u00e0 nh\u00f3m sinh non v\u00e0 nh\u00f3m PCOS \u0111\u1ec1u c\u00f3 bi\u1ec3u hi\u1ec7n kh\u00e1c bi\u1ec7t so v\u1edbi nh\u00f3m ch\u1ee9ng. C\u00e1c ch\u1ec9 d\u1ea5u sinh h\u1ecdc n\u00e0y g\u1ed3m: Pyruvate kinase M1\/M2, Vimentin, Fructose bisphosphonate aldolase A, Heat shock protein beta-1, Peroxiredoxin-1 and Transferrin.<\/p>\n<p>PKM1\/M2 t\u0103ng c\u00f3 li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng ph\u00e2n h\u1ee7y glycogen cao c\u1ee7a b\u00e1nh nhau. Vimentin li\u00ean quan \u0111\u1ebfn c\u01a1 ch\u1ebf vi\u00eam v\u00e0 mi\u1ec5n d\u1ecbch. Transferrin t\u0103ng trong ph\u1ea3n \u1ee9ng \u0111\u00e1p \u1ee9ng c\u1ea5p t\u00ednh v\u00e0 stress. Heat shock protein beta-1 t\u0103ng do stress oxy ho\u00e1, shock nhi\u1ec7t, nhi\u1ec5m tr\u00f9ng, vi\u00eam v\u00e0 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. Peroxiredoxin-1 t\u0103ng c\u0169ng l\u00e0 m\u1ed9t bi\u1ec3u hi\u1ec7n c\u1ee7a ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch.<\/p>\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hi v\u1ecdng b\u1eb1ng vi\u1ec7c nghi\u00ean c\u1ee9u 6 ch\u1ec9 d\u1ea5u sinh h\u1ecdc proteomic tr\u00ean nh\u00f3m sinh non b\u1ecb PCOS trong t\u01b0\u01a1ng lai, h\u1ecd c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u00e0 c\u00f3 bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba th\u00edch h\u1ee3p nguy c\u01a1 sinh non cho \u0111\u1ed1i t\u01b0\u1ee3ng PCOS.<\/p>\n<p>Ngu\u1ed3n: Proteomic Biomarkers of Preterm Birth Risk in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review and Biomarker Database Integration. PLoS ONE 8(1): e53801. doi:10.1371\/journal.pone.0053801. Link\u00a0<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0053801\" rel=\"noopener\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0053801<\/a><\/p>\n<p>T\u00e1c gi\u1ea3:\u00a0Nguy\u1ec5n Kh\u00e1nh Linh \u2013 Nh\u00f3m nghi\u00ean c\u1ee9u sinh non \u2013 B\u1ec7nh vi\u1ec7n M\u1ef9 \u0110\u1ee9c.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ch\u1ec9 d\u1ea5u sinh h\u1ecdc protein v\u1ec1 nguy c\u01a1 sinh non \u1edf thai ph\u1ee5 b\u1ecb h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang: M\u1ed9t T\u1ed5ng quan h\u1ec7 th\u1ed1ng v\u00e0 T\u00edch h\u1ee3p d\u1eef li\u1ec7u Ch\u1ec9 d\u1ea5u sinh h\u1ecdc. Thai ph\u1ee5 b\u1ecb h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang (PCOS) c\u00f3 nguy c\u01a1 sinh non cao \u00edt nh\u1ea5t 2 l\u1ea7n so [&#8230;]\n","protected":false},"author":1,"featured_media":5963,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5962","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5962"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5962\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5963"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}