{"id":5521,"date":"2019-03-26T10:47:19","date_gmt":"2019-03-26T03:47:19","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5521"},"modified":"2019-03-26T10:49:47","modified_gmt":"2019-03-26T03:49:47","slug":"tang-nguy-co-cuc-mau-dong-o-phoi-va-tu-vong-o-benh-nhan-viem-khop-dang-thap-khi-dung-tofacitinb-lieu-cao","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/tang-nguy-co-cuc-mau-dong-o-phoi-va-tu-vong-o-benh-nhan-viem-khop-dang-thap-khi-dung-tofacitinb-lieu-cao\/","title":{"rendered":"T\u0103ng nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p khi d\u00f9ng tofacitinb li\u1ec1u cao"},"content":{"rendered":"<h2>TGA: T\u0103ng nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p khi d\u00f9ng tofacitinb li\u1ec1u cao.<\/h2>\n<p>Nh\u00e0 s\u1ea3n xu\u1ea5t Pfizer Australia th\u00f4ng b\u00e1o r\u1eb1ng k\u1ebft qu\u1ea3 t\u1eeb th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong t\u0103ng \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p d\u00f9ng<strong> tofacitinib<\/strong> li\u1ec1u 10mg 2 l\u1ea7n m\u1ed7i ng\u00e0y (so s\u00e1nh v\u1edbi b\u1ec7nh nh\u00e2n tham gia th\u1eed nghi\u1ec7m d\u00f9ng li\u1ec1u 5mg 2 l\u1ea7n m\u1ed7i ng\u00e0y).<\/p>\n<p>TGA \u0111ang gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd m\u1ed9t v\u1ea5n \u0111\u1ec1 an to\u00e0n li\u00ean quan \u0111\u1ebfn tofacitinib &#8211; m\u1ed9t ho\u1ea1t ch\u1ea5t c\u00f3 m\u1eb7t tr\u00ean th\u1ecb tr\u01b0\u1eddng Australia v\u1edbi bi\u1ec7t d\u01b0\u1ee3c Xeljanz.<\/p>\n<p>Nh\u00e0 s\u1ea3n xu\u1ea5t Pfizer Australia th\u00f4ng b\u00e1o r\u1eb1ng k\u1ebft qu\u1ea3 t\u1eeb th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong t\u0103ng \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p d\u00f9ng tofacitinib li\u1ec1u 10mg 2 l\u1ea7n m\u1ed7i ng\u00e0y (so s\u00e1nh v\u1edbi b\u1ec7nh nh\u00e2n tham gia th\u1eed nghi\u1ec7m d\u00f9ng li\u1ec1u 5mg 2 l\u1ea7n m\u1ed7i ng\u00e0y).<\/p>\n<p>Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch (VD: \u0111au tim, b\u1ec7nh m\u1ea1ch v\u00e0nh, suy tim v\u00e0 lo\u1ea1n nh\u1ecbp tim) \u1edf b\u1ec7nh nh\u00e2n t\u1eeb 50 tu\u1ed5i tr\u1edf l\u00ean c\u00f3 \u00edt nh\u1ea5t m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch kh\u00e1c. T\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u \u0111\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexat tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Tuy nhi\u00ean, nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong nghi\u00ean c\u1ee9u n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng kh\u00e1c, trong theo d\u00f5i t\u00edch c\u1ef1c pha IV, c\u0169ng nh\u01b0 c\u00e1c b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i.<\/p>\n<p>L\u01b0u \u00fd r\u1eb1ng, li\u1ec1u 10mg 2 l\u1ea7n\/ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u1edf Australia nh\u01b0ng \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ban \u0111\u1ea7u, ng\u1eafn h\u1ea1n \u1edf b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh b\u1ecb vi\u00eam lo\u00e9t \u0111\u1ea1i tr\u00e0ng t\u1eeb v\u1eeba \u0111\u1ebfn n\u1eb7ng, ch\u1ec9 d\u00f9ng khi c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c \u0111\u1ec1u kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3.<\/p>\n<p>Pfizer Australia \u0111ang ti\u1ebfp t\u1ee5c h\u1ee3p t\u00e1c v\u1edbi c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd, trong \u0111\u00f3 c\u00f3 TGA \u0111\u1ec3 \u0111i\u1ec1u tra v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n<h2>Th\u00f4ng tin cho ng\u01b0\u1eddi d\u00f9ng:<\/h2>\n<p>B\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean ng\u1eebng thu\u1ed1c ho\u1eb7c thay \u0111\u1ed5i li\u1ec1u n\u1ebfu kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u1ef9.<\/p>\n<p>C\u1ea7n \u0111i kh\u00e1m ngay l\u1eadp t\u1ee9c n\u1ebfu th\u1ea5y xu\u1ea5t hi\u1ec7n b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o c\u1ee7a c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i hay c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng kh\u00e1c nh\u01b0: kh\u00f3 th\u1edf, th\u1edf nhanh, \u0111au ng\u1ef1c, \u0111au l\u01b0ng, ho ra m\u00e1u, v\u00e3 m\u1ed3 h\u00f4i, da s\u1ea1m.<\/p>\n<p>Trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u1ef9 n\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 lo ng\u1ea1i n\u00e0o v\u1ec1 v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n<h2>Th\u00f4ng tin cho c\u00e1n b\u1ed9 y t\u1ebf:<\/h2>\n<p>Tham kh\u1ea3o v\u00e0 l\u00e0m theo c\u00e1c khuy\u1ebfn c\u00e1o trong t\u1edd Th\u00f4ng tin B\u1ec7nh nh\u00e2n v\u1ec1 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3 n\u00ean s\u1eed d\u1ee5ng tofacitinib<\/p>\n<p>Theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng thuy\u00ean t\u1eafc \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i tr\u00ean b\u1ec7nh nh\u00e2n v\u00e0 khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n c\u1ea7n \u0111i kh\u00e1m ngay l\u1eadp t\u1ee9c n\u1ebfu th\u1ea5y c\u00e1c d\u1ea5u hi\u1ec7u tr\u00ean.<\/p>\n<p>N\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 lo ng\u1ea1i n\u00e0o v\u1ec1 v\u1ea5n \u0111\u1ec1 n\u00e0y, li\u00ean h\u1ec7 v\u1edbi Pfizer trong \u0111\u1ecba b\u00e0n.<\/p>\n<p>Ngu\u1ed3n:<a href=\"https:\/\/www.tga.gov.au\/alert\/tofacitinib\" rel=\"noopener\"> https:\/\/www.tga.gov.au\/alert\/tofacitinib<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: V\u00f5 Th\u1ecb Th\u00f9y \u2013 Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fay &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TGA: T\u0103ng nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p khi d\u00f9ng tofacitinb li\u1ec1u cao. Nh\u00e0 s\u1ea3n xu\u1ea5t Pfizer Australia th\u00f4ng b\u00e1o r\u1eb1ng k\u1ebft qu\u1ea3 t\u1eeb th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y nguy c\u01a1 c\u1ee5c m\u00e1u \u0111\u00f4ng \u1edf ph\u1ed5i v\u00e0 t\u1eed vong t\u0103ng \u1edf b\u1ec7nh nh\u00e2n [&#8230;]\n","protected":false},"author":1,"featured_media":5523,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5521","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5521"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5521\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5523"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}