{"id":5360,"date":"2019-03-24T01:16:51","date_gmt":"2019-03-23T18:16:51","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5360"},"modified":"2019-03-24T01:16:51","modified_gmt":"2019-03-23T18:16:51","slug":"fda-chuan-thuan-brexanolone-cho-dieu-tri-tram-cam-sau-sinh","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/fda-chuan-thuan-brexanolone-cho-dieu-tri-tram-cam-sau-sinh\/","title":{"rendered":"FDA chu\u1ea9n thu\u1eadn Brexanolone cho \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m sau sinh"},"content":{"rendered":"<p>T\u00e0o lao D\u01b0\u1ee3c l\u00fd h\u1ecdc th\u1ea7n kinh: &#8221; <strong>th\u01b0a th\u1ea7y FDA v\u1eeba chu\u1ea9n thu\u1eadn Brexanolone cho tr\u1ea7m c\u1ea3m sau sinh tr\u01b0\u1edbc \u0111\u00e2y kh\u00f4ng bao gi\u1edd nghe th\u1ea7y n\u00f3i \u0111i\u1ec1u n\u00e0y. Th\u1ea7y c\u00f3 \u00fd ki\u1ebfn g\u00ec kh\u00f4ng<\/strong> ?&#8221;<\/p>\n<p>Th\u1ea7y th\u1ea5y tr\u1ea7m c\u1ea3m v\u00ec c\u00e2u h\u1ecfi c\u1ee7a em, th\u1ea7y c\u0169ng ch\u1eafc ch\u1eafn em \u0111\u00e3 qu\u00ean s\u1ea1ch nh\u1eefng g\u00ec \u0111\u00e3 h\u1ecdc v\u1ec1 chemistry, Molecular biology &amp; Neuropharmacology.<\/p>\n<p>Tr\u01b0\u1edbc h\u1ebft brexanolone l\u00e0 g\u00ec?h1 ch\u1ea5t n\u00e0y c\u00f2n c\u00f3 t\u00ean h\u00f3a h\u1ecdc l\u00e0 Allopregnanolone ( Allo: kh\u00e1c) c\u00f3 ph\u1ea3i tr\u00ean b\u00ecnh di\u1ec7n h\u00f3a h\u1ecdc Allo \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 ch\u1ec9 m\u1ed9t ch\u1ea5t isomer ? Em \u0111\u00e3 qu\u00ean h\u00f3a h\u1ecdc ? Th\u1ee9 hai t\u00e1c \u0111\u1ed9ng c\u1ee7a ch\u1ea5t n\u00e0y l\u00e0 Positive allosteric modulation ( PAM- ch\u1ea5t \u0111i\u1ec1u bi\u1ebfn d\u01b0\u01a1ng t\u1ea1i m\u1ed9t v\u1ecb tr\u00ed kh\u00e1c ) \u0111\u1ebfn \u0111\u00e2y c\u00f3 ph\u1ea3i em \u0111\u00e3 qu\u00ean c\u1ea3 Molecular biology l\u1eabn Pharmacology ? C\u00f3 ph\u1ea3i c\u00e1c Benzodiazepines l\u00e0 PAM c\u1ee7a th\u1ee5 th\u1ec3 GABAA trong khi Flumazenil l\u00e0 NAM (negative allosteric modulator ) c\u0169ng tr\u00ean th\u1ee5 th\u1ec3 GABAA ? C\u00f3 ph\u1ea3i t\u1ea5t c\u1ea3 thu\u1ed1c ng\u1ee7-an th\u1ea7n k\u1ec3 c\u1ea3 thu\u1ed1c m\u00ea \u0111\u1ec1u l\u00e0 PAM tr\u00ean th\u1ee5 th\u1ec3 GABAA ? h2 &amp; h3. Pregnanolone v\u00e0 allopregnanolone l\u00e0 nh\u1eefng neurosteroid transmitters nh\u01b0 v\u1eady ch\u00fang \u0111\u00e3 c\u00f3 binding sites t\u1eeb thu\u1edf khai thi\u00ean l\u1eadp \u0111\u1ecba tr\u00ean th\u1ee5 th\u1ec3 GABAA h4. \u0110\u01b0\u1eddng chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c steroid-transmitters n\u00e0y \u1edf Astrocytes \u0111\u00e3 bi\u1ebft t\u1eeb 30 n\u0103m nay h5 &amp; h6. Brexanolone t\u00e1c \u0111\u1ed9ng tr\u00ean th\u1ee5 th\u1ec3 GABAA ph\u1ea3i \u0111\u00e2u l\u00e0 chuy\u1ec7n tr\u00ean tr\u1eddi r\u01a1i xu\u1ed1ng h7 ? Trong hai t\u00ecnh hu\u1ed1ng b\u1ec7nh l\u00fd tr\u1ea7m c\u1ea3m sau sinh (post partum depression- PPD) &amp; r\u1ed1i lo\u1ea1n c\u1ea3m x\u00fac sau ch\u1ea5n th\u01b0\u01a1ng (post traumatic stress disorder &#8211; PTSD ) ng\u01b0\u1eddi ta th\u1ea5y c\u00f3 s\u1ef1 thi\u1ebfu h\u1ee5t tr\u1ea7m tr\u1ecdng pregnanolone do \u0111\u00f3 allopregnanolone ch\u00ednh l\u00e0 y\u1ebfu t\u1ed1 ngo\u1ea1i sinh \u0111\u01b0\u1ee3c tr\u00e1m v\u00e0o khi\u1ebfm khuy\u1ebft c\u1ee7a pregnanolone. Thu\u1ed1c l\u00e0 m\u1ed9t ph\u00e2n t\u1eed kh\u00f4ng ch\u1ec9 l\u00e0 m\u1ed9t c\u00e1i t\u00ean.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u00e0o lao D\u01b0\u1ee3c l\u00fd h\u1ecdc th\u1ea7n kinh: &#8221; th\u01b0a th\u1ea7y FDA v\u1eeba chu\u1ea9n thu\u1eadn Brexanolone cho tr\u1ea7m c\u1ea3m sau sinh tr\u01b0\u1edbc \u0111\u00e2y kh\u00f4ng bao gi\u1edd nghe th\u1ea7y n\u00f3i \u0111i\u1ec1u n\u00e0y. Th\u1ea7y c\u00f3 \u00fd ki\u1ebfn g\u00ec kh\u00f4ng ?&#8221; Th\u1ea7y th\u1ea5y tr\u1ea7m c\u1ea3m v\u00ec c\u00e2u h\u1ecfi c\u1ee7a em, th\u1ea7y c\u0169ng ch\u1eafc ch\u1eafn em \u0111\u00e3 qu\u00ean s\u1ea1ch nh\u1eefng [&#8230;]\n","protected":false},"author":1,"featured_media":5361,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5360","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5360"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5360\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5361"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}