Nh\u00e2n m\u1ed9t c\u00e2u h\u1ecfi c\u1ee7a m\u1ed9t sinh vi\u00ean Y khoa n\u0103m th\u1ee9 hai :”Con ch\u00e0o th\u1ea7y, L\u00e2u l\u00e2u \u00f4n l\u1ea1i d\u01b0\u1ee3c l\u00fd b\u00e0i c\u0169 con ph\u00e1t hi\u1ec7n m\u1ed9t ch\u1ed7 ch\u01b0a hi\u1ec3u m\u00e0 l\u00fac tr\u01b0\u1edbc kh\u00f4ng th\u1ea5y n\u00ean con xin ph\u00e9p h\u1ecfi th\u1ea7y m\u1ed9t ch\u00fat.<\/p>\n
H\u1ed3i module tim m\u1ea1ch th\u1ea7y c\u00f3 nh\u1eafc \u0111\u1ebfn thu\u1ed1c l\u1ee3i ti\u1ec3u lo\u1ea1i Aquaretics ch\u1ec9 l\u00e0m m\u1ea5t n\u01b0\u1edbc ch\u1ee9 ko l\u00e0m m\u1ea5t mu\u1ed1i, n\u00f3 chi\u1ebfm ch\u1ed7 g\u1eafn c\u1ee7a ADH. Con th\u1ea5y th\u1eafc m\u1eafc ch\u1ed7 n\u00e0y: ADH con th\u1ea5y n\u00f3 v\u1eeba k\u00edch th\u00edch \u0111\u01b0a AQP2 trong b\u00e0o t\u01b0\u01a1ng l\u00ean m\u00e0ng \u0111\u1ec3 h\u1ea5p thu n\u01b0\u1edbc, v\u1eeba \u1ee9c ch\u1ebf NEDD4-2 \u0111\u1ec3 ch\u1ed1ng down-regulation ENaC \u0111\u1ec3 t\u00e1i h\u1ea5p thu mu\u1ed1i.<\/p>\n
N\u1ebfu m\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u Aquaretics n\u00f3 chi\u1ebfm ch\u1ed7 g\u1eafn c\u1ee7a ADH th\u00ec m\u1ea5t n\u01b0\u1edbc r\u1ed3i, nh\u01b0ng c\u00e1i NEDD4-2 ko c\u00f3 ai \u1ee9c ch\u1ebf n\u00f3 down-regulation h\u1ebft m\u1ea5y c\u00e1i ENaC th\u00ec qu\u00e1 tr\u00ecnh t\u00e1i h\u1ea5p thu \u1edf \u1ed1ng l\u01b0\u1ee3n xa s\u1ebd gi\u1ea3m. V\u1eady n\u00f3 v\u1eabn m\u1ea5t mu\u1ed1i!
\nCon c\u1ea3m \u01a1n th\u1ea7y tr\u01b0\u1edbc!”<\/p>\n
Tr\u01b0\u1edbc h\u1ebft th\u00e0y xin l\u1ed7i c\u00e1c em v\u00ec sau module “D\u01b0\u1ee3c l\u00fd \u0111\u1ea1i c\u01b0\u01a1ng” th\u00e0y v\u1eabn ch\u01b0a l\u00e0m r\u00f5 cho c\u00e1c em \u0111\u01b0\u1ee3c m\u1ed9t \u0111i\u1ec1u m\u00e0 th\u00e0y cho l\u00e0 nguy\u00ean t\u1eafc khi d\u1ea1y h\u1ecdc l\u00e0 cung c\u1ea5p “tri th\u1ee9c” ch\u1ee9 kh\u00f4ng cung c\u1ea5p th\u00f4ng tin. S\u1ef1 hi\u1ec3u l\u1ea7m c\u1ee7a em l\u00e0 l\u1ed7i c\u1ee7a ng\u01b0\u1eddi d\u1ea1y h\u1ecdc ch\u01b0a l\u00e0m s\u00e1ng t\u1ecf \u0111\u01b0\u1ee3c nguy\u00ean t\u1eafc n\u00e0y. H\u00ecnh 1 cho th\u1ea5y c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ADH (Arginine vasopressin) \u0111\u00f3 l\u00e0 ho\u1ea1t ho\u00e1 th\u1ee5 th\u1ec3 thu\u1ed9c nh\u00f3m k\u1ebft h\u1ee3p v\u1edbi protein G, s\u1ef1 ho\u1ea1t ho\u00e1 n\u00e0y k\u00edch th\u00edch Adenylyl cyclase chuy\u1ec3n ATP th\u00e0nh cAMP, ph\u00e2n t\u1eed AMP v\u00f2ng n\u00e0y s\u1ebd g\u1eafn k\u1ebft v\u1edbi protein kinase A l\u00e0m ph\u00e2n ly th\u00e0nh 2 ti\u1ec3u \u0111\u01a1n v\u1ecb x\u00fac t\u00e1c (catalytic subunit) v\u00e0 2 ti\u1ec3u \u0111\u01a1n v\u1ecb \u0111i\u1ec1u ti\u1ebft (regulatory subunit). C\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb x\u00fac t\u00e1c c\u00f3 ch\u1ee9c n\u0103ng phosphoryl ho\u00e1 nhi\u1ec1u protein kh\u00e1c theo th\u1ee9 t\u1ef1 \u0111\u1ec3 cu\u1ed1i c\u00f9ng cho 2 hi\u1ec7n t\u01b0\u1ee3ng sinh h\u1ecdc ch\u00ednh l\u00e0 t\u1ed5ng h\u1ee3p Aquaporin 2 v\u00e0 chuy\u1ec3n v\u1eadn protein n\u00e0y l\u00ean m\u00e0ng b\u00e0o t\u01b0\u01a1ng. Trong h\u00ecnh 2 l\u00e0 c\u01a1 ch\u1ebf bi\u1ec3u hi\u1ec7n c\u1ee7a k\u00eanh Sodium bi\u1ec3u m\u00f4 (epithelial sodium channel-ENaC), khi n\u00f3i v\u1ec1 c\u00e1c k\u00eanh ion th\u00e0y c\u00f3 nh\u1ea5n m\u1ea1nh k\u00eanh sodium n\u00e0y kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t k\u00eanh ion c\u1ea3m \u1ee9ng \u0111i\u1ec7n th\u1ebf (voltage gated sodium channel) m\u00e0 l\u00e0 m\u1ed9t k\u00eanh th\u1ea5m (leaking sodium channel) H3. SGk (serum-glucocorticoid inducible kinase) l\u00e0 m\u1ed9t men \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Nedd4-2 (neural precursor cell expressed developmentally down-regulated protein 4) m\u1ed9t men ligase g\u1eafn ubiquitin v\u00e0o ENaC ch\u00fang ta bi\u1ebft r\u1eb1ng khi \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi ubiquitin k\u00eanh ion n\u00e0y s\u1ebd b\u1ecb down regulation, aldosterone c\u00f3 ch\u1ee9c n\u0103ng t\u1ea1o ra ENaC \u0111\u1ee9a l\u00ean m\u00e0ng v\u00e0 t\u1ed5ng h\u1ee3p SGk t\u1eeb 2 \u0111o\u1ea1n gene kh\u00e1c nhau. Khi d\u1ea1y c\u00e1c em th\u00e0y kh\u00f4ng mu\u1ed1n l\u00e0m n\u1eb7ng n\u1ec1 n\u00ean kh\u00f4ng nh\u1ea5n m\u1ea1nh th\u00e0y \u0111ang n\u00f3i v\u1ec1 Structural biology ngh\u0129a l\u00e0 c\u1ea5u tr\u00fac t\u01b0\u01a1ng quan v\u1edbi ch\u1ee9c n\u0103ng c\u1ee7a protein. H2 l\u00e0 m\u1ed9t \u0111i\u1ec3n h\u00ecnh c\u1ee7a d\u1ea1ng tr\u00ecnh b\u00e0y th\u00f4ng tin v\u1ea5n \u0111\u1ec1 \u1edf \u0111\u00e2y l\u00e0 ph\u1ea3i ki\u1ec3m so\u00e1t ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 renin-angiotensin-aldosterone cho n\u00ean th\u00e0y c\u00f3 n\u00f3i ph\u1ed1i h\u1ee3p t\u1ed1i \u01b0u cho t\u00e1c d\u1ee5ng c\u1ee7a tolvaptan v\u00e0 conivaptan la c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf men chuy\u1ec3n, k\u1ebf \u0111\u1ebfn l\u00e0 c\u00e1c ch\u1ea5t kho\u00e1 th\u1ee5 th\u1ec3 beta adrenergic 1 k\u00e9m nh\u1ea5t l\u00e0 d\u00f9ng k\u00e8m v\u1edbi thu\u1ed1c kh\u00e1ng aldosterone. T\u00f3m l\u1ea1i, h\u00e3y c\u1ea9n th\u1eadn v\u1edbi th\u00f4ng tin \u0111i\u1ec1u c\u00e1c em c\u1ea7n l\u00e0 tri th\u1ee9c.<\/p>\n
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Nh\u00e2n m\u1ed9t c\u00e2u h\u1ecfi c\u1ee7a m\u1ed9t sinh vi\u00ean Y khoa n\u0103m th\u1ee9 hai :”Con ch\u00e0o th\u1ea7y, L\u00e2u l\u00e2u \u00f4n l\u1ea1i d\u01b0\u1ee3c l\u00fd b\u00e0i c\u0169 con ph\u00e1t hi\u1ec7n m\u1ed9t ch\u1ed7 ch\u01b0a hi\u1ec3u m\u00e0 l\u00fac tr\u01b0\u1edbc kh\u00f4ng th\u1ea5y n\u00ean con xin ph\u00e9p h\u1ecfi th\u1ea7y m\u1ed9t ch\u00fat. H\u1ed3i module tim m\u1ea1ch th\u1ea7y c\u00f3 nh\u1eafc \u0111\u1ebfn thu\u1ed1c l\u1ee3i ti\u1ec3u […]\n","protected":false},"author":1,"featured_media":5370,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5369","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5369"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5369\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5370"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}