{"id":5363,"date":"2019-03-24T01:20:56","date_gmt":"2019-03-23T18:20:56","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5363"},"modified":"2019-03-24T01:20:56","modified_gmt":"2019-03-23T18:20:56","slug":"quantum-pharmacology-la-gi-co-ich-loi-gi-khong","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/quantum-pharmacology-la-gi-co-ich-loi-gi-khong\/","title":{"rendered":"Quantum Pharmacology l\u00e0 g\u00ec ? C\u00f3 \u00edch l\u1ee3i g\u00ec kh\u00f4ng ?"},"content":{"rendered":"<p>T\u00e0o lao D\u01b0\u1ee3c l\u00fd h\u1ecdc : &#8221; <strong>Nh\u1edd th\u1ea7y gi\u1ea3i th\u00edch quantum pharmacology l\u00e0 g\u00ec ? C\u00f3 \u00edch l\u1ee3i g\u00ec kh\u00f4ng<\/strong> ? N\u1ebfu c\u00f3 xin th\u1ea7y cho v\u00ed d\u1ee5.&#8221;<\/p>\n<p>Tr\u01b0\u1edbc \u0111\u00e2y khi gi\u1ea3ng b\u00e0i cho c\u00e1c b\u1ea1n t\u00f4i ch\u1eb3ng bao gi\u1edd n\u00f3i v\u1ec1 kh\u00eda c\u1ea1nh n\u00e0y nh\u01b0ng t\u00f4i c\u00f3 nh\u1eafc nh\u1edf c\u00e1c b\u1ea1n nh\u1eefng g\u00ec kh\u00f4ng n\u00f3i t\u1edbi trong nh\u00e0 tr\u01b0\u1eddng kh\u00f4ng c\u00f3 ngh\u0129a \u0111\u00f3 l\u00e0 nh\u1eefng v\u1ea5n \u0111\u1ec1 kh\u00f4ng c\u00f3 trong cu\u1ed9c \u0111\u1eddi n\u00e0y, ch\u1ec9 m\u1edbi d\u1ea1y Molecular pharmacology \u0111\u00e3 b\u1ecb coi l\u00e0 k\u1ebb d\u1ecb gi\u00e1o n\u1ebfu c\u00f2n d\u1ea1i d\u1ed9t n\u00f3i v\u1ec1 quantum pharmacology ch\u1eafc t\u00f4i s\u1ebd \u0111\u01b0\u1ee3c g\u1eedi v\u00e0o b\u1ec7nh vi\u1ec7n t\u00e2m th\u1ea7n \u0111\u1ec3 gi\u00e1m \u0111\u1ecbnh.<\/p>\n<p>Tr\u01b0\u1edbc h\u1ebft ta h\u00e3y xem v\u1ec1 h\u1ecdc thuy\u1ebft th\u1ee5 th\u1ec3 ( Receptor theory) c\u00f3 ph\u1ea3i ch\u00fang ta \u0111\u1ec1u bi\u1ebft m\u1ed9t ligand hay thu\u1ed1c mu\u1ed1n c\u00f3 t\u00e1c \u0111\u1ed9ng tr\u01b0\u1edbc ti\u00ean ph\u1ea3i g\u1eafn v\u00e0o th\u1ee5 th\u1ec3. Th\u1ef1c ch\u1ea5t \u0111i\u1ec1u n\u00e0y l\u00e0 g\u00ec ? C\u00f3 ph\u1ea3i l\u1ef1c n\u1ed1i h\u00f3a h\u1ecdc d\u00f9 l\u00e0 l\u1ef1c n\u1ed1i y\u1ebfu v\u1eabn d\u1ef1a tr\u00ean c\u01a1 h\u1ecdc h\u1ecdc Newton ? Stereochemistry cho ta bi\u1ebft v\u1ecb tr\u00ed n\u1ed1i k\u1ebft c\u1ee7a m\u1ed9t thu\u1ed1c hay ligand c\u00e1i g\u1ecdi l\u00e0 pharmacophore ch\u1eb3ng qua l\u00e0 v\u1ecb tr\u00ed n\u1ed1i k\u1ebft m\u00e0 l\u1ef1c n\u1ed1i k\u1ebft ch\u00ednh l\u00e0 l\u1ef1c h\u1ea5p d\u1eabn c\u1ee7a Newton. h1. C\u00f3 ph\u1ea3i n\u1ebfu nh\u01b0 th\u1ebf th\u00ec 2 ph\u00e2n t\u1eed c\u00f3 pharmacophore nh\u01b0 nhau s\u1ebd c\u00f3 t\u00e1c \u0111\u1ed9ng nh\u01b0 nhau \u0111i\u1ec1u n\u00e0y s\u1ebd d\u1eabn \u0111\u1ebfn m\u1ed9t h\u1ec7 lu\u1eadn l\u00e0 t\u1ea5t c\u1ea3 thu\u1ed1c betablocker \u0111\u1ebfu t\u00e1c \u0111\u1ed9ng nh\u01b0 nhau v\u00ec c\u00f3 pharmacophore nh\u01b0 nhau ? C\u00e1c b\u1ea1n bi\u1ebft r\u1ed3i h\u1ecdc thuy\u1ebft th\u1ee5 th\u1ec3 s\u1ebd ho\u00e0n to\u00e0n b\u1ea5t l\u1ef1c trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y h\u00e3y nh\u1edb l\u1ea1i khi Sir W. Black t\u1ed5ng h\u1ee3p ph\u00e2n t\u1eed betablocker \u0111\u1ea7u ti\u00ean l\u00e0 propranolol ch\u1ea5t n\u00e0y kh\u00f3a c\u1ea3 2 lo\u1ea1i th\u1ee5 th\u1ec3 beta v\u1ec1 sau ng\u01b0\u1eddi ta t\u1ed5ng h\u1ee3p nhi\u1ebfu betablockers c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc tr\u00ean th\u1ee5 th\u1ec3 beta1 v\u00e0 c\u1ea3 lo\u1ea1i kh\u00f3a c\u1ea3 th\u1ee5 th\u1ec3 Alpha l\u1eabn beta. \u0110i\u1ec1u qu\u00e1i qu\u1ef7 g\u00ec \u0111ang x\u1ea3y ra c\u00e1c b\u1ea1n ? Th\u1eadt ra d\u00f9 t\u1ea5t c\u1ea3 nh\u1ef1ng ch\u1ea5t n\u00e0y c\u00f3 pharmacophore g\u1ea7n t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nhau nh\u01b0ng ch\u00ednh ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a ph\u00e2n t\u1eed t\u1ea1o ra t\u00e1c \u0111\u1ed9ng kh\u00e1c nhau \u0111\u00f4i ch\u00fat m\u00e0 ph\u1ea7n c\u00f2n l\u1ea1i n\u00e0y tr\u00ean t\u1eebng ph\u00e2n t\u1eed thu\u1ed1c c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng kh\u00e1c nhau nh\u01b0 v\u1eady ph\u1ea3i ch\u0103ng ch\u00ednh kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed quy\u1ebft \u0111\u1ecbnh t\u00e1c \u0111\u1ed9ng kh\u00e1c bi\u1ec7t c\u1ee7a t\u1eebng ph\u00e2n t\u1eed thu\u1ed1c ? C\u00e2u h\u1ecfi n\u00e0y d\u1eabn t\u1edbi b\u1ebf t\u1eafc m\u1ed9t th\u1eddi gian d\u00e0i. B\u00e2y gi\u1edd c\u00e1c b\u1ea1n th\u1eed nh\u00ecn xem 2 ph\u00e2n t\u1eed Benzaldehyde ( m\u00f9i h\u01b0\u01a1ng c\u1ee7a h\u1ea1t h\u1ea1nh nh\u00e2n) &amp; Cyanide potassium d\u1eabn xu\u1ea5t t\u1eeb Cyanhydric acid ( thu\u1ed1c \u0111\u1ed9c m\u00e0 c\u00e1c \u0111i\u1ec7p vi\u00ean d\u00f9ng \u0111\u1ec3 t\u1ef1 t\u1eed r\u1ea5t ch\u1eafc \u0103n) h2 &amp; h3 c\u1ea3 2 ch\u1ea5t n\u00e0y \u0111\u1ec1u c\u00f3 m\u00f9i h\u1ea1nh nh\u00e2n nh\u01b0 nhau. R\u00f5 r\u00e0ng l\u00e0 2 ch\u1ea5t c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng kh\u00e1c nhau v\u00ec sao l\u1ea1i c\u00f3 m\u00f9i nh\u01b0 nhau khi g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 kh\u1ee9u gi\u00e1c (odor receptor) ? M\u1ed9t b\u1ebf t\u1eafc n\u1eefa n\u1ebfu h\u1ecdc thuy\u1ebft th\u1ee5 th\u1ec3 ch\u1ec9 d\u1ef1a v\u00e0o c\u01a1 h\u1ecdc Newton, nh\u1eefng kh\u1ea3o s\u00e1t chi ti\u1ebft cho th\u1ea5y c\u1ea3 2 ch\u1ea5t n\u00e0y khi g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 cho m\u1ed9t t\u1ea7n s\u1ed1 dao \u0111\u1ed9ng (oscilatory frequency) nh\u01b0 nhau v\u00ec th\u1ebf cho c\u1ea3m nh\u1eadn m\u00f9i nh\u01b0 nhau. Ng\u01b0\u1eddi ta l\u00e0m l\u1ea1i th\u1ef1c nghi\u1ec7m v\u1edbi v\u1edbi acid cyanhydrique nh\u01b0ng Hydrogen \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng Deuterium c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng g\u1ea5p \u0111\u00f4i Hydrogen \u0111\u1ec3 thay \u0111\u1ed5i t\u1ea7n s\u1ed1 dao \u0111\u1ed9ng c\u1ee7a li\u00ean k\u1ebft c\u1ecdng h\u00f3a tr\u1ecb gi\u1eefa H-C b\u00e2y gi\u1edd l\u00e0 D-C . C\u00e1c b\u1ea1n bi\u1ebft \u0111i\u1ec1u g\u00ed x\u1ea3y ra kh\u00f4ng ng\u01b0\u1eddi ta kh\u00f4ng c\u00f2n c\u1ea3m nh\u1eadn \u0111\u01b0\u1ee3c m\u00f9i h\u1ea1nh nh\u00e2n. C\u00e1i g\u00ec v\u1eeba g\u1eafn v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng (h\u1ea1t) v\u1eeba g\u1eafn v\u1edbi dao \u0111\u1ed9ng (s\u00f3ng ) n\u1ebfu kh\u00f4ng ph\u1ea3i l\u00e0 c\u01a1 h\u1ecdc l\u01b0\u1ee3ng t\u1eed th\u00ec l\u00e0 c\u00e1i qu\u00e1i g\u00ec c\u00e1c b\u1ea1n?<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u00e0o lao D\u01b0\u1ee3c l\u00fd h\u1ecdc : &#8221; Nh\u1edd th\u1ea7y gi\u1ea3i th\u00edch quantum pharmacology l\u00e0 g\u00ec ? C\u00f3 \u00edch l\u1ee3i g\u00ec kh\u00f4ng ? N\u1ebfu c\u00f3 xin th\u1ea7y cho v\u00ed d\u1ee5.&#8221; Tr\u01b0\u1edbc \u0111\u00e2y khi gi\u1ea3ng b\u00e0i cho c\u00e1c b\u1ea1n t\u00f4i ch\u1eb3ng bao gi\u1edd n\u00f3i v\u1ec1 kh\u00eda c\u1ea1nh n\u00e0y nh\u01b0ng t\u00f4i c\u00f3 nh\u1eafc nh\u1edf c\u00e1c b\u1ea1n nh\u1eefng g\u00ec [&#8230;]\n","protected":false},"author":1,"featured_media":5364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5363","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5363"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5363\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5364"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}