{"id":5366,"date":"2019-03-24T01:25:17","date_gmt":"2019-03-23T18:25:17","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5366"},"modified":"2019-03-24T01:25:17","modified_gmt":"2019-03-23T18:25:17","slug":"hien-nay-ly-thuyet-chinh-chi-phoi-suy-nghi-cua-chung-ta-ve-schizophrenia-la-gi","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/hien-nay-ly-thuyet-chinh-chi-phoi-suy-nghi-cua-chung-ta-ve-schizophrenia-la-gi\/","title":{"rendered":"Hi\u1ec7n nay l\u00fd thuy\u1ebft ch\u00ednh chi ph\u1ed1i suy ngh\u0129 c\u1ee7a ch\u00fang ta v\u1ec1 Schizophrenia l\u00e0 g\u00ec ?"},"content":{"rendered":"<p>Tr\u01b0\u1edbc h\u1ebft c\u1ea3m \u01a1n \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 \u0111\u1eb7t v\u1ea5n \u0111\u1ec1 v\u1edbi c\u00e2u c\u00e2u h\u1ecfi n\u00e0y: &#8221; <strong>Hi\u1ec7n nay l\u00fd thuy\u1ebft ch\u00ednh chi ph\u1ed1i suy ngh\u0129 c\u1ee7a ch\u00fang ta v\u1ec1 Schizophrenia l\u00e0 g\u00ec ?&#8221;.\u00a0<\/strong><\/p>\n<p>C\u1ea7n ph\u1ea3i kh\u1eb3ng \u0111\u1ecbnh ch\u00fang ta ch\u1eb3ng c\u00f3 l\u00fd thuy\u1ebft n\u00e0o c\u1ee7a c\u0103n b\u1ec7nh Schizophrenia qu\u00e1i \u00e1c n\u00e0y, tuy nhi\u00ean cho \u0111\u1ebfn nay ch\u1ec9 c\u00f3 2 gi\u1ea3 thuy\u1ebft 1. S\u1ef1 qu\u00e1 ho\u1ea1t c\u1ee7a h\u1ec7 th\u1ed1ng dopaminergic \u0111\u00e3 th\u1ed1ng tr\u1ecb t\u1eeb 50 n\u0103m qua. 2. Gi\u1ea3 thuy\u1ebft v\u1ec1 h\u1ec7 th\u1ed1ng Glutamatergic xu\u1ea5t hi\u1ec7n kho\u1ea3ng 25 n\u0103m v\u1eeba qua. \u0110\u1ed3ng nghi\u1ec7p c\u00f3 th\u1ec3 tham kh\u1ea3o \u00fd ki\u1ebfn t\u1eeb nh\u1eefng nh\u00e0 t\u00e2m th\u1ea7n h\u1ecdc l\u00e2m s\u00e0ng xem sao, t\u00f4i ch\u1ec9 tr\u00ecnh b\u00e0y tr\u00ean quan \u0111i\u1ec3m pharmacology.<\/p>\n<p>Tho\u1ea1t \u0111\u1ea7u m\u1ed9t ph\u00e1t hi\u1ec7n ng\u1eabu nhi\u00ean cho th\u1ea5y d\u1eabn xu\u1ea5t c\u1ee7a phenothiazine l\u00e0 chlorpromazine c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 positive symtoms nh\u01b0 hallucination m\u1eb7c d\u00f9 chlorpromazine \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p v\u1edbi ch\u1ee9c n\u0103ng antihistaminic, m\u00e3i \u0111\u1ebfn th\u1eadp ni\u00ean 70 khi ng\u01b0\u1eddi ta \u0111\u00e3 x\u00e1c d\u1ecbnh c\u00e1c l\u1ed9 tr\u00ecnh t\u00edn hi\u1ec7u dopaminergic \u1edf n\u00e3o v\u00e0 \u0111\u1ed3ng th\u1eddi v\u1edbi s\u1ef1 t\u1ed5ng h\u1ee3p haloperidol ng\u01b0\u1eddi ta m\u1edbi th\u1ea5y s\u00e1ng t\u1ecf vai tr\u00f2 antipsychotic c\u1ee7a 2 thu\u1ed1c n\u00e0y h1 \u0111\u00f3 l\u00e0 l\u00fd do 2 thu\u1ed1c \u0111\u1ea7u ti\u00ean n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 thu\u1ed1c tr\u1ecb t\u00e2m th\u1ea7n th\u1ebf h\u1ec7 1. c\u00e1ch \u0111\u00e2y h\u01a1n 30 n\u0103m ng\u01b0\u1eddi ta d\u1ea7n d\u1ea7n hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 h\u1ec7 th\u1ed1ng glutamatergic h2 ng\u01b0\u1eddi ta m\u1edbi th\u1ea5y l\u00e0 ch\u00ednh th\u1ee5 th\u1ec3 NMDA c\u1ee7a glutamate m\u1edbi l\u00e0 y\u1ebfu t\u1ed1 \u0111i\u1ec1u bi\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1ee5 th\u1ec3 dopaminergic D1 &amp; D5 h3 (D1&amp;D5 l\u00e0 th\u1ee5 th\u1ec3 k\u00edch th\u00edch c\u1ee7a dopamine), h\u01a1n n\u1eefa NMDA d\u01b0\u1edbi s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a D1 c\u00f2n g\u00e2y ph\u00f3ng th\u00edch GABA t\u1ea1i nh\u1eefng FS interneuron (fast spiking interneuron) v\u00e0 vai tr\u00f2 c\u1ee7a th\u1ee5 th\u1ec3 GABAA b\u1eaft \u0111\u1ea7u \u0111\u01b0\u1ee3c ch\u00fa \u00fd h4. Th\u1ee5 th\u1ec3 NMDA h5 cho th\u1ea5y glycine v\u1ed1n l\u00e0 aminoacid ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t neurotransmitter c\u0169ng c\u00f3 vai tr\u00f2 \u0111i\u1ec1u bi\u1ebfn ho\u1ea1t \u0111\u1ed9ng c\u1ee7a NMDA. M\u1eb7t kh\u00e1c NMDA c\u00f2n b\u1ecb k\u00edch ho\u1ea1t b\u1edfi th\u1ee5 th\u1ec3 AMPA c\u1ee7a glutamate h6 ch\u00fa \u00fd l\u00e0 aniracetam m\u1ed9t \u0111\u1ed3ng ph\u00e2n quang h\u1ecdc c\u1ee7a piracetam c\u0169ng c\u00f3 vai tr\u00f2 gi\u00e1n ti\u1ebfp v\u1edbi NMDA. Gi\u1ea3 thuy\u1ebft Glutamatergic n\u1edbi r\u1ed9ng b\u00ecnh di\u1ec7n c\u1ee7a Schizophrenia li\u00ean quan \u0111\u1ebfn nhi\u1ec1u neurotransmitters kh\u00e1c h\u01a1n l\u00e0 dopamine, th\u1eddi gian t\u1edbi c\u00f3 th\u1ec3 b\u1ea1n s\u1ebd th\u1ea5y m\u1ed9t lo\u1ea1t nh\u1eefng thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n m\u1edbi c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng kh\u00f4ng ph\u1ea3i l\u00e0 tr\u00ean dopamine m\u00e0 tr\u00ean th\u1ee5 th\u1ec3 glutamate, glycine, GABA-ergic v\u00e0 c\u1ea3 nh\u1eefng d\u1eabn ch\u1ea5t kh\u00e1c c\u1ee7a aniracetam ch\u1eb3ng c\u00f3 g\u00ec l\u1ea1 c\u1ea3. C\u1ea3m \u01a1n b\u1ea1n \u0111\u00e3 quan t\u00e2m \u0111\u1ebfn c\u00f4ng vi\u1ec7c t\u00f4i l\u00e0m \u0111\u00f3 l\u00e0 m\u1ed9t l\u00e3nh v\u1ef1c ch\u00e1n ng\u1eaft v\u00e0 ch\u1ea3 ai th\u00e8m l\u00e0m c\u1ea3 \u0111\u00f3 l\u00e1 pharmacology.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tr\u01b0\u1edbc h\u1ebft c\u1ea3m \u01a1n \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 \u0111\u1eb7t v\u1ea5n \u0111\u1ec1 v\u1edbi c\u00e2u c\u00e2u h\u1ecfi n\u00e0y: &#8221; Hi\u1ec7n nay l\u00fd thuy\u1ebft ch\u00ednh chi ph\u1ed1i suy ngh\u0129 c\u1ee7a ch\u00fang ta v\u1ec1 Schizophrenia l\u00e0 g\u00ec ?&#8221;.\u00a0 C\u1ea7n ph\u1ea3i kh\u1eb3ng \u0111\u1ecbnh ch\u00fang ta ch\u1eb3ng c\u00f3 l\u00fd thuy\u1ebft n\u00e0o c\u1ee7a c\u0103n b\u1ec7nh Schizophrenia qu\u00e1i \u00e1c n\u00e0y, tuy nhi\u00ean cho \u0111\u1ebfn [&#8230;]\n","protected":false},"author":1,"featured_media":5367,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5366","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5366"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5366\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5367"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}